MX2013004338A - Secuencias de repeticiones palindromicas cortas separadas regularmente agrupadas-cas (crisp-cas). - Google Patents
Secuencias de repeticiones palindromicas cortas separadas regularmente agrupadas-cas (crisp-cas).Info
- Publication number
- MX2013004338A MX2013004338A MX2013004338A MX2013004338A MX2013004338A MX 2013004338 A MX2013004338 A MX 2013004338A MX 2013004338 A MX2013004338 A MX 2013004338A MX 2013004338 A MX2013004338 A MX 2013004338A MX 2013004338 A MX2013004338 A MX 2013004338A
- Authority
- MX
- Mexico
- Prior art keywords
- lactococcus crispr
- cas sequences
- lactococcus
- crispr
- cas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
Abstract
La presente invención se refiere a un ácido nucleico que comprende una región de repetición de CRISPR de Lactococcus y/o una región separadora de CRISPR de Lactococcus.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39497610P | 2010-10-20 | 2010-10-20 | |
US40531710P | 2010-10-21 | 2010-10-21 | |
PCT/US2011/057102 WO2012054726A1 (en) | 2010-10-20 | 2011-10-20 | Lactococcus crispr-cas sequences |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013004338A true MX2013004338A (es) | 2013-05-20 |
Family
ID=44863288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013004338A MX2013004338A (es) | 2010-10-20 | 2011-10-20 | Secuencias de repeticiones palindromicas cortas separadas regularmente agrupadas-cas (crisp-cas). |
Country Status (11)
Country | Link |
---|---|
US (1) | US9951341B2 (es) |
EP (1) | EP2630156B1 (es) |
CN (1) | CN103261213A (es) |
AU (1) | AU2011316980A1 (es) |
BR (1) | BR112013009583A2 (es) |
CA (1) | CA2814810A1 (es) |
DK (1) | DK2630156T3 (es) |
EA (1) | EA201390586A1 (es) |
MX (1) | MX2013004338A (es) |
NZ (1) | NZ607870A (es) |
WO (1) | WO2012054726A1 (es) |
Families Citing this family (69)
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NZ597299A (en) | 2005-08-26 | 2013-03-28 | Dupont Nutrition Biosci Aps | Use of a cas gene in combination with CRISPR repeats for modulating resistance in a cell |
ES2373586T3 (es) | 2006-05-19 | 2012-02-06 | Danisco A/S | Microorganismos marcados y métodos para marcar. |
JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
PE20190844A1 (es) | 2012-05-25 | 2019-06-17 | Emmanuelle Charpentier | Modulacion de transcripcion con arn de direccion a adn generico |
KR102145760B1 (ko) | 2012-12-06 | 2020-08-19 | 시그마-알드리치 컴퍼니., 엘엘씨 | Crispr-기초된 유전체 변형과 조절 |
DK3620534T3 (da) | 2013-03-14 | 2021-12-06 | Caribou Biosciences Inc | Crispr-cas sammensætninger af nucleinsyre-targeting nucleinsyrer |
US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
EP3741868A1 (en) | 2013-03-15 | 2020-11-25 | The General Hospital Corporation | Rna-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
WO2014204578A1 (en) | 2013-06-21 | 2014-12-24 | The General Hospital Corporation | Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing |
US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
JP2016522679A (ja) | 2013-04-04 | 2016-08-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | CRISPR/Cas系を用いたゲノム編集の治療的使用 |
US9902973B2 (en) | 2013-04-11 | 2018-02-27 | Caribou Biosciences, Inc. | Methods of modifying a target nucleic acid with an argonaute |
JP2016528890A (ja) | 2013-07-09 | 2016-09-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | CRISPR/Cas系を用いるゲノム編集の治療用の使用 |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
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US10584358B2 (en) * | 2013-10-30 | 2020-03-10 | North Carolina State University | Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri |
WO2015069682A2 (en) * | 2013-11-05 | 2015-05-14 | President And Fellows Of Harvard College | Precise microbiota engineering at the cellular level |
LT3066201T (lt) | 2013-11-07 | 2018-08-10 | Editas Medicine, Inc. | Su crispr susiję būdai ir kompozicijos su valdančiomis grnr |
US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
US10787654B2 (en) | 2014-01-24 | 2020-09-29 | North Carolina State University | Methods and compositions for sequence guiding Cas9 targeting |
AU2015236045B2 (en) | 2014-03-25 | 2021-09-23 | Ginkgo Bioworks, Inc. | Methods and genetic systems for cell engineering |
JP2017512481A (ja) | 2014-04-08 | 2017-05-25 | ノースカロライナ ステート ユニバーシティーNorth Carolina State University | Crispr関連遺伝子を用いた、rna依存性の転写抑制のための方法および組成物 |
WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
EP3633032A3 (en) | 2014-08-28 | 2020-07-29 | North Carolina State University | Novel cas9 proteins and guiding features for dna targeting and genome editing |
GB201506509D0 (en) | 2015-04-16 | 2015-06-03 | Univ Wageningen | Nuclease-mediated genome editing |
KR20200091499A (ko) * | 2015-05-06 | 2020-07-30 | 스니프르 테크놀로지스 리미티드 | 미생물 개체군 변경 및 미생물군 변형 |
EP3303607A4 (en) | 2015-05-29 | 2018-10-10 | North Carolina State University | Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids |
JP7051438B2 (ja) | 2015-06-15 | 2022-04-11 | ノース カロライナ ステート ユニバーシティ | 核酸およびrnaに基づく抗菌剤の効率的な送達のための方法および組成物 |
US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
US10648020B2 (en) | 2015-06-18 | 2020-05-12 | The Broad Institute, Inc. | CRISPR enzymes and systems |
US9926546B2 (en) | 2015-08-28 | 2018-03-27 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
AU2016316845B2 (en) | 2015-08-28 | 2022-03-10 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
US9512446B1 (en) | 2015-08-28 | 2016-12-06 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
EP3356533A1 (en) | 2015-09-28 | 2018-08-08 | North Carolina State University | Methods and compositions for sequence specific antimicrobials |
US20190225955A1 (en) | 2015-10-23 | 2019-07-25 | President And Fellows Of Harvard College | Evolved cas9 proteins for gene editing |
US11542466B2 (en) | 2015-12-22 | 2023-01-03 | North Carolina State University | Methods and compositions for delivery of CRISPR based antimicrobials |
KR20180136435A (ko) | 2016-01-27 | 2018-12-24 | 온코루스, 인크. | 종양 살상형 바이러스 벡터 및 그의 용도 |
EP3219799A1 (en) | 2016-03-17 | 2017-09-20 | IMBA-Institut für Molekulare Biotechnologie GmbH | Conditional crispr sgrna expression |
EP3445853A1 (en) | 2016-04-19 | 2019-02-27 | The Broad Institute, Inc. | Cpf1 complexes with reduced indel activity |
KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
US11078481B1 (en) | 2016-08-03 | 2021-08-03 | KSQ Therapeutics, Inc. | Methods for screening for cancer targets |
AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
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KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
EP3592777A1 (en) | 2017-03-10 | 2020-01-15 | President and Fellows of Harvard College | Cytosine to guanine base editor |
US11268082B2 (en) | 2017-03-23 | 2022-03-08 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
US11591589B2 (en) | 2017-04-21 | 2023-02-28 | The General Hospital Corporation | Variants of Cpf1 (Cas12a) with altered PAM specificity |
US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
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AU2018306455A1 (en) | 2017-07-26 | 2020-02-27 | Virogin Biotech Canada Ltd | Oncolytic viral vectors and uses thereof |
WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
US10711267B2 (en) | 2018-10-01 | 2020-07-14 | North Carolina State University | Recombinant type I CRISPR-Cas system |
US20220177943A1 (en) * | 2018-10-01 | 2022-06-09 | Rodolphe Barrangou | Recombinant type i crispr-cas system and uses thereof for screening for variant cells |
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NZ597299A (en) | 2005-08-26 | 2013-03-28 | Dupont Nutrition Biosci Aps | Use of a cas gene in combination with CRISPR repeats for modulating resistance in a cell |
ES2373586T3 (es) | 2006-05-19 | 2012-02-06 | Danisco A/S | Microorganismos marcados y métodos para marcar. |
CN104531672B (zh) | 2007-03-02 | 2020-01-10 | 杜邦营养生物科学有限公司 | 具有改善的噬菌体抗性的培养物 |
WO2010054154A2 (en) | 2008-11-07 | 2010-05-14 | Danisco A/S | Bifidobacteria crispr sequences |
-
2011
- 2011-10-20 WO PCT/US2011/057102 patent/WO2012054726A1/en active Application Filing
- 2011-10-20 MX MX2013004338A patent/MX2013004338A/es unknown
- 2011-10-20 EP EP11775892.0A patent/EP2630156B1/en active Active
- 2011-10-20 US US13/880,391 patent/US9951341B2/en active Active
- 2011-10-20 AU AU2011316980A patent/AU2011316980A1/en not_active Abandoned
- 2011-10-20 NZ NZ607870A patent/NZ607870A/en not_active IP Right Cessation
- 2011-10-20 CA CA2814810A patent/CA2814810A1/en not_active Abandoned
- 2011-10-20 CN CN2011800487182A patent/CN103261213A/zh active Pending
- 2011-10-20 DK DK11775892.0T patent/DK2630156T3/en active
- 2011-10-20 BR BR112013009583A patent/BR112013009583A2/pt not_active IP Right Cessation
- 2011-10-20 EA EA201390586A patent/EA201390586A1/ru unknown
Also Published As
Publication number | Publication date |
---|---|
EP2630156A1 (en) | 2013-08-28 |
CN103261213A (zh) | 2013-08-21 |
AU2011316980A1 (en) | 2013-04-18 |
US20130288251A1 (en) | 2013-10-31 |
CA2814810A1 (en) | 2012-04-26 |
EP2630156B1 (en) | 2018-08-22 |
EA201390586A1 (ru) | 2014-11-28 |
DK2630156T3 (en) | 2018-12-17 |
NZ607870A (en) | 2015-09-25 |
BR112013009583A2 (pt) | 2017-05-30 |
US9951341B2 (en) | 2018-04-24 |
WO2012054726A1 (en) | 2012-04-26 |
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