MX2022003448A - Mejora de la hidrogenacion enantioselectiva de 1,2-dihidroquinolinas 4-sustituidas en presencia de un catalizador quiral de iridio y un aditivo. - Google Patents

Mejora de la hidrogenacion enantioselectiva de 1,2-dihidroquinolinas 4-sustituidas en presencia de un catalizador quiral de iridio y un aditivo.

Info

Publication number
MX2022003448A
MX2022003448A MX2022003448A MX2022003448A MX2022003448A MX 2022003448 A MX2022003448 A MX 2022003448A MX 2022003448 A MX2022003448 A MX 2022003448A MX 2022003448 A MX2022003448 A MX 2022003448A MX 2022003448 A MX2022003448 A MX 2022003448A
Authority
MX
Mexico
Prior art keywords
substituted
dihydroquinolines
additive
enantioselective hydrogenation
chiral iridium
Prior art date
Application number
MX2022003448A
Other languages
English (en)
Inventor
Matthias Beller
Christoph Schotes
Kathrin Junge
Weiping Liu
Jacob Schneekönig
Thomas Leischner
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2022003448A publication Critical patent/MX2022003448A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

La invención se refiere a un proceso para preparar 1,2,3,4-tetrahidroquinolinas 4-sustituidas ópticamente activas que comprende la hidrogenación enantioselectiva de las correspondientes 1,2-dihidroquinolinas 4-sustituidas en presencia de un catalizador quiral de iridio (P,N)-ligando y un aditivo.
MX2022003448A 2019-09-25 2020-09-22 Mejora de la hidrogenacion enantioselectiva de 1,2-dihidroquinolinas 4-sustituidas en presencia de un catalizador quiral de iridio y un aditivo. MX2022003448A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19199632 2019-09-25
PCT/EP2020/076373 WO2021058457A1 (en) 2019-09-25 2020-09-22 Improved enantioselective hydrogenation of 4-substituted 1,2-dihydroquinolines in presence of a chiral iridium catalyst and an additive

Publications (1)

Publication Number Publication Date
MX2022003448A true MX2022003448A (es) 2022-04-19

Family

ID=68069589

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022003448A MX2022003448A (es) 2019-09-25 2020-09-22 Mejora de la hidrogenacion enantioselectiva de 1,2-dihidroquinolinas 4-sustituidas en presencia de un catalizador quiral de iridio y un aditivo.

Country Status (10)

Country Link
US (1) US20220306583A1 (es)
EP (1) EP4034527A1 (es)
JP (1) JP2022549635A (es)
KR (1) KR20220069021A (es)
CN (1) CN114423739B (es)
BR (1) BR112022005473A2 (es)
IL (1) IL291566A (es)
MX (1) MX2022003448A (es)
TW (1) TW202126626A (es)
WO (1) WO2021058457A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024041976A1 (en) 2022-08-23 2024-02-29 Bayer Aktiengesellschaft Process for distillative recovery of 1,1,1,3,3,3-hexafluoro-2-propanol (hfip) from mixtures with 4- substituted 1,2,3,4-tetrahydroquinolines

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0654464A1 (en) 1993-10-22 1995-05-24 Shell Internationale Researchmaatschappij B.V. Processes for the preparation of pesticides and intermediates
DE19831137A1 (de) * 1998-07-11 2000-01-13 Studiengesellschaft Kohle Mbh Asymmetrische katalytische Hydrierung von Olefinen
CN1194969C (zh) * 2003-05-30 2005-03-30 中国科学院大连化学物理研究所 对映选择性铱催化氢化取代芳香吡啶环和吡嗪环的方法
US7538228B2 (en) * 2003-12-17 2009-05-26 The Penn State Research Foundation Oxazoline ligands for asymmetric catalysis
CN101845016B (zh) * 2009-03-25 2012-02-01 中国科学院大连化学物理研究所 一种铱催化不对称硅氢化合成手性四氢喹啉衍生物的方法
CN102803271B (zh) * 2009-06-19 2016-03-23 力奇制药公司 氢化卤代烯烃而不脱卤的方法
JP2012025735A (ja) 2010-06-24 2012-02-09 Sumitomo Chemical Co Ltd 植物病害防除組成物及び植物病害防除方法
IT1403275B1 (it) 2010-12-20 2013-10-17 Isagro Ricerca Srl Indanilanilidi ad elevata attività fungicida e loro composizioni fitosanitarie
US9108986B2 (en) * 2011-07-15 2015-08-18 Hamari Chemicals, Ltd. Method for producing optically active tetrahydroquinolines
WO2015118793A1 (ja) 2014-02-07 2015-08-13 住友化学株式会社 （ｒ）－１，１，３－トリメチル－４－アミノインダンの製造方法
JP6624050B2 (ja) 2014-03-18 2019-12-25 住友化学株式会社 光学活性な化合物の製造方法
AR101820A1 (es) 2014-06-25 2017-01-18 Bayer Cropscience Ag Difluorometil-indanil-carboxamidas nicotínicas
CN107540606B (zh) * 2016-06-29 2020-09-01 中国科学院大连化学物理研究所 一种铱催化的双向对映选择性合成手性四氢异喹啉的方法
MX2020010010A (es) * 2018-03-26 2020-10-14 Bayer Ag Hidrogenacion enantioselectiva de 1,2-dihidroquinolinas 4-sustituidas en presencia de un catalizador quiral de iridio.

Also Published As

Publication number Publication date
CN114423739B (zh) 2024-06-25
BR112022005473A2 (pt) 2022-06-14
TW202126626A (zh) 2021-07-16
JP2022549635A (ja) 2022-11-28
US20220306583A1 (en) 2022-09-29
WO2021058457A1 (en) 2021-04-01
CN114423739A (zh) 2022-04-29
EP4034527A1 (en) 2022-08-03
KR20220069021A (ko) 2022-05-26
IL291566A (en) 2022-05-01

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