BRPI0518109A - cepa bacteriana, nucleocapsìdeo, preparação de vacina, método para criar uma bactéria recombinante, bactéria mutante, seqüências de rna fluorado para deslanchar rdsrna e meio para eletroporação - Google Patents

cepa bacteriana, nucleocapsìdeo, preparação de vacina, método para criar uma bactéria recombinante, bactéria mutante, seqüências de rna fluorado para deslanchar rdsrna e meio para eletroporação

Info

Publication number
BRPI0518109A
BRPI0518109A BRPI0518109-7A BRPI0518109A BRPI0518109A BR PI0518109 A BRPI0518109 A BR PI0518109A BR PI0518109 A BRPI0518109 A BR PI0518109A BR PI0518109 A BRPI0518109 A BR PI0518109A
Authority
BR
Brazil
Prior art keywords
bacterium
creating
bacteria
rna sequences
vaccine preparation
Prior art date
Application number
BRPI0518109-7A
Other languages
English (en)
Inventor
David Michael Hone
John Fulkerson
Jerald C Sadoff
David Onyabe
Michele Stone
Original Assignee
Aeras Global Tb Vaccine Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeras Global Tb Vaccine Foundation filed Critical Aeras Global Tb Vaccine Foundation
Publication of BRPI0518109A publication Critical patent/BRPI0518109A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora

Abstract

CEPA BACTERIANA, NUCLEOCAPSìDEOS, PREPARAçãO DE VACINA, MéTODO PARA CRIAR UMA BACTéRIA RECOMBINANTE, BACTéRIA MUTANTE, SEQUêNCIAS DE RNA FLUORADO PARA DESLANCHAR rdsRna E MEIO PARA ELETRO PORAçãO. A presente invenção se refere a cepas para englobar bactérias com utilidade na geracão de nucleocapsídeos recombínantes ce RNA de fita dupla (rdsRNs) são aqui proporcionadas. As cepas para englobar bactérias são de utilidade para a produção de antígenos de RNA para a codificação de vacinas, para proteínas bíoatívas, para proteínas imunoreguladoras, para RNAs antísentído e para RNAs catalíticos em células ou em tecidos eucaríótícos. O ssRNA recombínante é introduzido na cepa e é englobado para formar os rdsRNs de novo.
BRPI0518109-7A 2004-11-30 2005-11-23 cepa bacteriana, nucleocapsìdeo, preparação de vacina, método para criar uma bactéria recombinante, bactéria mutante, seqüências de rna fluorado para deslanchar rdsrna e meio para eletroporação BRPI0518109A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99907404A 2004-11-30 2004-11-30
US71372905P 2005-09-06 2005-09-06
PCT/US2005/042480 WO2006060257A2 (en) 2004-11-30 2005-11-23 Bacterial packaging strains usefuel for generation and production of recombinant double-stranded rna nucleocapsids and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0518109A true BRPI0518109A (pt) 2008-11-04

Family

ID=36565556

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518109-7A BRPI0518109A (pt) 2004-11-30 2005-11-23 cepa bacteriana, nucleocapsìdeo, preparação de vacina, método para criar uma bactéria recombinante, bactéria mutante, seqüências de rna fluorado para deslanchar rdsrna e meio para eletroporação

Country Status (13)

Country Link
US (1) US8053568B2 (pt)
EP (1) EP1817408B1 (pt)
JP (1) JP2008521434A (pt)
KR (1) KR20070101854A (pt)
AP (1) AP2007004020A0 (pt)
AU (1) AU2005310119A1 (pt)
BR (1) BRPI0518109A (pt)
CA (1) CA2587493A1 (pt)
EA (1) EA011282B1 (pt)
MX (1) MX2007006366A (pt)
PE (1) PE20061169A1 (pt)
TW (1) TW200631593A (pt)
WO (1) WO2006060257A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69930147T2 (de) * 1998-12-04 2007-01-11 University Of Manitoba, Winnipeg Zwei-schritte-verfahren zur impfung gegen chlamydia
US7018835B2 (en) * 2002-08-20 2006-03-28 David Michael Hone Recombinant double-stranded RNA phage, and use of the same
US20080107683A1 (en) * 2004-11-30 2008-05-08 David Hone Bacterial Packaging Strains Useful for Generation and Production of Recombinant Double-Stranded RNA Nucleocapsids and Uses Thereof
US7829104B2 (en) * 2004-12-01 2010-11-09 Aeras Global Tb Vaccine Foundation Electroporation of Mycobacterium and overexpression of antigens in mycobacteria
CN1276076C (zh) * 2004-12-14 2006-09-20 华东理工大学 一种鳗弧菌野生毒株的无标记基因缺失减毒突变株及其应用
WO2008127486A2 (en) * 2006-12-29 2008-10-23 Bacilligen, Inc. Replication-proficient dsrna capsids and uses thereof
JP7098330B2 (ja) * 2015-06-10 2022-07-11 ホオキパ バイオテック ジーエムビーエイチ Ｈｐｖワクチン
CA3102078A1 (en) 2018-06-02 2019-12-05 Synlogic Operating Company, Inc. Bacteria engineered to treat liver disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736388A (en) * 1994-12-30 1998-04-07 Chada; Sunil Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells
CA2231332C (en) * 1995-09-06 2007-04-17 Arthur A. Branstrom Bacterial delivery system
US6887483B2 (en) * 1995-12-01 2005-05-03 University Of Iowa Research Foundation Non-toxic mutants of pathogenic gram-negative bacteria
CA2305785A1 (en) * 1997-10-07 1999-04-15 University Of Maryland Biotechnology Institute Method for introducing and expressing rna in animal cells
JP4709545B2 (ja) * 2002-07-26 2011-06-22 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 修飾された低分子干渉ｒｎａ分子および使用方法
US7018835B2 (en) * 2002-08-20 2006-03-28 David Michael Hone Recombinant double-stranded RNA phage, and use of the same
US20040198640A1 (en) * 2003-04-02 2004-10-07 Dharmacon, Inc. Stabilized polynucleotides for use in RNA interference

Also Published As

Publication number Publication date
JP2008521434A (ja) 2008-06-26
EA011282B1 (ru) 2009-02-27
EA200701129A1 (ru) 2007-12-28
CA2587493A1 (en) 2006-06-08
EP1817408B1 (en) 2013-01-16
PE20061169A1 (es) 2006-11-08
MX2007006366A (es) 2008-03-10
EP1817408A2 (en) 2007-08-15
AU2005310119A1 (en) 2006-06-08
KR20070101854A (ko) 2007-10-17
EP1817408A4 (en) 2009-01-28
US8053568B2 (en) 2011-11-08
WO2006060257A2 (en) 2006-06-08
TW200631593A (en) 2006-09-16
WO2006060257A3 (en) 2006-12-14
US20060115493A1 (en) 2006-06-01
AP2007004020A0 (en) 2007-06-30

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DA 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2208 DE 30/04/2013.