MX366701B - Métodos mejorados para la acilación del maitansinol. - Google Patents
Métodos mejorados para la acilación del maitansinol.Info
- Publication number
- MX366701B MX366701B MX2015003745A MX2015003745A MX366701B MX 366701 B MX366701 B MX 366701B MX 2015003745 A MX2015003745 A MX 2015003745A MX 2015003745 A MX2015003745 A MX 2015003745A MX 366701 B MX366701 B MX 366701B
- Authority
- MX
- Mexico
- Prior art keywords
- maytansinol
- amino acid
- acylation
- improved methods
- carboxyanhydride
- Prior art date
Links
- QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 title abstract 5
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 230000010933 acylation Effects 0.000 title 1
- 238000005917 acylation reaction Methods 0.000 title 1
- -1 amino acid ester Chemical class 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 239000002274 desiccant Substances 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R12/00—Structural associations of a plurality of mutually-insulated electrical connecting elements, specially adapted for printed circuits, e.g. printed circuit boards [PCB], flat or ribbon cables, or like generally planar structures, e.g. terminal strips, terminal blocks; Coupling devices specially adapted for printed circuits, flat or ribbon cables, or like generally planar structures; Terminals specially adapted for contact with, or insertion into, printed circuits, flat or ribbon cables, or like generally planar structures
- H01R12/50—Fixed connections
- H01R12/51—Fixed connections for rigid printed circuits or like structures
- H01R12/55—Fixed connections for rigid printed circuits or like structures characterised by the terminals
- H01R12/58—Fixed connections for rigid printed circuits or like structures characterised by the terminals terminals for insertion into holes
- H01R12/585—Terminals having a press fit or a compliant portion and a shank passing through a hole in the printed circuit board
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/02—Details
- H05K1/0201—Thermal arrangements, e.g. for cooling, heating or preventing overheating
- H05K1/0203—Cooling of mounted components
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/02—Details
- H05K1/11—Printed elements for providing electric connections to or between printed circuits
- H05K1/115—Via connections; Lands around holes or via connections
- H05K1/116—Lands, clearance holes or other lay-out details concerning the surrounding of a via
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/18—Printed circuits structurally associated with non-printed electric components
- H05K1/181—Printed circuits structurally associated with non-printed electric components associated with surface mounted components
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705731P | 2012-09-26 | 2012-09-26 | |
| PCT/US2013/061839 WO2014052537A1 (en) | 2012-09-26 | 2013-09-26 | Improved methods for the acylation of maytansinol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015003745A MX2015003745A (es) | 2015-06-24 |
| MX366701B true MX366701B (es) | 2019-07-22 |
Family
ID=49328648
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015003745A MX366701B (es) | 2012-09-26 | 2013-09-26 | Métodos mejorados para la acilación del maitansinol. |
| MX2019008652A MX390615B (es) | 2012-09-26 | 2013-09-26 | Metodos mejorados para la acilacion del maitansinol. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019008652A MX390615B (es) | 2012-09-26 | 2013-09-26 | Metodos mejorados para la acilacion del maitansinol. |
Country Status (27)
| Country | Link |
|---|---|
| US (9) | US9012629B2 (https=) |
| EP (3) | EP3904358A1 (https=) |
| JP (7) | JP6517693B2 (https=) |
| CN (2) | CN104768955B (https=) |
| AU (4) | AU2013323572B2 (https=) |
| BR (2) | BR122021022582B1 (https=) |
| CA (2) | CA2884873C (https=) |
| CY (2) | CY1121415T1 (https=) |
| DK (2) | DK2900676T3 (https=) |
| ES (2) | ES2880754T3 (https=) |
| HR (2) | HRP20190473T1 (https=) |
| HU (2) | HUE043285T2 (https=) |
| IL (2) | IL237899A (https=) |
| LT (2) | LT2900676T (https=) |
| MX (2) | MX366701B (https=) |
| MY (1) | MY169250A (https=) |
| NZ (2) | NZ739573A (https=) |
| PL (2) | PL3486248T3 (https=) |
| PT (2) | PT3486248T (https=) |
| RS (2) | RS58493B1 (https=) |
| RU (2) | RU2648992C2 (https=) |
| SG (1) | SG11201501918UA (https=) |
| SI (2) | SI3486248T1 (https=) |
| SM (2) | SMT202100390T1 (https=) |
| TR (1) | TR201903625T4 (https=) |
| WO (1) | WO2014052537A1 (https=) |
| ZA (1) | ZA201501898B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2900676T (lt) * | 2012-09-26 | 2019-03-25 | Immunogen, Inc. | Maitanzinolio acilinimo patobulintas būdas |
| CN105585579A (zh) * | 2014-10-24 | 2016-05-18 | 南京联宁生物制药有限公司 | 一种化合物及其制备方法以及美登素dm1的制备方法 |
| JP6649961B2 (ja) * | 2015-03-17 | 2020-02-19 | レゲネロン ファーマシューティカルス，インコーポレーテッド | アミノ酸アシル化試薬及びその使用方法 |
| EP3554544A4 (en) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine, Inc. | ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE |
| DK3956332T3 (da) | 2019-04-18 | 2023-05-01 | Indena Spa | Diasteroselektiv fremgangsmåde til fremstilling af thiol- eller disulfid-holdige maytansionidestere og mellemprodukter deraf |
| US12473579B2 (en) | 2019-11-29 | 2025-11-18 | Microbiopharm Japan Co., Ltd. | Method for enzymatically producing maytansinol |
| EP4685150A1 (en) | 2023-04-28 | 2026-01-28 | Chugai Seiyaku Kabushiki Kaisha | Method for producing amide group-containing compound using n-carboxyamino acid anhydride |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| JPS6034556B2 (ja) * | 1977-03-31 | 1985-08-09 | 武田薬品工業株式会社 | 抗生物質ｃ−１５００３ |
| US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| US4265814A (en) | 1978-03-24 | 1981-05-05 | Takeda Chemical Industries | Matansinol 3-n-hexadecanoate |
| JPS5562090A (en) | 1978-10-27 | 1980-05-10 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164687A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS5566585A (en) | 1978-11-14 | 1980-05-20 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS55164685A (en) | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164686A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US4309428A (en) | 1979-07-30 | 1982-01-05 | Takeda Chemical Industries, Ltd. | Maytansinoids |
| JPS5622790A (en) * | 1979-07-31 | 1981-03-03 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| JP3054741B2 (ja) * | 1989-09-29 | 2000-06-19 | 武田薬品工業株式会社 | Ｔａｎ―１３１３およびそのアシル誘導体 |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| AU775373B2 (en) * | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| TWI298067B (en) * | 2002-01-31 | 2008-06-21 | Daiso Co Ltd | New optically active compound, method for kinetic resolution of carbonic acid derivatives and catalyst thereof |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| PL3524611T3 (pl) * | 2003-05-20 | 2021-06-14 | Immunogen, Inc. | Udoskonalone czynniki cytotoksyczne zawierające nowe maitansynoidy |
| CA2536378A1 (en) | 2003-08-22 | 2005-03-10 | Activbiotics, Inc. | Rifamycin analogs and uses thereof |
| KR101270829B1 (ko) | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
| PL1819359T3 (pl) * | 2004-12-09 | 2015-08-31 | Janssen Biotech Inc | Immunokoniugaty skierowane przeciw integrynie, metody ich wytwarzania oraz ich zastosowanie |
| US7301019B2 (en) * | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
| WO2007011721A1 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| WO2007021674A2 (en) | 2005-08-09 | 2007-02-22 | Millennium Pharmaceuticals, Inc. | Method of acylating maytansinol with chiral amino acids |
| CA2668134A1 (en) * | 2006-11-06 | 2008-05-15 | Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag | Ascomycin and pimecrolimus having reduced levels of des-methylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof |
| JP2008288289A (ja) | 2007-05-16 | 2008-11-27 | Oki Electric Ind Co Ltd | 電界効果トランジスタとその製造方法 |
| BRPI1010620B8 (pt) | 2009-06-03 | 2021-05-25 | Immunogen Inc | métodos de conjugação |
| WO2011051960A2 (en) * | 2009-09-25 | 2011-05-05 | Cadila Healthcare Limited | Process for the preparation of rapamycin derivatives |
| JP5889912B2 (ja) * | 2010-11-17 | 2016-03-22 | ジェネンテック， インコーポレイテッド | アラニニルメイタンシノール抗体コンジュゲート |
| LT2900676T (lt) | 2012-09-26 | 2019-03-25 | Immunogen, Inc. | Maitanzinolio acilinimo patobulintas būdas |
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2013
- 2013-09-26 LT LTEP13774881.0T patent/LT2900676T/lt unknown
- 2013-09-26 SG SG11201501918UA patent/SG11201501918UA/en unknown
- 2013-09-26 DK DK13774881.0T patent/DK2900676T3/en active
- 2013-09-26 TR TR2019/03625T patent/TR201903625T4/tr unknown
- 2013-09-26 CN CN201380049853.8A patent/CN104768955B/zh active Active
- 2013-09-26 EP EP21166484.2A patent/EP3904358A1/en active Pending
- 2013-09-26 SI SI201331899T patent/SI3486248T1/sl unknown
- 2013-09-26 RS RS20190314A patent/RS58493B1/sr unknown
- 2013-09-26 NZ NZ73957313A patent/NZ739573A/en unknown
- 2013-09-26 RU RU2015111635A patent/RU2648992C2/ru active
- 2013-09-26 DK DK18213678.8T patent/DK3486248T3/da active
- 2013-09-26 ES ES18213678T patent/ES2880754T3/es active Active
- 2013-09-26 EP EP13774881.0A patent/EP2900676B1/en active Active
- 2013-09-26 CA CA2884873A patent/CA2884873C/en active Active
- 2013-09-26 MY MYPI2015000663A patent/MY169250A/en unknown
- 2013-09-26 HR HRP20190473TT patent/HRP20190473T1/hr unknown
- 2013-09-26 US US14/037,657 patent/US9012629B2/en active Active
- 2013-09-26 SI SI201331374T patent/SI2900676T1/sl unknown
- 2013-09-26 RS RS20210825A patent/RS62075B1/sr unknown
- 2013-09-26 LT LTEP18213678.8T patent/LT3486248T/lt unknown
- 2013-09-26 HU HUE13774881A patent/HUE043285T2/hu unknown
- 2013-09-26 BR BR122021022582-6A patent/BR122021022582B1/pt active IP Right Grant
- 2013-09-26 HU HUE18213678A patent/HUE055443T2/hu unknown
- 2013-09-26 WO PCT/US2013/061839 patent/WO2014052537A1/en not_active Ceased
- 2013-09-26 BR BR112015006505-8A patent/BR112015006505B1/pt active IP Right Grant
- 2013-09-26 AU AU2013323572A patent/AU2013323572B2/en active Active
- 2013-09-26 PT PT182136788T patent/PT3486248T/pt unknown
- 2013-09-26 PL PL18213678T patent/PL3486248T3/pl unknown
- 2013-09-26 PT PT13774881T patent/PT2900676T/pt unknown
- 2013-09-26 PL PL13774881T patent/PL2900676T3/pl unknown
- 2013-09-26 EP EP18213678.8A patent/EP3486248B1/en active Active
- 2013-09-26 CA CA3133906A patent/CA3133906C/en active Active
- 2013-09-26 SM SM20210390T patent/SMT202100390T1/it unknown
- 2013-09-26 CN CN201810251853.0A patent/CN108586487B/zh active Active
- 2013-09-26 RU RU2018109295A patent/RU2765072C2/ru active
- 2013-09-26 ES ES13774881T patent/ES2716561T3/es active Active
- 2013-09-26 JP JP2015534641A patent/JP6517693B2/ja active Active
- 2013-09-26 MX MX2015003745A patent/MX366701B/es active IP Right Grant
- 2013-09-26 MX MX2019008652A patent/MX390615B/es unknown
- 2013-09-26 NZ NZ706019A patent/NZ706019A/en unknown
- 2013-09-26 SM SM20190170T patent/SMT201900170T1/it unknown
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2015
- 2015-03-17 US US14/660,050 patent/US9469655B2/en active Active
- 2015-03-19 ZA ZA2015/01898A patent/ZA201501898B/en unknown
- 2015-03-23 IL IL237899A patent/IL237899A/en active IP Right Grant
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2016
- 2016-09-19 US US15/269,163 patent/US9796731B2/en active Active
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2017
- 2017-08-14 IL IL253988A patent/IL253988B/en active IP Right Grant
- 2017-09-19 US US15/708,346 patent/US10100062B2/en active Active
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2018
- 2018-02-27 JP JP2018032684A patent/JP2018109044A/ja not_active Ceased
- 2018-02-27 AU AU2018201392A patent/AU2018201392B2/en active Active
- 2018-09-12 US US16/129,268 patent/US10461449B2/en active Active
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2019
- 2019-03-13 CY CY20191100302T patent/CY1121415T1/el unknown
- 2019-09-18 US US16/574,718 patent/US10944190B2/en active Active
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2020
- 2020-04-06 JP JP2020068137A patent/JP6735000B1/ja active Active
- 2020-06-10 AU AU2020203823A patent/AU2020203823B2/en active Active
- 2020-07-10 JP JP2020118929A patent/JP2020180150A/ja active Pending
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2021
- 2021-06-29 HR HRP20211030TT patent/HRP20211030T1/hr unknown
- 2021-07-02 CY CY20211100594T patent/CY1124337T1/el unknown
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2022
- 2022-02-28 JP JP2022029253A patent/JP2022068367A/ja active Pending
- 2022-03-07 AU AU2022201557A patent/AU2022201557A1/en not_active Abandoned
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2023
- 2023-09-05 US US18/242,321 patent/US20240145953A1/en not_active Abandoned
- 2023-10-23 JP JP2023181529A patent/JP2024010055A/ja active Pending
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2024
- 2024-01-19 US US18/417,406 patent/US20240313444A1/en not_active Abandoned
- 2024-05-31 US US18/679,863 patent/US20250007192A1/en active Pending
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2025
- 2025-03-31 JP JP2025058629A patent/JP2025098242A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |