MX336726B - Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa-3. - Google Patents
Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa-3.Info
- Publication number
- MX336726B MX336726B MX2013003620A MX2013003620A MX336726B MX 336726 B MX336726 B MX 336726B MX 2013003620 A MX2013003620 A MX 2013003620A MX 2013003620 A MX2013003620 A MX 2013003620A MX 336726 B MX336726 B MX 336726B
- Authority
- MX
- Mexico
- Prior art keywords
- glycogen synthase
- inhibitors
- synthase kinase
- heterocyclic compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38684910P | 2010-09-27 | 2010-09-27 | |
PCT/EP2011/066684 WO2012041814A1 (fr) | 2010-09-27 | 2011-09-26 | Composés hétérocycliques et leur utilisation en tant qu'inhibiteurs de la glycogène synthase kinase-3 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013003620A MX2013003620A (es) | 2013-10-28 |
MX336726B true MX336726B (es) | 2016-01-27 |
Family
ID=44773057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013003620A MX336726B (es) | 2010-09-27 | 2011-09-26 | Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa-3. |
Country Status (7)
Country | Link |
---|---|
US (3) | US9266855B2 (fr) |
EP (1) | EP2621914B1 (fr) |
JP (1) | JP5998142B2 (fr) |
CN (1) | CN103119035B (fr) |
CA (1) | CA2810954A1 (fr) |
MX (1) | MX336726B (fr) |
WO (1) | WO2012041814A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3102576T1 (sl) | 2014-02-03 | 2019-08-30 | Vitae Pharmaceuticals, Llc | Inhibitorji dihidropirolopiridina ROR-gama |
BR112017007460A2 (pt) | 2014-10-14 | 2017-12-19 | Vitae Pharmaceuticals Inc | inibidores de di-hidropirrolopiridina de ror-gama |
US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
ES2856931T3 (es) | 2015-08-05 | 2021-09-28 | Vitae Pharmaceuticals Llc | Moduladores de ROR-gamma |
JP6770775B2 (ja) | 2015-10-16 | 2020-10-21 | アッヴィ・インコーポレイテッド | (3S,4R)−3−エチル−4−(3H−イミダゾ[1,2−a]ピロロ[2,3−e]−ピラジン−8−イル)−N−(2,2,2−トリフルオロエチル)ピロリジン−1−カルボキサミドおよびそれの固体型の製造方法 |
US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11780848B2 (en) | 2015-10-16 | 2023-10-10 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof |
US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
WO2017087608A1 (fr) | 2015-11-20 | 2017-05-26 | Vitae Pharmaceuticals, Inc. | Modulateurs de ror-gamma |
TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
WO2019018975A1 (fr) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | Inhibiteurs de ror gamma |
KR20200053481A (ko) | 2017-07-24 | 2020-05-18 | 비타이 파마슈티컬즈, 엘엘씨 | RORγ의 억제제 |
US20220133740A1 (en) | 2019-02-08 | 2022-05-05 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
US6277985B1 (en) | 1995-09-15 | 2001-08-21 | Pharmacia & Upjohn Company | Aminoaryl oxazolidinone N-oxides |
AUPP003197A0 (en) | 1997-09-03 | 1997-11-20 | Fujisawa Pharmaceutical Co., Ltd. | New heterocyclic compounds |
US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
JP4533534B2 (ja) | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | グリコーゲンシンターゼキナーゼ3のインヒビター |
AU779550B2 (en) | 1999-04-09 | 2005-01-27 | Meiji Seika Kaisha Ltd. | Nitrogen-containing heterocyclic compounds and benamide compounds and drugs containing the same |
GB9918037D0 (en) | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
US6387900B1 (en) | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
GT200100147A (es) | 2000-07-31 | 2002-06-25 | Derivados de imidazol | |
JP2004507526A (ja) | 2000-08-31 | 2004-03-11 | ファイザー・プロダクツ・インク | ピラゾール誘導体及びそのプロテインキナーゼ阻害剤としての使用 |
US6638926B2 (en) | 2000-09-15 | 2003-10-28 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
CN1317030C (zh) | 2001-04-30 | 2007-05-23 | 赞塔里斯有限公司 | 用中等剂量的lhrh拮抗剂治疗阿尔茨海默氏病 |
DE10123586A1 (de) | 2001-05-08 | 2002-11-28 | Schering Ag | 3,5-Diamino-1,2,4-triazole als Kinase Inhibitoren |
ES2254611T3 (es) | 2001-05-11 | 2006-06-16 | Pfizer Products Inc. | Derivados de tiazol. |
SE0102439D0 (sv) | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
WO2003035065A1 (fr) | 2001-10-26 | 2003-05-01 | Aventis Pharmaceuticals Inc | Benzimidazoles et analogues et leur utilisation comme inhibiteurs de proteines kinases |
ATE466581T1 (de) | 2001-12-07 | 2010-05-15 | Vertex Pharma | Verbindungen auf pyrimidin-basis als gsk-3-hemmer |
SE0104341D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New use |
SE0104340D0 (sv) * | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
TW200301123A (en) | 2001-12-21 | 2003-07-01 | Astrazeneca Uk Ltd | New use |
DE60221283T2 (de) | 2001-12-21 | 2008-03-20 | Astrazeneca Ab | Verwendung von oxindolderivaten zur behandlung von mit demenz in zusammenhang stehenden krankheiten, alzheimer-krankheit und mit glycogensynthasekinase-3 assoziierten leiden |
SE0200979D0 (sv) | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
US7601718B2 (en) | 2003-02-06 | 2009-10-13 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
JP4681548B2 (ja) | 2003-07-22 | 2011-05-11 | アステックス・セラピューティクス・リミテッド | 3,4−ジ置換1h−ピラゾール化合物および、そのサイクリン依存性キナーゼ(cdk)およびグリコーゲン・シンセターゼ・キナーゼ−3(gsk−3)調節剤としての使用 |
ATE536353T1 (de) | 2003-08-20 | 2011-12-15 | Vertex Pharma | 2-(4-amino-1,2,5-oxadiazol-4-yl)-imidazol- verbindungen als protein kinase inhibitoren |
JP2007513155A (ja) | 2003-12-04 | 2007-05-24 | スミスクライン ビーチャム コーポレーション | 新規化合物 |
US7572914B2 (en) | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
EP1586318A1 (fr) | 2004-04-05 | 2005-10-19 | Neuropharma S.A.U. | Thiazolidinones comme inhibiteurs de GSK-3 |
WO2005099353A2 (fr) | 2004-04-19 | 2005-10-27 | Symed Labs Limited | Nouveau procede pour preparer du linezolide et des composes associes |
CA2569404A1 (fr) | 2004-06-04 | 2005-12-22 | Amphora Discovery Corporation | Composes a base de quinoleine et d'isoquinoleine presentant une activite d'inhibition d'enzymes utilisant de l'atp et compositions et utilisations de ceux-ci |
WO2005123672A2 (fr) * | 2004-06-14 | 2005-12-29 | Takeda San Diego, Inc. | Inhibiteurs de kinase |
EP1781653A1 (fr) | 2004-07-05 | 2007-05-09 | Astex Therapeutics Limited | Pyrazoles 3,4-disubstitutes servant d'inhibiteurs de kinases cyclines dependantes (cdk), ou de kinases aurora ou de glycogene syntases 3 (gsk-3) |
ATE429423T1 (de) | 2004-07-20 | 2009-05-15 | Symed Labs Ltd | Neue zwischenprodukte für linezolid und verwandte verbindungen |
US7511013B2 (en) | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
WO2006091737A1 (fr) | 2005-02-24 | 2006-08-31 | Kemia, Inc. | Modulateurs de l'activite de gsk-3 |
TW200716636A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
AU2006265205B2 (en) | 2005-06-30 | 2011-06-30 | Janssen Pharmaceutica N.V. | Cyclic anilino - pyridinotriazines |
EP1749523A1 (fr) | 2005-07-29 | 2007-02-07 | Neuropharma, S.A. | Des inhibiteurs de GSK-3 |
US7514068B2 (en) | 2005-09-14 | 2009-04-07 | Concert Pharmaceuticals Inc. | Biphenyl-pyrazolecarboxamide compounds |
UY29825A1 (es) | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones |
KR20070077468A (ko) | 2006-01-23 | 2007-07-26 | 크리스탈지노믹스(주) | 단백질 키나아제 활성을 저해하는 이미다조피리딘 유도체,이의 제조방법 및 이를 함유하는 약학 조성물 |
US20090221576A1 (en) | 2006-02-02 | 2009-09-03 | Astrazeneca Ab Global Intellectual Property | Pharmaceutical Use of 2-Hydroxy-3-[5-(Morpholin-4-Ylmethyl) Pyridin-2-YL]-1H-IN-Dole-5-Carbonitrile as a Free Base or Salts |
WO2007120102A1 (fr) | 2006-04-19 | 2007-10-25 | Astrazeneca Ab | Nouveaux derives substitues d'oxindole |
EP1849785A1 (fr) | 2006-04-28 | 2007-10-31 | Neuropharma, S.A. | Dérivés de N-(2-Thiazolyl)-amide en tant qu'inhibiteurs de GSK-3 |
US7851468B2 (en) * | 2006-05-15 | 2010-12-14 | Cephalon, Inc. | Substituted pyrazolo[3,4-d]pyrimidines |
US7622495B2 (en) | 2006-10-03 | 2009-11-24 | Neurim Pharmaceuticals (1991) Ltd. | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
MX2009004140A (es) | 2006-10-21 | 2009-07-10 | Abbott Gmbh & Co Kg | Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa 3. |
US8796267B2 (en) | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
DE602007007985D1 (de) | 2006-12-19 | 2010-09-02 | Vertex Pharma | Als inhibitoren von proteinkinasen geeignete aminopyrimidine |
EP2125683B1 (fr) | 2006-12-19 | 2013-10-23 | The Board of Trustees of the University of Illinois | 3-benzofuranyl-4-indolyl-maléimides en tant qu'inhibiteurs de gsk-3 puissants pour troubles neurodégéneratifs |
RU2460725C2 (ru) | 2007-02-15 | 2012-09-10 | Ф. Хоффманн-Ля Рош Аг | Новые 2-аминооксазолины в качестве лигандов taar1 |
KR20090129479A (ko) | 2007-04-18 | 2009-12-16 | 아스트라제네카 아베 | 화합물 2-히드록시-3-[5-(모르폴린-4-일메틸)피리딘-2-일]1h-인돌-5-카르보니트릴 701의 신규 제조 방법 |
CA2686545C (fr) | 2007-04-19 | 2010-11-02 | Concert Pharmaceuticals Inc. | Composes substitues de morpholinyle |
EP1992624A1 (fr) | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Composés de pyrimidonine d'hétéroarylamide |
US7531685B2 (en) | 2007-06-01 | 2009-05-12 | Protia, Llc | Deuterium-enriched oxybutynin |
US20090131485A1 (en) | 2007-09-10 | 2009-05-21 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
US20090118238A1 (en) | 2007-09-17 | 2009-05-07 | Protia, Llc | Deuterium-enriched alendronate |
US20090088416A1 (en) | 2007-09-26 | 2009-04-02 | Protia, Llc | Deuterium-enriched lapaquistat |
US20090082471A1 (en) | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched fingolimod |
US20090137457A1 (en) | 2007-10-02 | 2009-05-28 | Concert Pharmaceuticals, Inc. | Pyrimidinedione derivatives |
WO2009051782A1 (fr) | 2007-10-18 | 2009-04-23 | Concert Pharmaceuticals Inc. | Étravirine deutérée |
US20090105338A1 (en) | 2007-10-18 | 2009-04-23 | Protia, Llc | Deuterium-enriched gabexate mesylate |
US20090131363A1 (en) | 2007-10-26 | 2009-05-21 | Harbeson Scott L | Deuterated darunavir |
JP5756011B2 (ja) | 2008-04-24 | 2015-07-29 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | グリコーゲン合成酵素キナーゼ3(gsk−3)としての1−(7−(ヘキサヒドロピロロ[3,4−c]ピロール−2(1h)−イル)キノリン−4−イル)−3−(ピラジン−2−イル)尿素誘導体とその関連化合物 |
TW201040191A (en) | 2009-03-27 | 2010-11-16 | Abbott Gmbh & Co Kg | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
US9090592B2 (en) | 2010-12-30 | 2015-07-28 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
-
2011
- 2011-09-26 MX MX2013003620A patent/MX336726B/es unknown
- 2011-09-26 WO PCT/EP2011/066684 patent/WO2012041814A1/fr active Application Filing
- 2011-09-26 EP EP11767211.3A patent/EP2621914B1/fr not_active Not-in-force
- 2011-09-26 CN CN201180045839.1A patent/CN103119035B/zh not_active Expired - Fee Related
- 2011-09-26 US US13/245,123 patent/US9266855B2/en not_active Expired - Fee Related
- 2011-09-26 JP JP2013529671A patent/JP5998142B2/ja not_active Expired - Fee Related
- 2011-09-26 CA CA2810954A patent/CA2810954A1/fr active Pending
-
2015
- 2015-09-30 US US14/870,566 patent/US10100048B2/en not_active Expired - Fee Related
-
2016
- 2016-01-07 US US14/990,680 patent/US20160194320A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2013537897A (ja) | 2013-10-07 |
EP2621914B1 (fr) | 2016-12-28 |
CA2810954A1 (fr) | 2012-04-05 |
US20160016932A1 (en) | 2016-01-21 |
US10100048B2 (en) | 2018-10-16 |
US20120077840A1 (en) | 2012-03-29 |
CN103119035B (zh) | 2015-09-30 |
EP2621914A1 (fr) | 2013-08-07 |
US20160194320A1 (en) | 2016-07-07 |
WO2012041814A1 (fr) | 2012-04-05 |
CN103119035A (zh) | 2013-05-22 |
MX2013003620A (es) | 2013-10-28 |
JP5998142B2 (ja) | 2016-09-28 |
US9266855B2 (en) | 2016-02-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX336726B (es) | Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa-3. | |
MX2012013197A (es) | Inhibidores de indazol de cinasa. | |
MX2012000709A (es) | Inhibidores de pirrolopiridina de cinasas. | |
MX2012000711A (es) | Inhibidores de pirrolopirazina de cinasas. | |
TN2014000016A1 (en) | 4 - piperidinyl compounds for use as tankyrase inhibitors | |
MX2012004114A (es) | Compuestos heterociclicos utiles como inhibidores de proteina cinasa-1 dependiente de 3-fosfoinositido (pdk1). | |
GEP20135785B (en) | Pyrrolopyrimidine compounds as cdk inhibitors | |
MX336346B (es) | Compuestos heterociclicos y su uso como inhibidores de la cinasa 3 de glucogeno sintasa. | |
MX340402B (es) | Inhibidores triciclicos de cinasas. | |
NZ700928A (en) | Dna-pk inhibitors | |
NZ711376A (en) | Heteroaryl compounds and uses thereof | |
JO3181B1 (ar) | مشتقات كمحول ثاني الكيل البايردينيل - أحادي الفينيل كأنزيم ثنائي استرات الفوسفود | |
MX2011007750A (es) | Composiciones y metodos para inhibicion de la ruta jak. | |
EP2571876A4 (fr) | Composés hétérocycliques substitués à sept chaînons en tant qu'inhibiteurs de la dipeptidyl-peptidase iv pour le traitement du diabète | |
WO2009117676A3 (fr) | Nouveaux dérivés de pipéridine servant d'inhibiteurs de stéaroyle-coa-désaturase | |
SG195319A1 (en) | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | |
MX2020009397A (es) | Composiciones y metodos para inhibicion de la via jak. | |
MX2013001361A (es) | 4-(1h-indol-3-il) - pirimidina como inhibidores de alk. | |
MX2011013325A (es) | 2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa. | |
MX348451B (es) | Derivados de n-[(1h-pirazol-1-il)aril]-1h-indol o 1h-indazol-3-carboxamida, su preparación y su uso como antagonistas p2y12. | |
MY179042A (en) | Kinase inhibitors with improved cyp safety profile | |
MX2011014019A (es) | Derivados de diazahomoadamantano y sus metodos de uso. | |
MX2009004140A (es) | Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa 3. | |
UY32529A (es) | Compuestos heterocíclicos y su uso como inhibidores de la glucógeno sintetasa quinasa 3 | |
MX2015000980A (es) | Inhibidores de aril lactama cinasa. |