MX360979B - Composiciones de galacto-ramnogalacturonato para el tratamiento de la esteatohepatitis no alcohólica y de la enfermedad del higado graso no alcohólico. - Google Patents
Composiciones de galacto-ramnogalacturonato para el tratamiento de la esteatohepatitis no alcohólica y de la enfermedad del higado graso no alcohólico.Info
- Publication number
- MX360979B MX360979B MX2014003213A MX2014003213A MX360979B MX 360979 B MX360979 B MX 360979B MX 2014003213 A MX2014003213 A MX 2014003213A MX 2014003213 A MX2014003213 A MX 2014003213A MX 360979 B MX360979 B MX 360979B
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- galacto
- alcoholic
- liver disease
- fatty liver
- Prior art date
Links
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 title abstract 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/732—Pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161535655P | 2011-09-16 | 2011-09-16 | |
| US201261656288P | 2012-06-06 | 2012-06-06 | |
| PCT/US2012/055360 WO2013040324A1 (en) | 2011-09-16 | 2012-09-14 | Galacto-rhamnogalacturonate compositions for the treatment of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014003213A MX2014003213A (es) | 2015-05-15 |
| MX360979B true MX360979B (es) | 2018-11-22 |
Family
ID=47883762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014003213A MX360979B (es) | 2011-09-16 | 2012-09-14 | Composiciones de galacto-ramnogalacturonato para el tratamiento de la esteatohepatitis no alcohólica y de la enfermedad del higado graso no alcohólico. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20130259870A1 (https=) |
| EP (1) | EP2755480B1 (https=) |
| JP (1) | JP6185473B2 (https=) |
| KR (1) | KR101974675B1 (https=) |
| CN (1) | CN103945695B (https=) |
| AU (1) | AU2012308491B2 (https=) |
| BR (1) | BR112014006220A2 (https=) |
| CA (1) | CA2848711C (https=) |
| ES (1) | ES2869884T3 (https=) |
| IL (1) | IL231512B (https=) |
| MX (1) | MX360979B (https=) |
| WO (2) | WO2013040324A1 (https=) |
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| WO2008011216A2 (en) * | 2006-05-16 | 2008-01-24 | Pro-Pharmaceuticals, Inc. | Galactose-pronged polysaccharides in a formulation for antifibrotic therapies |
| AU2012363033B2 (en) | 2011-12-28 | 2016-06-02 | Galectin Therapeutics, Inc. | Composition of novel carbohydrate drug for treatment of human diseases |
| ES2848538T3 (es) * | 2012-06-06 | 2021-08-10 | Galectin Therapeutics Inc | Composiciones de galacto-ramnogalacturonato para el tratamiento de enfermedades asociadas con elevada óxido nítrico sintasa inducible |
| DK2900061T3 (da) | 2012-09-17 | 2020-03-02 | Galectin Therapeutics Inc | Fremgangsmåde til forstærkning af specifikke immunterapier ved cancerbehandling |
| AU2014321711B2 (en) * | 2013-09-19 | 2019-11-14 | The Research Foundation For The State University Of New York | Methods and materials for treating diabetes or liver steatosis |
| JP2017512205A (ja) * | 2014-03-10 | 2017-05-18 | ラ ホヤ ファーマシューティカル カンパニーLa Jolla Pharmaceutical Company | 腎臓障害を治療するための組成物及び方法 |
| EP3191110A4 (en) * | 2014-08-18 | 2018-04-18 | Pharmagenesis, Inc. | Polygalacturonan rhamnogalacturonan1 (pgrg1) composition |
| MA41120A (fr) * | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| WO2016140237A1 (ja) * | 2015-03-03 | 2016-09-09 | 興人ライフサイエンス株式会社 | 非アルコール性脂肪肝改善又は予防組成物 |
| WO2016160594A1 (en) | 2015-03-27 | 2016-10-06 | The Research Foundation For The State University Of New York | Methods and materials for reducing amyloid beta levels within a mammal |
| CN117402059A (zh) | 2015-05-13 | 2024-01-16 | Ds生物制药有限公司 | 包含15-氧代-epa或15-氧代-dgla的组合物及其制备和使用方法 |
| CA3178499A1 (en) * | 2015-06-30 | 2017-01-05 | Eiger Group International, Inc. | Use of clemizole, deuterated analogs of clemizole, or clemizole metabolites in treatment of an inflammatory condition |
| CN108367053A (zh) * | 2015-12-22 | 2018-08-03 | 诺华股份有限公司 | 使用生长分化因子15(gdf-15)治疗或改善代谢性疾病的方法 |
| JP7086008B2 (ja) * | 2016-03-04 | 2022-06-17 | ガレクティン・サイエンシーズ・リミテッド・ライアビリティ・カンパニー | ガレクチンに関連する疾患を予防および処置するためのセレノガラクトシド化合物およびその使用 |
| FR3050112B1 (fr) | 2016-04-15 | 2020-09-04 | Soc Civ Immobiliere Gecinq | Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques |
| SG11201810602YA (en) * | 2016-06-03 | 2018-12-28 | Chemocentryx Inc | Method of treating liver fibrosis |
| US10342785B2 (en) * | 2016-11-04 | 2019-07-09 | Askat Inc. | Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer |
| MX2019012086A (es) | 2017-04-14 | 2021-01-08 | Gelesis Llc | Composiciones y métodos para tratar o prevenir trastornos relacionados con la permeabilidad intestinal. |
| CA3062648A1 (en) | 2017-05-12 | 2018-11-15 | Galectin Sciences, Llc | Compounds for the prevention and treatment of diseases and the use thereof |
| US20200163897A1 (en) * | 2017-07-04 | 2020-05-28 | The Regents Of The University Of California | Methods of treating liver diseases associated with portal tract or periportal inflammation |
| US11808772B2 (en) * | 2017-07-19 | 2023-11-07 | Bio-Rad Europe Gmbh | Biomarker combinations to simultaneously evaluate non-alcoholic steatohepatitis and hepatic fibrosis status |
| GB201804922D0 (en) * | 2018-03-27 | 2018-05-09 | Ucl Business Plc | Traatment |
| US20210138080A1 (en) | 2018-06-29 | 2021-05-13 | Glykos Biomedical Oy | Conjugates |
| US20230038373A1 (en) | 2019-12-18 | 2023-02-09 | Glykos Biomedical Oy | Stabile conjugate |
| CN115916181A (zh) * | 2020-05-22 | 2023-04-04 | 度勒科特公司 | 非酒精性脂肪性肝炎(nash)的治疗 |
| WO2022099052A1 (en) * | 2020-11-06 | 2022-05-12 | Bioxytran, Inc. | Polysaccharides for use in treating sars-cov-2 infections |
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| DE4011285A1 (de) * | 1990-04-06 | 1991-10-10 | Steigerwald Arzneimittelwerk | Arzneimittel zur behandlung von hyperlipidaemie und/oder atherosklerose |
| US6297229B1 (en) | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
| US5760010A (en) | 1995-01-01 | 1998-06-02 | Klein; Ira | Method of treating liver disorders with a macrolide antibiotic |
| US6180139B1 (en) | 1998-12-04 | 2001-01-30 | Viva America Marketing, Inc. | Composition and method for treating nonalcoholic steatohepatitis |
| AU4055000A (en) | 1999-04-13 | 2000-11-14 | Daniel K. Hsu | Galectin expression is induced in cirrhotic liver and hepatocellular carcinoma |
| CA2368784A1 (en) | 1999-04-20 | 2000-10-26 | William J. Banz | Methods of treating clinical diseases with isoflavones |
| CN1142272C (zh) * | 2000-02-02 | 2004-03-17 | 中国人民解放军军事医学科学院百环生物医学研究中心 | 携带人肝细胞生长因子基因的重组腺病毒的用途 |
| EP1255566A2 (en) * | 2000-02-04 | 2002-11-13 | Seo Hong Yoo | Preparation of aqueous clear solution dosage forms with bile acids |
| US6596762B2 (en) | 2001-05-17 | 2003-07-22 | The Regents Of The University Of Colorado | Antioxidant compositions and use for treatment of hepatic steatosis and steatohepatitis |
| JP2004535464A (ja) * | 2001-07-20 | 2004-11-25 | インターミューン インコーポレイテッド | 肝臓の線維症を治療する方法 |
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| US7078064B2 (en) | 2003-12-03 | 2006-07-18 | George Zabrecky | Compositions and methods useful for treating and preventing chronic liver disease, chronic HCV infection and non-alcoholic steatohepatitis |
| CN102293773A (zh) | 2004-02-27 | 2011-12-28 | 旭化成制药株式会社 | 含有苯并硫氮杂卓和苯并虑平化合物的药物 |
| WO2005095463A1 (en) * | 2004-03-26 | 2005-10-13 | Glycogenesys, Inc. | Modified pectins, compositions and methods related thereto |
| JP2008105945A (ja) | 2005-02-07 | 2008-05-08 | Ajinomoto Co Inc | アディポネクチンの分泌促進又は誘導作用を有するアシルアミド化合物 |
| EP1924294A4 (en) | 2005-05-24 | 2010-11-03 | Isis Pharmaceuticals Inc | COMPOSITIONS AND ITS USES AGAINST PTPRU |
| WO2006128056A2 (en) * | 2005-05-26 | 2006-11-30 | Metabasis Therapeutics, Inc. | Novel phosphinic acid-containing thyromimetics |
| DE602006010870D1 (de) | 2005-06-20 | 2010-01-14 | Schering Corp | Als antagonisten von histamin h3 geeignete piperidinderivate |
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| JP5105297B2 (ja) | 2006-05-25 | 2012-12-26 | 味の素株式会社 | Ppar活性調節剤 |
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| US20080194575A1 (en) * | 2006-10-04 | 2008-08-14 | Naiara Beraza | Treatment for non-alcoholic-steatohepatitis |
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| EP2636404B1 (en) | 2007-11-30 | 2019-03-20 | The Regents of The University of California | Methods of Treating Non-Alcoholic Steatohepatitis (Nash) Using Cysteamine Products |
| ES2541141T3 (es) * | 2008-01-31 | 2015-07-16 | Astellas Pharma Inc. | Composición farmacéutica para el tratamiento de las enfermedades del hígado graso |
| WO2009118343A1 (en) * | 2008-03-27 | 2009-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for determining the occurrence of a liver disease in a subject |
| JPWO2009151116A1 (ja) | 2008-06-13 | 2011-11-17 | 持田製薬株式会社 | 非アルコール性脂肪肝炎の予防/改善・治療薬 |
| EP2359285B1 (en) * | 2008-11-18 | 2017-01-11 | Universite D'angers | Non-invasive in vitro method for quantifying liver lesions |
| JP2010229099A (ja) * | 2009-03-27 | 2010-10-14 | Mochida Pharmaceut Co Ltd | 脂質異常症の改善または治療薬 |
| US20110183948A1 (en) * | 2010-01-15 | 2011-07-28 | Infinity Pharmaceuticals, Inc. | Treatment of fibrotic conditions using hedgehog inhibitors |
| AU2012363033B2 (en) * | 2011-12-28 | 2016-06-02 | Galectin Therapeutics, Inc. | Composition of novel carbohydrate drug for treatment of human diseases |
-
2012
- 2012-09-14 ES ES12831657T patent/ES2869884T3/es active Active
- 2012-09-14 KR KR1020147009796A patent/KR101974675B1/ko active Active
- 2012-09-14 US US13/573,436 patent/US20130259870A1/en not_active Abandoned
- 2012-09-14 MX MX2014003213A patent/MX360979B/es active IP Right Grant
- 2012-09-14 AU AU2012308491A patent/AU2012308491B2/en active Active
- 2012-09-14 WO PCT/US2012/055360 patent/WO2013040324A1/en not_active Ceased
- 2012-09-14 EP EP12831657.7A patent/EP2755480B1/en active Active
- 2012-09-14 WO PCT/US2012/055348 patent/WO2013040316A1/en not_active Ceased
- 2012-09-14 US US13/573,454 patent/US8658787B2/en active Active
- 2012-09-14 BR BR112014006220A patent/BR112014006220A2/pt not_active Application Discontinuation
- 2012-09-14 JP JP2014530821A patent/JP6185473B2/ja active Active
- 2012-09-14 CA CA2848711A patent/CA2848711C/en active Active
- 2012-09-14 CN CN201280049079.6A patent/CN103945695B/zh active Active
-
2014
- 2014-03-13 IL IL231512A patent/IL231512B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014526513A (ja) | 2014-10-06 |
| IL231512B (en) | 2019-02-28 |
| EP2755480B1 (en) | 2021-03-31 |
| AU2012308491A1 (en) | 2014-04-03 |
| KR20140107180A (ko) | 2014-09-04 |
| CA2848711C (en) | 2019-08-06 |
| CN103945695A (zh) | 2014-07-23 |
| US20130171151A1 (en) | 2013-07-04 |
| CA2848711A1 (en) | 2013-03-21 |
| EP2755480A1 (en) | 2014-07-23 |
| BR112014006220A2 (pt) | 2017-04-11 |
| US8658787B2 (en) | 2014-02-25 |
| IL231512A0 (en) | 2014-04-30 |
| ES2869884T3 (es) | 2021-10-26 |
| WO2013040324A1 (en) | 2013-03-21 |
| AU2012308491B2 (en) | 2016-01-07 |
| CN103945695B (zh) | 2018-04-17 |
| JP6185473B2 (ja) | 2017-08-23 |
| MX2014003213A (es) | 2015-05-15 |
| KR101974675B1 (ko) | 2019-05-02 |
| WO2013040316A1 (en) | 2013-03-21 |
| US20130259870A1 (en) | 2013-10-03 |
| EP2755480A4 (en) | 2015-04-29 |
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| FG | Grant or registration |