MX349081B - Amidotiazoles aromaticos, preparaciones cosmeticas o dermatologicas que contienen los mismos y su uso para el control y la profilaxis de pigmentacion indeseada de la piel. - Google Patents

Amidotiazoles aromaticos, preparaciones cosmeticas o dermatologicas que contienen los mismos y su uso para el control y la profilaxis de pigmentacion indeseada de la piel.

Info

Publication number
MX349081B
MX349081B MX2014003450A MX2014003450A MX349081B MX 349081 B MX349081 B MX 349081B MX 2014003450 A MX2014003450 A MX 2014003450A MX 2014003450 A MX2014003450 A MX 2014003450A MX 349081 B MX349081 B MX 349081B
Authority
MX
Mexico
Prior art keywords
hydroxy
polysubstituted
cosmetic
amidothiazoles
aromatic
Prior art date
Application number
MX2014003450A
Other languages
English (en)
Other versions
MX2014003450A (es
Inventor
Schläger Torsten
Kolbe Ludger
Scherner Cathrin
Breitkreutz Sabrina
Wöhrmann Michael
Mann Tobias
Gerwat Wolfram
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Ag filed Critical Beiersdorf Ag
Publication of MX2014003450A publication Critical patent/MX2014003450A/es
Publication of MX349081B publication Critical patent/MX349081B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Amidotiazoles aromáticos de fórmula general en la que R1 significa = -arilo C3-C24 (dado el caso sustituido una o varias veces con -OH, -F, -Cl, -Br, -I, -OMe, -NH2, -CN, acetilo, sustituido varias veces con hidroxilo, pudiendo estar unidas estas funcionalidades hidroxilo como acetal), - heteroarilo C3-C24 (dado el caso sustituido una o varias veces con -OH, -F, -Cl, -Br, -I, -OMe, -NH2, -CN, acetilo, sustituido varias veces con hidroxilo, pudiendo estar unidas estas funcionalidades hidroxilo como acetal), -arilo C3-C24 alquilo C1-C24 (lineal y ramificado), -heteroarilo C3-C24 -alquilo C1-C24 (lineal y ramificado), -arilo C3-C24-alquilo C1-C24-hidroxilo (lineal y ramificado), -heteroarilo C3-C24-alquilo C1-C24-hidroxilo (lineal y ramificado) -2-hidroxifenilo, -3-hidroxifenilo, -4-hidroxifenilo, -piridin-2-ilo, -piridin-3-ilo, -piridin-4-ilo, piridin-1(2H)-ilo, -pirimidin-2-ilo, -pirazin-2-ilo, -pirimidin-4-ilo, -piridazin-3-ilo, -piridazin-4-ilo, -pirimidin-2-ilo, -pirimidin-5-ilo, -1,2,4-triazin-3-ilo, -1,3,5-triazin-2-ilo,-1,2,3-triazin-4-ilo, -1,2,3-triazin-5-ilo, -1,2,3,4-tetrazin-5-ilo, -1,2,3,5-tetrazin-4-ilo, -1,2,4,5-tetrazin-3-ilo, -pentazin-6-ilo, -tiazol, -imidazol, -oxazol, -isoxazol, -NH-arilo (dado el caso sustituido una o varias veces con - OH, -F, -Cl, -Br, -I, -OMe, -NH2, -CN, acetilo, sustituido varias veces con hidroxilo, pudiendo estar unidas estas funcionalidades hidroxilo como acetal), -NH-heteroarilo (dado el caso sustituido una o varias veces con -OH, -F, -Cl, -Br, -I, -OMe, -NH2, -CN, acetilo, sustituido varias veces con hidroxilo, pudiendo estar unidas estas funcionalidades hidroxilo como acetal), mono (hidroxialquil)-fenil o-, oligo(hidroxialquil)-fenilo-, así como preparaciones cosméticas o dermatológicas con un contenido eficaz de uno o varios amidotiazoles aromáticos así como su uso para el tratamiento y/o la profilaxis cosméticos o dermatológicos de pigmentación de la piel indeseada.
MX2014003450A 2011-09-23 2012-09-18 Amidotiazoles aromaticos, preparaciones cosmeticas o dermatologicas que contienen los mismos y su uso para el control y la profilaxis de pigmentacion indeseada de la piel. MX349081B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011083271A DE102011083271A1 (de) 2011-09-23 2011-09-23 Aromatische Amidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Aromatischen Amidothiazolen
PCT/EP2012/068373 WO2013041535A1 (de) 2011-09-23 2012-09-18 Aromatische amidothiazole, sie enthaltende kosmetische oder dermatologische zubereitungen und deren verwendung zur bekämpfung und prophylaxe unerwünschter pigmentierung der haut

Publications (2)

Publication Number Publication Date
MX2014003450A MX2014003450A (es) 2015-06-05
MX349081B true MX349081B (es) 2017-07-10

Family

ID=46963695

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003450A MX349081B (es) 2011-09-23 2012-09-18 Amidotiazoles aromaticos, preparaciones cosmeticas o dermatologicas que contienen los mismos y su uso para el control y la profilaxis de pigmentacion indeseada de la piel.

Country Status (8)

Country Link
EP (1) EP2758383B1 (es)
JP (2) JP6157475B2 (es)
CN (1) CN103930409B (es)
DE (1) DE102011083271A1 (es)
ES (1) ES2609580T3 (es)
MX (1) MX349081B (es)
PL (1) PL2758383T3 (es)
WO (1) WO2013041535A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011083271A1 (de) * 2011-09-23 2013-03-28 Beiersdorf Ag Aromatische Amidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Aromatischen Amidothiazolen
DE102013204088A1 (de) * 2013-03-11 2014-09-11 Beiersdorf Ag Wirkstoffkombinationen aus Alkylamidothiazolen und einen oder mehreren kosmetisch oder dermatologisch relevanten Duftstoffen
DE102013204081A1 (de) * 2013-03-11 2014-09-11 Beiersdorf Ag Wirkstoffkombinationen aus Alkylamidothiazolen und einen oder mehreren kosmetisch oder dermatologisch unbedenklichen Konservierungsmitteln
DE102013226746A1 (de) * 2013-12-19 2015-06-25 Beiersdorf Ag Verwendung von Alkylamidothiazolen als Antioxidans oder Radikalfänger in kosmetischen oder dermatologischen Zubereitungen
DE102013226711A1 (de) 2013-12-19 2015-06-25 Beiersdorf Ag Verwendung von Alkylamidothiazolen in kosmetischen oder dermatologischen Zubereitungen zur Prophylaxe vor und Behandlung von sensibler Haut
CN105439978B (zh) * 2015-12-15 2018-02-16 山东金城医药化工股份有限公司 阿考替胺中间体的制备方法
CN108929271B (zh) * 2018-06-29 2021-08-31 中国药科大学 酪氨酸酶抑制剂及其制备方法与用途
CA3159766A1 (en) * 2019-11-05 2021-05-14 Dermira, Inc. Mrgprx2 antagonists for the treatment of inflammatory disorders
CN116554122B (zh) * 2023-06-29 2023-09-19 南京桦冠生物技术有限公司 α-酮酸酰胺或取代草酸酰胺酯类化合物及其组合物

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IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
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CA2487900A1 (en) * 2002-06-05 2003-12-18 Institute Of Medicinal Molecular Design, Inc. Immunity-related protein kinase inhibitors
CA2487891A1 (en) * 2002-06-05 2003-12-18 Institute Of Medicinal Molecular Design, Inc. Inhibitors against the activation of ap-1 and nfat
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DE102011083271A1 (de) * 2011-09-23 2013-03-28 Beiersdorf Ag Aromatische Amidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Aromatischen Amidothiazolen

Also Published As

Publication number Publication date
EP2758383A1 (de) 2014-07-30
ES2609580T3 (es) 2017-04-21
CN103930409B (zh) 2016-08-24
JP6157475B2 (ja) 2017-07-05
CN103930409A (zh) 2014-07-16
MX2014003450A (es) 2015-06-05
JP2014526536A (ja) 2014-10-06
JP2017141242A (ja) 2017-08-17
DE102011083271A1 (de) 2013-03-28
JP6584443B2 (ja) 2019-10-02
EP2758383B1 (de) 2016-11-09
WO2013041535A1 (de) 2013-03-28
PL2758383T3 (pl) 2017-07-31

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