MX364922B - Vacuna de adn que dirige wt-1 novedosa para inmunoterapia contra cáncer. - Google Patents

Vacuna de adn que dirige wt-1 novedosa para inmunoterapia contra cáncer.

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Publication number
MX364922B
MX364922B MX2015014851A MX2015014851A MX364922B MX 364922 B MX364922 B MX 364922B MX 2015014851 A MX2015014851 A MX 2015014851A MX 2015014851 A MX2015014851 A MX 2015014851A MX 364922 B MX364922 B MX 364922B
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MX
Mexico
Prior art keywords
salmonella
cancer immunotherapy
based vectors
tumor gene
immunotherapy targeting
Prior art date
Application number
MX2015014851A
Other languages
English (en)
Other versions
MX2015014851A (es
Inventor
Lubenau Heinz
Springer Marco
Original Assignee
Vaximm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaximm Ag filed Critical Vaximm Ag
Publication of MX2015014851A publication Critical patent/MX2015014851A/es
Publication of MX364922B publication Critical patent/MX364922B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42—Salmonella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a una cepa mutante atenuada de Salmonella caracterizada porque comprende al menos una copia de una molécula de ADN recombinante que comprende un casete de expresión eucariótico que codifica la proteína del tumor de Wilms (WT1).
MX2015014851A 2013-04-25 2014-04-24 Vacuna de adn que dirige wt-1 novedosa para inmunoterapia contra cáncer. MX364922B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13002245 2013-04-25
PCT/EP2014/001099 WO2014173542A1 (en) 2013-04-25 2014-04-24 Salmonella-based vectors for cancer immunotherapy targeting wilms' tumor gene wt1

Publications (2)

Publication Number Publication Date
MX2015014851A MX2015014851A (es) 2016-03-09
MX364922B true MX364922B (es) 2019-05-14

Family

ID=48190068

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015014851A MX364922B (es) 2013-04-25 2014-04-24 Vacuna de adn que dirige wt-1 novedosa para inmunoterapia contra cáncer.

Country Status (15)

Country Link
US (2) US9920297B2 (es)
EP (1) EP2988762B1 (es)
JP (1) JP6416877B2 (es)
CN (1) CN105246496A (es)
AU (1) AU2014256457B2 (es)
CA (1) CA2910213A1 (es)
DK (1) DK2988762T3 (es)
ES (1) ES2675020T3 (es)
HU (1) HUE038861T2 (es)
LT (1) LT2988762T (es)
MX (1) MX364922B (es)
PL (1) PL2988762T3 (es)
SG (1) SG11201508521SA (es)
SI (1) SI2988762T1 (es)
WO (1) WO2014173542A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1951281B1 (en) 2005-10-17 2015-04-15 Sloan Kettering Institute For Cancer Research Wt1 hla class ii-binding peptides and compositions and methods comprising same
EP3117836A1 (en) 2006-04-10 2017-01-18 Sloan Kettering Institute For Cancer Research Immunogenic wt-1 peptides and uses thereof
CN104684577B (zh) 2012-01-13 2018-05-08 纪念斯隆凯特林癌症中心 免疫原性wt-1肽及其使用方法
PT2945647T (pt) 2013-01-15 2020-11-26 Memorial Sloan Kettering Cancer Center Péptidos imunogénicos wt-1 e métodos de uso dos mesmos
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
MX364922B (es) 2013-04-25 2019-05-14 Vaximm Ag Vacuna de adn que dirige wt-1 novedosa para inmunoterapia contra cáncer.
RU2016129044A (ru) 2013-12-18 2018-01-23 Факсимм Гмбх Новая вакцина днк, нацеленная на мезотелин, для иммунотерапии рака
US20180153976A1 (en) 2015-06-18 2018-06-07 Vaximm Ag Novel cmv pp65 targeting dna vaccine for cancer immunotherapy
ES2760699T3 (es) * 2015-06-18 2020-05-14 Vaximm Ag Vacuna de ADN dirigida al VEGFR-2 para terapia de combinación
US10695385B2 (en) 2015-06-25 2020-06-30 National University Corporation Kobe University Oral cancer vaccine
JP7098599B2 (ja) 2016-07-13 2022-07-11 エンエーセー オンコイミュニティ アクスイェ セルスカプ 癌免疫療法用のｄｎａワクチンの製造方法
US20230158133A1 (en) 2016-11-04 2023-05-25 Vaximm Ag Wt1 targeting dna vaccine for combination therapy
CA3050833A1 (en) * 2017-02-17 2018-08-23 Vaximm Ag Novel vegfr-2 targeting immunotherapy approach
JP7247097B2 (ja) * 2017-03-17 2023-03-28 バクシム アクチェンゲゼルシャフト がん免疫療法のための新規ｐｄ－ｌ１標的ｄｎａワクチン
AU2019334131A1 (en) * 2018-09-05 2021-03-04 NEC Oncolmmunity AS Neoantigen targeting DNA vaccine for combination therapy
CN114980871A (zh) 2020-01-13 2022-08-30 万科斯蒙股份有限公司 基于沙门氏菌的dna疫苗联合抗生素
CN111647066B (zh) * 2020-07-01 2020-12-18 维肽瀛(上海)生物技术有限公司 Wt1多肽肿瘤抑制剂
WO2023105076A1 (en) * 2021-12-09 2023-06-15 Prokarium Limited Combination cancer therapy

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726288A (en) * 1989-11-13 1998-03-10 Massachusetts Institute Of Technology Localization and characterization of the Wilms' tumor gene
EP0977874B1 (en) * 1997-04-18 2005-11-09 Gesellschaft für biotechnologische Forschung mbH (GBF) Attenuated salmonella strain used as a vehicle for oral immunization
CN1859851A (zh) 2002-07-12 2006-11-08 约翰斯霍普金斯大学 间皮素疫苗与模型系统
EP1575500A4 (en) 2002-07-12 2007-01-03 Univ Johns Hopkins MESOTHELIN VACCINE AND MODEL SYSTEMS
US9200036B2 (en) 2002-07-12 2015-12-01 The Johns Hopkins University Mesothelin vaccines and model systems
JP4769247B2 (ja) * 2004-06-18 2011-09-07 インディアン・イムノロジカルズ・リミテッド ヒトパピローマウイルス１６型に対するＳａｌｍｏｎｅｌｌａワクチン株に関するコドン最適化されたＨＰＶ１６Ｌ１
US20060068469A1 (en) * 2004-08-17 2006-03-30 Research Development Foundation Bacterial vector systems
RU2007137122A (ru) * 2005-03-09 2009-04-20 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем (Us) НОВЫЙ ПРОМОТОР hTMC И ВЕКТОРЫ ДЛЯ ОПУХОЛЕСЕЛЕКТИВНОЙ И ВЫСОКОЭФФЕКТИВНОЙ ЭКСПРЕССИИ ТЕРАПЕВТИЧЕСКИХ ПРОТИВОРАКОВЫХ ГЕНОВ
EP1951281B1 (en) * 2005-10-17 2015-04-15 Sloan Kettering Institute For Cancer Research Wt1 hla class ii-binding peptides and compositions and methods comprising same
US7935804B2 (en) 2006-03-01 2011-05-03 Aduro Biotech Engineered Listeria and methods of use thereof
EP1921149A1 (en) * 2006-11-13 2008-05-14 AEterna Zentaris GmbH Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof
WO2012149364A1 (en) * 2011-04-28 2012-11-01 Diamond Don J Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy
CN104812890A (zh) * 2012-09-17 2015-07-29 美国健康及人类服务部 基于染色体重组工程的多功能口服疫苗
MX364922B (es) * 2013-04-25 2019-05-14 Vaximm Ag Vacuna de adn que dirige wt-1 novedosa para inmunoterapia contra cáncer.
RU2016129044A (ru) * 2013-12-18 2018-01-23 Факсимм Гмбх Новая вакцина днк, нацеленная на мезотелин, для иммунотерапии рака

Also Published As

Publication number Publication date
JP6416877B2 (ja) 2018-10-31
CN105246496A (zh) 2016-01-13
EP2988762A1 (en) 2016-03-02
DK2988762T3 (en) 2018-07-16
SI2988762T1 (sl) 2018-10-30
AU2014256457A1 (en) 2015-11-05
JP2016518835A (ja) 2016-06-30
PL2988762T3 (pl) 2019-01-31
WO2014173542A1 (en) 2014-10-30
US20160068801A1 (en) 2016-03-10
HUE038861T2 (hu) 2018-12-28
US20180163169A1 (en) 2018-06-14
AU2014256457B2 (en) 2018-02-22
ES2675020T3 (es) 2018-07-05
EP2988762B1 (en) 2018-06-06
MX2015014851A (es) 2016-03-09
US9920297B2 (en) 2018-03-20
SG11201508521SA (en) 2015-11-27
CA2910213A1 (en) 2014-10-30
LT2988762T (lt) 2018-09-25
US10815455B2 (en) 2020-10-27

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