MX342892B - Un procedimiento para sintetizar compuestos de p-hidroxifenilglicina levorrotatoria. - Google Patents

Un procedimiento para sintetizar compuestos de p-hidroxifenilglicina levorrotatoria.

Info

Publication number
MX342892B
MX342892B MX2013006993A MX2013006993A MX342892B MX 342892 B MX342892 B MX 342892B MX 2013006993 A MX2013006993 A MX 2013006993A MX 2013006993 A MX2013006993 A MX 2013006993A MX 342892 B MX342892 B MX 342892B
Authority
MX
Mexico
Prior art keywords
compound
laevo
synthesizing
hydroxyphenylglycine
reaction
Prior art date
Application number
MX2013006993A
Other languages
English (en)
Other versions
MX2013006993A (es
Inventor
Xie Jianzhong
Guo Xiubin
Zhao Lixian
Liu Chao
Original Assignee
Henan Newland Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henan Newland Pharm Co Ltd filed Critical Henan Newland Pharm Co Ltd
Publication of MX2013006993A publication Critical patent/MX2013006993A/es
Publication of MX342892B publication Critical patent/MX342892B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C07B37/02—Addition
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se refiere al campo de la síntesis química, en particular a un procedimiento para sintetizar compuestos de p-hidroxifenilglicina levorrotatoria, que elimina los procesos posteriores de resolución, los procesamientos de racemización, etc., simplifica las etapas operativas; y se eligen ácidos de molécula orgánica pequeña como catalizador en la segunda etapa, que no solo conduce a la realización de una producción industrializada, sino que también hace que el valor de ee de los productos finales sea del 88,1~98,0% determinando el catalizador, el disolvente de reacción, la sustancia reactiva, la temperatura de reacción y la duración de la reacción; se usa un disolvente no acuoso en la segunda etapa para evitar la descarga de agua residual que contiene fenol, por lo que se reduce la contaminación medioambiental.
MX2013006993A 2012-02-15 2012-02-15 Un procedimiento para sintetizar compuestos de p-hidroxifenilglicina levorrotatoria. MX342892B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2012/071159 WO2013120257A1 (zh) 2012-02-15 2012-02-15 一种左旋对羟基苯甘氨酸类化合物的合成方法

Publications (2)

Publication Number Publication Date
MX2013006993A MX2013006993A (es) 2013-12-06
MX342892B true MX342892B (es) 2016-10-18

Family

ID=48672096

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006993A MX342892B (es) 2012-02-15 2012-02-15 Un procedimiento para sintetizar compuestos de p-hidroxifenilglicina levorrotatoria.

Country Status (7)

Country Link
US (1) US8940928B2 (es)
JP (1) JP5767346B2 (es)
CA (1) CA2818094C (es)
ES (1) ES2429431B2 (es)
GB (1) GB2503341B (es)
MX (1) MX342892B (es)
WO (1) WO2013120257A1 (es)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860631A (en) * 1973-12-06 1975-01-14 Smithkline Corp Process for the preparation of n-acyl-2- and 4-hydroxyphenylglycines
CH614928A5 (es) * 1975-09-12 1979-12-28 Nobel Hoechst Chimie
NL9000653A (nl) 1990-03-21 1991-10-16 Kessels Gerard Werkwijze voor de bereiding van d-(-)-4-hydroxyfenylglycine en l-(+)-4-hydroxyfenylglycine, uitgaande van d.l.-4-hydroxyfenylglycine.
NL9101380A (nl) * 1991-08-13 1993-03-01 Dsm Nv Werkwijze voor de bereiding van een alfa-aminozuur, de overeenkomstige ester en amide.
CN1072926A (zh) 1992-11-19 1993-06-09 河北师范学院 D-(-)-[4-r]-苯甘氨酸的制备方法
JPH10279541A (ja) * 1997-04-02 1998-10-20 Nippon Shokubai Co Ltd ２−置換グリコール酸化合物及びその製造方法
CN100494165C (zh) 2006-03-29 2009-06-03 宝山钢铁股份有限公司 D-对羟基苯甘氨酸的制备方法
CN101362703B (zh) * 2007-08-09 2011-11-16 谢建中 对羟基苯甘氨酸合成技术
CN100519514C (zh) 2008-03-13 2009-07-29 河北宏源化工有限公司 D-对羟基苯甘氨酸的制备方法
WO2009127446A1 (en) * 2008-04-17 2009-10-22 Deretil, S.A. METHOD FOR THE PREPARATION OF D-p-HYDROXYPHENYLGLYCINE
CN101613298A (zh) * 2008-06-25 2009-12-30 河南新天地药业有限公司 水相拆分法生产d-(-)-对羟基苯甘氨酸技术
CN102603449B (zh) * 2012-02-15 2015-07-15 河南新天地药业股份有限公司 一种左旋对羟基苯甘氨酸类化合物的合成方法

Also Published As

Publication number Publication date
US8940928B2 (en) 2015-01-27
ES2429431A2 (es) 2013-11-14
ES2429431B2 (es) 2014-05-30
CA2818094C (en) 2016-11-08
GB201308404D0 (en) 2013-06-19
JP5767346B2 (ja) 2015-08-19
JP2014515733A (ja) 2014-07-03
GB2503341B (en) 2020-04-15
GB2503341A (en) 2013-12-25
ES2429431R1 (es) 2013-12-17
US20140350295A1 (en) 2014-11-27
CA2818094A1 (en) 2013-08-15
WO2013120257A1 (zh) 2013-08-22
MX2013006993A (es) 2013-12-06

Similar Documents

Publication Publication Date Title
WO2014014835A3 (en) Criystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid
MY175370A (en) Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto
WO2013011292A3 (en) Microorganism for converting carbon dioxide to aliphatic carboxylic acids via formic acid intermediate
WO2012066059A3 (de) Verfahren zur biokatalytischen cyclisierung von terpenen und darin einsetzbare cyclase-mutanten
EP3792352A3 (en) Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto
BR112012019006A2 (pt) processo para a produção de ácidos carboxilícos com 1 a 3 átomos de carbono a partir de fontes renováveis
MX336507B (es) Proceso para fabricar compuestos beta-hidroxiamino.
MX2013014421A (es) Procedimiento para la preparacion de una composicion que comprende complejos metalicos en una matriz organica aceitosa.
IN2014DN07035A (es)
MY187636A (en) Pyruvate dehydrogenase variants, a microorganism comprising the same and a method for producing l-amino acid using the same
BR112013024257A2 (pt) método para reduzir ou prevenir a incrustação em um processo de produção de ácido fosfórico em processo a úmido
MY165269A (en) Method for producing bioresourced acrylic acid from glycerol
MY145056A (en) Method for aging alcoholic liquids
WO2008105464A1 (ja) カルボン酸クロライドの製造方法
WO2012002662A3 (ko) 편광자의 제조방법
MY158885A (en) Method for producing glycerol
BR112012026705A2 (pt) método para produzir um produto natural fermentado.
EA201690570A1 (ru) Процесс ферментации
WO2014036140A3 (en) Methods for production of a terpene and a co-product
MX342892B (es) Un procedimiento para sintetizar compuestos de p-hidroxifenilglicina levorrotatoria.
GB201008401D0 (en) Novel process
IN2014DE03067A (es)
MY202418A (en) Process for the production of methyl methacrylate
EA201300325A1 (ru) Получение 6-аминокапроновой кислоты из альфа-кетопимелиновой кислоты
MX342471B (es) Procedimiento de preparacion de un ester de acido carboxilico.

Legal Events

Date Code Title Description
FG Grant or registration