MX366633B - Nuevos compuestos antiinvasivos. - Google Patents
Nuevos compuestos antiinvasivos.Info
- Publication number
- MX366633B MX366633B MX2015003706A MX2015003706A MX366633B MX 366633 B MX366633 B MX 366633B MX 2015003706 A MX2015003706 A MX 2015003706A MX 2015003706 A MX2015003706 A MX 2015003706A MX 366633 B MX366633 B MX 366633B
- Authority
- MX
- Mexico
- Prior art keywords
- group
- pyrimidinyl
- pyridyl
- pharmaceutically acceptable
- methylpiperazinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Abstract
La presente invención se relaciona a un compuesto de la fórmula (I) : en donde A y A´ representan independientemente un grupo fen ileno o un grupo piridileno; R2 es un átomo de hidrógeno o un grupo alquilo (C1-C4), R3 es un grupo 2-piridilo, grupo 3-piridilo, un grupo 4-piridilo, un grupo 2-pirimidinilo, un grupo 4-pirimidinilo, o un grupo 5-pirimidinilo; R4 es un grupo carbonilo o un grupo sulfonilo, y R5 es un grupo NH (CH2)aNR6R7 o un grupo 4-metilpiperazinilo, con a que es un entero de 1 a 4, R6 y R7 representan independientemente un grupo alquilo de (C1-C4), o R6 y R7 junto con el átomo de nitrógeno al cual se enlazan que forman un grupo heterociclo el cual es elegido entre un grupo 4-metilpiperazinilo, un grupo morfolino, un grupo pirrolidinilo y un grupo piperidino, o cualquiera de sus sales aceptables farmacéuticamente. La invención se relaciona además a composiciones farmacéuticas que contienen un compuesto de la fórmula (I) o cualesquiera de sus sales aceptables farmacéuticamente y un proceso para preparación para obtenerlos. Los compuestos (I) son útiles para tratamiento de cáncer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12186684.2A EP2712862A1 (en) | 2012-09-28 | 2012-09-28 | New anti-invasive compounds |
| PCT/IB2013/058992 WO2014049578A1 (en) | 2012-09-28 | 2013-09-30 | New anti-invasive compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015003706A MX2015003706A (es) | 2016-01-14 |
| MX366633B true MX366633B (es) | 2019-07-17 |
Family
ID=47018046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015003706A MX366633B (es) | 2012-09-28 | 2013-09-30 | Nuevos compuestos antiinvasivos. |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9969715B2 (es) |
| EP (2) | EP2712862A1 (es) |
| JP (1) | JP6209215B2 (es) |
| KR (1) | KR102175775B1 (es) |
| CN (1) | CN104903293B (es) |
| AU (1) | AU2013322131B2 (es) |
| BR (1) | BR112015006979B1 (es) |
| CA (1) | CA2886804C (es) |
| CU (1) | CU24282B1 (es) |
| DK (1) | DK2900635T3 (es) |
| ES (1) | ES2598056T3 (es) |
| HK (1) | HK1213884A1 (es) |
| HR (1) | HRP20161286T1 (es) |
| MX (1) | MX366633B (es) |
| PL (1) | PL2900635T3 (es) |
| PT (1) | PT2900635T (es) |
| RU (1) | RU2641650C2 (es) |
| WO (1) | WO2014049578A1 (es) |
| ZA (1) | ZA201502126B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2926297B1 (fr) | 2008-01-10 | 2013-03-08 | Centre Nat Rech Scient | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
| EP2505198A1 (en) | 2011-04-01 | 2012-10-03 | Société Splicos | Compounds for use as therapeutic agents affecting p53 expression and/or activity |
| EP2712862A1 (en) * | 2012-09-28 | 2014-04-02 | Splicos | New anti-invasive compounds |
| CA2929528A1 (en) * | 2013-11-06 | 2015-05-14 | Bristol-Myers Squibb Company | Gsk-3 inhibitors |
| KR102412220B1 (ko) | 2013-12-24 | 2022-06-23 | 온코타르티스, 아이엔씨. | 벤즈아미드 및 니코틴아미드 화합물 및 이를 사용하는 방법 |
| EP3594205A1 (en) * | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-aryl derivatives for treating a rna virus infection |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4423065A (en) | 1982-05-04 | 1983-12-27 | Eli Lilly And Company | Naphthalenamine insecticides |
| IL68500A (en) | 1982-05-04 | 1986-07-31 | Lilly Co Eli | N-(2,4-dinitro-6-trifluoromethylphenyl)-1-naphthylamines,their preparation and anti coccidial compositions containing them |
| KR860001567A (ko) * | 1984-08-30 | 1986-03-20 | 김순영 | 상의용 무가봉 입체 재단법 |
| WO2002098363A2 (en) * | 2001-06-06 | 2002-12-12 | Agouron Pharmaceuticals, Inc. | NON-PEPTIDE GnRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USES, AND PROCESSES FOR PREPARING THEM |
| EP1655295A1 (en) * | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
| US8030487B2 (en) * | 2006-07-07 | 2011-10-04 | Targegen, Inc. | 2-amino—5-substituted pyrimidine inhibitors |
| FR2926297B1 (fr) * | 2008-01-10 | 2013-03-08 | Centre Nat Rech Scient | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
| WO2010007756A1 (ja) * | 2008-07-14 | 2010-01-21 | 塩野義製薬株式会社 | Ｔｔｋ阻害作用を有するピリジン誘導体 |
| US20110230467A1 (en) * | 2008-11-21 | 2011-09-22 | Astellas Pharma Inc. | 4,6-diaminonicotinamide compound |
| FR2943669B1 (fr) * | 2009-03-24 | 2011-05-06 | Sanofi Aventis | Derives de nicotinamide,leur preparation et leur application en therapeutique |
| US8703768B2 (en) * | 2010-06-09 | 2014-04-22 | Hoffmann-La Roche Inc. | Nitrogen containing heteroaryl compounds |
| EP2712862A1 (en) * | 2012-09-28 | 2014-04-02 | Splicos | New anti-invasive compounds |
-
2012
- 2012-09-28 EP EP12186684.2A patent/EP2712862A1/en not_active Withdrawn
-
2013
- 2013-09-30 PT PT138120860T patent/PT2900635T/pt unknown
- 2013-09-30 CA CA2886804A patent/CA2886804C/en active Active
- 2013-09-30 DK DK13812086.0T patent/DK2900635T3/en active
- 2013-09-30 WO PCT/IB2013/058992 patent/WO2014049578A1/en active Application Filing
- 2013-09-30 CN CN201380060496.5A patent/CN104903293B/zh active Active
- 2013-09-30 RU RU2015115360A patent/RU2641650C2/ru active
- 2013-09-30 JP JP2015533750A patent/JP6209215B2/ja active Active
- 2013-09-30 EP EP13812086.0A patent/EP2900635B1/en active Active
- 2013-09-30 BR BR112015006979-7A patent/BR112015006979B1/pt active IP Right Grant
- 2013-09-30 MX MX2015003706A patent/MX366633B/es active IP Right Grant
- 2013-09-30 US US14/432,328 patent/US9969715B2/en active Active
- 2013-09-30 CU CUP2015000029A patent/CU24282B1/es unknown
- 2013-09-30 AU AU2013322131A patent/AU2013322131B2/en active Active
- 2013-09-30 PL PL13812086T patent/PL2900635T3/pl unknown
- 2013-09-30 ES ES13812086.0T patent/ES2598056T3/es active Active
- 2013-09-30 KR KR1020157010969A patent/KR102175775B1/ko active IP Right Grant
-
2015
- 2015-03-27 ZA ZA2015/02126A patent/ZA201502126B/en unknown
-
2016
- 2016-02-18 HK HK16101763.5A patent/HK1213884A1/zh unknown
- 2016-10-06 HR HRP20161286TT patent/HRP20161286T1/hr unknown
-
2018
- 2018-04-05 US US15/946,120 patent/US10717724B2/en active Active
-
2020
- 2020-04-15 US US16/848,916 patent/US11427566B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |