MX2023001270A - Proceso de fermentacion industrial para bacillus mediante el uso de recoleccion parcial. - Google Patents
Proceso de fermentacion industrial para bacillus mediante el uso de recoleccion parcial.Info
- Publication number
- MX2023001270A MX2023001270A MX2023001270A MX2023001270A MX2023001270A MX 2023001270 A MX2023001270 A MX 2023001270A MX 2023001270 A MX2023001270 A MX 2023001270A MX 2023001270 A MX2023001270 A MX 2023001270A MX 2023001270 A MX2023001270 A MX 2023001270A
- Authority
- MX
- Mexico
- Prior art keywords
- host cell
- bacillus host
- interest
- protein
- bacillus
- Prior art date
Links
- 241000193830 Bacillus <bacterium> Species 0.000 title abstract 7
- 230000004151 fermentation Effects 0.000 title abstract 3
- 238000009655 industrial fermentation Methods 0.000 title abstract 2
- 238000003306 harvesting Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 239000012527 feed solution Substances 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere al campo de la fermentación industrial. En particular, se refiere a un proceso para producir una proteína de interés a partir de una célula huésped de Bacillus que comprende las etapas de inocular un medio de fermentación con una célula huésped de Bacillus que comprende un constructo de expresión para un gen que codifica una proteína de interés, cultivar la célula huésped de Bacillus en dicho medio de fermentación en condiciones propicias para el crecimiento de la célula huésped de Bacillus y la expresión de la proteína de interés para una fase de cultivo, en donde el cultivo de la célula huésped de Bacillus durante dicha fase de cultivo comprende la adición de al menos una solución de alimentación y en donde la al menos una solución de alimentación proporciona una fuente de carbono, y separar porciones de dicho cultivo de célula huésped de Bacillus durante la fase de cultivo en diferentes puntos temporales y obtener la proteína de interés a partir de dichas porciones.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20188161 | 2020-07-28 | ||
| PCT/EP2021/071057 WO2022023371A1 (en) | 2020-07-28 | 2021-07-27 | Industrial fermentation process for bacillus using partial harvest |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023001270A true MX2023001270A (es) | 2023-03-03 |
Family
ID=71842607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023001270A MX2023001270A (es) | 2020-07-28 | 2021-07-27 | Proceso de fermentacion industrial para bacillus mediante el uso de recoleccion parcial. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230272333A1 (es) |
| EP (1) | EP4189104A1 (es) |
| KR (1) | KR20230042353A (es) |
| CN (1) | CN116323960A (es) |
| BR (1) | BR112023001392A2 (es) |
| CA (1) | CA3186931A1 (es) |
| MX (1) | MX2023001270A (es) |
| WO (1) | WO2022023371A1 (es) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK639689D0 (da) | 1989-12-18 | 1989-12-18 | Novo Nordisk As | Indfoering af dna i celler |
| CA2123496C (en) | 1991-11-14 | 2004-02-03 | Steen T. Jorgensen | A bacillus promoter derived from a variant of a bacillus licheniforms x-amylase promoter |
| FR2704860B1 (fr) | 1993-05-05 | 1995-07-13 | Pasteur Institut | Sequences de nucleotides du locus cryiiia pour le controle de l'expression de sequences d'adn dans un hote cellulaire. |
| US5955310A (en) | 1998-02-26 | 1999-09-21 | Novo Nordisk Biotech, Inc. | Methods for producing a polypeptide in a bacillus cell |
| WO2004003216A2 (en) | 2002-07-01 | 2004-01-08 | Novozymes A/S | Sterilization of a fermentation medium comprising hydrolysed n-source |
| EP1735455A2 (en) | 2004-03-31 | 2006-12-27 | Novozymes Biopolymer A/S | Methods for producing hyaluronic acid in a bacillus cell |
| DK3102669T3 (da) | 2014-02-07 | 2019-08-19 | Dsm Ip Assets Bv | Forbedret bacillevært |
-
2021
- 2021-07-27 BR BR112023001392A patent/BR112023001392A2/pt unknown
- 2021-07-27 CN CN202180059541.XA patent/CN116323960A/zh active Pending
- 2021-07-27 US US18/018,112 patent/US20230272333A1/en active Pending
- 2021-07-27 EP EP21755908.7A patent/EP4189104A1/en active Pending
- 2021-07-27 CA CA3186931A patent/CA3186931A1/en active Pending
- 2021-07-27 WO PCT/EP2021/071057 patent/WO2022023371A1/en active Application Filing
- 2021-07-27 KR KR1020237006578A patent/KR20230042353A/ko unknown
- 2021-07-27 MX MX2023001270A patent/MX2023001270A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN116323960A (zh) | 2023-06-23 |
| CA3186931A1 (en) | 2022-02-03 |
| US20230272333A1 (en) | 2023-08-31 |
| BR112023001392A2 (pt) | 2023-02-14 |
| KR20230042353A (ko) | 2023-03-28 |
| EP4189104A1 (en) | 2023-06-07 |
| WO2022023371A1 (en) | 2022-02-03 |
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