MX366445B - Hidrogenacion catalitica de nitrilos. - Google Patents

Hidrogenacion catalitica de nitrilos.

Info

Publication number
MX366445B
MX366445B MX2016005727A MX2016005727A MX366445B MX 366445 B MX366445 B MX 366445B MX 2016005727 A MX2016005727 A MX 2016005727A MX 2016005727 A MX2016005727 A MX 2016005727A MX 366445 B MX366445 B MX 366445B
Authority
MX
Mexico
Prior art keywords
catalytic hydrogenation
nitriles
pyridin
trifluoromethyl
chloro
Prior art date
Application number
MX2016005727A
Other languages
English (en)
Other versions
MX2016005727A (es
Inventor
Himmler Thomas
Norbert Müller Thomas
Ahmed Moradi Wahed
Schnatterer Albert
Schlegel Günter
Original Assignee
Bayer Cropscience Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Ag filed Critical Bayer Cropscience Ag
Publication of MX2016005727A publication Critical patent/MX2016005727A/es
Publication of MX366445B publication Critical patent/MX366445B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a una nueva hidrogenación catalítica de derivados 2-metilcianopiridilo sustituidos, en particular, 3-cloro-5-(trifluorometil)piridin-2-il]acetonitrilo [= Py-CN) hasta derivados de 2-etilaminopiridina sustituidos, en particular, 2-[3-cloro-5-(trifluorometil)piridin-2-il]etanamina [= Py-etanamina] o sales de los mismos en presencia de catalizadores metálicos, en particular, catalizadores de paladio.
MX2016005727A 2013-11-15 2014-11-11 Hidrogenacion catalitica de nitrilos. MX366445B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13193164 2013-11-15
PCT/EP2014/074212 WO2015071230A1 (en) 2013-11-15 2014-11-11 Catalytic hydrogenation of nitriles

Publications (2)

Publication Number Publication Date
MX2016005727A MX2016005727A (es) 2016-08-12
MX366445B true MX366445B (es) 2019-07-09

Family

ID=49585315

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016005727A MX366445B (es) 2013-11-15 2014-11-11 Hidrogenacion catalitica de nitrilos.

Country Status (12)

Country Link
US (2) US9988353B2 (es)
EP (1) EP3068766B1 (es)
JP (2) JP6882891B2 (es)
KR (1) KR102314669B1 (es)
CN (1) CN105745194B (es)
BR (1) BR112016010568B1 (es)
DK (1) DK3068766T3 (es)
ES (1) ES2665579T3 (es)
IL (1) IL244947B (es)
MX (1) MX366445B (es)
TW (1) TWI650305B (es)
WO (1) WO2015071230A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015071230A1 (en) * 2013-11-15 2015-05-21 Bayer Cropscience Ag Catalytic hydrogenation of nitriles
ES2912531T3 (es) * 2016-12-21 2022-05-26 Bayer Cropscience Ag Hidrogenación de un derivado de 2-metil cianopiridilo sustituido en presencia de un catalizador de cobalto Raney
ES2882526T3 (es) * 2016-12-21 2021-12-02 Bayer Cropscience Ag Procedimiento para la preparación de un derivado de N-¬2-(2-piridinil)etil|carboxamida
CN112638875A (zh) 2018-07-26 2021-04-09 拜耳公司 氟吡菌酰胺的结晶形式
CN111170932A (zh) * 2020-01-13 2020-05-19 大连九信精细化工有限公司 一种2-氨甲基-5-三氟甲基吡啶盐的制备方法
CN112552231B (zh) * 2020-12-11 2022-03-11 南京正荣医药化学有限公司 一种2-(3-氯-5-(三氟甲基)吡啶-2-基)乙胺的合成方法
CN116037153A (zh) * 2023-01-03 2023-05-02 上海华谊（集团）公司 加氢脱氯催化剂及其工艺

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07138209A (ja) * 1993-11-12 1995-05-30 Sumitomo Seika Chem Co Ltd 含ハロゲンアミノメチル化合物の製造法
EP0806205A3 (en) * 1996-05-06 1997-11-19 Eli Lilly And Company Urea, thiourea and guanidine compounds and their use as anti-viral agents
US6645990B2 (en) * 2000-08-15 2003-11-11 Amgen Inc. Thiazolyl urea compounds and methods of uses
DE10207926A1 (de) * 2002-02-23 2003-09-11 Clariant Gmbh Verfahren zur Herstellung von primären Aminen durch Hydrierung von Nitrilen
KR100853967B1 (ko) 2002-08-12 2008-08-25 바이엘 크롭사이언스 소시에떼아노님 신규한 2-피리딜에틸벤즈아미드 유도체
AU2003291227A1 (en) * 2002-11-05 2004-06-07 Smithkline Beecham Corporation Antibacterial agents
EP1674455A1 (en) * 2004-12-21 2006-06-28 Bayer CropScience S.A. Process for the preparation of a 2-ethylaminopyridine derivative
CA2683624A1 (en) * 2007-04-12 2008-10-23 F. Hoffmann-La Roche Ag Pharmaceutical compounds
JP5758395B2 (ja) 2009-10-15 2015-08-05 ザ チルドレンズ メディカル センター コーポレイション 疼痛を治療するためのセピアプテリンレダクターゼ阻害薬
JP5659860B2 (ja) * 2011-02-28 2015-01-28 エヌ・イーケムキャット株式会社 ニトリル化合物水素化用パラジウム含有触媒および該触媒を用いたニトリル化合物の水素化方法
US8829238B2 (en) * 2011-09-22 2014-09-09 Ut-Battelle, Llc Methods for the synthesis of deuterated acrylate salts
GB201309340D0 (en) * 2013-05-23 2013-07-10 Led Lighting Consultants Ltd Improvements relating to power adaptors
WO2015071230A1 (en) * 2013-11-15 2015-05-21 Bayer Cropscience Ag Catalytic hydrogenation of nitriles

Also Published As

Publication number Publication date
US10414730B2 (en) 2019-09-17
EP3068766B1 (en) 2018-01-10
CN105745194A (zh) 2016-07-06
TW201533012A (zh) 2015-09-01
JP2016538287A (ja) 2016-12-08
US20180244621A1 (en) 2018-08-30
WO2015071230A1 (en) 2015-05-21
BR112016010568B1 (pt) 2021-09-21
KR20160085778A (ko) 2016-07-18
ES2665579T3 (es) 2018-04-26
TWI650305B (zh) 2019-02-11
IL244947A0 (en) 2016-05-31
MX2016005727A (es) 2016-08-12
DK3068766T3 (en) 2018-04-23
EP3068766A1 (en) 2016-09-21
BR112016010568A2 (pt) 2018-05-02
IL244947B (en) 2019-03-31
KR102314669B1 (ko) 2021-10-18
CN105745194B (zh) 2018-09-25
US9988353B2 (en) 2018-06-05
JP6882891B2 (ja) 2021-06-02
US20160280648A1 (en) 2016-09-29
JP2019210293A (ja) 2019-12-12

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