SI2988762T1 - Vektorji na osnovi salmonele za imunoterapijo raka, usmerjeno v Wilmsov tumorski gen WT1 - Google Patents
Vektorji na osnovi salmonele za imunoterapijo raka, usmerjeno v Wilmsov tumorski gen WT1Info
- Publication number
- SI2988762T1 SI2988762T1 SI201430778T SI201430778T SI2988762T1 SI 2988762 T1 SI2988762 T1 SI 2988762T1 SI 201430778 T SI201430778 T SI 201430778T SI 201430778 T SI201430778 T SI 201430778T SI 2988762 T1 SI2988762 T1 SI 2988762T1
- Authority
- SI
- Slovenia
- Prior art keywords
- salmonella
- cancer immunotherapy
- based vectors
- tumor gene
- immunotherapy targeting
- Prior art date
Links
- 241000607142 Salmonella Species 0.000 title 1
- 108700025700 Wilms Tumor Genes Proteins 0.000 title 1
- 238000002619 cancer immunotherapy Methods 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/42—Salmonella
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13002245 | 2013-04-25 | ||
| EP14721208.8A EP2988762B1 (en) | 2013-04-25 | 2014-04-24 | Salmonella-based vectors for cancer immunotherapy targeting wilms' tumor gene wt1 |
| PCT/EP2014/001099 WO2014173542A1 (en) | 2013-04-25 | 2014-04-24 | Salmonella-based vectors for cancer immunotherapy targeting wilms' tumor gene wt1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2988762T1 true SI2988762T1 (sl) | 2018-10-30 |
Family
ID=48190068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201430778T SI2988762T1 (sl) | 2013-04-25 | 2014-04-24 | Vektorji na osnovi salmonele za imunoterapijo raka, usmerjeno v Wilmsov tumorski gen WT1 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9920297B2 (sl) |
| EP (1) | EP2988762B1 (sl) |
| JP (1) | JP6416877B2 (sl) |
| CN (1) | CN105246496A (sl) |
| AU (1) | AU2014256457B2 (sl) |
| CA (1) | CA2910213A1 (sl) |
| DK (1) | DK2988762T3 (sl) |
| ES (1) | ES2675020T3 (sl) |
| HU (1) | HUE038861T2 (sl) |
| LT (1) | LT2988762T (sl) |
| MX (1) | MX364922B (sl) |
| PL (1) | PL2988762T3 (sl) |
| SG (1) | SG11201508521SA (sl) |
| SI (1) | SI2988762T1 (sl) |
| WO (1) | WO2014173542A1 (sl) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1951281B1 (en) | 2005-10-17 | 2015-04-15 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| PL2010209T3 (pl) | 2006-04-10 | 2017-04-28 | Sloan Kettering Inst For Cancer Res | Immunogeniczne peptydy WT-1 i sposoby ich użycia |
| CA2861206C (en) | 2012-01-13 | 2021-07-06 | Richard J. O'reilly | Immunogenic wt-1 peptides and methods of use thereof |
| HUE052541T2 (hu) | 2013-01-15 | 2021-05-28 | Memorial Sloan Kettering Cancer Center | Immunogén WT-1 peptidek és eljárások azok alkalmazására |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| SI2988762T1 (sl) * | 2013-04-25 | 2018-10-30 | Vaximm Ag | Vektorji na osnovi salmonele za imunoterapijo raka, usmerjeno v Wilmsov tumorski gen WT1 |
| KR20160130979A (ko) | 2013-12-18 | 2016-11-15 | 백심 게엠베하 | 암 면역요법을 위한 신규한 msln 표적화 dna 백신 |
| US10905752B2 (en) | 2015-06-18 | 2021-02-02 | Vaximm Ag | VEGFR-2 targeting DNA vaccine for combination therapy |
| US20180153976A1 (en) | 2015-06-18 | 2018-06-07 | Vaximm Ag | Novel cmv pp65 targeting dna vaccine for cancer immunotherapy |
| CN108350411B (zh) * | 2015-06-25 | 2021-06-22 | 白川利朗 | 口服肿瘤疫苗 |
| AU2017295004B2 (en) | 2016-07-13 | 2020-08-13 | NEC Oncolmmunity AS | Process for the production of a DNA vaccine for cancer immunotherapy |
| WO2018083209A1 (en) | 2016-11-04 | 2018-05-11 | Vaximm Ag | Wt1 targeting dna vaccine for combination therapy |
| SG11201907391SA (en) * | 2017-02-17 | 2019-09-27 | Vaximm Ag | Novel vegfr-2 targeting immunotherapy approach |
| EP3595704A1 (en) * | 2017-03-17 | 2020-01-22 | Vaximm AG | Novel pd-l1 targeting dna vaccine for cancer immunotherapy |
| CN112638408A (zh) * | 2018-09-05 | 2021-04-09 | 万科斯蒙股份有限公司 | 用于联合疗法的靶向新抗原的dna疫苗 |
| AU2021208400A1 (en) | 2020-01-13 | 2022-08-11 | Vaximm Ag | Salmonella-based DNA vaccines in combination with an antibiotic |
| CN111647066B (zh) * | 2020-07-01 | 2020-12-18 | 维肽瀛(上海)生物技术有限公司 | Wt1多肽肿瘤抑制剂 |
| CA3238816A1 (en) * | 2021-12-09 | 2023-06-15 | Prokarium Limited | Combination cancer therapy |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726288A (en) * | 1989-11-13 | 1998-03-10 | Massachusetts Institute Of Technology | Localization and characterization of the Wilms' tumor gene |
| DE69734605T2 (de) * | 1997-04-18 | 2006-08-03 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Abgeschwächter salmonellenstamm, gebraucht als vehikel zur oralen immunisierung |
| AU2003259109A1 (en) | 2002-07-12 | 2004-02-02 | The Johns Hopkins University | Mesothelin vaccines and model systems |
| CN1859851A (zh) | 2002-07-12 | 2006-11-08 | 约翰斯霍普金斯大学 | 间皮素疫苗与模型系统 |
| US9200036B2 (en) | 2002-07-12 | 2015-12-01 | The Johns Hopkins University | Mesothelin vaccines and model systems |
| CN101115766B (zh) * | 2004-06-18 | 2013-05-08 | 印度免疫有限公司 | 用于抗人乳头瘤病毒型16的salmonella疫苗菌株的密码子经优化的hpv16l1 |
| US20060068469A1 (en) * | 2004-08-17 | 2006-03-30 | Research Development Foundation | Bacterial vector systems |
| CA2601187A1 (en) * | 2005-03-09 | 2006-09-14 | Board Of Regents, The University Of Texas System | Novel htmc promoter and vectors for the tumor-selective and high-efficient expression of cancer therapeutic genes |
| EP1951281B1 (en) * | 2005-10-17 | 2015-04-15 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| EP1921149A1 (en) * | 2006-11-13 | 2008-05-14 | AEterna Zentaris GmbH | Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof |
| WO2012149364A1 (en) * | 2011-04-28 | 2012-11-01 | Diamond Don J | Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy |
| EP2895596A4 (en) * | 2012-09-17 | 2016-07-27 | Us Health | ORAL MULTIFUNCTION VACCINE BASED ON CHROMOSOME RECOMBINEERING |
| SI2988762T1 (sl) | 2013-04-25 | 2018-10-30 | Vaximm Ag | Vektorji na osnovi salmonele za imunoterapijo raka, usmerjeno v Wilmsov tumorski gen WT1 |
| KR20160130979A (ko) * | 2013-12-18 | 2016-11-15 | 백심 게엠베하 | 암 면역요법을 위한 신규한 msln 표적화 dna 백신 |
-
2014
- 2014-04-24 SI SI201430778T patent/SI2988762T1/sl unknown
- 2014-04-24 JP JP2016509326A patent/JP6416877B2/ja active Active
- 2014-04-24 AU AU2014256457A patent/AU2014256457B2/en not_active Ceased
- 2014-04-24 SG SG11201508521SA patent/SG11201508521SA/en unknown
- 2014-04-24 CA CA2910213A patent/CA2910213A1/en not_active Abandoned
- 2014-04-24 WO PCT/EP2014/001099 patent/WO2014173542A1/en active Application Filing
- 2014-04-24 MX MX2015014851A patent/MX364922B/es active IP Right Grant
- 2014-04-24 EP EP14721208.8A patent/EP2988762B1/en active Active
- 2014-04-24 PL PL14721208T patent/PL2988762T3/pl unknown
- 2014-04-24 ES ES14721208.8T patent/ES2675020T3/es active Active
- 2014-04-24 CN CN201480023775.9A patent/CN105246496A/zh active Pending
- 2014-04-24 US US14/786,652 patent/US9920297B2/en active Active
- 2014-04-24 HU HUE14721208A patent/HUE038861T2/hu unknown
- 2014-04-24 LT LTEP14721208.8T patent/LT2988762T/lt unknown
- 2014-04-24 DK DK14721208.8T patent/DK2988762T3/en active
-
2018
- 2018-01-16 US US15/872,750 patent/US10815455B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014173542A1 (en) | 2014-10-30 |
| AU2014256457A1 (en) | 2015-11-05 |
| EP2988762A1 (en) | 2016-03-02 |
| PL2988762T3 (pl) | 2019-01-31 |
| US20160068801A1 (en) | 2016-03-10 |
| CA2910213A1 (en) | 2014-10-30 |
| US20180163169A1 (en) | 2018-06-14 |
| JP2016518835A (ja) | 2016-06-30 |
| JP6416877B2 (ja) | 2018-10-31 |
| EP2988762B1 (en) | 2018-06-06 |
| AU2014256457B2 (en) | 2018-02-22 |
| LT2988762T (lt) | 2018-09-25 |
| SG11201508521SA (en) | 2015-11-27 |
| US10815455B2 (en) | 2020-10-27 |
| CN105246496A (zh) | 2016-01-13 |
| MX2015014851A (es) | 2016-03-09 |
| MX364922B (es) | 2019-05-14 |
| ES2675020T3 (es) | 2018-07-05 |
| US9920297B2 (en) | 2018-03-20 |
| DK2988762T3 (en) | 2018-07-16 |
| HUE038861T2 (hu) | 2018-12-28 |
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