MX366369B - Metodo para un ensayo de deteccion de farmacos basado en celulas y el uso del mismo. - Google Patents
Metodo para un ensayo de deteccion de farmacos basado en celulas y el uso del mismo.Info
- Publication number
- MX366369B MX366369B MX2015014892A MX2015014892A MX366369B MX 366369 B MX366369 B MX 366369B MX 2015014892 A MX2015014892 A MX 2015014892A MX 2015014892 A MX2015014892 A MX 2015014892A MX 366369 B MX366369 B MX 366369B
- Authority
- MX
- Mexico
- Prior art keywords
- cell
- screening assay
- time
- drug screening
- based drug
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
Abstract
La presente invención se refiere a un ensayo de detección de fármacos basado en células que comprende los pasos de: (i) cultivar una población de células en un ambiente de cultivo, (ii) definir por lo menos dos puntos de monitoreo en el tiempo en dependencia de por lo menos uno de los tipos de células, las características fisiológicas de las células, las características fisiológicas del tejido formado, el modo de acción de un principio activo y el ambiente de cultivo, (iii) aplicar principios activos a las células cultivadas por lo menos en un punto de tratamiento en el tiempo, (iv) monitorear el efecto de dicho principio activo en las células o tejidos formados por lo menos a dichos dos puntos de monitoreo en el tiempo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13165419.6A EP2796873A1 (en) | 2013-04-25 | 2013-04-25 | Method for a cell-based drug screening assay and the use thereof |
PCT/EP2014/058152 WO2014173907A1 (en) | 2013-04-25 | 2014-04-22 | Method for a cell-based drug screening assay and the use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015014892A MX2015014892A (es) | 2016-03-07 |
MX366369B true MX366369B (es) | 2019-07-05 |
Family
ID=48326111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015014892A MX366369B (es) | 2013-04-25 | 2014-04-22 | Metodo para un ensayo de deteccion de farmacos basado en celulas y el uso del mismo. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20160077081A1 (es) |
EP (2) | EP2796873A1 (es) |
JP (1) | JP6484219B2 (es) |
KR (1) | KR102255944B1 (es) |
CN (1) | CN105143883B (es) |
AU (1) | AU2014257584B2 (es) |
BR (1) | BR112015026601B1 (es) |
CA (1) | CA2910146C (es) |
ES (1) | ES2729341T3 (es) |
IL (1) | IL242172B (es) |
MX (1) | MX366369B (es) |
RU (1) | RU2702643C2 (es) |
SG (1) | SG11201508611WA (es) |
WO (1) | WO2014173907A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
US11584916B2 (en) | 2014-10-17 | 2023-02-21 | Children's Hospital Medical Center | Method of making in vivo human small intestine organoids from pluripotent stem cells |
JP2016136848A (ja) * | 2015-01-26 | 2016-08-04 | 富士フイルム株式会社 | 薬剤の評価方法及び薬剤スクリーニング方法 |
GB201514864D0 (en) * | 2015-08-20 | 2015-10-07 | Insphero Ag | An in vitro 3D cell culture model-based tumor relapse assay |
EP3452578B1 (en) | 2016-05-05 | 2022-08-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
KR101916801B1 (ko) * | 2016-08-12 | 2018-11-08 | 경북대학교 산학협력단 | 3차원 생체 모사 시스템을 이용한 맥락막 혈관신생을 수반하는 질환의 치료제 스크리닝 방법 |
IT201600099380A1 (it) * | 2016-10-04 | 2018-04-04 | Univ Bologna Alma Mater Studiorum | Composizioni, dispositivi e metodi per il controllo in vitro del microambiente chimico in colture cellulari |
CN110062764A (zh) | 2016-12-05 | 2019-07-26 | 儿童医院医学中心 | 结肠类器官及其制备和使用方法 |
JP7405373B2 (ja) | 2018-10-05 | 2023-12-26 | 国立大学法人東海国立大学機構 | 化学物質のスクリーニング方法、プログラム、制御装置、及び培養観察装置 |
GB201818885D0 (en) * | 2018-11-20 | 2019-01-02 | Precomb Therapeutics Ag | 3d human cancer model-based combinatiorial drug development method |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5728541A (en) * | 1996-07-12 | 1998-03-17 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays |
IL158128A0 (en) * | 2001-04-03 | 2004-03-28 | Biocept Inc | Methods and gel compositions for encapsulating living cells and organic molecules |
EP1758989A2 (en) * | 2004-06-08 | 2007-03-07 | PrimeGen Biotech LLC | Therapeutic reprogramming, hybrid stem cells and maturation |
US20090324596A1 (en) * | 2008-06-30 | 2009-12-31 | The Trustees Of Princeton University | Methods of identifying and treating poor-prognosis cancers |
JP5490803B2 (ja) | 2008-09-22 | 2014-05-14 | ウニヴェルジテート チューリッヒ プロレクトラート エムエヌヴェー | 懸滴プレートおよび同懸滴プレートを使用する方法 |
US8802702B2 (en) * | 2009-01-15 | 2014-08-12 | The General Hospital Corporation | Compounds for reducing drug resistance and uses thereof |
WO2010141954A1 (en) * | 2009-06-06 | 2010-12-09 | Ceetox, Inc. | Method for predicting respiratory toxicity of compounds |
EP2380920A1 (en) | 2010-04-22 | 2011-10-26 | QGel SA | Hydrogel precursor formulation and production process thereof |
EP2626414B1 (en) * | 2010-10-06 | 2020-07-15 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell mass and process for production thereof |
JP6028236B2 (ja) * | 2011-09-12 | 2016-11-16 | 国立大学法人 熊本大学 | 物質のスクリーニング方法 |
-
2013
- 2013-04-25 EP EP13165419.6A patent/EP2796873A1/en not_active Withdrawn
-
2014
- 2014-04-22 WO PCT/EP2014/058152 patent/WO2014173907A1/en active Application Filing
- 2014-04-22 CA CA2910146A patent/CA2910146C/en active Active
- 2014-04-22 CN CN201480022749.4A patent/CN105143883B/zh active Active
- 2014-04-22 BR BR112015026601-0A patent/BR112015026601B1/pt active IP Right Grant
- 2014-04-22 US US14/786,637 patent/US20160077081A1/en active Pending
- 2014-04-22 JP JP2016509438A patent/JP6484219B2/ja active Active
- 2014-04-22 ES ES14718624T patent/ES2729341T3/es active Active
- 2014-04-22 KR KR1020157033467A patent/KR102255944B1/ko active IP Right Grant
- 2014-04-22 EP EP14718624.1A patent/EP2989460B1/en active Active
- 2014-04-22 SG SG11201508611WA patent/SG11201508611WA/en unknown
- 2014-04-22 MX MX2015014892A patent/MX366369B/es active IP Right Grant
- 2014-04-22 RU RU2015150203A patent/RU2702643C2/ru active
- 2014-04-22 AU AU2014257584A patent/AU2014257584B2/en active Active
-
2015
- 2015-10-20 IL IL242172A patent/IL242172B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JP6484219B2 (ja) | 2019-03-13 |
CA2910146C (en) | 2024-04-09 |
EP2796873A1 (en) | 2014-10-29 |
AU2014257584B2 (en) | 2020-05-14 |
ES2729341T3 (es) | 2019-10-31 |
KR20160003761A (ko) | 2016-01-11 |
CN105143883A (zh) | 2015-12-09 |
EP2989460B1 (en) | 2019-03-06 |
KR102255944B1 (ko) | 2021-05-25 |
CA2910146A1 (en) | 2014-10-30 |
AU2014257584A1 (en) | 2015-11-05 |
CN105143883B (zh) | 2018-10-23 |
RU2015150203A (ru) | 2017-05-31 |
SG11201508611WA (en) | 2015-11-27 |
BR112015026601A2 (pt) | 2017-07-25 |
BR112015026601B1 (pt) | 2023-11-21 |
IL242172B (en) | 2019-03-31 |
EP2989460A1 (en) | 2016-03-02 |
JP2016518129A (ja) | 2016-06-23 |
MX2015014892A (es) | 2016-03-07 |
RU2702643C2 (ru) | 2019-10-09 |
WO2014173907A1 (en) | 2014-10-30 |
US20160077081A1 (en) | 2016-03-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX366369B (es) | Metodo para un ensayo de deteccion de farmacos basado en celulas y el uso del mismo. | |
CY1123142T1 (el) | Βελτιωμενες μεθοδοι για την παραγωγη θετων κυτταρικων θεραπειων | |
EP4306636A3 (en) | Monolayer of pbmcs or bone-marrow cells and uses thereof | |
NZ765695A (en) | Immune cell organoid co-cultures | |
WO2016015058A3 (en) | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same | |
MY171710A (en) | Culture medium composition, and method for culturing cell or tissue using said composition | |
MX2021005777A (es) | Suministro selectivo de material a celulas. | |
TR201904270T4 (tr) | Tanımlı koşullar altında insan pluripotent kök hücrelerinin hematoendotelyal farklılaşması için yöntemler ve materyaller. | |
GB2562396A (en) | Devices for simulating a function of a liver tissue and methods of use and manufacturing thereof | |
BR112014028881A2 (pt) | populações de células, banco de células, métodos de obtenção de uma população de células, métodos de identificação de um fator, métodos de seleção, métodos de fornecimento de terapia, populações de hepatócitos e método de obtenção de células | |
MX2015018035A (es) | Metodos para predecir respuestas a sustancias quimicas o biologicas. | |
RS54525B1 (en) | DLBCL TREATMENT MEANS AND PROCEDURES | |
CY1120800T1 (el) | Μεθοδοι και συνθεσεις για την in vivo ενεργοποιηση του σχηματισμου παγκρεατικων βητα κυτταρων | |
BR112017017886A2 (pt) | gerando populações de células endoteliais arteriais | |
MX2022003399A (es) | Metodo basado en celulas para determinar la potencia de la defibrotida. | |
EP3608400A4 (en) | CELL POPULATION WITH MESENCHYMAL STEM CELLS, METHOD OF MANUFACTURING THEREFORE AND PHARMACEUTICAL COMPOSITION | |
MX2015008436A (es) | Composiciones para permeabilizar celulas sanguineos fijos y sus usos. | |
GB2508782A (en) | Facile laboratory method for localising biomolecules to the surface of cells and viruses | |
EP3620529A4 (en) | PROCESS FOR MONITORING DYNAMIC CHANGES IN CELLS OR A SUBSTANCE DERIVED THEREOF, AND PROCESS FOR CELL CLASSIFICATION USING THIS MONITORING PROCEDURE | |
GB2523034A (en) | Screen and method of making the same | |
MX2018005228A (es) | Un metodo ex vivo para ensayar la respuesta de poblaciones celulares primarias a un farmaco o combinacion de farmacos. | |
EP2610337A4 (en) | MASS TEST OF BLOOD CELL BLOOD CELLS USING CELL COAGULATION, ADULT BLOOD STEM CELLS USING THE SAME, METHOD OF EXPANDING PROGENITOR CELLS AND STEM CELLS PRODUCED USING THE METHOD | |
WO2015051166A3 (en) | Use of cox-3 binding molecules for modulating autophagy | |
WO2016004250A3 (en) | Biological characterization of a glatiramer acetate related drug product using mammalian and human cells | |
WO2015017535A3 (en) | Cell-based control and method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |