MX347883B - Anticuerpo monoclonal ds6, antigeno ca6 asociado con tumor, y metodos de uso de los mismos. - Google Patents

Anticuerpo monoclonal ds6, antigeno ca6 asociado con tumor, y metodos de uso de los mismos.

Info

Publication number
MX347883B
MX347883B MX2013004010A MX2013004010A MX347883B MX 347883 B MX347883 B MX 347883B MX 2013004010 A MX2013004010 A MX 2013004010A MX 2013004010 A MX2013004010 A MX 2013004010A MX 347883 B MX347883 B MX 347883B
Authority
MX
Mexico
Prior art keywords
monoclonal antibody
methods
tumor
associated antigen
antigen
Prior art date
Application number
MX2013004010A
Other languages
English (en)
Inventor
Anne Elizabeth Wennerberg
Diane A Semer
Original Assignee
East Carolina Univ *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by East Carolina Univ * filed Critical East Carolina Univ *
Publication of MX347883B publication Critical patent/MX347883B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a un anticuerpo monoclonal seleccionado del grupo que consiste de anticuerpo DS6 monoclonal, anticuerpos monoclonales que específicamente se unen al enlace de epítope o de antígeno a través de anticuerpo DS6 monoclonal, y fragmentos de lo anterior que específicamente se unen al enlace de antígeno epítope, a través de anticuerpo DS6 monoclonal; los métodos de uso de tales anticuerpos y el antígeno aislado, unido a través de los anticuerpos, también se describen.
MX2013004010A 2000-08-18 2001-08-17 Anticuerpo monoclonal ds6, antigeno ca6 asociado con tumor, y metodos de uso de los mismos. MX347883B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/641,499 US6596503B1 (en) 2000-08-18 2000-08-18 Monoclonal antibody DS6, tumor-associated antigen CA6, and methods of use thereof
PCT/US2001/041765 WO2002016401A2 (en) 2000-08-18 2001-08-17 Monoclonal antibody ds6, tumor-associated antigen ca6, and methods of use thereof

Publications (1)

Publication Number Publication Date
MX347883B true MX347883B (es) 2017-05-16

Family

ID=24572648

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013004010A MX347883B (es) 2000-08-18 2001-08-17 Anticuerpo monoclonal ds6, antigeno ca6 asociado con tumor, y metodos de uso de los mismos.
MXPA03001460A MXPA03001460A (es) 2000-08-18 2001-08-17 Anticuerpo monoclonal ds6, antigeno ca6 asociado con tumor, y metodos de uso de los mismos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MXPA03001460A MXPA03001460A (es) 2000-08-18 2001-08-17 Anticuerpo monoclonal ds6, antigeno ca6 asociado con tumor, y metodos de uso de los mismos.

Country Status (7)

Country Link
US (5) US6596503B1 (es)
EP (1) EP1362060A4 (es)
AU (1) AU2001289145A1 (es)
CA (1) CA2419270C (es)
GB (1) GB2383331B (es)
MX (2) MX347883B (es)
WO (1) WO2002016401A2 (es)

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CA2525553C (en) 2003-05-14 2011-07-05 Immunogen, Inc. Maytansinoid-antibody conjugate compositions
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US7834155B2 (en) * 2003-07-21 2010-11-16 Immunogen Inc. CA6 antigen-specific cytotoxic conjugate and methods of using the same
NZ580855A (en) * 2003-07-21 2012-03-30 Immunogen Inc A CA6 antigen-specific cytotoxic conjugate and methods of using the same
AU2012201260B2 (en) * 2003-07-21 2014-10-23 Immunogen, Inc. A CA6 antigen-specific cytotoxic conjugate and methods of using the same
EP1732596A2 (en) * 2004-03-11 2006-12-20 Shantha West, Inc. Therapeutic use of rm1 antigen
ES2503719T3 (es) 2005-02-11 2014-10-07 Immunogen, Inc. Procedimiento para preparar conjugados de anticuerpos y de maitansinoides
NZ599176A (en) 2005-08-03 2014-04-30 Immunogen Inc Immunoconjugate formulations
CN104804094A (zh) * 2005-08-22 2015-07-29 伊缪诺金公司 Ca6抗原特异性细胞毒性偶联物及其应用方法
AU2005335743A1 (en) * 2005-08-22 2007-03-01 Immunogen, Inc. A CA6 antigen-specific cytotoxic conjugate and methods of using the same
NZ565964A (en) 2005-08-24 2011-11-25 Immunogen Inc Process for preparing maytansinoid antibody conjugates by purifying with tangential flow filtration
US20070248539A1 (en) * 2006-04-24 2007-10-25 Shantha West Inc. AgRM2 antigen
EP2431053A1 (en) 2006-11-27 2012-03-21 Patrys Limited Novel glycosylated peptide target in neoplastic cells
WO2009015294A1 (en) * 2007-07-24 2009-01-29 Wisconsin Alumni Research Foundation Biomarkers for human papillomavirus-associated cancers
PL2281006T3 (pl) 2008-04-30 2018-01-31 Immunogen Inc Środki łączące i ich zastosowania
WO2010004438A2 (en) 2008-06-16 2010-01-14 Patrys Limited Lm-antibodies, functional fragments, lm-1 target antigen, and methods for making and using same
US10359425B2 (en) 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
MX2011002322A (es) * 2008-09-09 2011-05-10 Somalogic Inc Biomarcadores de cancer de pulmon y uso de los mismos.
WO2012006632A2 (en) 2010-07-09 2012-01-12 Somalogic, Inc. Lung cancer biomarkers and uses thereof
SG176068A1 (en) 2009-06-03 2011-12-29 Immunogen Inc Conjugation methods
IN2012DN02780A (es) 2009-10-06 2015-09-18 Immunogen Inc
US20120040861A1 (en) 2010-08-13 2012-02-16 Somalogic, Inc. Pancreatic Cancer Biomarkers and Uses Thereof
WO2012135517A2 (en) 2011-03-29 2012-10-04 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
SI2691155T1 (sl) 2011-03-29 2019-03-29 Immunogen, Inc. Priprava majtanzinoidnih konjugatov protiteles v postopku z enim korakom
CA3064363C (en) * 2011-10-24 2022-05-17 Somalogic, Inc. Non-small cell lung cancer biomarkers and uses thereof
WO2013059886A1 (en) 2011-10-28 2013-05-02 Patrys Limited Pat-lm1 epitopes and methods for using same
JP2012161321A (ja) * 2012-03-30 2012-08-30 Immunogen Inc Ｃａ６抗原特異的細胞傷害性コンジュゲート、および該コンジュゲートを用いる方法
JP6345181B2 (ja) 2012-10-04 2018-06-20 イムノゲン インコーポレーティッド 細胞結合剤細胞毒性剤コンジュゲートを精製するためのｐｖｄｆ膜の使用
US9844607B2 (en) 2013-02-05 2017-12-19 Sanofi Immuno imaging agent for use with antibody-drug conjugate therapy
US9989524B2 (en) * 2013-02-05 2018-06-05 Sanofi Immuno imaging agent for use with antibody-drug conjugate therapy
US10413615B2 (en) 2014-11-19 2019-09-17 Immunogen, Inc. Process for preparing cell-binding agent-cytotoxic agent conjugates
CN108601848A (zh) 2016-02-05 2018-09-28 伊缪诺金公司 用于制备细胞结合剂-细胞毒性剂缀合物的有效方法
TW201808336A (zh) 2016-05-11 2018-03-16 賽諾菲公司 用抗ｍｕｃ１類美登素免疫綴合物抗體治療腫瘤的治療方案

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931385A (en) * 1985-06-24 1990-06-05 Hygeia Sciences, Incorporated Enzyme immunoassays and immunologic reagents
US5366866A (en) 1991-07-25 1994-11-22 Duke University Method of diagnosing ovarian and endometrial cancer with monoclonal antibodies OXA and OXB
AU6445894A (en) 1993-03-19 1994-10-11 Duke University Method of treatment of tumors with an antibody binding to tenascin
WO1994021294A1 (en) 1993-03-19 1994-09-29 Bigner Darell D Method of treating tumors with antibodies
US5871941A (en) 1995-07-28 1999-02-16 Univ British Columbia Method of testing expression of CA125 antigen in cultured ovarian surface epithelial cells to identify and monitor individuals having a predisposition to develop ovarian cancer
US7037667B1 (en) * 1998-06-01 2006-05-02 Agensys, Inc. Tumor antigen useful in diagnosis and therapy of prostate and colon cancer
NZ580855A (en) 2003-07-21 2012-03-30 Immunogen Inc A CA6 antigen-specific cytotoxic conjugate and methods of using the same
US7834155B2 (en) 2003-07-21 2010-11-16 Immunogen Inc. CA6 antigen-specific cytotoxic conjugate and methods of using the same

Also Published As

Publication number Publication date
MXPA03001460A (es) 2004-12-13
CA2419270A1 (en) 2002-02-28
EP1362060A4 (en) 2004-09-08
US8067186B2 (en) 2011-11-29
US20070196276A1 (en) 2007-08-23
CA2419270C (en) 2013-05-14
US6596503B1 (en) 2003-07-22
WO2002016401A3 (en) 2002-04-11
US7507410B2 (en) 2009-03-24
US20030215895A1 (en) 2003-11-20
GB2383331B (en) 2004-09-29
US20120045776A1 (en) 2012-02-23
US20090155930A1 (en) 2009-06-18
GB2383331A (en) 2003-06-25
AU2001289145A1 (en) 2002-03-04
EP1362060A2 (en) 2003-11-19
WO2002016401A2 (en) 2002-02-28
US8728741B2 (en) 2014-05-20
US7351805B2 (en) 2008-04-01
GB0306083D0 (en) 2003-04-23

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