MX362340B - Preparacion de intermediarios de agentes de contraste de rayos x. - Google Patents
Preparacion de intermediarios de agentes de contraste de rayos x.Info
- Publication number
- MX362340B MX362340B MX2015005981A MX2015005981A MX362340B MX 362340 B MX362340 B MX 362340B MX 2015005981 A MX2015005981 A MX 2015005981A MX 2015005981 A MX2015005981 A MX 2015005981A MX 362340 B MX362340 B MX 362340B
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- compound
- intermediates
- contrast agents
- ray contrast
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 4
- 239000002872 contrast media Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 229940126062 Compound A Drugs 0.000 abstract 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 2
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 abstract 2
- BHCBLTRDEYPMFZ-UHFFFAOYSA-N 5-acetamido-1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound CC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I BHCBLTRDEYPMFZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000020176 deacylation Effects 0.000 abstract 1
- 238000005947 deacylation reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a un proceso para la preparación de agentes de contraste de rayos X yodados y en particular a intermediarios clave de los mismos. En particular se refiere a un proceso mejorado para la preparación de 5-acetamido-N, N'-bis(2,3-dihidroxipropil)-2,4,6-triyodoisoftalamida (Compuesto A) o N,N'-bis(2,3- dihidroxipropil)-5-formamido-2,4,6-triyodoisoft alamida (Compuesto C), los cuales son intermediarios en la preparación industrial de agentes de contrate de rayos X no iónicos. De manera más particular, la invención proporciona un proceso para la deacilación de los grupos hidroxilo acilados de un compuesto intermediario de Compuesto A y Compuesto C.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12192193 | 2012-11-12 | ||
| PCT/US2013/066487 WO2014074315A1 (en) | 2012-11-12 | 2013-10-24 | Preparation of intermediates of x-ray contrast agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015005981A MX2015005981A (es) | 2015-09-10 |
| MX362340B true MX362340B (es) | 2019-01-11 |
Family
ID=47146268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015005981A MX362340B (es) | 2012-11-12 | 2013-10-24 | Preparacion de intermediarios de agentes de contraste de rayos x. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9403757B2 (es) |
| EP (1) | EP2917174B1 (es) |
| JP (1) | JP6248119B2 (es) |
| KR (1) | KR102172700B1 (es) |
| CN (2) | CN104768921A (es) |
| AU (1) | AU2013341615B2 (es) |
| BR (1) | BR112015006502B1 (es) |
| CA (1) | CA2881707C (es) |
| ES (1) | ES2692071T3 (es) |
| IN (1) | IN2015DN01143A (es) |
| MX (1) | MX362340B (es) |
| PL (1) | PL2917174T3 (es) |
| PT (1) | PT2917174T (es) |
| RU (1) | RU2659214C2 (es) |
| WO (1) | WO2014074315A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT108524B (pt) * | 2015-06-02 | 2017-12-15 | Hovione Farmaciência S A | Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos |
| CN108752230B (zh) * | 2018-07-12 | 2020-11-03 | 浙江海洲制药有限公司 | 一种造影剂碘克沙醇杂质e的关键中间体的合成方法 |
| KR102128423B1 (ko) | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
| EP4001261A1 (en) * | 2020-11-23 | 2022-05-25 | Justesa Imagen S.A.U | Procedure for obtaining high purity iohexol |
| CN114853625A (zh) * | 2022-03-31 | 2022-08-05 | 海南普利制药股份有限公司 | 一种工业化生产碘海醇中间体的方法 |
| CN114989034B (zh) * | 2022-06-28 | 2024-02-23 | 浙江海洲制药股份有限公司 | 一种碘海醇杂质的合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0108638B1 (en) | 1982-11-08 | 1986-07-16 | NYEGAARD & CO. A/S | X-ray contrast agents |
| GB9419203D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
| GB9624612D0 (en) | 1996-11-26 | 1997-01-15 | Nycomed Imaging As | Process |
| GB9903109D0 (en) * | 1999-02-11 | 1999-04-07 | Nycomed Imaging As | Process |
| IT1319670B1 (it) * | 2000-12-01 | 2003-10-23 | Bracco Spa | Processo per la preparazione di 5-ammino-n,n'-bis(2-idrossi-1-(idrossimetil)etil))-1,3-benzendicarbossammide (i) e 5-ammino-n,n'- |
| ITMI20010773A1 (it) * | 2001-04-11 | 2002-10-11 | Chemi Spa | Processo per la produzione di ioexolo ad elevata purezza |
| NO20043305D0 (no) * | 2004-08-09 | 2004-08-09 | Amersham Health As | Preparation of lodixanol |
| ES2486296T3 (es) * | 2007-07-12 | 2014-08-18 | Ge Healthcare As | Agentes de contraste |
| US20110021822A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents |
| US20110021828A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration |
-
2013
- 2013-10-24 WO PCT/US2013/066487 patent/WO2014074315A1/en active Application Filing
- 2013-10-24 CN CN201380058817.8A patent/CN104768921A/zh active Pending
- 2013-10-24 BR BR112015006502-3A patent/BR112015006502B1/pt active IP Right Grant
- 2013-10-24 PT PT13854067T patent/PT2917174T/pt unknown
- 2013-10-24 RU RU2015114789A patent/RU2659214C2/ru active
- 2013-10-24 PL PL13854067T patent/PL2917174T3/pl unknown
- 2013-10-24 EP EP13854067.9A patent/EP2917174B1/en active Active
- 2013-10-24 CN CN201910451005.9A patent/CN110229079A/zh active Pending
- 2013-10-24 JP JP2015541795A patent/JP6248119B2/ja active Active
- 2013-10-24 CA CA2881707A patent/CA2881707C/en active Active
- 2013-10-24 AU AU2013341615A patent/AU2013341615B2/en active Active
- 2013-10-24 MX MX2015005981A patent/MX362340B/es active IP Right Grant
- 2013-10-24 US US14/437,430 patent/US9403757B2/en active Active
- 2013-10-24 ES ES13854067.9T patent/ES2692071T3/es active Active
- 2013-10-24 KR KR1020157011933A patent/KR102172700B1/ko active IP Right Grant
-
2015
- 2015-02-12 IN IN1143DEN2015 patent/IN2015DN01143A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2015114789A (ru) | 2017-01-10 |
| BR112015006502A2 (pt) | 2017-07-04 |
| CA2881707C (en) | 2021-01-12 |
| IN2015DN01143A (es) | 2015-06-26 |
| EP2917174A4 (en) | 2016-06-08 |
| WO2014074315A1 (en) | 2014-05-15 |
| EP2917174A1 (en) | 2015-09-16 |
| EP2917174B1 (en) | 2018-09-12 |
| KR102172700B1 (ko) | 2020-11-03 |
| ES2692071T3 (es) | 2018-11-30 |
| AU2013341615B2 (en) | 2017-12-14 |
| JP6248119B2 (ja) | 2017-12-13 |
| KR20150082293A (ko) | 2015-07-15 |
| CN110229079A (zh) | 2019-09-13 |
| AU2013341615A1 (en) | 2015-02-26 |
| MX2015005981A (es) | 2015-09-10 |
| US20150274645A1 (en) | 2015-10-01 |
| CN104768921A (zh) | 2015-07-08 |
| BR112015006502B1 (pt) | 2021-03-09 |
| PT2917174T (pt) | 2018-11-14 |
| CA2881707A1 (en) | 2014-05-15 |
| JP2016501184A (ja) | 2016-01-18 |
| US9403757B2 (en) | 2016-08-02 |
| RU2659214C2 (ru) | 2018-07-05 |
| PL2917174T3 (pl) | 2019-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2015005981A (es) | Preparacion de intermediarios de agentes de contraste de rayos x. | |
| MX2013006378A (es) | Catalizadores de blanqueo. | |
| UA114611C2 (uk) | Пестицидні композиції і способи, що їх стосуються | |
| PH12014502697B1 (en) | New diazaspirocycloalkane and azaspirocycloalkane | |
| MX2013002264A (es) | Composiciones pesticidas. | |
| MX2013004338A (es) | Secuencias de repeticiones palindromicas cortas separadas regularmente agrupadas-cas (crisp-cas). | |
| BRPI1005940A2 (pt) | processo para preparar compostos de 2-nitrobifenila de fórmula i, compostos de 2-aminobifenila de fórmula vi, n-acil-2-aminobifenilas da fórmula geral (vii), composto de fórmula i, composto de fórmula ii, composto de fórmula iii e composto de fórmula x.1 ou x.2 | |
| MX2014015197A (es) | Tratamiento y prevencion de la enfermedad cardiovascular y trombosis. | |
| BR112015009034A2 (pt) | método para a preparação de uma suspensão aquosa, suspensão aquosa, e, uso de uma suspensão aquosa | |
| MX2013000793A (es) | Composicion que contiene galacto-oligosacarido y un metodo para producirla. | |
| BR112012004652A2 (pt) | composições de soluções concentradas compreendendo metal do grupo vi, metal do grupo viii e fósforo e processo de formação | |
| BR112013003121A2 (pt) | moduladores de trpv3 | |
| MX2010004546A (es) | Nuevos intermedios de pregabalina y procedimiento para prepararlos y para preparar pregabalina. | |
| BR112012022090A2 (pt) | utilização de ácido elágico como agente anticaspa | |
| MX2012007142A (es) | Uso de 2,3-dihidroxipropil dodecanoato para tratar seborrea. | |
| MX2012002299A (es) | Uso de cetoenoles ciclicos contra bacterias fitopatogenas. | |
| PH12014500158B1 (en) | Preparation of (r)- and (s)-n-(3, 4-difluoro-2-(2-fluoro-4-iodophenylamino)--6-methoxyphenyl) -1- (2, 3-dihydroxypropyl)cyclopropane-1-sulfonamide and protected derivatives thereof | |
| MX2013003859A (es) | Polimorfos de picropodofilina b o c para su uso en la terapia del cancer. | |
| NZ708503A (en) | Purification of x-ray contrast agents | |
| MX346980B (es) | Nuevos compuestos de hexahidrociclopentapirrolona, hexahidropirrolopirrolona, octahidropirrolopiridinona y octahidropiridinona. | |
| IN2015DN03944A (es) | ||
| IT1403988B1 (it) | Processo per la preparazione di agenti di contrasto. | |
| IN2015DN01186A (es) | ||
| IN2015DN01185A (es) | ||
| BR112013013306A8 (pt) | Processos para a preparação de enaminas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |