MX367562B - Composicion farmaceutica que contiene portador de oxigeno a base de hemoglobina para tratamiento dirigido a cancer y prevencion de recurrencia de cancer. - Google Patents
Composicion farmaceutica que contiene portador de oxigeno a base de hemoglobina para tratamiento dirigido a cancer y prevencion de recurrencia de cancer.Info
- Publication number
- MX367562B MX367562B MX2015004512A MX2015004512A MX367562B MX 367562 B MX367562 B MX 367562B MX 2015004512 A MX2015004512 A MX 2015004512A MX 2015004512 A MX2015004512 A MX 2015004512A MX 367562 B MX367562 B MX 367562B
- Authority
- MX
- Mexico
- Prior art keywords
- hemoglobin
- oxygen carrier
- based oxygen
- pharmaceutical composition
- cancer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención provee una composición farmacéutica que contiene un portador de oxígeno basado en hemoglobina para tratar cáncer, prevenir la recurrencia y metástasis de tumor canceroso. La composición se puede utilizar sola o en combinación con por lo menos un agente quimioterapéutico tal como 5FU, Bortezomib, doxorrubicina, cisplatino, o cualquier combinación de los mismos. El portador de oxígeno basado en hemoglobina en la composición es capaz de elegir como blanco un receptor de superficie expresado en células cancerosas y facilitar la absorción tanto del portador de oxígeno basado en hemoglobina como del agente quimioterapéutico por parte de las células cancerosas a través de un mecanismo mediado por receptor. El portador de oxígeno basado en hemoglobina inhibe la expresión de elementos de respuesta hipóxicos tales como HIF1a, VEGF, ET1, VHL, etc. La composición farmacéutica de la presente invención también es útil para inducir la apoptosis o muerte celular de un tipo de células auto20 renovadoras y células iniciadoras de tumor llamadas células madre de cáncer las cuales están localizadas en el nicho hipóxico de un tumor canceroso.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261712853P | 2012-10-12 | 2012-10-12 | |
US13/713,031 US20140106004A1 (en) | 2012-10-12 | 2012-12-13 | Hemoglobin-based oxygen carrier-containing pharmaceutical composition for cancer targeting treatment and prevention of cancer recurrence |
PCT/US2013/064418 WO2014059199A1 (en) | 2012-10-12 | 2013-10-11 | Hemoglobin-based oxygen carrier-containing pharmaceutical composition for cancer targeting treatment and prevention of cancer recurrence |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015004512A MX2015004512A (es) | 2015-12-01 |
MX367562B true MX367562B (es) | 2019-08-27 |
Family
ID=50475529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015004512A MX367562B (es) | 2012-10-12 | 2013-10-11 | Composicion farmaceutica que contiene portador de oxigeno a base de hemoglobina para tratamiento dirigido a cancer y prevencion de recurrencia de cancer. |
Country Status (22)
Country | Link |
---|---|
US (2) | US20140106004A1 (es) |
EP (1) | EP2906222A4 (es) |
JP (1) | JP6113850B2 (es) |
KR (1) | KR20150065881A (es) |
CN (1) | CN104717966B (es) |
AP (1) | AP2015008315A0 (es) |
AR (1) | AR093023A1 (es) |
AU (1) | AU2013329121B2 (es) |
BR (1) | BR112015007475A2 (es) |
CA (1) | CA2884521C (es) |
CL (1) | CL2015000897A1 (es) |
EA (1) | EA201500301A1 (es) |
HK (1) | HK1206281A1 (es) |
IL (1) | IL237763A (es) |
MA (1) | MA37994A2 (es) |
MX (1) | MX367562B (es) |
PH (1) | PH12015500562B1 (es) |
SG (3) | SG11201502133SA (es) |
TW (1) | TW201414489A (es) |
UY (1) | UY35082A (es) |
WO (1) | WO2014059199A1 (es) |
ZA (1) | ZA201501949B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112015028340A2 (pt) * | 2013-05-13 | 2017-09-19 | Vision Global Holdings Ltd | Composições farmacêuticas envolvendo agente terapêutico baseado em hemoglobina modificada para direcionamento e tratamento de câncer e diagnóstico por imagem e um método para o preparo do agente terapêutico |
WO2015192020A1 (en) | 2014-06-13 | 2015-12-17 | Children's Medical Center Corporation | Products and methods to isolate mitochondria |
US9814759B2 (en) * | 2014-07-02 | 2017-11-14 | Cheer Global Ltd. | Pharmaceutical composition comprising recombinant hemoglobin protein or subunit-based therapeutic agent for cancer targeting treatment |
WO2017095944A1 (en) | 2015-11-30 | 2017-06-08 | Flagship Pioneering, Inc. | Methods and compositions relating to chondrisomes from blood products |
JP7185527B2 (ja) | 2016-01-15 | 2022-12-07 | ザ チルドレンズ メディカル センター コーポレーション | ミトコンドリアおよび組み合わされたミトコンドリア剤の治療的使用 |
CA3028589A1 (en) * | 2016-06-21 | 2017-12-28 | Therapure Biopharma Inc. | Hemoglobin-targeted drug delivery for the treatment of cancer |
CA3060509A1 (en) * | 2017-04-21 | 2018-10-25 | Federica Sotgia | Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy |
EP3612187B1 (en) | 2017-04-21 | 2022-04-13 | Lunella Biotech, Inc. | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
MX2019013735A (es) | 2017-05-19 | 2020-01-15 | Lunella Biotech Inc | Antimitoscinas: inhibidores especificos de la biogenesis mitocondrial para erradicar celulas madre cancerosas. |
CU20190106A7 (es) | 2017-06-26 | 2020-11-30 | Lunella Biotech Inc | Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas |
WO2019124423A1 (ja) * | 2017-12-19 | 2019-06-27 | 国立大学法人 岡山大学 | がんの進行抑制、治療、予防及び/又は再発予防剤 |
CN111558032B (zh) * | 2020-05-19 | 2023-08-22 | 中国科学院宁波材料技术与工程研究所 | 一种蛋白纳米药物及其制备方法与应用 |
CN114344263B (zh) * | 2022-02-21 | 2023-08-01 | 杭州普略生物科技有限公司 | 一种用于靶向巨噬细胞增强肿瘤治疗效果的纳米蛋白胶束及其制备方法和应用 |
KR20230141306A (ko) | 2022-03-31 | 2023-10-10 | 충남대학교산학협력단 | 저산소증 완화능을 갖는 페길화 헤모글로빈 나노클러스터를 포함하는 항암 화학-광역학 치료용 조성물 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5478806A (en) * | 1989-11-22 | 1995-12-26 | Enzon, Inc. | Enhancement of antitumor therapy with hemoglobin-based conjugates |
CA2236344A1 (en) * | 1998-04-30 | 1999-10-30 | Hemosol Inc. | Hemoglobin-haptoglobin complexes |
US20050164915A1 (en) * | 2002-04-01 | 2005-07-28 | Sangart, Inc. | Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
CN1741821B (zh) * | 2002-10-29 | 2011-08-10 | 恩根尼公司 | 用于癌症治疗的组合物 |
WO2010085654A1 (en) * | 2009-01-23 | 2010-07-29 | Cancer Research Technology Limited | Hedgehog pathway inhibitors |
DK2440239T3 (en) * | 2009-06-09 | 2017-10-16 | Prolong Pharmaceuticals Llc | HEMOGLOBIN FORMATIONS |
EP2451459B1 (en) * | 2009-07-07 | 2017-11-22 | Normoxys, Inc. | Method of reducing multi-drug resistance using inositol tripyrophosphate |
US8808748B2 (en) * | 2010-04-20 | 2014-08-19 | Vindico NanoBio Technology Inc. | Biodegradable nanoparticles as novel hemoglobin-based oxygen carriers and methods of using the same |
US7989593B1 (en) * | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
US20110319332A1 (en) * | 2010-06-23 | 2011-12-29 | Bing Lou Wong | Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition |
US8048856B1 (en) * | 2010-06-23 | 2011-11-01 | Billion King, Ltd. | Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition |
US7932356B1 (en) * | 2010-06-23 | 2011-04-26 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition |
-
2012
- 2012-12-13 US US13/713,031 patent/US20140106004A1/en not_active Abandoned
-
2013
- 2013-10-11 CN CN201380053346.1A patent/CN104717966B/zh active Active
- 2013-10-11 EA EA201500301A patent/EA201500301A1/ru unknown
- 2013-10-11 MA MA37994A patent/MA37994A2/fr unknown
- 2013-10-11 MX MX2015004512A patent/MX367562B/es active IP Right Grant
- 2013-10-11 AP AP2015008315A patent/AP2015008315A0/xx unknown
- 2013-10-11 KR KR1020157012185A patent/KR20150065881A/ko active Search and Examination
- 2013-10-11 SG SG11201502133SA patent/SG11201502133SA/en unknown
- 2013-10-11 AU AU2013329121A patent/AU2013329121B2/en not_active Ceased
- 2013-10-11 SG SG10201607846PA patent/SG10201607846PA/en unknown
- 2013-10-11 BR BR112015007475A patent/BR112015007475A2/pt not_active IP Right Cessation
- 2013-10-11 SG SG10201608747RA patent/SG10201608747RA/en unknown
- 2013-10-11 EP EP13844670.3A patent/EP2906222A4/en not_active Ceased
- 2013-10-11 WO PCT/US2013/064418 patent/WO2014059199A1/en active Application Filing
- 2013-10-11 CA CA2884521A patent/CA2884521C/en active Active
- 2013-10-11 JP JP2015536905A patent/JP6113850B2/ja not_active Expired - Fee Related
- 2013-10-14 UY UY35082A patent/UY35082A/es not_active Application Discontinuation
- 2013-10-14 TW TW102136951A patent/TW201414489A/zh unknown
- 2013-10-15 AR ARP130103741A patent/AR093023A1/es unknown
-
2014
- 2014-06-19 US US14/308,725 patent/US9056098B2/en active Active
-
2015
- 2015-03-16 PH PH12015500562A patent/PH12015500562B1/en unknown
- 2015-03-16 IL IL237763A patent/IL237763A/en active IP Right Grant
- 2015-03-20 ZA ZA2015/01949A patent/ZA201501949B/en unknown
- 2015-04-09 CL CL2015000897A patent/CL2015000897A1/es unknown
- 2015-07-24 HK HK15107105.0A patent/HK1206281A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12015500562A1 (en) | Hemoglobin-based oxygen carrier-containing pharmaceutical composition for cancer targeting treatment and prevention of cancer recurrence | |
WO2013093508A3 (en) | Wnt pathway inhibitors | |
PH12015502536B1 (en) | Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging | |
CL2007002994A1 (es) | Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros. | |
WO2015154064A3 (en) | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer | |
CL2015000337A1 (es) | Compuestos derivados de 2,3-benzodiazepinas sustituidas; compuestos intermediarios; formulacion farmaceutica; uso para la profilaxis y/o terapia de trastornos tumorales tales como leucemias, carcinoma de prostata, carcinoma de mama, melanomas, entre otros y control de fertilidad masculina. | |
MX2014001218A (es) | Tratamiento de cancer de mama. | |
AR082340A1 (es) | Metodos y composiciones para la terapia del cancer de higado | |
MX365392B (es) | Composición de combinación de pac-1 y doxorrubicina. | |
MX335971B (es) | Ligandos sigma para la revolucion y/o el tratamiento de la emesis inducida por quimioterapia o radioterapia. | |
MX2015001551A (es) | Compuestos y composiciones activadoras de enzima. | |
BR112015005443A2 (pt) | tratamento combinado com fármaco interferente de netrina-1 e fármaco quimioterápico | |
MX2014010714A (es) | Terapia de combinacion de procaspasa para gliobastoma. | |
WO2013131089A3 (en) | Potent anticancer activity via dual compound activation | |
WO2014087240A3 (en) | Compositions, methods and kits for preventing, reducing, and eliminating cancer metastasis | |
MY186484A (en) | Hemoglobin-based oxygen carrier-containing pharmaceutical composition for cancer targeting treatment and prevention of cancer recurrence | |
WO2013013075A3 (en) | Peptides shared among lethal cancers and therapeutic compositions comprising said peptides | |
GR20090100483A (el) | Πρωτοτυπη συνεργειακη αντικαρκινικη δραστικοτητα των ν-στεαρουλ και ν-παλμιτουλ ντοπαμιδιων | |
野尻圭一郎 | Sorafenib and TRAIL have synergistic effect on hepatocellular carcinoma | |
AR087392A1 (es) | Combinacion antitumoral que comprende ombrabulina y cisplatino, asociada a radioterapia | |
CL2011001316A1 (es) | Uso de una combinacion que comprende ave8062 o una sal del mismo y docetaxel para preparar un medicamento util en el tratamiento de tumores solidos. | |
TH156797A (th) | การใช้ของ 3-(r)-[3-(2-เมทอกซีเฟนิลไทโอ)-2-(s)-เมทิล-โพรพิล]แอมิโน-3,4-ไดไฮโดร-2h-1,5-เบนโซซาไทอีพีนสำหรับการบำบัดมะเร็งและโดยเฉพาะอย่างยิ่งสำหรับการป้องกันและ/หรือการบำบัดการแพร่กระจายของมะเร็ง | |
GB2519004A (en) | Quinone compounds and their uses for the treatment of cancer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |