MX364790B - Procesamiento discontinuo de alimentacion por lotes con el uso de biorreactores alternantes. - Google Patents

Procesamiento discontinuo de alimentacion por lotes con el uso de biorreactores alternantes.

Info

Publication number
MX364790B
MX364790B MX2015005822A MX2015005822A MX364790B MX 364790 B MX364790 B MX 364790B MX 2015005822 A MX2015005822 A MX 2015005822A MX 2015005822 A MX2015005822 A MX 2015005822A MX 364790 B MX364790 B MX 364790B
Authority
MX
Mexico
Prior art keywords
fed batch
batch processing
discontinuous
bioreactors
alternating
Prior art date
Application number
MX2015005822A
Other languages
English (en)
Other versions
MX2015005822A (es
Inventor
Arthur Tijsterman Jacob
Original Assignee
Biosana Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosana Pty Ltd filed Critical Biosana Pty Ltd
Publication of MX2015005822A publication Critical patent/MX2015005822A/es
Publication of MX364790B publication Critical patent/MX364790B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Clinical Laboratory Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a cultivos celulares discontinuos de alimentación por lotes de células de mamífero (más específicamente células de CHO) con el uso de biorreactores alternos en combinación con la separación discontinua de biomasa de la sustancia biológica (más específicamente anticuerpos monoclonales) y los componentes residuales.
MX2015005822A 2012-11-09 2013-11-08 Procesamiento discontinuo de alimentacion por lotes con el uso de biorreactores alternantes. MX364790B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2012050798 2012-11-09
PCT/NL2013/050805 WO2014073967A1 (en) 2012-11-09 2013-11-08 Discontinuous fed batch processing with the use of alternating bioreactors

Publications (2)

Publication Number Publication Date
MX2015005822A MX2015005822A (es) 2016-02-10
MX364790B true MX364790B (es) 2019-05-03

Family

ID=47278493

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015005822A MX364790B (es) 2012-11-09 2013-11-08 Procesamiento discontinuo de alimentacion por lotes con el uso de biorreactores alternantes.

Country Status (11)

Country Link
US (1) US9982226B2 (es)
EP (1) EP2917323A1 (es)
AU (1) AU2013341858B2 (es)
BR (1) BR112015010544B1 (es)
CA (1) CA2890813C (es)
MX (1) MX364790B (es)
MY (1) MY181264A (es)
RU (1) RU2639556C2 (es)
SG (2) SG10201703385YA (es)
TW (1) TWI637057B (es)
WO (1) WO2014073967A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101680181B1 (ko) * 2008-07-16 2016-11-28 케이셉 시스템즈, 엘엘씨 유동층을 이용하여 입자들을 처리하는 방법 및 이를 위한 시스템
SG11201601681QA (en) 2013-10-11 2016-04-28 Regeneron Pharma Metabolically optimized cell culture
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
ES2709994T3 (es) 2014-06-04 2019-04-22 Amgen Inc Métodos de recolección en cultivos de células de mamífero
EP3487609A4 (en) * 2016-07-25 2020-04-22 Repligen Corporation FAST HARVESTING WITH ALTERNATING TANGENTIAL FLOW
US11920119B2 (en) 2018-02-09 2024-03-05 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
US11932842B2 (en) 2018-02-09 2024-03-19 Global Life Sciences Solutions Usa Llc Bioprocessing apparatus
US11371007B2 (en) * 2018-02-09 2022-06-28 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US11414639B2 (en) 2018-02-09 2022-08-16 Global Life Sciences Solutions Usa Llc Bioprocessing vessel
US10792618B2 (en) 2018-06-19 2020-10-06 Sartorius Stedim Biotech Gmbh Particle separation and/or purification of a fluid
TWI662122B (zh) * 2018-07-12 2019-06-11 聯發生物科技股份有限公司 發酵設備
GB201904083D0 (en) * 2019-03-25 2019-05-08 Ge Healthcare Bio Sciences Ab A bioreactor system
EP4189056A1 (en) * 2020-07-28 2023-06-07 Seagen Inc. Methods and systems for producing polypeptides
EP4056671A1 (en) * 2021-03-10 2022-09-14 Sartorius Stedim Biotech GmbH Method for operating a bioprocess installation
EP4124653A1 (en) * 2021-07-27 2023-02-01 Sartorius Stedim Biotech GmbH Method for producing a bioproduct
WO2023167584A1 (en) * 2022-03-01 2023-09-07 Biosanapharma B.V. Continuous manufacturing of a biological substance with process traceability

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK309184D0 (da) 1984-06-25 1984-06-25 Nordisk Insulinlab Fremgangsmaade til isolering af insulin eller insulinlignende materiale fra en fermenteringsvaeske
DE3833925A1 (de) * 1988-03-11 1989-09-21 Inst Angewandte Biotechnologie Verfahren und herstellung von virus und viralem antigen und vorrichtung hierzu
RU2058992C1 (ru) * 1993-07-14 1996-04-27 Антипин Георгий Васильевич Способ получения кормового белка и устройство для его осуществления
JP2006527642A (ja) * 2003-06-17 2006-12-07 セントカー・インコーポレーテツド バイオリアクターの組換えタンパク質の濾過のための方法及び装置
ES2565077T3 (es) * 2003-10-10 2016-03-31 Novo Nordisk Health Care Ag Método para producción en gran escala de un polipéptido en células eucariotas
CN1930281A (zh) 2004-03-05 2007-03-14 帝斯曼知识产权资产管理有限公司 用于通过连续灌注和交互切向流来培养细胞的方法
US8119368B2 (en) 2006-07-14 2012-02-21 Dsm Ip Assets B.V. Process for the culturing of cells
ES2657055T3 (es) * 2007-08-09 2018-03-01 Wyeth Llc Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores
JP5329644B2 (ja) * 2008-04-22 2013-10-30 ニューマチック スケール コーポレイション 単回使用のコンポーネントを備える遠心分離システム
KR101680181B1 (ko) * 2008-07-16 2016-11-28 케이셉 시스템즈, 엘엘씨 유동층을 이용하여 입자들을 처리하는 방법 및 이를 위한 시스템
WO2011044237A1 (en) 2009-10-06 2011-04-14 Kbi Biopharma, Inc. Methods, systems and apparatus for manipulating particles
US8765415B2 (en) * 2009-11-17 2014-07-01 Medarex, L.L.C. Methods for enhanced protein production
WO2012081931A2 (ko) * 2010-12-17 2012-06-21 Kim Sung-Chun 세포배양을 통한 세포 및 지용성물질의 생산 방법 및 장치

Also Published As

Publication number Publication date
RU2016105100A (ru) 2017-08-21
US9982226B2 (en) 2018-05-29
AU2013341858A1 (en) 2015-06-11
BR112015010544A2 (pt) 2017-07-11
SG11201601362VA (en) 2016-04-28
BR112015010544B1 (pt) 2021-01-05
RU2639556C2 (ru) 2017-12-21
SG10201703385YA (en) 2017-05-30
AU2013341858B2 (en) 2017-11-02
CA2890813C (en) 2022-07-12
WO2014073967A1 (en) 2014-05-15
US20150299644A1 (en) 2015-10-22
MY181264A (en) 2020-12-21
MX2015005822A (es) 2016-02-10
EP2917323A1 (en) 2015-09-16
TWI637057B (zh) 2018-10-01
TW201418468A (zh) 2014-05-16
CA2890813A1 (en) 2014-05-15

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