MX360564B - Análisis de coagulación de bajo volumen. - Google Patents

Análisis de coagulación de bajo volumen.

Info

Publication number
MX360564B
MX360564B MX2015000808A MX2015000808A MX360564B MX 360564 B MX360564 B MX 360564B MX 2015000808 A MX2015000808 A MX 2015000808A MX 2015000808 A MX2015000808 A MX 2015000808A MX 360564 B MX360564 B MX 360564B
Authority
MX
Mexico
Prior art keywords
blood
low
methods
coagulation assay
volume coagulation
Prior art date
Application number
MX2015000808A
Other languages
English (en)
Other versions
MX2015000808A (es
Inventor
Ian Gibbons
Elizabeth Holmes
Samartha Anekal
Mark Dayel
Paul Patel
Original Assignee
Theranos Ip Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theranos Ip Co Llc filed Critical Theranos Ip Co Llc
Publication of MX2015000808A publication Critical patent/MX2015000808A/es
Publication of MX360564B publication Critical patent/MX360564B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La presente invención se refiere a composiciones y métodos para medir parámetros de coagulación utilizando volúmenes de sangre muy pequeños. Ventajosamente, los métodos descritos en la presente pueden llevarse a cabo a partir de una sola gota de sangre (aproximadamente 20 µl) mientras queda generalmente sangre suficiente para llevar a cabo otras mediciones, opcionalmente en un formato múltiple. Los métodos y dispositivos no requieren un operador experto y pueden llevarse a cabo en el punto de servicio, lo cual puede ser una importante característica para el manejo de trastornos de coagulación sanguínea y sus tratamientos.
MX2015000808A 2012-07-18 2013-07-18 Análisis de coagulación de bajo volumen. MX360564B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261673227P 2012-07-18 2012-07-18
PCT/US2013/051162 WO2014015191A2 (en) 2012-07-18 2013-07-18 Low-volume coagulation assay

Publications (2)

Publication Number Publication Date
MX2015000808A MX2015000808A (es) 2015-05-07
MX360564B true MX360564B (es) 2018-11-07

Family

ID=49949383

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015000808A MX360564B (es) 2012-07-18 2013-07-18 Análisis de coagulación de bajo volumen.

Country Status (13)

Country Link
US (4) US9500639B2 (es)
EP (1) EP2875146B1 (es)
JP (4) JP2015528911A (es)
KR (1) KR102149318B1 (es)
CN (2) CN104662163A (es)
AU (1) AU2013292392A1 (es)
BR (1) BR112015001048B1 (es)
CA (2) CA2878875C (es)
HK (1) HK1210812A1 (es)
IL (1) IL236768B (es)
MX (1) MX360564B (es)
SG (2) SG10201603916UA (es)
WO (1) WO2014015191A2 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9500639B2 (en) 2012-07-18 2016-11-22 Theranos, Inc. Low-volume coagulation assay
JP2016532876A (ja) 2013-09-06 2016-10-20 セラノス， インコーポレイテッド 拭い取りを受け取るための機器、システム、方法及びキット
US10823743B1 (en) 2013-10-28 2020-11-03 Ifirst Medical Technologies, Inc. Methods of measuring coagulation of a biological sample
EP2975383A1 (en) * 2014-07-14 2016-01-20 Johann Wolfgang Goethe-Universität, Frankfurt am Main Method and device for analyzing a fluid medium such as a blood sample
FR3024237B1 (fr) * 2014-07-25 2016-08-05 Stago Diagnostica Methode de determination du profil de structure d'un caillot de fibrine, refletant sa stabilite, pour predire le risque de saignement, de thrombose ou de re-thrombose
CN107110875A (zh) 2014-09-26 2017-08-29 雅培医护站股份有限公司 用在凝固测定中的鞣花酸制剂
EP3197603A1 (en) 2014-09-26 2017-08-02 Abbott Point of Care Inc. Cartridge device with segmented fluidics for assaying coagulation in fluid samples
CN107107056B (zh) 2014-09-26 2020-04-14 雅培医护站股份有限公司 用于流体样本中的凝结测定的单通道盒设备
WO2016049515A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Microfabricated device with micro-environment sensors for assaying coagulation in fluid samples
US10048282B2 (en) 2014-09-26 2018-08-14 Abbott Point Of Care Inc. Cartridge device with fluidic junctions for coagulation assays in fluid samples
CN107110874B (zh) 2014-09-26 2019-06-04 雅培医护站股份有限公司 用于测定流体样品中的凝固的传感器
CN107107057B (zh) 2014-09-26 2020-12-15 雅培医护站股份有限公司 用于流体样本中的凝结测定的盒设备识别
CA3085118C (en) * 2015-06-29 2024-02-06 Ca Casyso Gmbh Blood testing system and method
MY197302A (en) 2016-04-15 2023-06-12 Takeda Pharmaceuticals Co Method and apparatus for providing a pharmacokinetic drug dosing regimen
WO2018069582A1 (fr) * 2016-10-14 2018-04-19 Commissariat à l'énergie atomique et aux énergies alternatives Procédé de caractérisation d'un échantillon comportant des particules
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
US10976305B2 (en) * 2017-04-27 2021-04-13 The University Of Chicago Coagulation testing in underfilled patient samples
CN108956542A (zh) * 2017-05-18 2018-12-07 微采视像科技股份有限公司 凝血酶原时间的测定方法及其应用装置
WO2020023726A1 (en) * 2018-07-25 2020-01-30 Ifirst Medical Technologies, Inc. Medical analyzer and diagnostic sample profiler
CN108982865B (zh) * 2018-08-16 2021-05-11 上海原科实业发展有限公司 一种血栓弹力图法肝素定量检测试剂盒及其制备方法
CN112654850B (zh) * 2018-08-24 2024-11-08 深圳迈瑞生物医疗电子股份有限公司 血样分析仪及血样混匀方法
JP7135620B2 (ja) * 2018-09-07 2022-09-13 ソニーグループ株式会社 血液凝固系解析装置、血液凝固系解析方法及び血液凝固系解析プログラム
CN109211729A (zh) * 2018-10-29 2019-01-15 杨忠思 一种用于精准医疗检测的血液凝滞状态检测装置及方法
CN114599973B (zh) * 2019-10-17 2026-02-13 诺尔生物医药有限公司 凝血测定装置及其方法
KR20220116509A (ko) * 2019-12-17 2022-08-23 란타 인코포레이티드 화학 분석을 위한 모바일 디바이스 및 관련 방법
EP4087939A1 (en) * 2020-01-08 2022-11-16 DSM IP Assets B.V. Combination of clot-based fibrinogen test and enzyme-based fibrinogen test
US12277814B2 (en) 2020-01-29 2025-04-15 Ifirst Medical Technologies, Inc. Medical analyzer and diagnostic sample profiler
CN113777332B (zh) * 2020-06-09 2024-06-18 深圳迈瑞生物医疗电子股份有限公司 免疫分析仪和自身免疫分析方法
WO2021262706A1 (en) * 2020-06-23 2021-12-30 The Brigham And Women's Hospital, Inc. Single molecule assays for ultrasensitive detection of biomolecules
TWI819402B (zh) * 2020-12-22 2023-10-21 財團法人工業技術研究院 反應物多相狀態的製程監控系統及其方法
CN115704825A (zh) * 2021-08-06 2023-02-17 深圳市帝迈生物技术有限公司 样本测试控制方法、样本分析设备和存储介质
WO2024091477A1 (en) * 2022-10-24 2024-05-02 The Johns Hopkins University Mini-scale euglobulin clot lysis assays and methods of using the same
CN116735304A (zh) * 2023-05-04 2023-09-12 希肯生物技术(苏州)有限公司 一种d-二聚体和fdp复合质控品及其制备方法和应用
FR3150028A1 (fr) * 2023-06-16 2024-12-20 Flau Procede et systeme d’analyse d’un liquide contenant des matieres en suspension
CN120890954B (zh) * 2025-09-19 2026-02-10 中国人民解放军总医院第三医学中心 一种血红蛋白分析用抗凝血样本凝集检测设备

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4121466A (en) * 1977-04-19 1978-10-24 Technicon Instruments Corporation Liquid dispenser with an improved probe
US5164598A (en) 1985-08-05 1992-11-17 Biotrack Capillary flow device
US5134229A (en) * 1990-01-12 1992-07-28 Johnson & Johnson Medical, Inc. Process for preparing a neutralized oxidized cellulose product and its method of use
US5840573A (en) * 1994-02-01 1998-11-24 Fields; Robert E. Molecular analyzer and method of use
US6284546B1 (en) * 1994-06-16 2001-09-04 Dade Behring Marburg Gmbh Method and device for photodetection
EP1004870A1 (en) * 1998-11-09 2000-05-31 Aurora Biosciences Corporation Liquid barriers for assays
US6582964B1 (en) 1999-05-12 2003-06-24 Cme Telemetrix Inc. Method and apparatus for rapid measurement of HbA1c
US7130046B2 (en) 2004-09-27 2006-10-31 Honeywell International Inc. Data frame selection for cytometer analysis
JP4384344B2 (ja) * 2000-08-09 2009-12-16 拓之 今野 レーザ反射光による粒状斑点模様を利用した血液凝固時間測定方法とその装置
US6432658B1 (en) 2000-09-13 2002-08-13 Affinity Biologicals, Inc. Method for measuring antithrombin activity
JP2002214241A (ja) * 2000-11-20 2002-07-31 Minolta Co Ltd マイクロチップ
US20030116447A1 (en) 2001-11-16 2003-06-26 Surridge Nigel A. Electrodes, methods, apparatuses comprising micro-electrode arrays
WO2004060172A1 (en) * 2002-12-31 2004-07-22 Marine Polymer Technologies, Inc. Hemostatic compositions and uses therefor
KR20140134338A (ko) 2003-09-11 2014-11-21 테라노스, 인코포레이티드 피분석물의 모니터링 및 약물 전달을 위한 의료 기기
JP5543052B2 (ja) 2003-11-22 2014-07-09 株式会社テクノメディカ アプタマーを用いた標的分子の検出方法
US7399637B2 (en) * 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
EP1745145A4 (en) 2004-05-11 2008-03-26 Heptest Lab Inc COMPOSITIONS, KIT AND METHOD IN ONE STEP FOR MONITORING COMPOUNDS HAVING XA AND / OR ANTIFACTOR IIA ANTIFACTOR ACTIVITIES
EP1775574B1 (en) 2004-07-27 2018-03-14 LSI Medience Corporation Method for automatic determination of sample
US7544514B2 (en) * 2004-12-27 2009-06-09 David Varon Method and system for determining platelet-mediated clot formation
US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
AU2006235025A1 (en) 2005-04-04 2006-10-19 The Regents Of The University Of California Inorganic materials for hemostatic modulation and therapeutic wound healing
JP5264478B2 (ja) * 2005-04-29 2013-08-14 ユニバーシティー オブ ルイヴィル リサーチ ファウンデーション，インコーポレーテッド 活性物質での細胞表面の装飾
ES2820430T3 (es) 2005-05-09 2021-04-21 Labrador Diagnostics Llc Sistemas de fluidos para centros de atención y usos de los mismos
JP2008546542A (ja) 2005-05-18 2008-12-25 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ マイクロ流体ネットワークにおける伝導通路、マイクロ回路、マイクロ構造の製造
US20070073590A1 (en) 2005-08-22 2007-03-29 Cosentino Louis C Remote monitor for physiological parameters and durable medical supplies
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
JP4999613B2 (ja) 2007-08-31 2012-08-15 シスメックス株式会社 血液凝固測定用試薬及び血液凝固時間測定方法
CA3170924A1 (en) * 2007-10-02 2009-04-09 Labrador Diagnostics Llc Modular point-of-care devices and uses thereof
US8372343B2 (en) 2007-12-07 2013-02-12 Sheldon Goldstein Multiple coagulation test cartridge and method of using same
EP2274699A4 (en) 2008-03-26 2011-04-27 Theranos Inc METHOD AND SYSTEMS FOR EVALUATING CLINICAL RESULTS
US20110104725A1 (en) * 2008-05-02 2011-05-05 Advanced Liquid Logic, Inc. Method of Effecting Coagulation in a Droplet
EP2304414B1 (en) 2008-07-24 2017-03-15 The Trustees of Princeton University Bump array device having asymmetric gaps for segregation of particles
JP5465850B2 (ja) 2008-08-01 2014-04-09 シスメックス株式会社 試料分析システム
EP2214011B1 (en) * 2008-08-01 2019-01-02 Sysmex Corporation Blood sample analyzing apparatus
EP2177624A1 (en) * 2008-10-02 2010-04-21 Siemens Healthcare Diagnostics Products GmbH Blood coagulation assays
JP5926958B2 (ja) * 2008-10-29 2016-05-25 ティー２ バイオシステムズ，インコーポレーテッド 凝固時間のｎｍｒ検出
FR2943789B1 (fr) 2009-03-26 2013-07-26 Commissariat Energie Atomique Procede et dispositif pour la caracterisation de la dynamique de coagulation ou sedimentation d'un fluide tel que le sang ou le plasma sanguin
JP2010266236A (ja) * 2009-05-12 2010-11-25 Sysmex Corp 試料分析装置
CA2778270C (en) 2009-10-19 2021-01-05 Theranos, Inc. Integrated health data capture and analysis system
US20110166875A1 (en) * 2010-01-05 2011-07-07 Abbott Diabetes Care Inc. System and method for managing medical data and facilitating reimbursement for health care
CN106323875B (zh) 2011-01-21 2019-07-09 西拉诺斯知识产权有限责任公司 样品使用最大化的系统和方法
US8697449B2 (en) * 2011-04-01 2014-04-15 Spectral Sciences, Inc. Optical blood coagulation monitor and method
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9500639B2 (en) 2012-07-18 2016-11-22 Theranos, Inc. Low-volume coagulation assay

Also Published As

Publication number Publication date
JP2019002939A (ja) 2019-01-10
EP2875146A4 (en) 2016-03-02
WO2014015191A3 (en) 2014-05-08
CN109884289A (zh) 2019-06-14
US9500639B2 (en) 2016-11-22
KR20150034793A (ko) 2015-04-03
CA2878875C (en) 2021-09-07
BR112015001048A2 (pt) 2017-06-27
EP2875146A2 (en) 2015-05-27
KR102149318B1 (ko) 2020-10-14
AU2013292392A1 (en) 2015-01-29
WO2014015191A2 (en) 2014-01-23
SG11201500346QA (en) 2015-02-27
BR112015001048A8 (pt) 2021-07-06
CN104662163A (zh) 2015-05-27
SG10201603916UA (en) 2016-07-28
US11119110B2 (en) 2021-09-14
EP2875146B1 (en) 2022-05-18
HK1210812A1 (en) 2016-05-06
US20140087403A1 (en) 2014-03-27
IL236768A0 (en) 2015-03-31
CA2878875A1 (en) 2014-01-23
CA3124500A1 (en) 2014-01-23
JP2021009153A (ja) 2021-01-28
US20220137075A1 (en) 2022-05-05
MX2015000808A (es) 2015-05-07
JP2022116194A (ja) 2022-08-09
BR112015001048B1 (pt) 2021-12-14
US20150301018A1 (en) 2015-10-22
JP2015528911A (ja) 2015-10-01
CN109884289B (zh) 2022-07-26
US20170023594A1 (en) 2017-01-26
IL236768B (en) 2019-10-31

Similar Documents

Publication Publication Date Title
MX360564B (es) Análisis de coagulación de bajo volumen.
WO2014160441A8 (en) Neuroactive steroids, compositions, and uses thereof
EP4652923A3 (en) Apparatus for determining damaged tissue using sub-epidermal moisture measurements
EP4343788A3 (en) Diagnostic methods
WO2014078379A3 (en) Apparatus and methods for three-dimensional tissue measurements based on controlled media flow
EP3055407A4 (en) Portable testing device for analyzing biological samples
WO2015195949A3 (en) Methods, compositions, and devices for rapid analysis of biological markers
EA201590027A1 (ru) Способы детекции заболеваний или состояний
MX362545B (es) Analisis de imagen y medicion de muestras biologicas.
FR2961087B1 (fr) Outil de prelevement d'un echantillon de tissu animal.
IN2014DE01077A (es)
EP3018464A4 (en) ADAPTER FOR BLOOD SAMPLING AS WELL AS DISPOSABLE SET AND NEEDLE SET THEREWITH
MX358474B (es) Biomarcadores salivales específicos para detección de riesgo, diagnóstico temprano, pronóstico y vigilancia de las enfermedades de alzheimer y de parkinson.
MX2019012375A (es) Formulaciones del inhibidor del antigeno-1 asociado a la funcion de linfocitos (lfa-1).
WO2014140362A3 (en) Lymphocyte biomarkers for determining the clinical response to therapy with mesenschymal stromal cells(msc)
WO2016196993A3 (en) Multi-mediator reagent formulations for use in electrochemical detection
EP2781263A3 (en) Microfluidic Device and Control Method Thereof
HK1204061A1 (en) Methods and kits for detecting and diagnosing neurotrauma
WO2013166153A3 (en) Methods and compositions for cancer diagnosis
WO2015032954A3 (en) Biomarkers for cholangiocellular carcinoma (ccc)
EP3888671A3 (en) Protein formulations
MX2015003192A (es) Composicion para su utilizacion como plasma de control anormal de la coagulacion de ensayos in vitro.
WO2013138487A8 (en) Liquid sampling device for use with mobile device and methods
WO2013173583A8 (en) Psma inhibitors
EP3236261A4 (en) Test strip for use in immunochromatography for detecting analyte in sample containing red blood cells, and immunochromatography using said test strip

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: THERANOS IP COMPANY, LLC

FG Grant or registration