MX361451B - Detección objetivo de múltiples aptámeros. - Google Patents
Detección objetivo de múltiples aptámeros.Info
- Publication number
- MX361451B MX361451B MX2016003320A MX2016003320A MX361451B MX 361451 B MX361451 B MX 361451B MX 2016003320 A MX2016003320 A MX 2016003320A MX 2016003320 A MX2016003320 A MX 2016003320A MX 361451 B MX361451 B MX 361451B
- Authority
- MX
- Mexico
- Prior art keywords
- multiaptamer
- target detection
- aptamer
- compositions
- target
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 108091023037 Aptamer Proteins 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1048—SELEX
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/13—Applications; Uses in screening processes in a process of directed evolution, e.g. SELEX, acquiring a new function
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/205—Aptamer
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361881629P | 2013-09-24 | 2013-09-24 | |
| PCT/US2014/057143 WO2015048084A1 (en) | 2013-09-24 | 2014-09-24 | Multiaptamer target detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016003320A MX2016003320A (es) | 2016-05-31 |
| MX361451B true MX361451B (es) | 2018-12-06 |
Family
ID=52744404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016003320A MX361451B (es) | 2013-09-24 | 2014-09-24 | Detección objetivo de múltiples aptámeros. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9926566B2 (OSRAM) |
| EP (1) | EP3049523B1 (OSRAM) |
| JP (1) | JP6506768B2 (OSRAM) |
| KR (1) | KR102348283B1 (OSRAM) |
| CN (2) | CN105555957A (OSRAM) |
| AU (1) | AU2014326975B2 (OSRAM) |
| BR (1) | BR112016005957A2 (OSRAM) |
| CA (1) | CA2924987C (OSRAM) |
| HK (1) | HK1218765A1 (OSRAM) |
| IL (1) | IL244284B (OSRAM) |
| MX (1) | MX361451B (OSRAM) |
| SG (1) | SG11201602063UA (OSRAM) |
| WO (1) | WO2015048084A1 (OSRAM) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102348283B1 (ko) | 2013-09-24 | 2022-01-10 | 소마로직, 인크. | 멀티앱타머 표적 검출 |
| EP3224361B1 (en) | 2014-11-24 | 2019-06-19 | Somalogic, Inc. | Nucleic acid compounds for binding growth differentiation factor 11 |
| PL3387152T3 (pl) * | 2015-12-08 | 2022-05-09 | Twinstrand Biosciences, Inc. | Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego |
| DK3430022T3 (da) | 2016-03-14 | 2020-05-18 | Somalogic Inc | Forbindelser og fremgangsmåder til syntese af 5-(N-beskyttet-tryptaminocarboxyamid)-2'-deoxyuridin-phosphoramidit til inkorporering i en nukleinsyresekvens |
| JP2019521680A (ja) * | 2016-06-17 | 2019-08-08 | プロクシミティー バイオサイエンシズ，エルエルシー | アプタマーペアを選択する方法 |
| EP3478843B1 (en) * | 2016-07-01 | 2021-08-04 | Somalogic, Inc. | Oligonucleotides comprising modified nucleosides |
| DK3548652T3 (da) | 2016-12-01 | 2024-07-08 | Nautilus Subsidiary Inc | Fremgangsmåder til proteinanalyse |
| WO2019103131A1 (ja) * | 2017-11-24 | 2019-05-31 | 国立大学法人 東京大学 | アプタマーの結合部位判別方法、アプタマーペアおよび目的物質からなる三元錯体の解離定数等の測定方法並びに最適なアプタマーペアの選択方法 |
| IL326759A (en) | 2017-12-29 | 2026-04-01 | Nautilus Subsidiary Inc | Decoding approaches for protein identification |
| EP3810563A4 (en) * | 2018-06-22 | 2022-03-23 | Somalogic, Inc. | IMPROVED PROTEOMIC MULTIPLEX TESTS |
| AU2021288692A1 (en) | 2020-06-11 | 2023-02-02 | Nautilus Subsidiary, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
| US12092642B2 (en) | 2021-01-20 | 2024-09-17 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule quantitation |
| EP4281775B1 (en) | 2021-01-21 | 2026-04-29 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule preparation |
| IL305336B2 (en) | 2021-03-11 | 2025-09-01 | Nautilus Subsidiary Inc | Systems and methods for preserving biomolecules |
| CA3227872A1 (en) | 2021-09-09 | 2023-03-16 | James Henry JOLY | Characterization and localization of protein modifications |
| JP2024537689A (ja) | 2021-09-22 | 2024-10-16 | ノーティラス・サブシディアリー・インコーポレイテッド | ポリペプチド相互作用を決定するための方法及びシステム |
| WO2023081728A1 (en) | 2021-11-03 | 2023-05-11 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| US12612656B2 (en) | 2021-11-30 | 2026-04-28 | Nautilus Subsidiary, Inc. | Particle-based isolation of proteins and other analytes |
| US12092578B2 (en) | 2022-03-29 | 2024-09-17 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
| WO2023212490A1 (en) | 2022-04-25 | 2023-11-02 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
| EP4544077A1 (en) | 2022-06-21 | 2025-04-30 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| WO2024059655A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| EP4619766A1 (en) | 2022-11-15 | 2025-09-24 | Nautilus Subsidiary, Inc. | Standard polypeptides |
| US20240192202A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | Fluidic media for single-analtye arrays |
| WO2024130000A1 (en) | 2022-12-15 | 2024-06-20 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| WO2024151373A1 (en) | 2023-01-12 | 2024-07-18 | Nautilus Subsidiary, Inc. | Characterization of glycans and glycoconjugates |
| EP4689173A1 (en) | 2023-03-24 | 2026-02-11 | Nautilus Subsidiary, Inc. | Improved transfer of nanoparticles to array surfaces |
| US20240353416A1 (en) | 2023-04-13 | 2024-10-24 | Nautilus Subsidiary, Inc. | Artificial proteins for displaying epitopes |
| EP4720641A1 (en) | 2023-05-24 | 2026-04-08 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| WO2025128588A1 (en) | 2023-12-11 | 2025-06-19 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| US20250205706A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
| WO2025199236A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| US20250305034A1 (en) | 2024-04-01 | 2025-10-02 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
| WO2026073213A1 (en) * | 2024-09-30 | 2026-04-02 | Illumina, Inc. | Protein capture techniques with surface linked aptamers |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020037506A1 (en) * | 2000-04-18 | 2002-03-28 | Yun Lin | Aptamer based two-site binding assay |
| EP2351855A1 (en) * | 2000-09-26 | 2011-08-03 | Duke University | RNA aptamers and methods for identifying the same |
| US20070071744A1 (en) | 2002-06-07 | 2007-03-29 | Gotz Munch | Agents which bind to epitopes of glycoprotein VI |
| US7595160B2 (en) | 2004-01-13 | 2009-09-29 | U.S. Genomics, Inc. | Analyte detection using barcoded polymers |
| US7795009B2 (en) * | 2005-06-15 | 2010-09-14 | Saint Louis University | Three-component biosensors for detecting macromolecules and other analytes |
| WO2007056250A2 (en) | 2005-11-04 | 2007-05-18 | U.S. Genomics, Inc. | Heterogeneous assay of analytes in solution using polymers |
| WO2008039642A2 (en) | 2006-09-26 | 2008-04-03 | Replidyne, Inc. | Methods and compounds for treatment of clostridium based infection |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| DK2172566T4 (da) * | 2007-07-17 | 2022-06-13 | Somalogic Inc | Fremgangsmåde til generering af aptamerer med forbedrede off-rates |
| WO2009037264A2 (en) | 2007-09-17 | 2009-03-26 | Da Volterra | Colonic delivery of antimicrobial agents |
| US8569252B2 (en) | 2009-04-15 | 2013-10-29 | Postech Academy-Industry Foundation | Nucleolin specific aptamer and use thereof |
| US20110256535A1 (en) | 2010-02-11 | 2011-10-20 | Intelligent Medical Devices, Inc. | Optimized oligonucleotides and methods of using same for the detection, isolation, amplification, quantification, monitoring, screening and sequencing of clostridium difficile genes encoding toxin b, and/or toxin a and/or binary toxin |
| GB201002627D0 (en) | 2010-02-16 | 2010-03-31 | Loxbridge Res Llp | Aptamer based analyte detection method |
| AU2011240774B2 (en) * | 2010-04-12 | 2014-04-10 | Otsuka Pharmaceutical Co., Ltd. | Aptamers to beta-NGF and their use in treating beta-NGF mediated diseases and disorders |
| US8785132B2 (en) * | 2010-04-23 | 2014-07-22 | Postech Academy-Industry Foundation | Aptamer sandwich assays |
| US20150031585A1 (en) | 2011-03-10 | 2015-01-29 | Somalogic, Inc. | Multiaptamer Target Detection |
| ES2629183T3 (es) | 2011-03-10 | 2017-08-07 | Somalogic, Inc. | Aptámeros para diagnóstico de Clostridium difficile |
| WO2012149198A2 (en) * | 2011-04-26 | 2012-11-01 | Regado Biosciences, Inc. | A method for manufacturing pegylated oligonucleotides |
| SG10201607331WA (en) * | 2011-09-30 | 2016-11-29 | Somalogic Inc | Cardiovascular risk event prediction and uses thereof |
| EP2798085B1 (en) | 2011-12-30 | 2018-01-24 | Quest Diagnostics Investments Incorporated | Aptamers and diagnostic methods for detecting the egf receptor |
| KR102348283B1 (ko) | 2013-09-24 | 2022-01-10 | 소마로직, 인크. | 멀티앱타머 표적 검출 |
-
2014
- 2014-09-24 KR KR1020167006262A patent/KR102348283B1/ko active Active
- 2014-09-24 AU AU2014326975A patent/AU2014326975B2/en active Active
- 2014-09-24 US US15/023,182 patent/US9926566B2/en active Active
- 2014-09-24 CA CA2924987A patent/CA2924987C/en active Active
- 2014-09-24 WO PCT/US2014/057143 patent/WO2015048084A1/en not_active Ceased
- 2014-09-24 HK HK16106780.3A patent/HK1218765A1/zh unknown
- 2014-09-24 MX MX2016003320A patent/MX361451B/es active IP Right Grant
- 2014-09-24 JP JP2016544355A patent/JP6506768B2/ja active Active
- 2014-09-24 CN CN201480051210.1A patent/CN105555957A/zh active Pending
- 2014-09-24 EP EP14847780.5A patent/EP3049523B1/en active Active
- 2014-09-24 BR BR112016005957A patent/BR112016005957A2/pt not_active IP Right Cessation
- 2014-09-24 SG SG11201602063UA patent/SG11201602063UA/en unknown
- 2014-09-24 CN CN202210264586.7A patent/CN114703193A/zh active Pending
-
2016
- 2016-02-25 IL IL244284A patent/IL244284B/en active IP Right Grant
-
2018
- 2018-02-13 US US15/895,723 patent/US10392621B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016005957A2 (pt) | 2017-09-26 |
| AU2014326975B2 (en) | 2020-05-07 |
| US20180187197A1 (en) | 2018-07-05 |
| MX2016003320A (es) | 2016-05-31 |
| CA2924987A1 (en) | 2015-04-02 |
| CN114703193A (zh) | 2022-07-05 |
| US10392621B2 (en) | 2019-08-27 |
| KR20160058777A (ko) | 2016-05-25 |
| US20160237435A1 (en) | 2016-08-18 |
| SG11201602063UA (en) | 2016-04-28 |
| EP3049523A1 (en) | 2016-08-03 |
| AU2014326975A2 (en) | 2017-01-05 |
| JP2016531593A (ja) | 2016-10-13 |
| KR102348283B1 (ko) | 2022-01-10 |
| WO2015048084A1 (en) | 2015-04-02 |
| EP3049523A4 (en) | 2017-05-17 |
| CN105555957A (zh) | 2016-05-04 |
| IL244284A0 (en) | 2016-04-21 |
| JP6506768B2 (ja) | 2019-04-24 |
| CA2924987C (en) | 2022-08-16 |
| IL244284B (en) | 2019-12-31 |
| EP3049523B1 (en) | 2019-08-07 |
| US9926566B2 (en) | 2018-03-27 |
| HK1218765A1 (zh) | 2017-03-10 |
| AU2014326975A1 (en) | 2016-04-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2016003320A (es) | Deteccion objetivo de multiples aptameros. | |
| PH12016501763A1 (en) | Multispecific antibodies | |
| MX2020009649A (es) | Anticuerpos monoclonales contra bcma. | |
| EP3039015A4 (en) | Substituted pyrimidine bmi-1 inhibitors | |
| MX366147B (es) | Homopolimero de propileno de baja emision. | |
| MX2016004802A (es) | Anticuerpos anti-r-espondina (anti-rspo) y metodos de uso. | |
| MX2021006732A (es) | Nanoemulsiones para bebidas producidas mediante un proceso de alto cizallamiento. | |
| FI3265123T3 (fi) | Vasta-aineita, käyttöjä & menetelmiä | |
| EP3244910A4 (en) | Cell penetrating antibodies | |
| WO2015009715A3 (en) | Molecular and cellular imaging using engineered hemodynamic responses | |
| WO2014197885A3 (en) | Inhibitors of complement factor h | |
| TWD186824S (zh) | 天線 | |
| EP3888671A3 (en) | Protein formulations | |
| BR112018004657A2 (pt) | composições ativas de alto ph. | |
| MX2015010789A (es) | Anticuerpos anti-pcsm. | |
| ES1078792Y (es) | Unidad de oficina - comisaría móvil. | |
| HK40031494A (en) | Multispecific antibody | |
| AU2017900255A0 (en) | Social Currency | |
| AU2017905058A0 (en) | Improved Density Tracer | |
| AU2017904857A0 (en) | Improved underwear | |
| GB201315626D0 (en) | Lols T.B.W. | |
| AU2016900493A0 (en) | Social Currency | |
| PH32013000496S1 (en) | School uniform (p.e.) | |
| AU2013904153A0 (en) | Improved Objects Type 4. | |
| EP3304092A4 (en) | Essential nutrient ratio determination |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |