MX2022003520A - Nuevos catalizadores de iridio para la hidrogenacion enantioselectiva de 1,2-dihidroquinolinas 4-sustituidas. - Google Patents

Nuevos catalizadores de iridio para la hidrogenacion enantioselectiva de 1,2-dihidroquinolinas 4-sustituidas.

Info

Publication number
MX2022003520A
MX2022003520A MX2022003520A MX2022003520A MX2022003520A MX 2022003520 A MX2022003520 A MX 2022003520A MX 2022003520 A MX2022003520 A MX 2022003520A MX 2022003520 A MX2022003520 A MX 2022003520A MX 2022003520 A MX2022003520 A MX 2022003520A
Authority
MX
Mexico
Prior art keywords
substituted
dihydroquinolines
enantioselective hydrogenation
iridium catalysts
new iridium
Prior art date
Application number
MX2022003520A
Other languages
English (en)
Inventor
Matthias Beller
Christoph Schotes
Kathrin Junge
Weiping Liu
Jacob Schneekönig
Thomas Leischner
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2022003520A publication Critical patent/MX2022003520A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1805—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing nitrogen
    • B01J31/181—Cyclic ligands, including e.g. non-condensed polycyclic ligands, comprising at least one complexing nitrogen atom as ring member, e.g. pyridine
    • B01J31/1825—Ligands comprising condensed ring systems, e.g. acridine, carbazole
    • B01J31/183—Ligands comprising condensed ring systems, e.g. acridine, carbazole with more than one complexing nitrogen atom, e.g. phenanthroline
    • B01J31/1835—Ligands comprising condensed ring systems, e.g. acridine, carbazole with more than one complexing nitrogen atom, e.g. phenanthroline comprising aliphatic or saturated rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1845—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing phosphorus
    • B01J31/1875—Phosphinites (R2P(OR), their isomeric phosphine oxides (R3P=O) and RO-substitution derivatives thereof)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

La invención se refiere a un proceso para preparar 1,2,3,4-tetrahidroquinolinas 4-sustituidas ópticamente activas que comprende la hidrogenación enantioselectiva de las correspondientes 1,2-dihidroquinolinas 4-sustituidas en presencia de un catalizador quiral de iridio (P,N)-ligando.
MX2022003520A 2019-09-25 2020-09-22 Nuevos catalizadores de iridio para la hidrogenacion enantioselectiva de 1,2-dihidroquinolinas 4-sustituidas. MX2022003520A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19199636 2019-09-25
PCT/EP2020/076375 WO2021058458A1 (en) 2019-09-25 2020-09-22 Process comprising the use of new iridium catalysts for enantioselective hydrogenation of 4-substituted 1,2-dihydroquinolines

Publications (1)

Publication Number Publication Date
MX2022003520A true MX2022003520A (es) 2022-04-25

Family

ID=68069591

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022003520A MX2022003520A (es) 2019-09-25 2020-09-22 Nuevos catalizadores de iridio para la hidrogenacion enantioselectiva de 1,2-dihidroquinolinas 4-sustituidas.

Country Status (9)

Country Link
US (1) US20220324810A1 (es)
EP (1) EP4034528A1 (es)
JP (1) JP2022549636A (es)
KR (1) KR20220069034A (es)
BR (1) BR112022005528A2 (es)
IL (1) IL291512A (es)
MX (1) MX2022003520A (es)
TW (1) TW202126625A (es)
WO (1) WO2021058458A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024041976A1 (en) 2022-08-23 2024-02-29 Bayer Aktiengesellschaft Process for distillative recovery of 1,1,1,3,3,3-hexafluoro-2-propanol (hfip) from mixtures with 4- substituted 1,2,3,4-tetrahydroquinolines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0654464A1 (en) 1993-10-22 1995-05-24 Shell Internationale Researchmaatschappij B.V. Processes for the preparation of pesticides and intermediates
JP2012025735A (ja) 2010-06-24 2012-02-09 Sumitomo Chemical Co Ltd 植物病害防除組成物及び植物病害防除方法
IT1403275B1 (it) 2010-12-20 2013-10-17 Isagro Ricerca Srl Indanilanilidi ad elevata attività fungicida e loro composizioni fitosanitarie
RU2016135762A (ru) 2014-02-07 2018-03-14 Сумитомо Кемикал Компани, Лимитед Способ получения (r)-1,1,3-триметил-4-аминоиндана
WO2015141564A1 (ja) 2014-03-18 2015-09-24 住友化学株式会社 光学活性な化合物の製造方法
AR101820A1 (es) 2014-06-25 2017-01-18 Bayer Cropscience Ag Difluorometil-indanil-carboxamidas nicotínicas
DK3774735T3 (da) 2018-03-26 2023-12-11 Bayer Ag Enantioselektiv hydrering af 4-substitueret 1,2-dihydroquinoliner i nærvær af en chiral iridiumkatalysator

Also Published As

Publication number Publication date
US20220324810A1 (en) 2022-10-13
CN114514223A (zh) 2022-05-17
BR112022005528A2 (pt) 2022-06-21
JP2022549636A (ja) 2022-11-28
WO2021058458A1 (en) 2021-04-01
EP4034528A1 (en) 2022-08-03
TW202126625A (zh) 2021-07-16
IL291512A (en) 2022-05-01
KR20220069034A (ko) 2022-05-26

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