MX367343B - Sintesis de poloxameros y poloxaminas etilenicamente insaturados polimerizables de radical libre. - Google Patents
Sintesis de poloxameros y poloxaminas etilenicamente insaturados polimerizables de radical libre.Info
- Publication number
- MX367343B MX367343B MX2015016562A MX2015016562A MX367343B MX 367343 B MX367343 B MX 367343B MX 2015016562 A MX2015016562 A MX 2015016562A MX 2015016562 A MX2015016562 A MX 2015016562A MX 367343 B MX367343 B MX 367343B
- Authority
- MX
- Mexico
- Prior art keywords
- poloxamines
- free radical
- poloxamers
- polmerizable
- synthesis
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 229920001983 poloxamer Polymers 0.000 title abstract 2
- 229920001987 poloxamine Polymers 0.000 title abstract 2
- 150000003254 radicals Chemical class 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000012535 impurity Substances 0.000 abstract 2
- 229910002056 binary alloy Inorganic materials 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/06—Polymers provided for in subclass C08G
- C08F290/062—Polyethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/337—Polymers modified by chemical after-treatment with organic compounds containing other elements
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/48—Polymers modified by chemical after-treatment
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Polyethers (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Abstract
La presente invención se refiere a un nuevo método sintético para formar poloxámeros y poloxaminas funcionalizadas terminales finales polimerizables de radical libre en lotes a escala comercial los cuales usan un sistema binario de inhibidores para eliminar la formación de impurezas de alto peso molecular. También se ha descubierto de manera sorprendente que las impurezas inorgánicas formadas durante el proceso sintético a escala comercial son removidas por el uso de materiales de resina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361836471P | 2013-06-18 | 2013-06-18 | |
| PCT/US2014/042951 WO2014205084A1 (en) | 2013-06-18 | 2014-06-18 | Synthesis of free radical polmerizable ethylenically unsaturated poloxamers and poloxamines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015016562A MX2015016562A (es) | 2016-03-31 |
| MX367343B true MX367343B (es) | 2019-08-15 |
Family
ID=51168448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015016562A MX367343B (es) | 2013-06-18 | 2014-06-18 | Sintesis de poloxameros y poloxaminas etilenicamente insaturados polimerizables de radical libre. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9309357B2 (es) |
| EP (1) | EP3010946B1 (es) |
| JP (1) | JP6159025B2 (es) |
| KR (1) | KR101767852B1 (es) |
| CN (1) | CN105308080B (es) |
| AU (1) | AU2014281549B2 (es) |
| BR (1) | BR112015031653A2 (es) |
| CA (1) | CA2914135C (es) |
| ES (1) | ES2659759T3 (es) |
| MX (1) | MX367343B (es) |
| PL (1) | PL3010946T3 (es) |
| WO (1) | WO2014205084A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190292362A1 (en) * | 2016-06-29 | 2019-09-26 | Holland Novochem Technical Coatings B.V. | Catalytically Active Radical Scavengers Based on Benzylic and Allylic Functionalities |
| CN112312791B (zh) | 2018-06-27 | 2023-05-26 | 鲍希与洛姆伯股份有限公司 | 包装溶液 |
| CN111285845B (zh) * | 2020-02-11 | 2021-01-01 | 深圳厚存纳米药业有限公司 | 末端官能团化的泊洛沙胺衍生物 |
| CA3190544A1 (en) | 2020-08-10 | 2022-02-17 | Bausch + Lomb Ireland Limited | Packaging solutions |
| MX2023010372A (es) | 2021-03-10 | 2023-09-12 | Bausch & Lomb Ireland Ltd | Soluciones oftálmicas. |
| US12012238B2 (en) | 2021-05-26 | 2024-06-18 | Bausch + Lomb Ireland Limited | Packaging solutions |
| CN115616096A (zh) * | 2021-07-16 | 2023-01-17 | 张家港市国泰华荣化工新材料有限公司 | 有机硅产品中bht和mehq的测定方法 |
| US20230159202A1 (en) | 2021-11-23 | 2023-05-25 | Bausch + Lomb Ireland Limited | Method for making a preservative-free packaged ophthalmic device product |
| US12510690B2 (en) | 2022-02-24 | 2025-12-30 | Bausch + Lomb Ireland Limited | Ophthalmic devices |
| CN114948795B (zh) * | 2022-07-08 | 2023-09-08 | 上海信悉智能技术有限公司 | 一种温敏感凝胶面膜液及其制备方法 |
| US20240166971A1 (en) | 2022-10-26 | 2024-05-23 | Bausch + Lomb Ireland Limited | Contact lens treating solution |
| US20240218291A1 (en) | 2022-12-22 | 2024-07-04 | Bausch + Lomb Ireland Limited | Contact lens treating solution |
| US20240317988A1 (en) | 2023-03-22 | 2024-09-26 | Bausch + Lomb Ireland Limited | Monofunctional silicone monomers and silicone hydrogels formed therefrom |
| US20250040673A1 (en) | 2023-07-28 | 2025-02-06 | Bausch + Lomb Ireland Limited | Packaging solutions |
| US20260169192A1 (en) | 2024-12-17 | 2026-06-18 | Bausch + Lomb Ireland Limited | Monofunctional urea-based organosilicon monomers and silicone hydrogels formed therefrom |
| US20260167781A1 (en) | 2024-12-17 | 2026-06-18 | Bausch + Lomb Ireland Limited | Silicone hydrogels formed from monofunctional urea-based silicone monomers |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000007603A2 (en) | 1998-08-04 | 2000-02-17 | Madash Llp | End modified thermal responsive hydrogels |
| US6517933B1 (en) | 2000-01-18 | 2003-02-11 | Nano-Tex, Llc | Hybrid polymer materials |
| MXPA03008498A (es) * | 2001-03-20 | 2005-06-30 | Univ Zuerich | Procesamiento en dos fases de polimeros termosensibles para uso como biomateriales. |
| JP2002296774A (ja) * | 2001-03-30 | 2002-10-09 | Fuji Photo Film Co Ltd | 平版印刷版用原版 |
| JP2005532432A (ja) * | 2002-06-11 | 2005-10-27 | ビーエーエスエフ アクチェンゲゼルシャフト | ポリアルコキシル化されたトリメチロールプロパンの（メタ）アクリルエステル |
| US8197841B2 (en) | 2004-12-22 | 2012-06-12 | Bausch & Lomb Incorporated | Polymerizable surfactants and their use as device forming comonomers |
| DE102006049803A1 (de) * | 2006-10-23 | 2008-04-30 | Clariant International Limited | Hydroxyfunktionelle, copolymerisierbare Polyalkylenglykol-Makromonomere, deren Herstellung und Verwendung |
| US20090142387A1 (en) | 2007-12-03 | 2009-06-04 | Blackwell Richard I | Method For Inhibiting Attachment Of Microorganisms To Biomedical Devices |
| US8293838B2 (en) | 2008-06-20 | 2012-10-23 | Adhezion Biomedical, Llc | Stable and sterile tissue adhesive composition with a controlled high viscosity |
| JP2013204001A (ja) * | 2012-03-29 | 2013-10-07 | Mitsubishi Chemicals Corp | 活性エネルギー線硬化性樹脂組成物およびそれを用いた積層体 |
-
2014
- 2014-06-18 MX MX2015016562A patent/MX367343B/es active IP Right Grant
- 2014-06-18 CN CN201480034803.7A patent/CN105308080B/zh active Active
- 2014-06-18 US US14/308,229 patent/US9309357B2/en active Active
- 2014-06-18 ES ES14737465.6T patent/ES2659759T3/es active Active
- 2014-06-18 BR BR112015031653A patent/BR112015031653A2/pt active Search and Examination
- 2014-06-18 PL PL14737465T patent/PL3010946T3/pl unknown
- 2014-06-18 WO PCT/US2014/042951 patent/WO2014205084A1/en not_active Ceased
- 2014-06-18 JP JP2016521543A patent/JP6159025B2/ja active Active
- 2014-06-18 AU AU2014281549A patent/AU2014281549B2/en active Active
- 2014-06-18 KR KR1020167000830A patent/KR101767852B1/ko active Active
- 2014-06-18 EP EP14737465.6A patent/EP3010946B1/en active Active
- 2014-06-18 CA CA2914135A patent/CA2914135C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2659759T3 (es) | 2018-03-19 |
| AU2014281549B2 (en) | 2017-02-02 |
| US9309357B2 (en) | 2016-04-12 |
| CA2914135A1 (en) | 2014-12-24 |
| PL3010946T3 (pl) | 2018-06-29 |
| CN105308080A (zh) | 2016-02-03 |
| JP6159025B2 (ja) | 2017-07-05 |
| WO2014205084A1 (en) | 2014-12-24 |
| BR112015031653A2 (pt) | 2017-07-25 |
| EP3010946B1 (en) | 2017-12-20 |
| CN105308080B (zh) | 2017-06-09 |
| CA2914135C (en) | 2017-11-14 |
| KR20160019536A (ko) | 2016-02-19 |
| KR101767852B1 (ko) | 2017-08-11 |
| MX2015016562A (es) | 2016-03-31 |
| AU2014281549A1 (en) | 2016-01-07 |
| EP3010946A1 (en) | 2016-04-27 |
| JP2016524014A (ja) | 2016-08-12 |
| US20140371481A1 (en) | 2014-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |