MX366369B - Metodo para un ensayo de deteccion de farmacos basado en celulas y el uso del mismo. - Google Patents

Metodo para un ensayo de deteccion de farmacos basado en celulas y el uso del mismo.

Info

Publication number
MX366369B
MX366369B MX2015014892A MX2015014892A MX366369B MX 366369 B MX366369 B MX 366369B MX 2015014892 A MX2015014892 A MX 2015014892A MX 2015014892 A MX2015014892 A MX 2015014892A MX 366369 B MX366369 B MX 366369B
Authority
MX
Mexico
Prior art keywords
cell
screening assay
time
drug screening
based drug
Prior art date
Application number
MX2015014892A
Other languages
English (en)
Other versions
MX2015014892A (es
Inventor
Rizzi Simone
Jacot Guillaume
Lutolf Matthias
Original Assignee
Qgel Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qgel Sa filed Critical Qgel Sa
Publication of MX2015014892A publication Critical patent/MX2015014892A/es
Publication of MX366369B publication Critical patent/MX366369B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)

Abstract

La presente invención se refiere a un ensayo de detección de fármacos basado en células que comprende los pasos de: (i) cultivar una población de células en un ambiente de cultivo, (ii) definir por lo menos dos puntos de monitoreo en el tiempo en dependencia de por lo menos uno de los tipos de células, las características fisiológicas de las células, las características fisiológicas del tejido formado, el modo de acción de un principio activo y el ambiente de cultivo, (iii) aplicar principios activos a las células cultivadas por lo menos en un punto de tratamiento en el tiempo, (iv) monitorear el efecto de dicho principio activo en las células o tejidos formados por lo menos a dichos dos puntos de monitoreo en el tiempo.
MX2015014892A 2013-04-25 2014-04-22 Metodo para un ensayo de deteccion de farmacos basado en celulas y el uso del mismo. MX366369B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13165419.6A EP2796873A1 (en) 2013-04-25 2013-04-25 Method for a cell-based drug screening assay and the use thereof
PCT/EP2014/058152 WO2014173907A1 (en) 2013-04-25 2014-04-22 Method for a cell-based drug screening assay and the use thereof

Publications (2)

Publication Number Publication Date
MX2015014892A MX2015014892A (es) 2016-03-07
MX366369B true MX366369B (es) 2019-07-05

Family

ID=48326111

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015014892A MX366369B (es) 2013-04-25 2014-04-22 Metodo para un ensayo de deteccion de farmacos basado en celulas y el uso del mismo.

Country Status (14)

Country Link
US (1) US20160077081A1 (es)
EP (2) EP2796873A1 (es)
JP (1) JP6484219B2 (es)
KR (1) KR102255944B1 (es)
CN (1) CN105143883B (es)
AU (1) AU2014257584B2 (es)
BR (1) BR112015026601B1 (es)
CA (1) CA2910146C (es)
ES (1) ES2729341T3 (es)
IL (1) IL242172B (es)
MX (1) MX366369B (es)
RU (1) RU2702643C2 (es)
SG (1) SG11201508611WA (es)
WO (1) WO2014173907A1 (es)

Families Citing this family (22)

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WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP3712254A1 (en) 2014-05-28 2020-09-23 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
JP2016136848A (ja) * 2015-01-26 2016-08-04 富士フイルム株式会社 薬剤の評価方法及び薬剤スクリーニング方法
GB201514864D0 (en) * 2015-08-20 2015-10-07 Insphero Ag An in vitro 3D cell culture model-based tumor relapse assay
EP4177335A1 (en) 2016-05-05 2023-05-10 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
KR101916801B1 (ko) * 2016-08-12 2018-11-08 경북대학교 산학협력단 3차원 생체 모사 시스템을 이용한 맥락막 혈관신생을 수반하는 질환의 치료제 스크리닝 방법
IT201600099380A1 (it) * 2016-10-04 2018-04-04 Univ Bologna Alma Mater Studiorum Composizioni, dispositivi e metodi per il controllo in vitro del microambiente chimico in colture cellulari
SG11201903697WA (en) 2016-11-04 2019-05-30 Childrens Hospital Med Ct Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
US12297457B2 (en) 2017-10-10 2025-05-13 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
US12421500B2 (en) 2018-07-26 2025-09-23 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
JP2021535753A (ja) 2018-09-12 2021-12-23 チルドレンズ ホスピタル メディカル センター 造血幹細胞およびその派生体の生成のためのオルガノイド組成物
JP7405373B2 (ja) * 2018-10-05 2023-12-26 国立大学法人東海国立大学機構 化学物質のスクリーニング方法、プログラム、制御装置、及び培養観察装置
GB201818885D0 (en) * 2018-11-20 2019-01-02 Precomb Therapeutics Ag 3d human cancer model-based combinatiorial drug development method
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
CA3141814A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CN114174494A (zh) 2019-05-31 2022-03-11 儿童医院医学中心 产生和扩增造血干细胞的方法
CA3155166A1 (en) * 2019-09-24 2021-04-01 Universite De Geneve Method to independently analyze multiple biological processes in encapsulated 3d cell co-cultures
CN120148693B (zh) * 2025-02-27 2025-11-11 西安高新医院有限公司 一种生殖科女性生殖药物筛选方法与系统

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US5728541A (en) * 1996-07-12 1998-03-17 Precision Therapeutics, Inc. Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays
DE60220893T2 (de) * 2001-04-03 2008-03-06 Biocept, Inc., San Diego Verfahren und gelzusammensetzungen zum einkapseln lebender zellen und organischer moleküle
AU2005253923A1 (en) * 2004-06-08 2005-12-29 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20090324596A1 (en) * 2008-06-30 2009-12-31 The Trustees Of Princeton University Methods of identifying and treating poor-prognosis cancers
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EP2380920A1 (en) 2010-04-22 2011-10-26 QGel SA Hydrogel precursor formulation and production process thereof
CN103328626B (zh) * 2010-10-06 2017-02-08 中外制药株式会社 癌干细胞群及其制备方法
US9523674B2 (en) * 2011-09-12 2016-12-20 National University Corporation Kumamoto University Method of screening for substances capable of promoting induction of induced pluripotent stem cells

Also Published As

Publication number Publication date
CN105143883A (zh) 2015-12-09
EP2989460B1 (en) 2019-03-06
MX2015014892A (es) 2016-03-07
KR20160003761A (ko) 2016-01-11
JP2016518129A (ja) 2016-06-23
ES2729341T3 (es) 2019-10-31
AU2014257584B2 (en) 2020-05-14
CA2910146C (en) 2024-04-09
BR112015026601B1 (pt) 2023-11-21
US20160077081A1 (en) 2016-03-17
WO2014173907A1 (en) 2014-10-30
IL242172B (en) 2019-03-31
CN105143883B (zh) 2018-10-23
CA2910146A1 (en) 2014-10-30
AU2014257584A1 (en) 2015-11-05
RU2015150203A (ru) 2017-05-31
SG11201508611WA (en) 2015-11-27
RU2702643C2 (ru) 2019-10-09
BR112015026601A2 (pt) 2017-07-25
EP2796873A1 (en) 2014-10-29
JP6484219B2 (ja) 2019-03-13
KR102255944B1 (ko) 2021-05-25
EP2989460A1 (en) 2016-03-02

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