CN104768955B - 用于美登醇酰化的改进的方法 - Google Patents

用于美登醇酰化的改进的方法 Download PDF

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Publication number
CN104768955B
CN104768955B CN201380049853.8A CN201380049853A CN104768955B CN 104768955 B CN104768955 B CN 104768955B CN 201380049853 A CN201380049853 A CN 201380049853A CN 104768955 B CN104768955 B CN 104768955B
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alkyl
formula
acid
compound
method described
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Chinese (zh)
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CN104768955A (zh
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W·C·威迪逊
R·Y·赵
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Immunogen Inc
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Immunogen Inc
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
    • H01R12/00—Structural associations of a plurality of mutually-insulated electrical connecting elements, specially adapted for printed circuits, e.g. printed circuit boards [PCB], flat or ribbon cables, or like generally planar structures, e.g. terminal strips, terminal blocks; Coupling devices specially adapted for printed circuits, flat or ribbon cables, or like generally planar structures; Terminals specially adapted for contact with, or insertion into, printed circuits, flat or ribbon cables, or like generally planar structures
    • H01R12/50—Fixed connections
    • H01R12/51—Fixed connections for rigid printed circuits or like structures
    • H01R12/55—Fixed connections for rigid printed circuits or like structures characterised by the terminals
    • H01R12/58—Fixed connections for rigid printed circuits or like structures characterised by the terminals terminals for insertion into holes
    • H01R12/585—Terminals having a press fit or a compliant portion and a shank passing through a hole in the printed circuit board
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/0201—Thermal arrangements, e.g. for cooling, heating or preventing overheating
    • H05K1/0203—Cooling of mounted components
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/11—Printed elements for providing electric connections to or between printed circuits
    • H05K1/115—Via connections; Lands around holes or via connections
    • H05K1/116—Lands, clearance holes or other lay-out details concerning the surrounding of a via
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/18—Printed circuits structurally associated with non-printed electric components
    • H05K1/181—Printed circuits structurally associated with non-printed electric components associated with surface mounted components

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201380049853.8A 2012-09-26 2013-09-26 用于美登醇酰化的改进的方法 Active CN104768955B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810251853.0A CN108586487B (zh) 2012-09-26 2013-09-26 用于美登醇酰化的改进的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261705731P 2012-09-26 2012-09-26
US61/705,731 2012-09-26
PCT/US2013/061839 WO2014052537A1 (en) 2012-09-26 2013-09-26 Improved methods for the acylation of maytansinol

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810251853.0A Division CN108586487B (zh) 2012-09-26 2013-09-26 用于美登醇酰化的改进的方法

Publications (2)

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CN104768955A CN104768955A (zh) 2015-07-08
CN104768955B true CN104768955B (zh) 2018-04-27

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CN201810251853.0A Active CN108586487B (zh) 2012-09-26 2013-09-26 用于美登醇酰化的改进的方法

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US (9) US9012629B2 (https=)
EP (3) EP2900676B1 (https=)
JP (7) JP6517693B2 (https=)
CN (2) CN104768955B (https=)
AU (4) AU2013323572B2 (https=)
BR (2) BR122021022582B1 (https=)
CA (2) CA2884873C (https=)
CY (2) CY1121415T1 (https=)
DK (2) DK3486248T3 (https=)
ES (2) ES2880754T3 (https=)
HR (2) HRP20190473T1 (https=)
HU (2) HUE055443T2 (https=)
IL (2) IL237899A (https=)
LT (2) LT3486248T (https=)
MX (2) MX366701B (https=)
MY (1) MY169250A (https=)
NZ (2) NZ739573A (https=)
PL (2) PL3486248T3 (https=)
PT (2) PT2900676T (https=)
RS (2) RS62075B1 (https=)
RU (2) RU2648992C2 (https=)
SG (1) SG11201501918UA (https=)
SI (2) SI2900676T1 (https=)
SM (2) SMT202100390T1 (https=)
TR (1) TR201903625T4 (https=)
WO (1) WO2014052537A1 (https=)
ZA (1) ZA201501898B (https=)

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LT3486248T (lt) * 2012-09-26 2021-08-25 Immunogen, Inc. Patobulinti maitansinolio acilinimo būdai
CN105585579A (zh) * 2014-10-24 2016-05-18 南京联宁生物制药有限公司 一种化合物及其制备方法以及美登素dm1的制备方法
MX376146B (es) 2015-03-17 2025-03-07 Regeneron Pharma Reactivos de acilacion de aminoacidos y metodos para usar los mismos.
EP3554544A4 (en) 2016-12-16 2020-07-29 Bluefin Biomedicine, Inc. ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE
US11420981B2 (en) 2019-04-18 2022-08-23 Indena S.P.A. Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof
JP7772363B2 (ja) 2019-11-29 2025-11-18 日本マイクロバイオファーマ株式会社 メイタンシノールの酵素的生産方法
EP4685150A1 (en) 2023-04-28 2026-01-28 Chugai Seiyaku Kabushiki Kaisha Method for producing amide group-containing compound using n-carboxyamino acid anhydride

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WO2012074757A1 (en) * 2010-11-17 2012-06-07 Genentech, Inc. Alaninyl maytansinol antibody conjugates

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CN1956722A (zh) * 2003-05-20 2007-05-02 伊缪诺金公司 含有新的美登素类的改进的细胞毒剂
WO2006078809A2 (en) * 2005-01-21 2006-07-27 Immunogen, Inc. Method for the preparation of maytansinoid esters
WO2007021674A2 (en) * 2005-08-09 2007-02-22 Millennium Pharmaceuticals, Inc. Method of acylating maytansinol with chiral amino acids
WO2012074757A1 (en) * 2010-11-17 2012-06-07 Genentech, Inc. Alaninyl maytansinol antibody conjugates

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US20190013604A1 (en) 2019-01-10
SMT202100390T1 (it) 2021-09-14
RU2015111635A (ru) 2016-11-20
JP6517693B2 (ja) 2019-05-22
AU2013323572A1 (en) 2015-04-02
AU2018201392A1 (en) 2018-03-15
JP2025098242A (ja) 2025-07-01
CN108586487A (zh) 2018-09-28
BR112015006505A2 (pt) 2017-07-04
CN108586487B (zh) 2021-11-05
LT2900676T (lt) 2019-03-25
RS58493B1 (sr) 2019-04-30
JP2020117527A (ja) 2020-08-06
HRP20211030T1 (hr) 2021-10-01
RU2765072C2 (ru) 2022-01-25
IL253988B (en) 2019-02-28
ES2716561T3 (es) 2019-06-13
MY169250A (en) 2019-03-19
CA3133906A1 (en) 2014-04-03
US10461449B2 (en) 2019-10-29
BR122021022582B1 (pt) 2023-01-10
US20250007192A1 (en) 2025-01-02
TR201903625T4 (tr) 2019-04-22
AU2022201557A1 (en) 2022-03-31
ZA201501898B (en) 2019-06-26
CY1121415T1 (el) 2020-05-29
US20150191488A1 (en) 2015-07-09
JP2024010055A (ja) 2024-01-23
NZ706019A (en) 2018-03-23
HUE043285T2 (hu) 2019-08-28
DK3486248T3 (da) 2021-07-12
US9796731B2 (en) 2017-10-24
MX2015003745A (es) 2015-06-24
US20180099980A1 (en) 2018-04-12
IL237899A (en) 2017-08-31
PL3486248T3 (pl) 2021-10-25
HRP20190473T1 (hr) 2019-05-03
JP6735000B1 (ja) 2020-08-05
MX390615B (es) 2025-03-20
PT3486248T (pt) 2021-07-12
CA2884873A1 (en) 2014-04-03
AU2020203823B2 (en) 2021-12-09
AU2020203823A1 (en) 2020-07-02
MX2019008652A (es) 2019-09-13
US10944190B2 (en) 2021-03-09
US10100062B2 (en) 2018-10-16
ES2880754T3 (es) 2021-11-25
US20140142297A1 (en) 2014-05-22
PT2900676T (pt) 2019-03-29
EP3904358A1 (en) 2021-11-03
EP3486248A1 (en) 2019-05-22
LT3486248T (lt) 2021-08-25
EP2900676B1 (en) 2018-12-19
JP2022068367A (ja) 2022-05-09
US20240145953A1 (en) 2024-05-02
HK1212341A1 (en) 2016-06-10
MX366701B (es) 2019-07-22
HUE055443T2 (hu) 2021-11-29
CY1124337T1 (el) 2022-07-22
JP2016500657A (ja) 2016-01-14
RS62075B1 (sr) 2021-07-30
NZ739573A (en) 2019-11-29
SMT201900170T1 (it) 2019-05-10
SI3486248T1 (sl) 2021-10-29
US9469655B2 (en) 2016-10-18
SG11201501918UA (en) 2015-05-28
US20200153130A1 (en) 2020-05-14
RU2018109295A3 (https=) 2021-06-24
BR112015006505B1 (pt) 2022-03-15
IL253988A0 (en) 2017-10-31
JP2018109044A (ja) 2018-07-12
JP2020180150A (ja) 2020-11-05
EP2900676A1 (en) 2015-08-05
SI2900676T1 (sl) 2019-04-30
CA2884873C (en) 2021-11-23
CA3133906C (en) 2023-05-02
US9012629B2 (en) 2015-04-21
DK2900676T3 (en) 2019-04-08
RU2648992C2 (ru) 2018-03-29
WO2014052537A1 (en) 2014-04-03
PL2900676T3 (pl) 2019-06-28
EP3486248B1 (en) 2021-04-07
US20170137440A1 (en) 2017-05-18
CN104768955A (zh) 2015-07-08
US20240313444A1 (en) 2024-09-19
RU2018109295A (ru) 2019-02-26
AU2013323572B2 (en) 2017-12-07
AU2018201392B2 (en) 2020-03-12

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