MX2015014851A - Vacuna de adn que dirige wt-1 novedosa para inmunoterapia del cancer. - Google Patents

Vacuna de adn que dirige wt-1 novedosa para inmunoterapia del cancer.

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Publication number
MX2015014851A
MX2015014851A MX2015014851A MX2015014851A MX2015014851A MX 2015014851 A MX2015014851 A MX 2015014851A MX 2015014851 A MX2015014851 A MX 2015014851A MX 2015014851 A MX2015014851 A MX 2015014851A MX 2015014851 A MX2015014851 A MX 2015014851A
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MX
Mexico
Prior art keywords
salmonella
cancer immunotherapy
based vectors
tumor gene
immunotherapy targeting
Prior art date
Application number
MX2015014851A
Other languages
English (en)
Other versions
MX364922B (es
Inventor
Heinz Lubenau
Marco Springer
Original Assignee
Vaximm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaximm Ag filed Critical Vaximm Ag
Publication of MX2015014851A publication Critical patent/MX2015014851A/es
Publication of MX364922B publication Critical patent/MX364922B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42—Salmonella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a una cepa mutante atenuada de Salmonella que comprende una molécula de ADN recombinante que codifica la proteína del tumor de Wilms 1. En particular, la presente invención se refiere al uso de dicha cepa mutante atenuada de Salmonella en la inmunoterapia del cáncer.
MX2015014851A 2013-04-25 2014-04-24 Vacuna de adn que dirige wt-1 novedosa para inmunoterapia contra cáncer. MX364922B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13002245 2013-04-25
PCT/EP2014/001099 WO2014173542A1 (en) 2013-04-25 2014-04-24 Salmonella-based vectors for cancer immunotherapy targeting wilms' tumor gene wt1

Publications (2)

Publication Number Publication Date
MX2015014851A true MX2015014851A (es) 2016-03-09
MX364922B MX364922B (es) 2019-05-14

Family

ID=48190068

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015014851A MX364922B (es) 2013-04-25 2014-04-24 Vacuna de adn que dirige wt-1 novedosa para inmunoterapia contra cáncer.

Country Status (15)

Country Link
US (2) US9920297B2 (es)
EP (1) EP2988762B1 (es)
JP (1) JP6416877B2 (es)
CN (1) CN105246496A (es)
AU (1) AU2014256457B2 (es)
CA (1) CA2910213A1 (es)
DK (1) DK2988762T3 (es)
ES (1) ES2675020T3 (es)
HU (1) HUE038861T2 (es)
LT (1) LT2988762T (es)
MX (1) MX364922B (es)
PL (1) PL2988762T3 (es)
SG (1) SG11201508521SA (es)
SI (1) SI2988762T1 (es)
WO (1) WO2014173542A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2565201B1 (en) 2005-10-17 2014-11-26 Sloan-Kettering Institute For Cancer Research WT1 HLA class II-binding peptides and compositions and methods comprising same
CA2645766A1 (en) 2006-04-10 2007-10-25 Sloan Kettering Institute For Cancer Research Immunogenic wt-1 peptides and methods of use thereof
CN104684577B (zh) 2012-01-13 2018-05-08 纪念斯隆凯特林癌症中心 免疫原性wt-1肽及其使用方法
PT2945647T (pt) 2013-01-15 2020-11-26 Memorial Sloan Kettering Cancer Center Péptidos imunogénicos wt-1 e métodos de uso dos mesmos
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
HUE038861T2 (hu) * 2013-04-25 2018-12-28 Vaximm Ag Salmonella-alapú vektorok Wilms-tumor WZ1 gént célzó rák immunterápiához
AU2014365900B2 (en) 2013-12-18 2020-04-09 Vaximm Gmbh Novel MSLN targeting DNA vaccine for cancer immunotherapy
US20180153976A1 (en) 2015-06-18 2018-06-07 Vaximm Ag Novel cmv pp65 targeting dna vaccine for cancer immunotherapy
DK3310379T3 (da) * 2015-06-18 2019-12-16 Vaximm Ag Vegfr-2-targeterende dna-vaccine til kombinationsterapi
JP6770269B2 (ja) * 2015-06-25 2020-10-14 国立大学法人神戸大学 経口腫瘍ワクチン
EP3484503A1 (en) 2016-07-13 2019-05-22 Vaximm AG Process for the production of a dna vaccine for cancer immunotherapy
BR112019009003A2 (pt) * 2016-11-04 2019-07-16 Vaximm Ag cepa atenuada de salmonela e composição farmacêutica
EP3583200A1 (en) * 2017-02-17 2019-12-25 Vaximm AG Novel vegfr-2 targeting immunotherapy approach
SG11201908528UA (en) * 2017-03-17 2019-10-30 Vaximm Ag Novel pd-l1 targeting dna vaccine for cancer immunotherapy
US20210213121A1 (en) * 2018-09-05 2021-07-15 Vaximm Ag Neoantigen targeting dna vaccine for combination therapy
CN114980871A (zh) 2020-01-13 2022-08-30 万科斯蒙股份有限公司 基于沙门氏菌的dna疫苗联合抗生素
CN111647066B (zh) * 2020-07-01 2020-12-18 维肽瀛(上海)生物技术有限公司 Wt1多肽肿瘤抑制剂
CA3238816A1 (en) * 2021-12-09 2023-06-15 Prokarium Limited Combination cancer therapy

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726288A (en) * 1989-11-13 1998-03-10 Massachusetts Institute Of Technology Localization and characterization of the Wilms' tumor gene
ATE309378T1 (de) * 1997-04-18 2005-11-15 Biotechnolog Forschung Gmbh Abgeschwächter salmonellenstamm, gebraucht als vehikel zur oralen immunisierung
CN1859851A (zh) 2002-07-12 2006-11-08 约翰斯霍普金斯大学 间皮素疫苗与模型系统
WO2004006837A2 (en) 2002-07-12 2004-01-22 The Johns Hopkins University Mesothelin vaccines and model systems
US9200036B2 (en) 2002-07-12 2015-12-01 The Johns Hopkins University Mesothelin vaccines and model systems
CN101115766B (zh) * 2004-06-18 2013-05-08 印度免疫有限公司 用于抗人乳头瘤病毒型16的salmonella疫苗菌株的密码子经优化的hpv16l1
WO2006137836A2 (en) * 2004-08-17 2006-12-28 Research Development Foundation Bacterial vector systems
CA2601187A1 (en) * 2005-03-09 2006-09-14 Board Of Regents, The University Of Texas System Novel htmc promoter and vectors for the tumor-selective and high-efficient expression of cancer therapeutic genes
EP2565201B1 (en) * 2005-10-17 2014-11-26 Sloan-Kettering Institute For Cancer Research WT1 HLA class II-binding peptides and compositions and methods comprising same
US7935804B2 (en) 2006-03-01 2011-05-03 Aduro Biotech Engineered Listeria and methods of use thereof
EP1921149A1 (en) * 2006-11-13 2008-05-14 AEterna Zentaris GmbH Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof
WO2012149364A1 (en) * 2011-04-28 2012-11-01 Diamond Don J Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy
EP2895596A4 (en) * 2012-09-17 2016-07-27 Us Health ORAL MULTIFUNCTION VACCINE BASED ON CHROMOSOME RECOMBINEERING
HUE038861T2 (hu) 2013-04-25 2018-12-28 Vaximm Ag Salmonella-alapú vektorok Wilms-tumor WZ1 gént célzó rák immunterápiához
AU2014365900B2 (en) * 2013-12-18 2020-04-09 Vaximm Gmbh Novel MSLN targeting DNA vaccine for cancer immunotherapy

Also Published As

Publication number Publication date
JP2016518835A (ja) 2016-06-30
SI2988762T1 (sl) 2018-10-30
US20180163169A1 (en) 2018-06-14
AU2014256457B2 (en) 2018-02-22
CN105246496A (zh) 2016-01-13
MX364922B (es) 2019-05-14
US10815455B2 (en) 2020-10-27
ES2675020T3 (es) 2018-07-05
US20160068801A1 (en) 2016-03-10
US9920297B2 (en) 2018-03-20
EP2988762A1 (en) 2016-03-02
AU2014256457A1 (en) 2015-11-05
CA2910213A1 (en) 2014-10-30
HUE038861T2 (hu) 2018-12-28
PL2988762T3 (pl) 2019-01-31
JP6416877B2 (ja) 2018-10-31
DK2988762T3 (en) 2018-07-16
LT2988762T (lt) 2018-09-25
SG11201508521SA (en) 2015-11-27
WO2014173542A1 (en) 2014-10-30
EP2988762B1 (en) 2018-06-06

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