DK3415619T3 - Identifikation af polynukleotider forbundet med en prøve - Google Patents
Identifikation af polynukleotider forbundet med en prøve Download PDFInfo
- Publication number
- DK3415619T3 DK3415619T3 DK18180597.9T DK18180597T DK3415619T3 DK 3415619 T3 DK3415619 T3 DK 3415619T3 DK 18180597 T DK18180597 T DK 18180597T DK 3415619 T3 DK3415619 T3 DK 3415619T3
- Authority
- DK
- Denmark
- Prior art keywords
- polynucleotids
- identification
- sample
- polynucleotids associated
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161517976P | 2011-04-28 | 2011-04-28 | |
US201161575652P | 2011-08-24 | 2011-08-24 | |
US201261599870P | 2012-02-16 | 2012-02-16 | |
US201261608571P | 2012-03-08 | 2012-03-08 | |
EP12775920.7A EP2702146B1 (en) | 2011-04-28 | 2012-04-27 | Identification of polynucleotides associated with a sample |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3415619T3 true DK3415619T3 (da) | 2021-03-08 |
Family
ID=47072978
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12775920.7T DK2702146T3 (da) | 2011-04-28 | 2012-04-27 | Identifikation af polynukleotider forbundet med en prøve |
DK18180597.9T DK3415619T3 (da) | 2011-04-28 | 2012-04-27 | Identifikation af polynukleotider forbundet med en prøve |
DK18180599.5T DK3418380T3 (da) | 2011-04-28 | 2012-04-27 | Identifikation af polynukleotider forbundet med en prøve |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12775920.7T DK2702146T3 (da) | 2011-04-28 | 2012-04-27 | Identifikation af polynukleotider forbundet med en prøve |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18180599.5T DK3418380T3 (da) | 2011-04-28 | 2012-04-27 | Identifikation af polynukleotider forbundet med en prøve |
Country Status (21)
Country | Link |
---|---|
US (2) | US11098302B2 (da) |
EP (6) | EP3415619B1 (da) |
JP (8) | JP5998203B2 (da) |
KR (6) | KR102151656B1 (da) |
CN (3) | CN103732738A (da) |
AU (6) | AU2012249158B2 (da) |
BR (1) | BR112013027540A2 (da) |
CA (2) | CA2833917C (da) |
DK (3) | DK2702146T3 (da) |
ES (3) | ES2716013T3 (da) |
HK (4) | HK1257812A1 (da) |
IL (3) | IL229122B (da) |
MX (1) | MX346359B (da) |
NZ (1) | NZ616956A (da) |
PL (3) | PL3418380T3 (da) |
PT (3) | PT3418380T (da) |
RU (1) | RU2644681C2 (da) |
SG (2) | SG10201900183VA (da) |
SI (3) | SI2702146T1 (da) |
WO (1) | WO2012148497A2 (da) |
ZA (1) | ZA201308027B (da) |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
ES2781754T3 (es) | 2008-11-07 | 2020-09-07 | Adaptive Biotechnologies Corp | Métodos para supervisar las condiciones por análisis de secuencia |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
DK2387627T3 (da) | 2009-01-15 | 2016-07-04 | Adaptive Biotechnologies Corp | Adaptiv immunitetsprofilering og fremgangsmåder til at frembringe monoklonale antistoffer |
US8298767B2 (en) | 2009-08-20 | 2012-10-30 | Population Genetics Technologies Ltd | Compositions and methods for intramolecular nucleic acid rearrangement |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
WO2013033721A1 (en) | 2011-09-02 | 2013-03-07 | Atreca, Inc. | Dna barcodes for multiplexed sequencing |
EP3388535B1 (en) | 2011-12-09 | 2021-03-24 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
CN104364392B (zh) | 2012-02-27 | 2018-05-25 | 赛卢拉研究公司 | 用于分子计数的组合物和试剂盒 |
EP2823060B1 (en) | 2012-03-05 | 2018-02-14 | Adaptive Biotechnologies Corporation | Determining paired immune receptor chains from frequency matched subunits |
AU2013259544B9 (en) | 2012-05-08 | 2017-09-28 | Adaptive Biotechnologies Corporation | Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions |
EP2861761A1 (en) * | 2012-06-15 | 2015-04-22 | Adaptive Biotechnologies Corporation | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
CN113528634A (zh) | 2012-08-14 | 2021-10-22 | 10X基因组学有限公司 | 微胶囊组合物及方法 |
US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10400280B2 (en) | 2012-08-14 | 2019-09-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
EP3567116A1 (en) | 2012-12-14 | 2019-11-13 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
KR20200140929A (ko) | 2013-02-08 | 2020-12-16 | 10엑스 제노믹스, 인크. | 폴리뉴클레오티드 바코드 생성 |
CN105189748B (zh) | 2013-03-15 | 2021-06-08 | 血统生物科学公司 | 测序免疫组库的方法 |
US9816088B2 (en) | 2013-03-15 | 2017-11-14 | Abvitro Llc | Single cell bar-coding for antibody discovery |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
KR102536833B1 (ko) | 2013-08-28 | 2023-05-26 | 벡톤 디킨슨 앤드 컴퍼니 | 대량의 동시 단일 세포 분석 |
CN114717291A (zh) | 2013-12-30 | 2022-07-08 | 阿特雷卡公司 | 使用核酸条形码分析与单细胞缔合的核酸 |
WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
AU2015243445B2 (en) | 2014-04-10 | 2020-05-28 | 10X Genomics, Inc. | Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same |
ES2777529T3 (es) | 2014-04-17 | 2020-08-05 | Adaptive Biotechnologies Corp | Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células |
CN113249435B (zh) | 2014-06-26 | 2024-09-03 | 10X基因组学有限公司 | 分析来自单个细胞或细胞群体的核酸的方法 |
CA2961210A1 (en) * | 2014-09-15 | 2016-03-24 | Abvitro, Inc. | High-throughput nucleotide library sequencing |
CA2966201A1 (en) * | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
AU2015339148B2 (en) | 2014-10-29 | 2022-03-10 | 10X Genomics, Inc. | Methods and compositions for targeted nucleic acid sequencing |
WO2016068714A2 (en) * | 2014-10-30 | 2016-05-06 | Erasmus University Medical Center Rotterdam | Reagents, methods and kits for diagnosing primary immunodeficiencies |
US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
US10246701B2 (en) * | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
WO2016114970A1 (en) | 2015-01-12 | 2016-07-21 | 10X Genomics, Inc. | Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same |
WO2016138148A1 (en) | 2015-02-24 | 2016-09-01 | 10X Genomics, Inc. | Methods for targeted nucleic acid sequence coverage |
AU2016222788B2 (en) | 2015-02-24 | 2022-03-31 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing |
US10697000B2 (en) | 2015-02-24 | 2020-06-30 | 10X Genomics, Inc. | Partition processing methods and systems |
EP3262192B1 (en) | 2015-02-27 | 2020-09-16 | Becton, Dickinson and Company | Spatially addressable molecular barcoding |
US11535882B2 (en) | 2015-03-30 | 2022-12-27 | Becton, Dickinson And Company | Methods and compositions for combinatorial barcoding |
WO2016161273A1 (en) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
WO2016172373A1 (en) | 2015-04-23 | 2016-10-27 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
MX2017013471A (es) * | 2015-04-27 | 2018-08-01 | Abvitro Llc | Metodo de secuenciamiento, determinacion, apareamiento y validacion de agentes terapeuticos y antigenos especificos de enfermedades. |
WO2017040491A1 (en) | 2015-08-31 | 2017-03-09 | The United States Of America As Represented By The Secretary Of The Army | Methods for molecularly characterizing cervical cell samples |
CA2997929A1 (en) | 2015-09-08 | 2017-03-16 | Cold Spring Harbor Laboratory | Genetic copy number determination using high throughput multiplex sequencing of smashed nucleotides |
US10619186B2 (en) | 2015-09-11 | 2020-04-14 | Cellular Research, Inc. | Methods and compositions for library normalization |
US11098304B2 (en) | 2015-11-04 | 2021-08-24 | Atreca, Inc. | Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells |
WO2017096158A1 (en) | 2015-12-04 | 2017-06-08 | 10X Genomics, Inc. | Methods and compositions for nucleic acid analysis |
KR20240017421A (ko) | 2016-03-10 | 2024-02-07 | 비엘라 바이오, 인크. | Ilt7 결합 분자 및 이의 사용 방법 |
WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
US11713482B2 (en) | 2016-06-15 | 2023-08-01 | Genecapture, Inc. | Compositions, methods and devices comprising stem-loop captor molecules |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
CA3034924A1 (en) | 2016-09-26 | 2018-03-29 | Cellular Research, Inc. | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
WO2018081113A1 (en) * | 2016-10-24 | 2018-05-03 | Sawaya Sterling | Concealing information present within nucleic acids |
JP7050057B2 (ja) | 2016-11-10 | 2022-04-07 | タカラ バイオ ユーエスエー, インコーポレイテッド | 増幅二本鎖デオキシリボ核酸の作製方法ならびに該方法で使用する組成物及びキット |
US20180163201A1 (en) * | 2016-12-12 | 2018-06-14 | Grail, Inc. | Methods for tagging and amplifying rna template molecules for preparing sequencing libraries |
US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
MY201744A (en) | 2016-12-23 | 2024-03-15 | Visterra Inc | Binding polypeptides and methods of making the same |
EP4310183A3 (en) | 2017-01-30 | 2024-02-21 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
EP3577232A1 (en) | 2017-02-01 | 2019-12-11 | Cellular Research, Inc. | Selective amplification using blocking oligonucleotides |
WO2018156106A1 (en) * | 2017-02-22 | 2018-08-30 | Ding Enyu | An mrna cancer vaccine encoding human gm-csf fused to multiple tandem epitopes |
KR102281923B1 (ko) | 2017-03-13 | 2021-07-27 | 기가젠, 인코포레이티드 | 단일 세포들의 초병렬 조합 분석을 위한 시스템들 및 방법들 |
CN109526228B (zh) | 2017-05-26 | 2022-11-25 | 10X基因组学有限公司 | 转座酶可接近性染色质的单细胞分析 |
US20180340169A1 (en) | 2017-05-26 | 2018-11-29 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
WO2018222741A1 (en) * | 2017-05-31 | 2018-12-06 | Oklahoma Medical Research Foundation | Bispecific antibodies for the treatment of streptococcus pneumonia |
CA3059559A1 (en) | 2017-06-05 | 2018-12-13 | Becton, Dickinson And Company | Sample indexing for single cells |
EP3641806A4 (en) | 2017-06-22 | 2021-06-23 | University of Maryland, Baltimore | BROAD NEUTRALIZING ANTIBODIES AGAINST HIV |
CN111051523B (zh) | 2017-11-15 | 2024-03-19 | 10X基因组学有限公司 | 功能化凝胶珠 |
US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
WO2019169028A1 (en) * | 2018-02-28 | 2019-09-06 | 10X Genomics, Inc. | Transcriptome sequencing through random ligation |
WO2019195166A1 (en) | 2018-04-06 | 2019-10-10 | 10X Genomics, Inc. | Systems and methods for quality control in single cell processing |
ES2945191T3 (es) | 2018-05-03 | 2023-06-29 | Becton Dickinson Co | Análisis de muestras multiómicas de alto rendimiento |
US11365409B2 (en) | 2018-05-03 | 2022-06-21 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
WO2020072380A1 (en) | 2018-10-01 | 2020-04-09 | Cellular Research, Inc. | Determining 5' transcript sequences |
WO2020092704A1 (en) * | 2018-10-31 | 2020-05-07 | Zymergen Inc. | Multiplexed deterministic assembly of dna libraries |
WO2020097315A1 (en) | 2018-11-08 | 2020-05-14 | Cellular Research, Inc. | Whole transcriptome analysis of single cells using random priming |
WO2020123384A1 (en) | 2018-12-13 | 2020-06-18 | Cellular Research, Inc. | Selective extension in single cell whole transcriptome analysis |
JP2022515466A (ja) * | 2018-12-28 | 2022-02-18 | ナショナル ユニヴァーシティー オブ シンガポール | 標的化された相補的dna富化のための方法 |
WO2020154247A1 (en) | 2019-01-23 | 2020-07-30 | Cellular Research, Inc. | Oligonucleotides associated with antibodies |
WO2020159524A1 (en) * | 2019-01-31 | 2020-08-06 | Nantbio, Inc. | Mrna display antibody library and methods |
WO2020167920A1 (en) | 2019-02-14 | 2020-08-20 | Cellular Research, Inc. | Hybrid targeted and whole transcriptome amplification |
CN110020726B (zh) * | 2019-03-04 | 2023-08-18 | 武汉希望组生物科技有限公司 | 一种对组装序列排序的方法及系统 |
EP4004231A1 (en) | 2019-07-22 | 2022-06-01 | Becton, Dickinson and Company | Single cell chromatin immunoprecipitation sequencing assay |
WO2021092386A1 (en) | 2019-11-08 | 2021-05-14 | Becton Dickinson And Company | Using random priming to obtain full-length v(d)j information for immune repertoire sequencing |
CN115244184A (zh) | 2020-01-13 | 2022-10-25 | 贝克顿迪金森公司 | 用于定量蛋白和rna的方法和组合物 |
WO2021150903A1 (en) | 2020-01-22 | 2021-07-29 | Atreca, Inc. | High throughput linking of multiple transcripts |
WO2021168427A1 (en) * | 2020-02-20 | 2021-08-26 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for rapid detection of sars-cov-2 |
US11919944B2 (en) | 2020-05-11 | 2024-03-05 | Augmenta Biosciences, Inc. | Antibodies for SARS-CoV-2 and uses thereof |
WO2021231779A1 (en) | 2020-05-14 | 2021-11-18 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
US20230227816A1 (en) * | 2020-06-15 | 2023-07-20 | Chan Zuckerberg Biohub, Inc. | Methods and compositions for selective pcr and cloning of antibody sequences |
GB2596803A (en) * | 2020-07-06 | 2022-01-12 | Petmedix Ltd | Expression vector production & high-throughput cell screening |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
WO2022081643A2 (en) * | 2020-10-13 | 2022-04-21 | 10X Genomics, Inc. | Compositions and methods for generating recombinant antigen binding molecules from single cells |
WO2022082225A2 (en) * | 2020-10-16 | 2022-04-21 | The Board Of Trustees Of The Leland Stanford Junior University | Genetic tools for recombining transgenes at the same locus |
CN116635533A (zh) | 2020-11-20 | 2023-08-22 | 贝克顿迪金森公司 | 高表达的蛋白和低表达的蛋白的谱分析 |
WO2022232258A1 (en) * | 2021-04-29 | 2022-11-03 | Pioneer Hi-Bred International, Inc. | Clubroot resistance in brassica |
IL309422A (en) | 2021-06-17 | 2024-02-01 | Atreca Inc | Antibodies against CSP |
WO2023154305A2 (en) * | 2022-02-10 | 2023-08-17 | Amgen Inc. | Antibody protein product expression constructs for high throughput sequencing |
WO2024015862A1 (en) * | 2022-07-13 | 2024-01-18 | 10X Genomics, Inc. | Methods for characterization of antigen-binding molecules from biological samples |
WO2024086167A2 (en) * | 2022-10-17 | 2024-04-25 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
US12110344B2 (en) | 2022-11-21 | 2024-10-08 | Dianthus Therapeutics Opco, Inc. | Antibodies that bind to cis and uses thereof |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
DK0597960T3 (da) | 1991-08-10 | 1999-09-13 | Medical Res Council | Behandling af cellepopulationer |
US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
US6011137A (en) * | 1996-04-03 | 2000-01-04 | University Of North Carolina At Chapel Hill | Identification and isolation of novel polypeptides having WW domains and methods of using same |
US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
WO1998031700A1 (en) | 1997-01-21 | 1998-07-23 | The General Hospital Corporation | Selection of proteins using rna-protein fusions |
DE69834032T2 (de) | 1997-04-23 | 2006-12-07 | Universität Zürich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
US6927025B1 (en) * | 1997-09-03 | 2005-08-09 | Biovation Limited | Methods for protein screening |
ATE361377T1 (de) | 1997-09-29 | 2007-05-15 | Hope City | Leistungstarke verknüpfung von nukleinsäuresegmenten |
CA2323638A1 (en) | 1998-04-03 | 1999-10-14 | Phylos, Inc. | Addressable protein arrays |
US6846655B1 (en) | 1998-06-29 | 2005-01-25 | Phylos, Inc. | Methods for generating highly diverse libraries |
US6602685B1 (en) | 1998-08-17 | 2003-08-05 | Phylos, Inc. | Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules |
WO2000009737A1 (en) | 1998-08-17 | 2000-02-24 | Phylos, Inc. | Methods for producing nucleic acids lacking 3'-untranslated regions and optimizing cellular rna-protein fusion formation |
WO2000032823A1 (en) | 1998-12-02 | 2000-06-08 | Phylos, Inc. | Dna-protein fusions and uses thereof |
ES2265917T3 (es) * | 1999-03-23 | 2007-03-01 | Biovation Limited | Aislamiento y analisis de proteinas. |
US6623926B1 (en) | 1999-06-01 | 2003-09-23 | Phylos, Inc. | Methods for producing 5′-nucleic acid-protein conjugates |
US20090233806A1 (en) * | 1999-07-06 | 2009-09-17 | Carr Francis J | Protein isolation and analysis |
AU778194B2 (en) | 1999-07-12 | 2004-11-18 | Bristol-Myers Squibb Company | C-terminal protein tagging |
US6429300B1 (en) | 1999-07-27 | 2002-08-06 | Phylos, Inc. | Peptide acceptor ligation methods |
EP1212452B1 (en) | 1999-08-27 | 2013-07-17 | Bristol-Myers Squibb Company | Methods for encoding and sorting in vitro translated proteins |
US6274321B1 (en) * | 1999-12-03 | 2001-08-14 | The Regents Of The University Of California | High throughput functional screening of cDNAs |
EP1250463B1 (en) | 2000-01-24 | 2006-04-05 | Compound Therapeutics, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
US7022479B2 (en) | 2000-01-24 | 2006-04-04 | Compound Therapeutics, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
WO2003000856A2 (en) | 2001-06-21 | 2003-01-03 | Phylos, Inc. | In vitro protein interaction detection systems |
US20040161741A1 (en) * | 2001-06-30 | 2004-08-19 | Elazar Rabani | Novel compositions and processes for analyte detection, quantification and amplification |
WO2003045975A2 (en) | 2001-11-27 | 2003-06-05 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
JP4324649B2 (ja) * | 2001-11-28 | 2009-09-02 | 福井県 | 繊維強化熱可塑性樹脂シート及びそれを用いた構造材並びに繊維強化熱可塑性樹脂シートの製造方法 |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
DE602004026077D1 (de) * | 2003-09-10 | 2010-04-29 | Althea Technologies Inc | Erstellung von expressionsprofilen unter verwendung von mikroarrays |
TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
CN101287831B (zh) | 2005-09-13 | 2013-05-15 | 国立大学法人三重大学 | T细胞受体和编码该受体的核酸 |
WO2007031550A2 (en) * | 2005-09-15 | 2007-03-22 | Crucell Holland B.V. | Method for preparing immunoglobulin libraries |
US20100024075A1 (en) | 2005-11-23 | 2010-01-28 | Aroian Raffi V | Method for Controlling Plant-Parasitic Nematode Infections in Plants |
KR101434682B1 (ko) * | 2005-12-02 | 2014-08-27 | 제넨테크, 인크. | 결합 폴리펩티드 및 이들의 용도 |
CA2633138A1 (en) | 2005-12-23 | 2007-06-28 | Viventia Biotech Inc. | Methods for generating and screening fusion protein libraries and uses thereof |
US8148085B2 (en) * | 2006-05-15 | 2012-04-03 | Sea Lane Biotechnologies, Llc | Donor specific antibody libraries |
JP2006271390A (ja) | 2006-05-15 | 2006-10-12 | Kudo Norio | 短縮型ミッドカイン(tMK)タンパク質特異的モノクローナル抗体の製造方法 |
US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
ATE521704T1 (de) | 2007-03-01 | 2011-09-15 | Symphogen As | Verfahren zur klonierung verwandter antikörper |
JP5205597B2 (ja) | 2007-06-01 | 2013-06-05 | 静岡県 | 1細胞レベルでの抗体遺伝子の解析・同定方法 |
JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
WO2009123756A1 (en) * | 2008-04-05 | 2009-10-08 | Single Cell Technology, Inc. | Multi-well system |
JP2011528905A (ja) * | 2008-07-25 | 2011-12-01 | セラクローン サイエンシーズ, インコーポレイテッド | 抗体レパートリーアレイ(ara)を使用する標的特異的抗体を発見するための方法および組成物 |
KR20110061629A (ko) * | 2008-09-30 | 2011-06-09 | 아보트 러보러터리즈 | 개선된 항체 라이브러리 |
KR101069146B1 (ko) * | 2008-10-01 | 2011-09-30 | 주식회사에이앤알쎄라퓨틱스 | 인간 항체 scFv 라이브러리 제작용 재조합 벡터, 발현벡터 및 이의 제조방법 |
EP2356270B1 (en) * | 2008-11-07 | 2016-08-24 | Fabrus Llc | Combinatorial antibody libraries and uses thereof |
DK2414548T3 (da) * | 2009-03-30 | 2015-12-21 | Illumina Inc | Genekspressionsanalyse i enkeltceller |
KR101829182B1 (ko) | 2009-04-02 | 2018-03-29 | 플루이다임 코포레이션 | 표적 핵산의 바코딩을 위한 멀티 프라이머 증폭 방법 |
DK2435568T3 (da) * | 2009-05-29 | 2014-09-08 | Morphosys Ag | Samling af syntetiske antistoffer til behandling af sygdom |
EP2470653A1 (en) | 2009-08-26 | 2012-07-04 | Research Development Foundation | Methods for creating antibody libraries |
US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
CN101845500B (zh) | 2010-05-18 | 2013-02-27 | 苏州众信生物技术有限公司 | 一种利用dna序列条码矫正二代高通量测序的序列丰度偏差的方法 |
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