MX2022013984A - Inhibidores de cinasa 7 relacionada con el gen nunca en mitosis a (nek7). - Google Patents
Inhibidores de cinasa 7 relacionada con el gen nunca en mitosis a (nek7).Info
- Publication number
- MX2022013984A MX2022013984A MX2022013984A MX2022013984A MX2022013984A MX 2022013984 A MX2022013984 A MX 2022013984A MX 2022013984 A MX2022013984 A MX 2022013984A MX 2022013984 A MX2022013984 A MX 2022013984A MX 2022013984 A MX2022013984 A MX 2022013984A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- nek7
- inhibitors
- compounds
- kinase
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 101000588545 Homo sapiens Serine/threonine-protein kinase Nek7 Proteins 0.000 abstract 1
- 108091008099 NLRP3 inflammasome Proteins 0.000 abstract 1
- 102100031400 Serine/threonine-protein kinase Nek7 Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se proporcionan compuestos que tienen actividad como inhibidores de NEK7. Los compuestos tienen la Estructura (I): (ver Fórmula) (I) o una sal, estereoisómero o profármaco farmacéuticamente aceptable de los mismos, caracterizado porque A, X, Y, R1, R2, R3, R 4y R5 son como se definen aquí. También se proporcionan métodos asociados con la preparación y el uso de los compuestos, composiciones farmacéuticas que comprenden los compuestos y métodos para modular la actividad del inflamasoma NLRP3.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063022159P | 2020-05-08 | 2020-05-08 | |
US202163170761P | 2021-04-05 | 2021-04-05 | |
PCT/US2021/031394 WO2021242505A1 (en) | 2020-05-08 | 2021-05-07 | Inhibitors of nek7 kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022013984A true MX2022013984A (es) | 2023-01-30 |
Family
ID=77774963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022013984A MX2022013984A (es) | 2020-05-08 | 2021-05-07 | Inhibidores de cinasa 7 relacionada con el gen nunca en mitosis a (nek7). |
Country Status (13)
Country | Link |
---|---|
US (3) | US11161852B1 (es) |
EP (1) | EP4146348A1 (es) |
JP (1) | JP2023524597A (es) |
KR (1) | KR20230008763A (es) |
CN (1) | CN115843272A (es) |
AU (1) | AU2021280893A1 (es) |
BR (1) | BR112022022669A2 (es) |
CA (1) | CA3182276A1 (es) |
CO (1) | CO2022017622A2 (es) |
IL (1) | IL297979A (es) |
MX (1) | MX2022013984A (es) |
TW (1) | TW202208356A (es) |
WO (1) | WO2021242505A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2022013984A (es) * | 2020-05-08 | 2023-01-30 | Halia Therapeutics Inc | Inhibidores de cinasa 7 relacionada con el gen nunca en mitosis a (nek7). |
CN114751874A (zh) * | 2022-05-30 | 2022-07-15 | 江南大学 | 作为TRPV4-KCa2.3促耦联剂的1-苄基-4-乙基哌嗪衍生物及其应用 |
JP2024032686A (ja) * | 2022-08-29 | 2024-03-12 | 日本たばこ産業株式会社 | ピラゾロピリミジン化合物及びその医薬用途 |
US20240158394A1 (en) * | 2022-09-14 | 2024-05-16 | Halia Therapeutics, Inc. | Nek7 inhibitors |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
CA2737639A1 (en) | 2008-09-25 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
EP2467137A1 (en) | 2009-08-19 | 2012-06-27 | Ambit Biosciences Corporation | Biaryl compounds and methods of use thereof |
JP2013525308A (ja) | 2010-04-16 | 2013-06-20 | キュリス,インコーポレイテッド | K−ras変異を有する癌の治療 |
JP2015504889A (ja) | 2012-01-12 | 2015-02-16 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 除草性イソオキサゾロ[5,4−b]ピリジン |
CN105431436B (zh) | 2013-05-14 | 2017-11-28 | 内尔维阿诺医学科学有限公司 | 吡咯并[2,3‑d]嘧啶衍生物,它们的制备方法和它们作为激酶抑制剂的用途 |
MX2017006366A (es) | 2014-11-14 | 2018-02-01 | Nerviano Medical Sciences Srl | Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteina quinasa. |
SI3359541T1 (sl) | 2015-10-09 | 2021-01-29 | Abbvie Overseas S.A R.L. | N-sulfonirani pirazolo(3,4 b)piridin-6-karboksamidi in postopki uporabe |
US10167703B2 (en) | 2016-03-31 | 2019-01-01 | Saudi Arabian Oil Company | Optimal well placement under constraints |
KR102500416B1 (ko) | 2016-06-21 | 2023-02-17 | 네르비아노 메디칼 사이언시스 에스.알.엘. | 키나제 억제제로서의 n-(치환된-페닐)-설폰아미드 유도체 |
EP3487503A1 (en) | 2016-07-20 | 2019-05-29 | GlaxoSmithKline Intellectual Property Development Limited | Isoquinoline derivatives as perk inhibitors |
CN111315733A (zh) | 2017-11-09 | 2020-06-19 | 英夫拉索姆有限公司 | 新颖磺酰胺甲酰胺化合物 |
WO2019192962A1 (en) * | 2018-04-05 | 2019-10-10 | Merck Patent Gmbh | Heteroaryl compounds as type ii irak inhibitors and uses hereof |
CN111646995B (zh) * | 2019-03-04 | 2023-03-21 | 四川大学 | 4-氨基-嘧啶并氮杂环-苯基脲类衍生物及其制备方法和用途 |
AU2020355359B2 (en) * | 2019-09-26 | 2023-08-24 | Shenzhen Targetrx, Inc. | Substituted aromatic fused ring derivative and composition comprising same, and use thereof |
WO2021184154A1 (en) | 2020-03-16 | 2021-09-23 | Flash Therapeutics, Llc | Compounds for treating or inhibiting recurrence of acute myeloid leukemia |
MX2022013984A (es) * | 2020-05-08 | 2023-01-30 | Halia Therapeutics Inc | Inhibidores de cinasa 7 relacionada con el gen nunca en mitosis a (nek7). |
-
2021
- 2021-05-07 MX MX2022013984A patent/MX2022013984A/es unknown
- 2021-05-07 TW TW110116590A patent/TW202208356A/zh unknown
- 2021-05-07 EP EP21770328.9A patent/EP4146348A1/en active Pending
- 2021-05-07 WO PCT/US2021/031394 patent/WO2021242505A1/en unknown
- 2021-05-07 US US17/315,209 patent/US11161852B1/en active Active
- 2021-05-07 AU AU2021280893A patent/AU2021280893A1/en active Pending
- 2021-05-07 KR KR1020227041803A patent/KR20230008763A/ko active Search and Examination
- 2021-05-07 JP JP2022567839A patent/JP2023524597A/ja active Pending
- 2021-05-07 IL IL297979A patent/IL297979A/en unknown
- 2021-05-07 CN CN202180048858.3A patent/CN115843272A/zh active Pending
- 2021-05-07 BR BR112022022669A patent/BR112022022669A2/pt unknown
- 2021-05-07 CA CA3182276A patent/CA3182276A1/en active Pending
- 2021-09-14 US US17/475,220 patent/US11713321B2/en active Active
-
2022
- 2022-12-06 CO CONC2022/0017622A patent/CO2022017622A2/es unknown
-
2023
- 2023-05-23 US US18/322,380 patent/US20230416259A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CO2022017622A2 (es) | 2022-12-20 |
EP4146348A1 (en) | 2023-03-15 |
AU2021280893A1 (en) | 2023-01-05 |
IL297979A (en) | 2023-01-01 |
CN115843272A (zh) | 2023-03-24 |
KR20230008763A (ko) | 2023-01-16 |
CA3182276A1 (en) | 2021-12-02 |
US20230416259A1 (en) | 2023-12-28 |
US11713321B2 (en) | 2023-08-01 |
TW202208356A (zh) | 2022-03-01 |
US20210355130A1 (en) | 2021-11-18 |
US20220064173A1 (en) | 2022-03-03 |
WO2021242505A1 (en) | 2021-12-02 |
BR112022022669A2 (pt) | 2023-01-17 |
US11161852B1 (en) | 2021-11-02 |
JP2023524597A (ja) | 2023-06-12 |
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