MX336947B - Ligandos esteroides y su uso en la modulacion de genes interruptores. - Google Patents
Ligandos esteroides y su uso en la modulacion de genes interruptores.Info
- Publication number
- MX336947B MX336947B MX2013006609A MX2013006609A MX336947B MX 336947 B MX336947 B MX 336947B MX 2013006609 A MX2013006609 A MX 2013006609A MX 2013006609 A MX2013006609 A MX 2013006609A MX 336947 B MX336947 B MX 336947B
- Authority
- MX
- Mexico
- Prior art keywords
- steroidal ligands
- gene switch
- switch modulation
- nuclear receptor
- steroidal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
- C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
- C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- High Energy & Nuclear Physics (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se relaciona con ligandos esteroides para uso en sistemas de expresión de genes inducibles basados al receptor nuclear. La invención se relaciona adicionalmente con métodos para modular la expresión de genes de interés con un sistema que contiene uno o más complejos de receptor nuclear y uno o más ligandos esteroides. Los aspectos adicionales incluyen composiciones de ligando que incluyen composiciones terapéuticas.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3664808P | 2008-03-14 | 2008-03-14 | |
US4705708P | 2008-04-22 | 2008-04-22 | |
US6070608P | 2008-06-11 | 2008-06-11 | |
PCT/US2009/001639 WO2009114201A2 (en) | 2008-03-14 | 2009-03-16 | Steroidal ligands and their use in gene switch modulation |
Publications (1)
Publication Number | Publication Date |
---|---|
MX336947B true MX336947B (es) | 2016-02-08 |
Family
ID=41065739
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010009996A MX2010009996A (es) | 2008-03-14 | 2009-03-16 | Ligandos esteroides y su uso en la modulacion de genes interruptores. |
MX2013006609A MX336947B (es) | 2008-03-14 | 2009-03-16 | Ligandos esteroides y su uso en la modulacion de genes interruptores. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010009996A MX2010009996A (es) | 2008-03-14 | 2009-03-16 | Ligandos esteroides y su uso en la modulacion de genes interruptores. |
Country Status (12)
Country | Link |
---|---|
US (2) | US8536354B2 (es) |
EP (1) | EP2265116A4 (es) |
JP (1) | JP5777890B2 (es) |
KR (1) | KR101695035B1 (es) |
CN (1) | CN102014626B (es) |
AU (1) | AU2009223721B2 (es) |
BR (1) | BRPI0908747A2 (es) |
CA (1) | CA2718494C (es) |
IL (1) | IL208692A (es) |
MX (2) | MX2010009996A (es) |
RU (1) | RU2487134C2 (es) |
WO (1) | WO2009114201A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101695035B1 (ko) | 2008-03-14 | 2017-01-23 | 인트렉손 코포레이션 | 스테로이드성 리간드 및 유전자 스위치 조절에서 이의 용도 |
CN102234303B (zh) * | 2010-05-07 | 2013-04-03 | 重庆植恩药业有限公司 | 蜕皮甾酮合成衍生物及其制备方法和用途 |
FR2982489B1 (fr) * | 2011-11-10 | 2013-12-27 | Inst Biophytis Sas | Phytoecdysones pour leur utilisation dans la stabilisation du poids apres un regime amaigrissant |
FR3021318B1 (fr) * | 2014-05-20 | 2017-04-28 | Inst Biophytis | Produits derives de la 20-hydroxyecdysone et leur utilisation dans la preparation de medicaments |
CN104756919B (zh) * | 2015-04-20 | 2017-05-03 | 福建师范大学 | 一种诱导龟足金星幼虫附着变态的方法 |
US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
AU2017222572A1 (en) | 2016-02-24 | 2018-08-23 | Aromyx Corporation | Biosensor for detecting smell, scent and taste |
WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
UY37343A (es) * | 2016-07-25 | 2018-02-28 | Intrexon Corp | Control del fenotipo en plantas |
CN112481217A (zh) | 2016-09-01 | 2021-03-12 | 嵌合体生物工程公司 | Gold优化的car t-细胞 |
EP3568474A1 (en) | 2017-01-10 | 2019-11-20 | Intrexon Corporation | Modulating expression of polypeptides via new gene switch expression systems |
FR3078252B1 (fr) * | 2018-02-28 | 2020-08-14 | Biophytis | Phytoecdysones pour leur utilisation dans la prevention de la perte de force musculaire lors d’une immobilisation |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4981784A (en) | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
CA2075192A1 (en) | 1990-03-22 | 1991-09-23 | Anthony E. Oro | Insect retinoid receptor compositions and methods |
ES2237764T3 (es) | 1995-03-03 | 2005-08-01 | Syngenta Participations Ag | Control de la expresion genica en plantas por transactivacion mediada por un receptor en presencia de un ligando quimico. |
CZ372297A3 (cs) | 1995-05-26 | 1998-03-18 | Zeneca Limited | Přepínání genové exprese využívající receptoru pro ekdyson |
AU734051B2 (en) | 1996-04-05 | 2001-05-31 | Salk Institute For Biological Studies, The | Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto |
AU738494B2 (en) | 1997-07-10 | 2001-09-20 | Salk Institute For Biological Studies, The | Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression |
US6333318B1 (en) * | 1998-05-14 | 2001-12-25 | The Salk Institute For Biological Studies | Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto |
US6258603B1 (en) | 1998-06-17 | 2001-07-10 | Rohm And Haas Company | Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
AU3642601A (en) * | 1999-11-05 | 2001-05-30 | Avigen, Inc. | Ecdysone-inducible adeno-associated virus expression vectors |
US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
CN1304578C (zh) | 2000-03-22 | 2007-03-14 | 罗姆和哈斯公司 | 新的基于蜕皮激素受体的可诱导的基因表达系统 |
US8105825B2 (en) | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
DK1456346T3 (da) | 2001-02-20 | 2012-05-29 | Intrexon Corp | Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor |
WO2002066615A2 (en) | 2001-02-20 | 2002-08-29 | Rheogene, Inc. | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
ES2424812T3 (es) | 2001-02-20 | 2013-10-08 | Intrexon Corporation | Receptores X retinoides quiméricos y su uso en un sistema inducible de expresión génica basado en receptores de ecdisona novedoso |
ES2422303T3 (es) | 2001-02-20 | 2013-09-10 | Intrexon Corp | Receptores mutantes por sustitución novedosos y su uso en un sistema de expresión génica inducible basado en receptores nucleares |
CA2459827C (en) | 2001-09-26 | 2013-09-03 | Subba Reddy Palli | Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof |
JP2005507247A (ja) | 2001-09-26 | 2005-03-17 | レオジーン・ホールディングス,インコーポレーテッド | コナジラミエクジソン受容体核酸、ポリペプチド、およびそれらの使用 |
US20050228016A1 (en) | 2002-06-13 | 2005-10-13 | Enrique Michelotti | Tetrahydroquinolines for modulating the expression of exogenous genes via an ecdysone receptor complex |
US7375093B2 (en) * | 2002-07-05 | 2008-05-20 | Intrexon Corporation | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
US20040049437A1 (en) | 2002-09-11 | 2004-03-11 | Govone Solutions, Lp | Method, system and computer program product for automating transaction tax calculation |
AU2003284316A1 (en) * | 2002-10-24 | 2004-05-13 | Albert Einstein College Of Medicine Of Yeshiva University | Caged ligands and uses thereof |
US7304161B2 (en) | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
US7304162B2 (en) | 2003-02-21 | 2007-12-04 | Intrexon Corporation | Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
US7456315B2 (en) | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
FR2863878B1 (fr) * | 2003-12-22 | 2006-06-30 | Oreal | Utilisation d'ecdysteroides pour la preparation de compositions dermathologiques ou cosmetiques anti-chute de cheveux. |
US7935510B2 (en) | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
US20050191385A1 (en) * | 2004-10-25 | 2005-09-01 | Amato Daniel K. | Natural product derivatives as food supplements and pharmaceuticals |
KR101695035B1 (ko) | 2008-03-14 | 2017-01-23 | 인트렉손 코포레이션 | 스테로이드성 리간드 및 유전자 스위치 조절에서 이의 용도 |
-
2009
- 2009-03-16 KR KR1020107022930A patent/KR101695035B1/ko active IP Right Grant
- 2009-03-16 JP JP2010550704A patent/JP5777890B2/ja not_active Expired - Fee Related
- 2009-03-16 CN CN200980116670.7A patent/CN102014626B/zh not_active Expired - Fee Related
- 2009-03-16 BR BRPI0908747A patent/BRPI0908747A2/pt not_active IP Right Cessation
- 2009-03-16 CA CA2718494A patent/CA2718494C/en not_active Expired - Fee Related
- 2009-03-16 MX MX2010009996A patent/MX2010009996A/es active IP Right Grant
- 2009-03-16 EP EP09718924A patent/EP2265116A4/en not_active Withdrawn
- 2009-03-16 AU AU2009223721A patent/AU2009223721B2/en not_active Ceased
- 2009-03-16 RU RU2010140194/04A patent/RU2487134C2/ru not_active IP Right Cessation
- 2009-03-16 WO PCT/US2009/001639 patent/WO2009114201A2/en active Application Filing
- 2009-03-16 MX MX2013006609A patent/MX336947B/es unknown
- 2009-03-16 US US12/404,943 patent/US8536354B2/en active Active
-
2010
- 2010-10-13 IL IL208692A patent/IL208692A/en active IP Right Grant
-
2013
- 2013-07-22 US US13/947,631 patent/US9243263B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20090298175A1 (en) | 2009-12-03 |
MX2010009996A (es) | 2010-10-20 |
RU2010140194A (ru) | 2012-04-20 |
WO2009114201A3 (en) | 2009-12-30 |
RU2487134C2 (ru) | 2013-07-10 |
IL208692A0 (en) | 2010-12-30 |
US20140057349A1 (en) | 2014-02-27 |
US8536354B2 (en) | 2013-09-17 |
EP2265116A4 (en) | 2013-02-06 |
WO2009114201A2 (en) | 2009-09-17 |
AU2009223721A1 (en) | 2009-09-17 |
IL208692A (en) | 2016-10-31 |
KR20100127828A (ko) | 2010-12-06 |
BRPI0908747A2 (pt) | 2023-04-18 |
KR101695035B1 (ko) | 2017-01-23 |
EP2265116A2 (en) | 2010-12-29 |
JP2011518121A (ja) | 2011-06-23 |
JP5777890B2 (ja) | 2015-09-09 |
US9243263B2 (en) | 2016-01-26 |
CN102014626A (zh) | 2011-04-13 |
CN102014626B (zh) | 2016-01-13 |
CA2718494A1 (en) | 2009-09-17 |
AU2009223721B2 (en) | 2015-01-29 |
CA2718494C (en) | 2016-05-17 |
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