MX2023000547A - Anticuerpos anti-betacelulina, fragmentos de los mismos, y moleculas de union multiespecificas. - Google Patents

Anticuerpos anti-betacelulina, fragmentos de los mismos, y moleculas de union multiespecificas.

Info

Publication number
MX2023000547A
MX2023000547A MX2023000547A MX2023000547A MX2023000547A MX 2023000547 A MX2023000547 A MX 2023000547A MX 2023000547 A MX2023000547 A MX 2023000547A MX 2023000547 A MX2023000547 A MX 2023000547A MX 2023000547 A MX2023000547 A MX 2023000547A
Authority
MX
Mexico
Prior art keywords
antibodies
specific binding
binding molecules
betacellulin
fragments
Prior art date
Application number
MX2023000547A
Other languages
English (en)
Spanish (es)
Inventor
Nicole Haubst
Michael Stefanidakis
Andrew Anh Nguyen
Engin Toksoz
Chad Eric Bigelow
Ana Maria Carrion
James Edgar Chastain
Kirk Lee Clark
Bijan Alexandre Etemad-Gilbertson
Joy Gispati Ghosh
Shawn Michael Hanks
Ganesh Rajan Iyer
Nina Moker
Stephen Hendrick Poor
Yubin Qiu
Nalini Velamur Rangaswamy
Michael Zbigniew Twarog
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2023000547A publication Critical patent/MX2023000547A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MX2023000547A 2020-07-16 2021-07-14 Anticuerpos anti-betacelulina, fragmentos de los mismos, y moleculas de union multiespecificas. MX2023000547A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063052789P 2020-07-16 2020-07-16
US202163156709P 2021-03-04 2021-03-04
PCT/IB2021/056363 WO2022013787A1 (en) 2020-07-16 2021-07-14 Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules

Publications (1)

Publication Number Publication Date
MX2023000547A true MX2023000547A (es) 2023-02-13

Family

ID=76971949

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023000547A MX2023000547A (es) 2020-07-16 2021-07-14 Anticuerpos anti-betacelulina, fragmentos de los mismos, y moleculas de union multiespecificas.

Country Status (20)

Country Link
US (3) US11524998B2 (https=)
EP (1) EP4182025A1 (https=)
JP (1) JP7826279B2 (https=)
CN (1) CN116323664A (https=)
AU (2) AU2021308712B2 (https=)
CA (1) CA3176556A1 (https=)
CL (2) CL2023000084A1 (https=)
CO (1) CO2023000112A2 (https=)
CR (1) CR20230009A (https=)
DO (1) DOP2023000005A (https=)
EC (1) ECSP23001118A (https=)
IL (1) IL299586A (https=)
JO (1) JOP20230008A1 (https=)
MX (1) MX2023000547A (https=)
PE (1) PE20231093A1 (https=)
PH (1) PH12023550015A1 (https=)
TW (1) TW202216761A (https=)
UY (1) UY39324A (https=)
WO (1) WO2022013787A1 (https=)
ZA (1) ZA202304787B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11103552B2 (en) 2018-05-10 2021-08-31 Regeneron Pharmaceuticals, Inc. High concentration VEGF receptor fusion protein containing formulations
CN118718181A (zh) 2019-06-05 2024-10-01 里珍纳龙药品有限公司 用于精确剂量递送的装置及方法
PH12023550015A1 (en) * 2020-07-16 2024-03-11 Novartis Ag Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
WO2025119329A1 (zh) * 2023-12-07 2025-06-12 信达生物制药(苏州)有限公司 抗c5和htra1双特异性抗体及其用途

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