MX2022001629A - Sistemas y metodos para determinar las concentraciones de proteinas de muestras de proteinas desconocidas basados en la calibracion de multiples longitudes de onda automatizada. - Google Patents

Sistemas y metodos para determinar las concentraciones de proteinas de muestras de proteinas desconocidas basados en la calibracion de multiples longitudes de onda automatizada.

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Publication number
MX2022001629A
MX2022001629A MX2022001629A MX2022001629A MX2022001629A MX 2022001629 A MX2022001629 A MX 2022001629A MX 2022001629 A MX2022001629 A MX 2022001629A MX 2022001629 A MX2022001629 A MX 2022001629A MX 2022001629 A MX2022001629 A MX 2022001629A
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MX
Mexico
Prior art keywords
wavelength
unknown
wavelength calibration
systems
methods
Prior art date
Application number
MX2022001629A
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English (en)
Inventor
Shang Zeng
Gang Xue
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2022001629A publication Critical patent/MX2022001629A/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2823—Imaging spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/255—Details, e.g. use of specially adapted sources, lighting or optical systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J2003/283—Investigating the spectrum computer-interfaced
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J2003/283—Investigating the spectrum computer-interfaced
    • G01J2003/2833—Investigating the spectrum computer-interfaced and memorised spectra collection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/127—Calibration; base line adjustment; drift compensation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods
    • G01N2201/1296—Using chemometrical methods using neural networks

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  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Software Systems (AREA)
  • Mathematical Physics (AREA)
  • Data Mining & Analysis (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Computation (AREA)
  • Computing Systems (AREA)
  • General Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Método de obtención de imágenes basado en ultravioleta (UV) para determinar las concentraciones de proteínas de muestras de proteínas desconocidas basándose en la calibración de múltiples longitudes de onda automatizada. En diversas realizaciones, un procesador recibe cada uno de un conjunto estándar de datos de longitud de onda y un conjunto desconocido de datos de longitud de onda registrados por un detector. Cada conjunto estándar de datos de longitud de onda y conjunto desconocido de datos de longitud de onda define una serie de pares de valores de absorbancia a longitud de onda en un primer rango de longitudes de onda seleccionadas de un rango de haces de luz de una longitud de onda única de espectros UV. El procesador genera un modelo de calibración de múltiples longitudes de onda basándose en cada una de una primera serie de primeros pares de valores de absorbancia a longitud de onda del conjunto estándar de datos de longitud de onda. El procesador implementa el modelo de calibración de múltiples longitudes de onda para determinar, para cada muestra de proteína desconocida de las muestras de proteína desconocidas dadas, una pluralidad de valores de concentración de proteína.
MX2022001629A 2019-08-06 2020-08-06 Sistemas y metodos para determinar las concentraciones de proteinas de muestras de proteinas desconocidas basados en la calibracion de multiples longitudes de onda automatizada. MX2022001629A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962883320P 2019-08-06 2019-08-06
PCT/US2020/045088 WO2021026284A1 (en) 2019-08-06 2020-08-06 Systems and methods for determining protein concentrations of unknown protein samples based on automated multi-wavelength calibration

Publications (1)

Publication Number Publication Date
MX2022001629A true MX2022001629A (es) 2022-03-02

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MX2022001629A MX2022001629A (es) 2019-08-06 2020-08-06 Sistemas y metodos para determinar las concentraciones de proteinas de muestras de proteinas desconocidas basados en la calibracion de multiples longitudes de onda automatizada.

Country Status (12)

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US (1) US20220276157A1 (es)
EP (1) EP4010688A1 (es)
JP (1) JP2022544082A (es)
KR (1) KR20220042191A (es)
CN (1) CN114207411A (es)
AU (1) AU2020325208A1 (es)
BR (1) BR112022002213A2 (es)
CA (1) CA3146697A1 (es)
CL (1) CL2022000299A1 (es)
IL (1) IL289582A (es)
MX (1) MX2022001629A (es)
WO (1) WO2021026284A1 (es)

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Publication number Priority date Publication date Assignee Title
WO2023285412A1 (en) * 2021-07-12 2023-01-19 Isa Pharmaceuticals B.V. Improved substance quantification in complex mixtures
FR3132770B1 (fr) * 2022-02-11 2024-02-02 Ifp Energies Now Procédé pour le suivi dans le temps de la concentration en un composé chimique d’un fluide, au moyen d’un système de mesure optique

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US20110045598A1 (en) * 2007-10-17 2011-02-24 Baylor University Methods for determining enantiomeric purity with improved chiral selectors
CN106769969B (zh) * 2017-02-21 2020-10-20 上海泰因生物技术有限公司 一种抗体蛋白含量的微量检测方法
CN109799203B (zh) * 2019-01-26 2021-05-07 上海交通大学 一种水体中cod浓度的宽量程高精度光谱检测方法

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BR112022002213A2 (pt) 2022-06-07
CL2022000299A1 (es) 2022-11-18
EP4010688A1 (en) 2022-06-15
IL289582A (en) 2022-03-01
US20220276157A1 (en) 2022-09-01
JP2022544082A (ja) 2022-10-17
KR20220042191A (ko) 2022-04-04
CA3146697A1 (en) 2021-02-11
WO2021026284A1 (en) 2021-02-11
AU2020325208A1 (en) 2022-02-24
CN114207411A (zh) 2022-03-18

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