MX344751B - Genes que codifican para la proteina l1 mayor de la capside del virus del papiloma humano y uso de los mismos. - Google Patents

Genes que codifican para la proteina l1 mayor de la capside del virus del papiloma humano y uso de los mismos.

Info

Publication number
MX344751B
MX344751B MX2014002449A MX2014002449A MX344751B MX 344751 B MX344751 B MX 344751B MX 2014002449 A MX2014002449 A MX 2014002449A MX 2014002449 A MX2014002449 A MX 2014002449A MX 344751 B MX344751 B MX 344751B
Authority
MX
Mexico
Prior art keywords
capsid protein
papilloma virus
human papilloma
major capsid
genes encoding
Prior art date
Application number
MX2014002449A
Other languages
English (en)
Inventor
Gaoxia Zhang
Qiong Shen
Jianqiang Lei
Jingyu Yuan
Menghua Zhang
Qianli Zhang
Yinghua Xiong
Roger Wei
Ke Wu
Original Assignee
Shanghai Zerun Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN 200710170935 external-priority patent/CN101440372B/zh
Priority claimed from CN200710170934A external-priority patent/CN101440371B/zh
Priority claimed from CN200710170936A external-priority patent/CN101440373B/zh
Priority claimed from CN200810032655A external-priority patent/CN101487010B/zh
Priority claimed from CN2008100326547A external-priority patent/CN101487009B/zh
Application filed by Shanghai Zerun Biotechnology Co Ltd filed Critical Shanghai Zerun Biotechnology Co Ltd
Publication of MX344751B publication Critical patent/MX344751B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
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    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a un gen aislado que codifica la proteína L1 mayor de cápside del virus de papiloma humano, caracterizado porque dicho gen tiene condones preferidos por la levadura Pichia, y en donde dicho gen codifica la proteína L1 mayor de cápside del virus del papiloma humano y tiene una secuencia de nucleótidos seleccionada de aquellas expuestas en SEQ ID NO: 7, SEQ ID NO: 8 y SEQ ID NO: 9.
MX2014002449A 2007-11-23 2008-11-24 Genes que codifican para la proteina l1 mayor de la capside del virus del papiloma humano y uso de los mismos. MX344751B (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN 200710170935 CN101440372B (zh) 2007-11-23 2007-11-23 一种18型人乳头状瘤病毒主要衣壳蛋白l1基因
CN200710170934A CN101440371B (zh) 2007-11-23 2007-11-23 一种16型人乳头状瘤病毒主要衣壳蛋白l1基因
CN200710170936A CN101440373B (zh) 2007-11-23 2007-11-23 一种截短型的18型人乳头状瘤病毒主要衣壳蛋白l1基因
CN200810032655A CN101487010B (zh) 2008-01-15 2008-01-15 用毕赤酵母表达系统制备抗人乳头瘤病毒18型感染的疫苗的方法
CN2008100326547A CN101487009B (zh) 2008-01-15 2008-01-15 用毕赤酵母表达系统制备抗人乳头瘤病毒16型感染的疫苗的方法
PCT/CN2008/073167 WO2009076824A1 (zh) 2007-11-23 2008-11-24 人乳头状瘤病毒主要衣壳蛋白l1基因及其用途

Publications (1)

Publication Number Publication Date
MX344751B true MX344751B (es) 2017-01-05

Family

ID=40795163

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2010005699A MX2010005699A (es) 2007-11-23 2008-11-24 Genes que codifican para la proteina l1 mayor de la capside del virus del papiloma humano y uso de los mismos.
MX2014002449A MX344751B (es) 2007-11-23 2008-11-24 Genes que codifican para la proteina l1 mayor de la capside del virus del papiloma humano y uso de los mismos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2010005699A MX2010005699A (es) 2007-11-23 2008-11-24 Genes que codifican para la proteina l1 mayor de la capside del virus del papiloma humano y uso de los mismos.

Country Status (9)

Country Link
US (2) US8795676B2 (es)
EP (3) EP2479187A1 (es)
KR (1) KR101588413B1 (es)
CN (1) CN101835797A (es)
BR (1) BRPI0818957B8 (es)
MX (2) MX2010005699A (es)
MY (2) MY162658A (es)
RU (1) RU2494106C2 (es)
WO (1) WO2009076824A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110699366B (zh) * 2013-12-26 2022-11-25 上海泽润生物科技有限公司 重组人乳头瘤病毒6和11亚型蛋白毕赤酵母表达
CN117187262A (zh) * 2014-02-18 2023-12-08 上海泽润生物科技有限公司 重组人乳头瘤病毒蛋白表达
JP2017528137A (ja) * 2014-09-11 2017-09-28 カディラ ヘルスケア リミティド 卓越した免疫学的特性を有する卓越したヒトパピローマウイルス抗原及びそれを含むワクチン
CN106893730B (zh) * 2015-12-18 2021-06-11 上海泽润生物科技有限公司 重组人乳头瘤蛋白表达
JOP20190242A1 (ar) * 2018-10-12 2020-04-12 Serum Institute Of India Pvt Ltd تركيبة لقاح توليفي تشمل فيروس شلل الأطفال ذو جرعة مخفّضة خاملة التنشيط وطريقة لتحضيرها

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0595935T3 (da) * 1991-07-19 2003-07-21 Csl Ltd Papillomavirusvaccine
AU693511B2 (en) * 1994-02-07 1998-07-02 Qiagen Gmbh Endotoxin reduction or removal process
HUT76354A (en) * 1994-05-16 1997-08-28 Merck & Co Inc Papillomavirus vaccines
WO1996011272A2 (de) * 1994-10-07 1996-04-18 Medigene Gesellschaft Für Molekularbiologische Diagnostik, Theraphie Und Technologie Mbh Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung
US6436402B1 (en) * 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
DE10055545A1 (de) * 2000-11-09 2002-07-25 Deutsches Krebsforsch Für Expression in Eukaryonten optimierte HPV 16-L1 und HPV 16-L2 kodierende DNA Sequenzen
KR101080628B1 (ko) * 2003-03-24 2011-11-08 머크 샤프 앤드 돔 코포레이션 효모에서 ｈｐｖ 31 ｌ1의 최적 발현
MY140664A (en) * 2003-09-29 2010-01-15 Merck Sharp & Dohme Optimized expression of hpv 45 l1 in yeast
MY139500A (en) * 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
PL1730175T3 (pl) * 2004-03-24 2010-09-30 Merck Sharp & Dohme Optymalizowana ekspresja L1 HPV 52 w drożdżach

Also Published As

Publication number Publication date
EP2479186A1 (en) 2012-07-25
CN101835797A (zh) 2010-09-15
EP2479186B1 (en) 2015-08-12
BRPI0818957B1 (pt) 2021-05-04
MY182347A (en) 2021-01-20
RU2494106C2 (ru) 2013-09-27
MY162658A (en) 2017-06-30
WO2009076824A1 (zh) 2009-06-25
US9034340B2 (en) 2015-05-19
EP2223933B1 (en) 2016-01-27
KR20100102114A (ko) 2010-09-20
KR101588413B1 (ko) 2016-02-02
EP2223933A4 (en) 2012-01-04
US20110256182A1 (en) 2011-10-20
US20140328935A1 (en) 2014-11-06
US8795676B2 (en) 2014-08-05
EP2479187A1 (en) 2012-07-25
MX2010005699A (es) 2010-09-14
RU2010125695A (ru) 2011-12-27
BRPI0818957B8 (pt) 2021-05-25
BRPI0818957A2 (pt) 2019-12-17
EP2223933A1 (en) 2010-09-01

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