MX2023003365A - Linfocitos t modificados por ingenieria genetica con disrupcion de regnasa-1 y/o tgfbrii tienen una funcionalidad y una persistencia mejoradas. - Google Patents
Linfocitos t modificados por ingenieria genetica con disrupcion de regnasa-1 y/o tgfbrii tienen una funcionalidad y una persistencia mejoradas.Info
- Publication number
- MX2023003365A MX2023003365A MX2023003365A MX2023003365A MX2023003365A MX 2023003365 A MX2023003365 A MX 2023003365A MX 2023003365 A MX2023003365 A MX 2023003365A MX 2023003365 A MX2023003365 A MX 2023003365A MX 2023003365 A MX2023003365 A MX 2023003365A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- genetically engineered
- tgfbrii
- persistence
- disrupted
- Prior art date
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063082357P | 2020-09-23 | 2020-09-23 | |
| US202063124429P | 2020-12-11 | 2020-12-11 | |
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| WO2023111913A1 (en) | 2021-12-15 | 2023-06-22 | Crispr Therapeutics Ag | Engineered anti-liv1 cell with regnase-1 and/or tgfbrii disruption |
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