MX2022014655A - Proceso para preparar (5s)-5-({2-[4-(butoxicarbonil)fenil]etil}[2- (2-{[3-cloro-4'-(trifluorometil)[bifenil]-4-il]metoxi}fenil)etil] amino)-5,6,7,8-tetrahidroquinolin-2-carboxilato de butilo. - Google Patents
Proceso para preparar (5s)-5-({2-[4-(butoxicarbonil)fenil]etil}[2- (2-{[3-cloro-4'-(trifluorometil)[bifenil]-4-il]metoxi}fenil)etil] amino)-5,6,7,8-tetrahidroquinolin-2-carboxilato de butilo.Info
- Publication number
- MX2022014655A MX2022014655A MX2022014655A MX2022014655A MX2022014655A MX 2022014655 A MX2022014655 A MX 2022014655A MX 2022014655 A MX2022014655 A MX 2022014655A MX 2022014655 A MX2022014655 A MX 2022014655A MX 2022014655 A MX2022014655 A MX 2022014655A
- Authority
- MX
- Mexico
- Prior art keywords
- phenyl
- ethyl
- biphenyl
- tetrahydroquinoline
- butoxycarbonyl
- Prior art date
Links
- HDFUYKDOTXOIBD-GWHBCOKCSA-N butyl (5S)-5-[2-(4-butoxycarbonylphenyl)ethyl-[2-[2-[[2-chloro-4-[4-(trifluoromethyl)phenyl]phenyl]methoxy]phenyl]ethyl]amino]-5,6,7,8-tetrahydroquinoline-2-carboxylate Chemical compound CCCCOC(C1=CC=C(CCN(CCC(C=CC=C2)=C2OCC(C=CC(C2=CC=C(C(F)(F)F)C=C2)=C2)=C2Cl)[C@@H](CCC2)C(C=C3)=C2N=C3C(OCCCC)=O)C=C1)=O HDFUYKDOTXOIBD-GWHBCOKCSA-N 0.000 title abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a un proceso novedoso y mejorado para preparar (5S)-5-({2-[4-(butoxicarbonil)fenil]etil}[2-(2-{[3-c loro-4'-(trifluorometil)[bifenil]-4-il]metoxi}fenil)etil]amino)-5 ,6,7,8-tetrahidroquinolin-2-carboxilato de butilo de la fórmula (XII) (ver Fórmula) (XII) a novedosos precursores para su preparación y al uso para la preparación de ácido (5S)-5-{[2-(4-carboxifenil)etil][2-(2-{[3-cloro-4'-(trifluorometi l)[bifenil]-4-il]metoxi}fenil)etil]amino}-5,6,7,8-tetrahidroquino lin-2-carboxílico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20175721 | 2020-05-20 | ||
PCT/EP2021/062837 WO2021233783A1 (de) | 2020-05-20 | 2021-05-14 | Verfahren zur herstellung von butyl-(5s)-5-({2-[4-(butoxycarbonyl)phenyl]ethyl}[2-(2-{[3-chlor-4'-(trifluormethyl)[biphenyl]-4-yl]methoxy}phenyl)ethyl]amino)-5,6,7,8-tetrahydrochinolin-2-carboxylat |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022014655A true MX2022014655A (es) | 2022-12-15 |
Family
ID=70802629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022014655A MX2022014655A (es) | 2020-05-20 | 2021-05-14 | Proceso para preparar (5s)-5-({2-[4-(butoxicarbonil)fenil]etil}[2- (2-{[3-cloro-4'-(trifluorometil)[bifenil]-4-il]metoxi}fenil)etil] amino)-5,6,7,8-tetrahidroquinolin-2-carboxilato de butilo. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20230183181A1 (es) |
EP (1) | EP4153569A1 (es) |
JP (1) | JP2023526402A (es) |
KR (1) | KR20230012494A (es) |
CN (1) | CN115803318A (es) |
AR (1) | AR122140A1 (es) |
AU (1) | AU2021276066A1 (es) |
BR (1) | BR112022020799A2 (es) |
CA (1) | CA3183771A1 (es) |
CL (1) | CL2022003220A1 (es) |
IL (1) | IL298316A (es) |
MX (1) | MX2022014655A (es) |
TW (1) | TW202202140A (es) |
WO (1) | WO2021233783A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023126436A1 (en) | 2021-12-29 | 2023-07-06 | Bayer Aktiengesellschaft | Process for preparing (5s)-{[2-(4-carboxyphenyl)ethyl] |2-(2-{|3-chloro-4'-(trifluoromethyl)biphenyl-4- yl]methoxy}phenyl)ethyl]aminol-5,6,7,8-tetrahydroquinoline-2-carboxylic acid and its crystalline forms for use as pharmaceutically active compound |
WO2023126437A1 (en) | 2021-12-29 | 2023-07-06 | Bayer Aktiengesellschaft | Treatment of cardiopulmonary disorders |
AR128145A1 (es) | 2021-12-29 | 2024-03-27 | Bayer Ag | Formulación farmacéutica de polvo seco para inhalación y proceso de preparación |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX365311B (es) * | 2011-08-12 | 2019-05-29 | Nissan Chemical Ind Ltd | Compuestos heterocíclicos tricíclicos inhibidores de jak. |
PT2875003T (pt) | 2012-07-20 | 2017-02-16 | Bayer Pharma AG | Novos ácidos 5-amino-tetra-hidroquinolina-2-carboxílicos e sua utilização |
-
2021
- 2021-05-14 JP JP2022570363A patent/JP2023526402A/ja active Pending
- 2021-05-14 WO PCT/EP2021/062837 patent/WO2021233783A1/de unknown
- 2021-05-14 EP EP21724712.1A patent/EP4153569A1/de active Pending
- 2021-05-14 IL IL298316A patent/IL298316A/en unknown
- 2021-05-14 CN CN202180036114.XA patent/CN115803318A/zh active Pending
- 2021-05-14 KR KR1020227040060A patent/KR20230012494A/ko unknown
- 2021-05-14 AU AU2021276066A patent/AU2021276066A1/en active Pending
- 2021-05-14 CA CA3183771A patent/CA3183771A1/en active Pending
- 2021-05-14 BR BR112022020799A patent/BR112022020799A2/pt unknown
- 2021-05-14 US US17/999,179 patent/US20230183181A1/en active Pending
- 2021-05-14 MX MX2022014655A patent/MX2022014655A/es unknown
- 2021-05-17 TW TW110117776A patent/TW202202140A/zh unknown
- 2021-05-20 AR ARP210101384A patent/AR122140A1/es unknown
-
2022
- 2022-11-17 CL CL2022003220A patent/CL2022003220A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA3183771A1 (en) | 2021-11-25 |
AU2021276066A1 (en) | 2022-12-08 |
CL2022003220A1 (es) | 2023-03-10 |
WO2021233783A1 (de) | 2021-11-25 |
TW202202140A (zh) | 2022-01-16 |
CN115803318A (zh) | 2023-03-14 |
AR122140A1 (es) | 2022-08-17 |
JP2023526402A (ja) | 2023-06-21 |
KR20230012494A (ko) | 2023-01-26 |
US20230183181A1 (en) | 2023-06-15 |
EP4153569A1 (de) | 2023-03-29 |
IL298316A (en) | 2023-01-01 |
BR112022020799A2 (pt) | 2022-11-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022014655A (es) | Proceso para preparar (5s)-5-({2-[4-(butoxicarbonil)fenil]etil}[2- (2-{[3-cloro-4'-(trifluorometil)[bifenil]-4-il]metoxi}fenil)etil] amino)-5,6,7,8-tetrahidroquinolin-2-carboxilato de butilo. | |
RU2498983C2 (ru) | Соединения фениламинопиримидина и их применения | |
RU2386626C2 (ru) | 1a, 5a-ТЕТРАГИДРО-S-ТИАЦИКЛОПРОПА[a]ПЕНТАЛЕНЫ:ТРИЦИКЛИЧЕСКИЕ ПРОИЗВОДНЫЕ ТИОФЕНА В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРОВ S1P1/EDG1 | |
PE20120136A1 (es) | Compuestos derivados de n-acilsulfonamidas como inhibidores de bcl-2 | |
AR048306A1 (es) | Derivados de acidos carboxilicos aromaticos con capacidad moduladora de los niveles de insulina, composiciones farmaceuticas que los contienen y su uso en el tratamiento de trastornos metabolicos que responden a la regulacion de gpr40 | |
RU2357959C2 (ru) | Получение и применение арилалкильных производных кислот для лечения ожирения | |
JP2005522438A5 (es) | ||
NZ603198A (en) | Novel hydroxamic acid derivative | |
RU2010140668A (ru) | Ингибиторы активности протеинтирозинкиназы | |
NZ604035A (en) | Glycine transporter-1 inhibitors, methods of making them, and uses thereof | |
HRP20110009T1 (hr) | Spoj kojim se aktivira ppar i farmaceutski pripravak koji ga sadrži | |
AR063946A1 (es) | Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden. | |
EA001436B1 (ru) | Антагонисты рецептора il-8 | |
RU2008108984A (ru) | Терапевтический агент от диабета | |
CA2564990A1 (en) | Morpholine compounds | |
RU2011143740A (ru) | Соединение пиримидина | |
JP2013505903A5 (es) | ||
MX2010009401A (es) | Forma cristalina de derivado de fenilamino pirimidina. | |
RU2009138351A (ru) | Биарильные и бигетероарильные соединения, применяемые при лечении нарушений баланса железа | |
US7868046B2 (en) | (2R)-2-[(4-sulfonyl) aminophenyl] propanamides and pharmaceutical compositions containing them | |
NZ602710A (en) | Use of novel pan-cdk inhibitors for treating tumors | |
EA019037B1 (ru) | 5-[5-[2-[3,5-бис(трифторметил)фенил-2-метилпропаноилметиламино]-4-(4-фтор-2-метилфенил)]-2-пиридинил]-2-алкилпролинамиды в качестве антагонистов рецептора nk1 | |
JP2007530478A5 (es) | ||
RU2367654C2 (ru) | Бензаннелированные соединения в качестве активаторов ppar | |
CA2416220A1 (en) | Preparation of phosphatase inhibitors |