MX359329B - Una combinación farmacéutica para usarse en el tratamiento de un paciente que padece diabetes tipo 2. - Google Patents
Una combinación farmacéutica para usarse en el tratamiento de un paciente que padece diabetes tipo 2.Info
- Publication number
- MX359329B MX359329B MX2014005139A MX2014005139A MX359329B MX 359329 B MX359329 B MX 359329B MX 2014005139 A MX2014005139 A MX 2014005139A MX 2014005139 A MX2014005139 A MX 2014005139A MX 359329 B MX359329 B MX 359329B
- Authority
- MX
- Mexico
- Prior art keywords
- treatment protocol
- diabetes type
- diabetes
- type
- protocol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
La presente invención se refiere a una combinación farmacéutica, para usarse en el tratamiento de un paciente que padece diabetes tipo 2, en donde la diabetes tipo 2 se controla de manera insuficiente por medio de por lo menos un fármaco antidiabético oral, dicha combinación comprende (a) desPro36Exendina-4(1-39)-Lys 6-NH2 y/o una sal farmacéuticamente aceptable del mismo, (b) insulina glargina y/o una sal farmacéuticamente aceptable de la misma, y (c) metformina y/o una sal farmacéuticamente aceptable de la misma, en donde el tratamiento del paciente que padece de diabetes tipo 2 comprende las etapas de: (i) administrar los compuesto (b) y (c) durante por lo menos 4 semanas, con la condición de que el compuesto (a) no se administre, y (ii) continuar el tratamiento de administrar los compuestos (a), (b) y (c), en donde al inicio de la etapa (i), el paciente tiene una concentración de glucosa plasmática posprandial a dos hora de por lo menos 12 mmol/L, y una excursión glucémica de por lo menos 5 mmol/L, en donde la excursión glucémica es la diferencia de la concentración de glucosa plasmática posprandial a dos horas y de la concentración de glucosa plasmática 30 minutos antes de una comida de prueba, y en donde la cantidad del compuesto (b) que se administrará en las etapas (i) y/o (ii) se ajusta para alcanzar o por lo menos estar aproximada a un predeterminado nivel del glucosa plasmática en ayunas y/o un predeterminado nivel del glucosa plasmática auto-supervisada.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11187169 | 2011-10-28 | ||
| PCT/EP2012/071271 WO2013060850A1 (en) | 2011-10-28 | 2012-10-26 | Treatment protocol of diabetes type 2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014005139A MX2014005139A (es) | 2014-08-27 |
| MX359329B true MX359329B (es) | 2018-09-25 |
Family
ID=47071308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014005139A MX359329B (es) | 2011-10-28 | 2012-10-26 | Una combinación farmacéutica para usarse en el tratamiento de un paciente que padece diabetes tipo 2. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20130296236A1 (es) |
| EP (1) | EP2771024B1 (es) |
| JP (1) | JP6329487B2 (es) |
| KR (1) | KR101967941B1 (es) |
| CN (2) | CN104066441A (es) |
| AU (1) | AU2012328388B2 (es) |
| BR (1) | BR112014010200A2 (es) |
| CA (1) | CA2851690C (es) |
| HK (1) | HK1198577A1 (es) |
| IL (1) | IL232251B (es) |
| IN (1) | IN2014CN02616A (es) |
| MX (1) | MX359329B (es) |
| MY (1) | MY170713A (es) |
| RU (1) | RU2014121386A (es) |
| SG (1) | SG11201401175SA (es) |
| WO (1) | WO2013060850A1 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3228320B1 (de) | 2008-10-17 | 2019-12-18 | Sanofi-Aventis Deutschland GmbH | Kombination von einem insulin und einem glp-1-agonisten |
| UY33025A (es) | 2009-11-13 | 2011-06-30 | Sanofi Aventis Deustschland Gmbh | Composicion farmaceutica que comprende un agonista de glp-1 metionina |
| US20110118178A1 (en) * | 2009-11-13 | 2011-05-19 | Sanofi-Aventis Deutschland Gmbh | Method of treatment of diabetes type 2 comprising add-on therapy to insulin glargine and metformin |
| AR080669A1 (es) | 2009-11-13 | 2012-05-02 | Sanofi Aventis Deutschland | Composicion farmaceutica que comprende un agonista de glp-1, una insulina y metionina |
| MX339614B (es) | 2010-08-30 | 2016-06-02 | Sanofi - Aventis Deutschland GmbH | Uso de ave0010 para la fabricacion de un medicamento para el tratamiento de la diabetes mellitus tipo 2. |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| RU2650616C2 (ru) | 2011-08-29 | 2018-04-16 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| HUE035803T2 (en) | 2012-12-21 | 2018-05-28 | Sanofi Sa | Dual GLP1 / GIP or trigonal GLP1 / GIP / glucagon agonists |
| TWI641381B (zh) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物 |
| US20160038077A1 (en) * | 2013-06-27 | 2016-02-11 | Inspark Technologies, Inc. | Systems, Devices, and/or Methods for Identifying Time Periods of Insufficient Blood Glucose Testing |
| TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重ｇｌｐ－１／ｇｉｐ受體促效劑的艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／ｇｉｐ受體促效劑 |
| RU2016132386A (ru) | 2014-01-09 | 2018-02-14 | Санофи | Стабилизированные фармацевтические составы без глицерина на основе инсулиновых аналогов и/или инсулиновых производных |
| WO2015104314A1 (en) | 2014-01-09 | 2015-07-16 | Sanofi | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| CN114939156A (zh) | 2014-01-09 | 2022-08-26 | 赛诺菲 | 门冬胰岛素的稳定化药物制剂 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| CN107206058A (zh) * | 2014-12-12 | 2017-09-26 | 赛诺菲-安万特德国有限公司 | 甘精胰岛素/利西拉来固定比率配制剂 |
| US20160235818A1 (en) * | 2015-01-16 | 2016-08-18 | Sanofi-Aventis Deutschland Gmbh | Treatment of Pediatric Type 2 Diabetes Mellitus Patients |
| TWI748945B (zh) * | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| AU2004267955A1 (en) * | 2003-09-02 | 2005-03-10 | Prosidion Ltd. | Combination therapy for glycaemic control |
| AU2005271526B2 (en) * | 2004-08-03 | 2011-12-08 | Emisphere Technologies, Inc. | Antidiabetic oral insulin-biguanide combination |
| CA2750049C (en) * | 2009-02-04 | 2021-02-23 | Sanofi-Aventis Deutschland Gmbh | Medical device and method for providing information for glycemic control |
| KR20110052990A (ko) * | 2009-11-13 | 2011-05-19 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린 글라르긴 및 메트포르민에 대한 부가적 요법을 포함하는 2형 당뇨병의 치료 방법 |
| US20110118178A1 (en) * | 2009-11-13 | 2011-05-19 | Sanofi-Aventis Deutschland Gmbh | Method of treatment of diabetes type 2 comprising add-on therapy to insulin glargine and metformin |
| ME01546B (me) * | 2009-11-13 | 2014-04-20 | Sanofi Aventis Deutschland | Liksisenatid kao dodatna terapija insulin glarginu i metforminu za liječenje dijabetesa tipa 2 |
| JP5980466B2 (ja) * | 2009-11-13 | 2016-08-31 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | インスリングラルギン及びメトホルミンへの付加療法を含む２型糖尿病の治療方法 |
| US9821032B2 (en) * | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
-
2012
- 2012-10-26 CN CN201280065132.1A patent/CN104066441A/zh active Pending
- 2012-10-26 US US13/661,476 patent/US20130296236A1/en not_active Abandoned
- 2012-10-26 WO PCT/EP2012/071271 patent/WO2013060850A1/en active Application Filing
- 2012-10-26 CN CN201711071123.4A patent/CN107693783A/zh active Pending
- 2012-10-26 SG SG11201401175SA patent/SG11201401175SA/en unknown
- 2012-10-26 BR BR112014010200-7A patent/BR112014010200A2/pt not_active Application Discontinuation
- 2012-10-26 EP EP12775720.1A patent/EP2771024B1/en active Active
- 2012-10-26 RU RU2014121386/15A patent/RU2014121386A/ru unknown
- 2012-10-26 IN IN2616CHN2014 patent/IN2014CN02616A/en unknown
- 2012-10-26 KR KR1020147011152A patent/KR101967941B1/ko active IP Right Grant
- 2012-10-26 MY MYPI2014000971A patent/MY170713A/en unknown
- 2012-10-26 JP JP2014537630A patent/JP6329487B2/ja active Active
- 2012-10-26 AU AU2012328388A patent/AU2012328388B2/en active Active
- 2012-10-26 MX MX2014005139A patent/MX359329B/es active IP Right Grant
- 2012-10-26 CA CA2851690A patent/CA2851690C/en active Active
-
2014
- 2014-04-24 IL IL23225114A patent/IL232251B/en active IP Right Grant
- 2014-12-01 HK HK14112062A patent/HK1198577A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY170713A (en) | 2019-08-27 |
| HK1198577A1 (en) | 2015-04-30 |
| EP2771024B1 (en) | 2018-11-28 |
| RU2014121386A (ru) | 2015-12-10 |
| CA2851690A1 (en) | 2013-05-02 |
| BR112014010200A2 (pt) | 2020-10-27 |
| MX2014005139A (es) | 2014-08-27 |
| CA2851690C (en) | 2022-07-26 |
| AU2012328388B2 (en) | 2017-06-15 |
| JP2015501314A (ja) | 2015-01-15 |
| IN2014CN02616A (es) | 2015-06-26 |
| KR101967941B1 (ko) | 2019-04-10 |
| US20130296236A1 (en) | 2013-11-07 |
| JP6329487B2 (ja) | 2018-05-23 |
| SG11201401175SA (en) | 2014-09-26 |
| CN104066441A (zh) | 2014-09-24 |
| CN107693783A (zh) | 2018-02-16 |
| EP2771024A1 (en) | 2014-09-03 |
| IL232251A0 (en) | 2014-06-30 |
| WO2013060850A1 (en) | 2013-05-02 |
| IL232251B (en) | 2019-10-31 |
| AU2012328388A1 (en) | 2014-05-15 |
| KR20140093935A (ko) | 2014-07-29 |
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Legal Events
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| FG | Grant or registration |