MX346359B - Identificacion de polinucleotidos asociados con una muestra. - Google Patents
Identificacion de polinucleotidos asociados con una muestra.Info
- Publication number
- MX346359B MX346359B MX2013012493A MX2013012493A MX346359B MX 346359 B MX346359 B MX 346359B MX 2013012493 A MX2013012493 A MX 2013012493A MX 2013012493 A MX2013012493 A MX 2013012493A MX 346359 B MX346359 B MX 346359B
- Authority
- MX
- Mexico
- Prior art keywords
- sample
- identification
- polynucleotides associated
- compositions
- disclosed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Abstract
La presente invención se refiere a una biblioteca de polinucleótidos que comprende una pluralidad de composiciones, en donde la biblioteca comprende cDNAs que codifican regiones variables de inmunoblobulina de cadena ligera y pesada, o alfa y beta receptoras de la célula T, de la misma familia clonal, y en donde: cada composición está presente en un recipiente separado, cada composición comprende (i) moléculas de cDNA derivadas de una sola muestra que comprende a. moléculas cDNa que codifican regiones variables de inmunoglobulina de cadena pesada y moléculas de cDNA que codifican regiones variables de inmunoglobulina de cadena ligera de una o más células B, o b. moléculas de cDNA que codifican secuencia de cadena alfa receptoras de la célula T y moléculas de cDNA que codifican secuencias de cadena beta receptoras de células T de una o más células T; y (ii) una región de identificación de muestra unida a las moléculas de cDNA, en donde la secuencia de nucleótidos de la región de identificación de muestra es distinta a la secuencia de nucleótidos de la región de identificación de muestra de las otras composiciones presentes en otros recipientes separados en la biblioteca.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161517976P | 2011-04-28 | 2011-04-28 | |
US201161575652P | 2011-08-24 | 2011-08-24 | |
US201261599870P | 2012-02-16 | 2012-02-16 | |
US201261608571P | 2012-03-08 | 2012-03-08 | |
PCT/US2012/000221 WO2012148497A2 (en) | 2011-04-28 | 2012-04-27 | Identification of polynucleotides associated with a sample |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013012493A MX2013012493A (es) | 2014-07-28 |
MX346359B true MX346359B (es) | 2017-03-15 |
Family
ID=47072978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013012493A MX346359B (es) | 2011-04-28 | 2012-04-27 | Identificacion de polinucleotidos asociados con una muestra. |
Country Status (21)
Country | Link |
---|---|
US (2) | US11098302B2 (es) |
EP (6) | EP3421591B1 (es) |
JP (8) | JP5998203B2 (es) |
KR (6) | KR102112205B1 (es) |
CN (3) | CN103732738A (es) |
AU (6) | AU2012249158B2 (es) |
BR (1) | BR112013027540A2 (es) |
CA (2) | CA2833917C (es) |
DK (3) | DK3415619T3 (es) |
ES (3) | ES2861595T3 (es) |
HK (4) | HK1257815A1 (es) |
IL (3) | IL229122B (es) |
MX (1) | MX346359B (es) |
NZ (1) | NZ616956A (es) |
PL (3) | PL3418380T3 (es) |
PT (3) | PT2702146T (es) |
RU (1) | RU2644681C2 (es) |
SG (2) | SG10201900183VA (es) |
SI (3) | SI2702146T1 (es) |
WO (1) | WO2012148497A2 (es) |
ZA (1) | ZA201308027B (es) |
Families Citing this family (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104195227B (zh) | 2008-11-07 | 2017-04-12 | 适应生物技术公司 | 通过序列分析监测状况的方法 |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
EP2387627B1 (en) | 2009-01-15 | 2016-03-30 | Adaptive Biotechnologies Corporation | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
WO2011021102A2 (en) | 2009-08-20 | 2011-02-24 | Population Genetics Technologies Ltd | Compositions and methods for intramolecular nucleic acid rearrangement |
WO2013033721A1 (en) | 2011-09-02 | 2013-03-07 | Atreca, Inc. | Dna barcodes for multiplexed sequencing |
CA2858070C (en) | 2011-12-09 | 2018-07-10 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
SG11201405274WA (en) | 2012-02-27 | 2014-10-30 | Cellular Res Inc | Compositions and kits for molecular counting |
ES2662128T3 (es) | 2012-03-05 | 2018-04-05 | Adaptive Biotechnologies Corporation | Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes |
ES2582554T3 (es) | 2012-05-08 | 2016-09-13 | Adaptive Biotechnologies Corporation | Composiciones y método para medir y calibrar el sesgo de la amplificación en reacciones de PCR multiplexadas |
EP2861761A1 (en) * | 2012-06-15 | 2015-04-22 | Adaptive Biotechnologies Corporation | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
MX364957B (es) | 2012-08-14 | 2019-05-15 | 10X Genomics Inc | Composiciones y metodos para microcapsulas. |
US10400280B2 (en) | 2012-08-14 | 2019-09-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US20150376609A1 (en) | 2014-06-26 | 2015-12-31 | 10X Genomics, Inc. | Methods of Analyzing Nucleic Acids from Individual Cells or Cell Populations |
CA2894694C (en) | 2012-12-14 | 2023-04-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
CA2900481A1 (en) | 2013-02-08 | 2014-08-14 | 10X Genomics, Inc. | Polynucleotide barcode generation |
CN114107458A (zh) | 2013-03-15 | 2022-03-01 | 血统生物科学公司 | 测序免疫组库的方法 |
GB2525568B (en) | 2013-03-15 | 2020-10-14 | Abvitro Llc | Single cell barcoding for antibody discovery |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
SG10201806890VA (en) | 2013-08-28 | 2018-09-27 | Cellular Res Inc | Massively parallel single cell analysis |
ES2912183T3 (es) | 2013-12-30 | 2022-05-24 | Atreca Inc | Análisis de ácidos nucleicos asociados a células individuales utilizando códigos de barras de ácidos nucleicos |
CA2941612A1 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
AU2015243445B2 (en) | 2014-04-10 | 2020-05-28 | 10X Genomics, Inc. | Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same |
ES2777529T3 (es) | 2014-04-17 | 2020-08-05 | Adaptive Biotechnologies Corp | Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células |
AU2015318011B2 (en) * | 2014-09-15 | 2020-07-23 | Abvitro Llc | High-throughput nucleotide library sequencing |
US10392663B2 (en) | 2014-10-29 | 2019-08-27 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples |
US20160122817A1 (en) | 2014-10-29 | 2016-05-05 | 10X Genomics, Inc. | Methods and compositions for targeted nucleic acid sequencing |
EP3213080B1 (en) * | 2014-10-30 | 2019-04-24 | Erasmus University Medical Center Rotterdam | Reagents, methods and kits for diagnosing primary immunodeficiencies |
US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
US10246701B2 (en) * | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
SG11201705615UA (en) | 2015-01-12 | 2017-08-30 | 10X Genomics Inc | Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same |
EP3262188B1 (en) | 2015-02-24 | 2021-05-05 | 10X Genomics, Inc. | Methods for targeted nucleic acid sequence coverage |
EP3262407B1 (en) | 2015-02-24 | 2023-08-30 | 10X Genomics, Inc. | Partition processing methods and systems |
ES2858306T3 (es) | 2015-02-24 | 2021-09-30 | Adaptive Biotechnologies Corp | Método para determinar el estado de HLA mediante secuenciación del repertorio inmunitario |
US9727810B2 (en) | 2015-02-27 | 2017-08-08 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
EP3277843A2 (en) | 2015-03-30 | 2018-02-07 | Cellular Research, Inc. | Methods and compositions for combinatorial barcoding |
WO2016161273A1 (en) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
CN107580632B (zh) | 2015-04-23 | 2021-12-28 | 贝克顿迪金森公司 | 用于全转录组扩增的方法和组合物 |
WO2016176322A1 (en) * | 2015-04-27 | 2016-11-03 | Abvitro Llc | Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens |
US10829820B2 (en) | 2015-08-31 | 2020-11-10 | The United States Government As Represented By The Secretary Of The Army | Methods for molecularly characterizing cervical cell samples |
CN108603190B (zh) | 2015-09-08 | 2023-05-23 | 美国冷泉港实验室 | 使用经破碎的核苷酸的高通量多重测序确定基因拷贝数 |
WO2017044574A1 (en) | 2015-09-11 | 2017-03-16 | Cellular Research, Inc. | Methods and compositions for nucleic acid library normalization |
KR20180097536A (ko) | 2015-11-04 | 2018-08-31 | 아트레카, 인크. | 단일 세포와 연관된 핵산의 분석을 위한 핵산 바코드의 조합 세트 |
SG11201804086VA (en) | 2015-12-04 | 2018-06-28 | 10X Genomics Inc | Methods and compositions for nucleic acid analysis |
KR102632796B1 (ko) | 2016-03-10 | 2024-02-02 | 비엘라 바이오, 인크. | Ilt7 결합 분자 및 이의 사용 방법 |
WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
EP3472355A4 (en) * | 2016-06-15 | 2020-07-29 | Genecapture, Inc. | COMPOSITIONS, METHODS AND DEVICES INCLUDING ROD LOOP MOLECULES-SENSORS |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
WO2018058073A2 (en) | 2016-09-26 | 2018-03-29 | Cellular Research, Inc. | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
WO2018081113A1 (en) * | 2016-10-24 | 2018-05-03 | Sawaya Sterling | Concealing information present within nucleic acids |
WO2018089550A1 (en) | 2016-11-10 | 2018-05-17 | Takara Bio Usa, Inc. | Methods of producing amplified double stranded deoxyribonucleic acids and compositions and kits for use therein |
US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10550429B2 (en) * | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
JP7360324B2 (ja) | 2016-12-23 | 2023-10-12 | ビステラ, インコーポレイテッド | 結合ポリペプチドおよびそれを作製する方法 |
EP4029939B1 (en) | 2017-01-30 | 2023-06-28 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
CN110382708A (zh) | 2017-02-01 | 2019-10-25 | 赛卢拉研究公司 | 使用阻断性寡核苷酸进行选择性扩增 |
CN110418648B (zh) * | 2017-02-22 | 2023-09-08 | 丁恩雨 | 一种编码人GM-CSF与多串连表位融合的mRNA癌症疫苗 |
KR102281923B1 (ko) * | 2017-03-13 | 2021-07-27 | 기가젠, 인코포레이티드 | 단일 세포들의 초병렬 조합 분석을 위한 시스템들 및 방법들 |
US10400235B2 (en) | 2017-05-26 | 2019-09-03 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
CN116064732A (zh) | 2017-05-26 | 2023-05-05 | 10X基因组学有限公司 | 转座酶可接近性染色质的单细胞分析 |
WO2018222741A1 (en) * | 2017-05-31 | 2018-12-06 | Oklahoma Medical Research Foundation | Bispecific antibodies for the treatment of streptococcus pneumonia |
CA3059559A1 (en) | 2017-06-05 | 2018-12-13 | Becton, Dickinson And Company | Sample indexing for single cells |
EP3641806A4 (en) | 2017-06-22 | 2021-06-23 | University of Maryland, Baltimore | BROAD NEUTRALIZING ANTIBODIES AGAINST HIV |
SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
WO2019169028A1 (en) * | 2018-02-28 | 2019-09-06 | 10X Genomics, Inc. | Transcriptome sequencing through random ligation |
SG11202009889VA (en) | 2018-04-06 | 2020-11-27 | 10X Genomics Inc | Systems and methods for quality control in single cell processing |
US11773441B2 (en) | 2018-05-03 | 2023-10-03 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
JP7358388B2 (ja) | 2018-05-03 | 2023-10-10 | ベクトン・ディキンソン・アンド・カンパニー | 反対側の転写物末端における分子バーコーディング |
US11639517B2 (en) | 2018-10-01 | 2023-05-02 | Becton, Dickinson And Company | Determining 5′ transcript sequences |
US11066663B2 (en) | 2018-10-31 | 2021-07-20 | Zymergen Inc. | Multiplexed deterministic assembly of DNA libraries |
US11932849B2 (en) | 2018-11-08 | 2024-03-19 | Becton, Dickinson And Company | Whole transcriptome analysis of single cells using random priming |
EP3894552A1 (en) | 2018-12-13 | 2021-10-20 | Becton, Dickinson and Company | Selective extension in single cell whole transcriptome analysis |
SG11202106810UA (en) * | 2018-12-28 | 2021-07-29 | Nat Univ Singapore | Methods for targeted complementary dna enrichment |
EP3914728B1 (en) | 2019-01-23 | 2023-04-05 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
DE19913048T1 (de) * | 2019-01-31 | 2022-01-27 | Nantbio, Inc. | Mrna-display-antikörper-bibliothek und verfahren |
CN110020726B (zh) * | 2019-03-04 | 2023-08-18 | 武汉希望组生物科技有限公司 | 一种对组装序列排序的方法及系统 |
US11939622B2 (en) | 2019-07-22 | 2024-03-26 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
CN114729350A (zh) | 2019-11-08 | 2022-07-08 | 贝克顿迪金森公司 | 使用随机引发获得用于免疫组库测序的全长v(d)j信息 |
WO2021146207A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and rna |
JP2023511440A (ja) | 2020-01-22 | 2023-03-17 | アトレカ インコーポレイテッド | 複数の転写産物のハイスループット連結 |
WO2021168427A1 (en) * | 2020-02-20 | 2021-08-26 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for rapid detection of sars-cov-2 |
WO2021231237A2 (en) * | 2020-05-11 | 2021-11-18 | Augmenta Bioworks, Inc. | Antibodies for sars-cov-2 and uses thereof |
WO2021231779A1 (en) | 2020-05-14 | 2021-11-18 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
US20230227816A1 (en) * | 2020-06-15 | 2023-07-20 | Chan Zuckerberg Biohub, Inc. | Methods and compositions for selective pcr and cloning of antibody sequences |
GB2596803A (en) * | 2020-07-06 | 2022-01-12 | Petmedix Ltd | Expression vector production & high-throughput cell screening |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
WO2022081643A2 (en) * | 2020-10-13 | 2022-04-21 | 10X Genomics, Inc. | Compositions and methods for generating recombinant antigen binding molecules from single cells |
WO2022082225A2 (en) * | 2020-10-16 | 2022-04-21 | The Board Of Trustees Of The Leland Stanford Junior University | Genetic tools for recombining transgenes at the same locus |
CN116635533A (zh) | 2020-11-20 | 2023-08-22 | 贝克顿迪金森公司 | 高表达的蛋白和低表达的蛋白的谱分析 |
WO2022232258A1 (en) * | 2021-04-29 | 2022-11-03 | Pioneer Hi-Bred International, Inc. | Clubroot resistance in brassica |
EP4355774A1 (en) | 2021-06-17 | 2024-04-24 | Atreca, Inc. | Anti-csp antibodies |
WO2023154305A2 (en) * | 2022-02-10 | 2023-08-17 | Amgen Inc. | Antibody protein product expression constructs for high throughput sequencing |
WO2024015862A1 (en) * | 2022-07-13 | 2024-01-18 | 10X Genomics, Inc. | Methods for characterization of antigen-binding molecules from biological samples |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
CA2114950A1 (en) | 1991-08-10 | 1993-02-11 | Michael J. Embleton | Treatment of cell populations |
US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
US6011137A (en) * | 1996-04-03 | 2000-01-04 | University Of North Carolina At Chapel Hill | Identification and isolation of novel polypeptides having WW domains and methods of using same |
US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
KR100566859B1 (ko) | 1997-01-21 | 2006-04-03 | 제너럴 하스피톨 코포레이션 | Rna-단백질 융합물을 이용한 단백질의 선별 |
US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
EP0975748B1 (en) | 1997-04-23 | 2006-03-29 | Universität Zürich | Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules |
US6927025B1 (en) * | 1997-09-03 | 2005-08-09 | Biovation Limited | Methods for protein screening |
ATE361377T1 (de) | 1997-09-29 | 2007-05-15 | Hope City | Leistungstarke verknüpfung von nukleinsäuresegmenten |
IL138668A0 (en) | 1998-04-03 | 2001-10-31 | Phylos Inc | Addressable protein arrays |
US6846655B1 (en) | 1998-06-29 | 2005-01-25 | Phylos, Inc. | Methods for generating highly diverse libraries |
CA2334946A1 (en) | 1998-08-17 | 2000-02-24 | Phylos, Inc. | Methods for producing nucleic acids lacking 3'-untranslated regions and optimizing cellular rna-protein fusion formation |
JP4278872B2 (ja) | 1998-08-17 | 2009-06-17 | フィロス インク. | 蛋白質・核酸融合分子ライブラリーを用いた化合物・蛋白質相互作用の同定 |
ATE354675T1 (de) | 1998-12-02 | 2007-03-15 | Adnexus Therapeutics Inc | Dna-protein fusionen sowie anwendungen derselben |
CA2366559C (en) * | 1999-03-23 | 2011-03-08 | Biovation Limited | Protein isolation and analysis |
US6623926B1 (en) | 1999-06-01 | 2003-09-23 | Phylos, Inc. | Methods for producing 5′-nucleic acid-protein conjugates |
US20090233806A1 (en) * | 1999-07-06 | 2009-09-17 | Carr Francis J | Protein isolation and analysis |
AU778194B2 (en) | 1999-07-12 | 2004-11-18 | Bristol-Myers Squibb Company | C-terminal protein tagging |
US6429300B1 (en) | 1999-07-27 | 2002-08-06 | Phylos, Inc. | Peptide acceptor ligation methods |
AU779653B2 (en) | 1999-08-27 | 2005-02-03 | Bristol-Myers Squibb Company | Methods for encoding and sorting in vitro translated proteins |
US6274321B1 (en) | 1999-12-03 | 2001-08-14 | The Regents Of The University Of California | High throughput functional screening of cDNAs |
WO2001053539A1 (en) | 2000-01-24 | 2001-07-26 | Phylos, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
US7022479B2 (en) | 2000-01-24 | 2006-04-04 | Compound Therapeutics, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
WO2003000856A2 (en) | 2001-06-21 | 2003-01-03 | Phylos, Inc. | In vitro protein interaction detection systems |
US20040161741A1 (en) * | 2001-06-30 | 2004-08-19 | Elazar Rabani | Novel compositions and processes for analyte detection, quantification and amplification |
US7125669B2 (en) | 2001-11-27 | 2006-10-24 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
JP4324649B2 (ja) * | 2001-11-28 | 2009-09-02 | 福井県 | 繊維強化熱可塑性樹脂シート及びそれを用いた構造材並びに繊維強化熱可塑性樹脂シートの製造方法 |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
CA2536565A1 (en) * | 2003-09-10 | 2005-05-12 | Althea Technologies, Inc. | Expression profiling using microarrays |
TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
WO2007094842A2 (en) * | 2005-12-02 | 2007-08-23 | Genentech, Inc. | Binding polypeptides and uses thereof |
KR101130597B1 (ko) | 2005-09-13 | 2012-04-02 | 다카라 바이오 가부시키가이샤 | T 세포 리셉터 및 그 리셉터를 코드하는 핵산 |
US8642513B2 (en) * | 2005-09-15 | 2014-02-04 | Crucell Holland B.V. | Method for preparing immunoglobulin libraries |
WO2007062064A2 (en) | 2005-11-23 | 2007-05-31 | Regents Of The University Of California, San Diego | Methods and compositions for controlling parasitic infections with bt crystal proteins |
JP2009520468A (ja) | 2005-12-23 | 2009-05-28 | ヴィヴェンティア バイオテック インコーポレーティッド | 融合タンパク質ライブラリーの作製法およびスクリーニング法、ならびにそれらの使用 |
JP2006271390A (ja) | 2006-05-15 | 2006-10-12 | Kudo Norio | 短縮型ミッドカイン(tMK)タンパク質特異的モノクローナル抗体の製造方法 |
US8148085B2 (en) * | 2006-05-15 | 2012-04-03 | Sea Lane Biotechnologies, Llc | Donor specific antibody libraries |
US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
ATE521704T1 (de) * | 2007-03-01 | 2011-09-15 | Symphogen As | Verfahren zur klonierung verwandter antikörper |
JP5205597B2 (ja) | 2007-06-01 | 2013-06-05 | 静岡県 | 1細胞レベルでの抗体遺伝子の解析・同定方法 |
JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
US9328172B2 (en) * | 2008-04-05 | 2016-05-03 | Single Cell Technology, Inc. | Method of obtaining antibodies of interest and nucleotides encoding same |
JP2011528905A (ja) | 2008-07-25 | 2011-12-01 | セラクローン サイエンシーズ, インコーポレイテッド | 抗体レパートリーアレイ(ara)を使用する標的特異的抗体を発見するための方法および組成物 |
TW201028432A (en) * | 2008-09-30 | 2010-08-01 | Abbott Lab | Improved antibody libraries |
KR101069146B1 (ko) * | 2008-10-01 | 2011-09-30 | 주식회사에이앤알쎄라퓨틱스 | 인간 항체 scFv 라이브러리 제작용 재조합 벡터, 발현벡터 및 이의 제조방법 |
CA2742968C (en) * | 2008-11-07 | 2020-06-09 | Fabrus Llc | Combinatorial antibody libraries and uses thereof |
US20120010091A1 (en) * | 2009-03-30 | 2012-01-12 | Illumina, Inc. | Gene expression analysis in single cells |
AU2010232439C1 (en) | 2009-04-02 | 2017-07-13 | Fluidigm Corporation | Multi-primer amplification method for barcoding of target nucleic acids |
RU2569187C2 (ru) * | 2009-05-29 | 2015-11-20 | МорфоСис АГ | Коллекция и способы ее применения |
CA2772298A1 (en) | 2009-08-26 | 2011-03-03 | Research Development Foundation | Methods for creating antibody libraries |
US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
CN101845500B (zh) | 2010-05-18 | 2013-02-27 | 苏州众信生物技术有限公司 | 一种利用dna序列条码矫正二代高通量测序的序列丰度偏差的方法 |
-
2012
- 2012-04-27 SI SI201231535T patent/SI2702146T1/sl unknown
- 2012-04-27 ES ES18180597T patent/ES2861595T3/es active Active
- 2012-04-27 SG SG10201900183VA patent/SG10201900183VA/en unknown
- 2012-04-27 AU AU2012249158A patent/AU2012249158B2/en active Active
- 2012-04-27 ES ES18180599T patent/ES2925799T3/es active Active
- 2012-04-27 BR BR112013027540A patent/BR112013027540A2/pt not_active Application Discontinuation
- 2012-04-27 ES ES12775920T patent/ES2716013T3/es active Active
- 2012-04-27 EP EP18180602.7A patent/EP3421591B1/en active Active
- 2012-04-27 SI SI201232007T patent/SI3418380T1/sl unknown
- 2012-04-27 PL PL18180599.5T patent/PL3418380T3/pl unknown
- 2012-04-27 PL PL12775920T patent/PL2702146T3/pl unknown
- 2012-04-27 PT PT12775920T patent/PT2702146T/pt unknown
- 2012-04-27 CA CA2833917A patent/CA2833917C/en active Active
- 2012-04-27 EP EP18180599.5A patent/EP3418380B1/en active Active
- 2012-04-27 US US13/261,763 patent/US11098302B2/en active Active
- 2012-04-27 DK DK18180597.9T patent/DK3415619T3/da active
- 2012-04-27 KR KR1020197002837A patent/KR102112205B1/ko active IP Right Grant
- 2012-04-27 DK DK12775920.7T patent/DK2702146T3/en active
- 2012-04-27 KR KR1020197002835A patent/KR102112204B1/ko active IP Right Grant
- 2012-04-27 CA CA3078215A patent/CA3078215A1/en active Pending
- 2012-04-27 KR KR1020197002839A patent/KR102151656B1/ko active IP Right Grant
- 2012-04-27 KR KR1020137031535A patent/KR101776192B1/ko active IP Right Grant
- 2012-04-27 PT PT181805979T patent/PT3415619T/pt unknown
- 2012-04-27 EP EP18180603.5A patent/EP3421592B1/en active Active
- 2012-04-27 CN CN201280031099.0A patent/CN103732738A/zh active Pending
- 2012-04-27 EP EP18180597.9A patent/EP3415619B1/en active Active
- 2012-04-27 EP EP23189059.1A patent/EP4286855A3/en active Pending
- 2012-04-27 NZ NZ616956A patent/NZ616956A/en unknown
- 2012-04-27 MX MX2013012493A patent/MX346359B/es active IP Right Grant
- 2012-04-27 CN CN201910010319.5A patent/CN110055593A/zh active Pending
- 2012-04-27 PL PL18180597T patent/PL3415619T3/pl unknown
- 2012-04-27 SG SG2013080106A patent/SG194233A1/en unknown
- 2012-04-27 JP JP2014508340A patent/JP5998203B2/ja active Active
- 2012-04-27 EP EP12775920.7A patent/EP2702146B1/en active Active
- 2012-04-27 KR KR1020197002834A patent/KR102151655B1/ko active IP Right Grant
- 2012-04-27 RU RU2013150707A patent/RU2644681C2/ru active
- 2012-04-27 WO PCT/US2012/000221 patent/WO2012148497A2/en active Application Filing
- 2012-04-27 PT PT181805995T patent/PT3418380T/pt unknown
- 2012-04-27 KR KR1020177024677A patent/KR102033659B1/ko active IP Right Grant
- 2012-04-27 DK DK18180599.5T patent/DK3418380T3/da active
- 2012-04-27 SI SI201231888T patent/SI3415619T1/sl unknown
- 2012-04-27 CN CN202211461711.XA patent/CN117026386A/zh active Pending
-
2013
- 2013-10-28 IL IL229122A patent/IL229122B/en active IP Right Grant
- 2013-10-29 ZA ZA2013/08027A patent/ZA201308027B/en unknown
-
2014
- 2014-09-02 HK HK19100159.6A patent/HK1257815A1/zh unknown
- 2014-09-02 HK HK19100158.7A patent/HK1257814A1/zh unknown
- 2014-09-02 HK HK19100157.8A patent/HK1257813A1/zh unknown
- 2014-09-02 HK HK19100156.9A patent/HK1257812A1/zh unknown
-
2016
- 2016-08-29 JP JP2016166624A patent/JP6660271B2/ja active Active
-
2017
- 2017-09-25 AU AU2017232235A patent/AU2017232235B2/en active Active
-
2018
- 2018-06-28 US US16/022,579 patent/US20240035019A1/en active Pending
- 2018-07-26 JP JP2018139977A patent/JP6703567B2/ja active Active
- 2018-12-31 AU AU2018286625A patent/AU2018286625B2/en active Active
- 2018-12-31 AU AU2018286622A patent/AU2018286622B2/en active Active
- 2018-12-31 AU AU2018286623A patent/AU2018286623B2/en active Active
- 2018-12-31 AU AU2018286624A patent/AU2018286624B2/en active Active
-
2019
- 2019-01-01 IL IL264056A patent/IL264056B/en unknown
- 2019-01-10 JP JP2019002388A patent/JP2019094336A/ja not_active Withdrawn
- 2019-01-10 JP JP2019002437A patent/JP2019077707A/ja not_active Withdrawn
- 2019-01-10 JP JP2019002451A patent/JP2019077708A/ja not_active Withdrawn
- 2019-01-10 JP JP2019002412A patent/JP7251985B2/ja active Active
-
2021
- 2021-11-04 JP JP2021180321A patent/JP7357661B2/ja active Active
-
2022
- 2022-02-27 IL IL290935A patent/IL290935B2/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG194233A1 (en) | Identification of polynucleotides associated with a sample | |
HK1250245A1 (zh) | 生物樣本的空間區別、多重核酸分析 | |
EP4270006A3 (en) | General detection and isolation of specific cells by binding of labeled molecules | |
ZA201700540B (en) | Instrument for analyzing biological samples and reagents | |
GB2511221A (en) | Methods and compositions for classification of samples | |
MX2019007742A (es) | Metodos para aislar microvesiculas. | |
MX2016016904A (es) | Analisis de secuencias de acidos nucleicos. | |
AU2015205612A8 (en) | Method for generating double stranded DNA libraries and sequencing methods for the identification of methylated cytosines | |
GB2526736A (en) | Methods, compositions, and kits for nucleic acid analysis | |
EP2784513A4 (en) | CHIP FOR SAMPLE ANALYSIS, SAMPLE ANALYSIS METHOD, AND GENE ANALYSIS METHOD | |
WO2014144822A3 (en) | Methods and compositions for tagging and analyzing samples | |
WO2010135705A3 (en) | Biological bar code | |
IN2014DN07531A (es) | ||
MY188348A (en) | Single-molecule sequencing of plasma dna | |
WO2013033609A3 (en) | Methods and compositions for the treatment and diagnosis of cancer | |
NZ731116A (en) | Method for the enrichment of circulating tumor dna | |
MX2015012319A (es) | Sistemas de instrumento analitico. | |
MX2018009505A (es) | Metodo para determinar helicobacter pylori. | |
WO2013166444A3 (en) | Biomarker analysis using scodaphoresis | |
BR112016028496A2 (pt) | análise quantitativa de proteínas transgênicas | |
MX363790B (es) | Muestreo embrionario para analisis molecular. | |
GB2496557A (en) | Products and methods for identifying rock samples | |
UA115321C2 (uk) | Спосіб та комплект для аналізу ahasl генів у рослин | |
EP2808397A3 (en) | Method for obtaining information on colon cancer and marker and kit for obtaining information on colon cancer | |
BR112017002622A2 (pt) | métodos e sistemas para quantificação seletiva e detecção de alergênicos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |