MX348130B - Transaminasas inmovilizadas y procedimiento para la preparacion y uso de transaminasa inmovilizada. - Google Patents

Transaminasas inmovilizadas y procedimiento para la preparacion y uso de transaminasa inmovilizada.

Info

Publication number
MX348130B
MX348130B MX2013014893A MX2013014893A MX348130B MX 348130 B MX348130 B MX 348130B MX 2013014893 A MX2013014893 A MX 2013014893A MX 2013014893 A MX2013014893 A MX 2013014893A MX 348130 B MX348130 B MX 348130B
Authority
MX
Mexico
Prior art keywords
immobilized
making
transaminases
transaminase
immobilized transaminases
Prior art date
Application number
MX2013014893A
Other languages
English (en)
Other versions
MX2013014893A (es
Inventor
Gregory Hughes
Matthew D Truppo
Jacob M Janey
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2013014893A publication Critical patent/MX2013014893A/es
Publication of MX348130B publication Critical patent/MX348130B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a las transaminasas inmovilizadas y a los procedimientos para la preparación y el uso de las mismas.
MX2013014893A 2011-06-24 2012-06-18 Transaminasas inmovilizadas y procedimiento para la preparacion y uso de transaminasa inmovilizada. MX348130B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161500642P 2011-06-24 2011-06-24
PCT/US2012/042853 WO2012177527A1 (en) 2011-06-24 2012-06-18 Immobilized transaminases and process for making and using immobilized transaminase

Publications (2)

Publication Number Publication Date
MX2013014893A MX2013014893A (es) 2014-02-17
MX348130B true MX348130B (es) 2017-05-26

Family

ID=47422892

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013014893A MX348130B (es) 2011-06-24 2012-06-18 Transaminasas inmovilizadas y procedimiento para la preparacion y uso de transaminasa inmovilizada.

Country Status (10)

Country Link
US (1) US9587229B2 (es)
EP (1) EP2723763A4 (es)
JP (2) JP6284474B2 (es)
CN (1) CN103608355B (es)
AR (1) AR086719A1 (es)
AU (1) AU2012273271A1 (es)
CA (1) CA2838744C (es)
MX (1) MX348130B (es)
TW (1) TW201311890A (es)
WO (1) WO2012177527A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014133960A1 (en) 2013-02-28 2014-09-04 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
SG11201505918TA (en) * 2013-02-28 2015-09-29 Merck Sharp & Dohme Immobilized transaminases and process for making and using immobilized transaminase
EP2970927A4 (en) 2013-03-15 2016-10-12 Merck Sharp & Dohme IMMOBILIZED KETOREDUCTASES AND METHODS OF MAKING AND USING IMMOBILIZED KETOREDUCTASE
CN103865964A (zh) * 2014-03-14 2014-06-18 上海朴颐化学科技有限公司 转氨酶法合成(r)-3-氨基哌啶的方法
GB201410514D0 (en) * 2014-06-12 2014-07-30 Fantex Ltd Polymer antimicrobial composition
CN104805069B (zh) * 2015-02-06 2017-11-17 上海弈柯莱生物医药科技有限公司 一种固定化转氨酶及其在合成西他列汀中间体中的应用
CN107686852B (zh) * 2016-08-04 2022-08-02 上海朴颐化学科技有限公司 一种莫西沙星中间体化合物的制备方法
CN109251925A (zh) * 2017-07-14 2019-01-22 上海蓝木化工有限公司 一种离子交换树脂固定化转氨酶的制备及其应用
CN110129306A (zh) * 2018-02-08 2019-08-16 广东东阳光药业有限公司 固定化转氨酶及其应用
CA3103721A1 (en) 2018-07-09 2020-01-16 Codexis, Inc. Engineered deoxyribose-phosphate aldolases
WO2021108957A1 (zh) * 2019-12-02 2021-06-10 吉林凯莱英医药化学有限公司 共固定化酶、其制备方法及其应用
CN115418362A (zh) * 2019-12-02 2022-12-02 吉林凯莱英医药化学有限公司 共固定化酶、其制备方法及其应用
CN110964710B (zh) * 2019-12-25 2022-01-21 吉林凯莱英医药化学有限公司 固定化酶、其制备方法及其应用
CN113061594B (zh) * 2019-12-31 2023-11-24 弈柯莱生物科技(集团)股份有限公司 转氨酶突变体、固定化转氨酶及用于制备西他列汀的用途
EP4133064A4 (en) 2020-04-10 2024-07-24 Codexis Inc GENETICALLY ENGINEERED TRANSAMINASE POLYPEPTIDES
BR112023015759A2 (pt) * 2021-02-05 2023-11-21 Apeloa Pharmaceutical Co Ltd Mutante de ¿-transaminase ata117 com enantiosseletivo invertido, sequência de nucleotídeos de dna, plasmídeo, bactéria geneticamente modificada que expressa um mutante da ¿-transaminase ata117, método para a construção da mesma e método para a produção de (1r,2r)-1,3-dihidroxi-2-amino-1-p-tiafenilfenilpropano 2b com base na ¿- transaminase ata117 mutante
CN115466756A (zh) * 2021-06-11 2022-12-13 弈柯莱生物科技(上海)股份有限公司 转氨酶、固定化转氨酶及用于制备西他列汀的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020132295A1 (en) * 1996-02-09 2002-09-19 Short Jay M. Enzymes having transaminase and aminotransferase activity and methods of use thereof
AR043515A1 (es) 2003-03-19 2005-08-03 Merck & Co Inc Procedimiento para preparar derivados quirales beta aminoacidos mediante hidrogenacion asimetrica
JO2625B1 (en) 2003-06-24 2011-11-01 ميرك شارب اند دوم كوربوريشن Phosphoric acid salts of dipeptidyl betidase inhibitor 4
ES2587572T3 (es) 2005-04-26 2016-10-25 Cargill, Incorporated Polipéptidos y rutas biosintéticas para la producción de estereoisómeros de monatina y sus precursores
IL180598A0 (en) * 2007-01-08 2007-07-04 Basheer Sobhi Immobilized interfacial enzymes of improved and stabilized activity
WO2008108998A2 (en) 2007-03-02 2008-09-12 Richmond Chemical Corporation Method to increase the yield and improve purification of products from transaminase reactions
CN104651381A (zh) * 2008-01-03 2015-05-27 巴斯夫酶有限责任公司 转移酶和氧化还原酶、编码它们的核酸以及其制备和应用方法
EP2401366B1 (en) * 2009-02-26 2013-12-18 Codexis, Inc. Transaminase biocatalysts
WO2011005477A1 (en) * 2009-06-22 2011-01-13 Codexis, Inc. Transaminase reactions
JP6141015B2 (ja) * 2009-08-05 2017-06-07 インフィニティ ファーマスーティカルズ、インク． シクロパミン類似体の酵素によるアミノ基転移

Also Published As

Publication number Publication date
CA2838744A1 (en) 2012-12-27
US20140106413A1 (en) 2014-04-17
EP2723763A1 (en) 2014-04-30
JP2017079774A (ja) 2017-05-18
WO2012177527A1 (en) 2012-12-27
JP2014519847A (ja) 2014-08-21
CN103608355A (zh) 2014-02-26
EP2723763A4 (en) 2015-02-18
MX2013014893A (es) 2014-02-17
US9587229B2 (en) 2017-03-07
TW201311890A (zh) 2013-03-16
AR086719A1 (es) 2014-01-15
JP6284474B2 (ja) 2018-02-28
CA2838744C (en) 2020-10-13
CN103608355B (zh) 2016-06-29
AU2012273271A1 (en) 2013-11-14

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