MX2015005822A - Procesamiento discontinuo de alimentacion por lotes con el uso de biorreactores alternantes. - Google Patents

Procesamiento discontinuo de alimentacion por lotes con el uso de biorreactores alternantes.

Info

Publication number
MX2015005822A
MX2015005822A MX2015005822A MX2015005822A MX2015005822A MX 2015005822 A MX2015005822 A MX 2015005822A MX 2015005822 A MX2015005822 A MX 2015005822A MX 2015005822 A MX2015005822 A MX 2015005822A MX 2015005822 A MX2015005822 A MX 2015005822A
Authority
MX
Mexico
Prior art keywords
fed batch
batch processing
discontinuous
bioreactors
alternating
Prior art date
Application number
MX2015005822A
Other languages
English (en)
Other versions
MX364790B (es
Inventor
Jacob Arthur Tijsterman
Original Assignee
Biosana Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosana Pty Ltd filed Critical Biosana Pty Ltd
Publication of MX2015005822A publication Critical patent/MX2015005822A/es
Publication of MX364790B publication Critical patent/MX364790B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a cultivos celulares discontinuos de alimentación por lotes de células de mamífero (más específicamente células de CHO) con el uso de biorreactores alternos en combinación con la separación discontinua de biomasa de la sustancia biológica (más específicamente anticuerpos monoclonales) y los componentes residuales.
MX2015005822A 2012-11-09 2013-11-08 Procesamiento discontinuo de alimentacion por lotes con el uso de biorreactores alternantes. MX364790B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2012050798 2012-11-09
PCT/NL2013/050805 WO2014073967A1 (en) 2012-11-09 2013-11-08 Discontinuous fed batch processing with the use of alternating bioreactors

Publications (2)

Publication Number Publication Date
MX2015005822A true MX2015005822A (es) 2016-02-10
MX364790B MX364790B (es) 2019-05-03

Family

ID=47278493

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015005822A MX364790B (es) 2012-11-09 2013-11-08 Procesamiento discontinuo de alimentacion por lotes con el uso de biorreactores alternantes.

Country Status (11)

Country Link
US (1) US9982226B2 (es)
EP (1) EP2917323A1 (es)
AU (1) AU2013341858B2 (es)
BR (1) BR112015010544B1 (es)
CA (1) CA2890813C (es)
MX (1) MX364790B (es)
MY (1) MY181264A (es)
RU (1) RU2639556C2 (es)
SG (2) SG11201601362VA (es)
TW (1) TWI637057B (es)
WO (1) WO2014073967A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2730528C (en) * 2008-07-16 2018-06-12 Kbi Biopharma, Inc. Methods and systems for manipulating particles using a fluidized bed
MX2016004564A (es) 2013-10-11 2016-07-12 Regeneron Pharma Cultivo celular metabolicamente optimizado.
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
US11384378B2 (en) 2014-06-04 2022-07-12 Amgen Inc. Methods for harvesting mammalian cell cultures
CA3032099A1 (en) * 2016-07-25 2018-02-01 Repligen Corporation Alternating tangential flow rapid harvesting
US11920119B2 (en) 2018-02-09 2024-03-05 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
US11932842B2 (en) 2018-02-09 2024-03-19 Global Life Sciences Solutions Usa Llc Bioprocessing apparatus
US11371007B2 (en) * 2018-02-09 2022-06-28 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US12077743B2 (en) 2018-02-09 2024-09-03 Global Life Sciences Solutions Usa Llc Apparatus for fluid line management in a bioprocessing system
US11414639B2 (en) 2018-02-09 2022-08-16 Global Life Sciences Solutions Usa Llc Bioprocessing vessel
EP3797149A1 (en) * 2018-05-22 2021-03-31 Nantkwest, Inc. Methods and systems for cell bed formation during bioprocessing
US12071607B2 (en) * 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
US10792618B2 (en) 2018-06-19 2020-10-06 Sartorius Stedim Biotech Gmbh Particle separation and/or purification of a fluid
TWI662122B (zh) * 2018-07-12 2019-06-11 聯發生物科技股份有限公司 發酵設備
GB201904083D0 (en) * 2019-03-25 2019-05-08 Ge Healthcare Bio Sciences Ab A bioreactor system
WO2022027013A1 (en) * 2020-07-28 2022-02-03 Seagen Inc. Methods and systems for producing polypeptides
EP4056671A1 (en) * 2021-03-10 2022-09-14 Sartorius Stedim Biotech GmbH Method for operating a bioprocess installation
EP4124653A1 (en) * 2021-07-27 2023-02-01 Sartorius Stedim Biotech GmbH Method for producing a bioproduct
WO2023167584A1 (en) * 2022-03-01 2023-09-07 Biosanapharma B.V. Continuous manufacturing of a biological substance with process traceability

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK309184D0 (da) * 1984-06-25 1984-06-25 Nordisk Insulinlab Fremgangsmaade til isolering af insulin eller insulinlignende materiale fra en fermenteringsvaeske
DE3833925A1 (de) * 1988-03-11 1989-09-21 Inst Angewandte Biotechnologie Verfahren und herstellung von virus und viralem antigen und vorrichtung hierzu
RU2058992C1 (ru) * 1993-07-14 1996-04-27 Антипин Георгий Васильевич Способ получения кормового белка и устройство для его осуществления
EP1648586A4 (en) 2003-06-17 2007-09-05 Centocor Inc METHOD AND APPARATUS FOR FILTRATION OF RECOMBINANT BIOREACTOR PROTEINS
ES2565077T3 (es) * 2003-10-10 2016-03-31 Novo Nordisk Health Care Ag Método para producción en gran escala de un polipéptido en células eucariotas
CN1930281A (zh) 2004-03-05 2007-03-14 帝斯曼知识产权资产管理有限公司 用于通过连续灌注和交互切向流来培养细胞的方法
DK2343362T4 (da) 2006-07-14 2024-07-08 Patheon Holdings I B V Forbedret fremgangsmåde til dyrkning af celler
US20090042253A1 (en) * 2007-08-09 2009-02-12 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
EP2285464A4 (en) * 2008-04-22 2014-01-01 Pneumatic Scale Corp CENTRIFUGE SYSTEM FOR UNIQUE USE
CA2730528C (en) 2008-07-16 2018-06-12 Kbi Biopharma, Inc. Methods and systems for manipulating particles using a fluidized bed
EP3391970B1 (en) 2009-10-06 2020-01-22 Sartorius Stedim North America Inc. Method and apparatus for manipulating particles
EP3255153A1 (en) * 2009-11-17 2017-12-13 E. R. Squibb & Sons, L.L.C. Methods for enhanced protein production
US20130309757A1 (en) * 2010-12-17 2013-11-21 Sung-Chun Kim Method and apparatus for producing cells and fat soluble materials by cell culture

Also Published As

Publication number Publication date
SG11201601362VA (en) 2016-04-28
AU2013341858A1 (en) 2015-06-11
AU2013341858B2 (en) 2017-11-02
TW201418468A (zh) 2014-05-16
US9982226B2 (en) 2018-05-29
TWI637057B (zh) 2018-10-01
EP2917323A1 (en) 2015-09-16
BR112015010544B1 (pt) 2021-01-05
MY181264A (en) 2020-12-21
CA2890813A1 (en) 2014-05-15
CA2890813C (en) 2022-07-12
BR112015010544A2 (pt) 2017-07-11
WO2014073967A1 (en) 2014-05-15
RU2016105100A (ru) 2017-08-21
SG10201703385YA (en) 2017-05-30
RU2639556C2 (ru) 2017-12-21
US20150299644A1 (en) 2015-10-22
MX364790B (es) 2019-05-03

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