SG11201808401QA - Real time monitoring of product purification - Google Patents
Real time monitoring of product purificationInfo
- Publication number
- SG11201808401QA SG11201808401QA SG11201808401QA SG11201808401QA SG11201808401QA SG 11201808401Q A SG11201808401Q A SG 11201808401QA SG 11201808401Q A SG11201808401Q A SG 11201808401QA SG 11201808401Q A SG11201808401Q A SG 11201808401QA SG 11201808401Q A SG11201808401Q A SG 11201808401QA
- Authority
- SG
- Singapore
- Prior art keywords
- wien
- international
- muthgasse
- real time
- potency
- Prior art date
Links
- 238000000746 purification Methods 0.000 title abstract 3
- 238000012544 monitoring process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 4
- 238000004886 process control Methods 0.000 abstract 2
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 abstract 1
- 238000009529 body temperature measurement Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000010946 mechanistic model Methods 0.000 abstract 1
- 238000005457 optimization Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 238000007619 statistical method Methods 0.000 abstract 1
- 238000013179 statistical model Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
- G05B19/042—Programme control other than numerical control, i.e. in sequence controllers or logic controllers using digital processors
- G05B19/0428—Safety, monitoring
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
- G05B19/05—Programmable logic controllers, e.g. simulating logic interconnections of signals according to ladder diagrams or function charts
- G05B19/056—Programming the PLC
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B17/00—Systems involving the use of models or simulators of said systems
- G05B17/02—Systems involving the use of models or simulators of said systems electric
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
- G05B19/10—Programme control other than numerical control, i.e. in sequence controllers or logic controllers using selector switches
- G05B19/106—Programme control other than numerical control, i.e. in sequence controllers or logic controllers using selector switches for selecting a programme, variable or parameter
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
- G05B19/4183—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM] characterised by data acquisition, e.g. workpiece identification
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
- G05B19/41885—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM] characterised by modeling, simulation of the manufacturing system
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B23/00—Testing or monitoring of control systems or parts thereof
- G05B23/02—Electric testing or monitoring
- G05B23/0205—Electric testing or monitoring by means of a monitoring system capable of detecting and responding to faults
- G05B23/0218—Electric testing or monitoring by means of a monitoring system capable of detecting and responding to faults characterised by the fault detection method dealing with either existing or incipient faults
- G05B23/0243—Electric testing or monitoring by means of a monitoring system capable of detecting and responding to faults characterised by the fault detection method dealing with either existing or incipient faults model based detection method, e.g. first-principles knowledge model
- G05B23/0254—Electric testing or monitoring by means of a monitoring system capable of detecting and responding to faults characterised by the fault detection method dealing with either existing or incipient faults model based detection method, e.g. first-principles knowledge model based on a quantitative model, e.g. mathematical relationships between inputs and outputs; functions: observer, Kalman filter, residual calculation, Neural Networks
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/50—Molecular design, e.g. of drugs
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N2021/3595—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using FTIR
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N2021/8411—Application to online plant, process monitoring
- G01N2021/8416—Application to online plant, process monitoring and process controlling, not otherwise provided for
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/4133—Refractometers, e.g. differential
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Manufacturing & Machinery (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Quality & Reliability (AREA)
- Artificial Intelligence (AREA)
- Mathematical Physics (AREA)
- Evolutionary Computation (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Theoretical Computer Science (AREA)
- Computing Systems (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Processcontrol Parametric release Process optimization Prediction of quantity, purity and potency Statistical model In-situ sensor e.g. temperature measurement Model training Engineering/mechanistic model On-line sensor e.g. UV sensor e.g. SLS On-line sensor e.g. FTIR () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/174580 Al 12 October 2017 (12.10.2017) WIPO I PCT (51) International Patent Classification: G05B 17/02 (2006.01) G05B 23/02 (2006.01) (21) International Application Number: PCT/EP2017/057986 (22) International Filing Date: 4 April 2017 (04.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16163713.7 4 April 2016 (04.04.2016) EP (71) Applicants: BOEHRINGER INGELHEIM RCV GMBH & CO KG [AT/AT]; Dr.-Boehringer-Gasse 5-11, 1121 Wien (AT). SANDOZ GMBH [AT/AT]; Biochemi- estrasse 10, 6250 Kundl (AT). (72) Inventors: JUNGBAUER, Alois; Muthgasse 18, 1190 Wien (AT). DURAUER, Astrid; Muthgasse 18, 1190 Wien (AT). WALCH, Nicole; Muthgasse 18, 1190 Wien (AT). SAUER, Dominik; Muthgasse 18, 1190 Wien (AT). SCHARL-HIRSCH, Theresa; Muthgasse 18, 1190 Wien (AT). MELCHER, Michael; Peter Jordan StraBe 82, 1190 Wien (AT). LEISCH, Friedrich; Peter Jordan StraBe 82, 1190 Wien (AT). (74) Agents: WEINZIERL, Gerhard et al.; Schiweck Weinzi- erl Koch, European Patent Attorneys, Landsberger Strasse 98, 80339 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) = (54) Title: REAL TIME MONITORING OF PRODUCT PURIFICATION Fig. 1 (57) : The invention relates to a method and device which allows in real-time the determination of concentration, purity and potency of a biological product during purification and/or concentration processes in order to intervene into the process, either for process control or real time release. The properties of the process stream are continuously monitored by at least two online sensors and with the aid of multivariate statistical analysis so that concentration, purity and potency is determined in real time. 1111111111111101110111111111110101111101110101110111111111111101111111111111110111111 W O 20 1717 / 45 80 Al
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16163713 | 2016-04-04 | ||
PCT/EP2017/057986 WO2017174580A1 (en) | 2016-04-04 | 2017-04-04 | Real time monitoring of product purification |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201808401QA true SG11201808401QA (en) | 2018-10-30 |
Family
ID=55970758
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202009671UA SG10202009671UA (en) | 2016-04-04 | 2017-04-04 | Real time monitoring of product purification |
SG11201808401QA SG11201808401QA (en) | 2016-04-04 | 2017-04-04 | Real time monitoring of product purification |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202009671UA SG10202009671UA (en) | 2016-04-04 | 2017-04-04 | Real time monitoring of product purification |
Country Status (9)
Country | Link |
---|---|
US (1) | US20210149361A1 (en) |
EP (1) | EP3440518A1 (en) |
JP (1) | JP6953508B2 (en) |
KR (1) | KR102344339B1 (en) |
CN (1) | CN109313419B (en) |
AU (1) | AU2017248025B2 (en) |
CA (1) | CA3019979A1 (en) |
SG (2) | SG10202009671UA (en) |
WO (1) | WO2017174580A1 (en) |
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CN111587125A (en) * | 2018-01-12 | 2020-08-25 | 伊缪诺金公司 | Methods for antibody drug conjugation, purification and formulation |
US11009452B2 (en) | 2018-01-26 | 2021-05-18 | Viavi Solutions Inc. | Reduced false positive identification for spectroscopic quantification |
US11656174B2 (en) | 2018-01-26 | 2023-05-23 | Viavi Solutions Inc. | Outlier detection for spectroscopic classification |
US10810408B2 (en) | 2018-01-26 | 2020-10-20 | Viavi Solutions Inc. | Reduced false positive identification for spectroscopic classification |
US20190272894A1 (en) * | 2018-03-02 | 2019-09-05 | Genzyme Corporation | Multivariate Spectral Analysis and Monitoring for Biomanufacturing |
WO2019180618A1 (en) | 2018-03-20 | 2019-09-26 | Sanofi Pasteur Limited | Methods for determining adjuvanted protein concentration and percent adsorption using intrinsic fluorescence |
GB201814233D0 (en) * | 2018-08-31 | 2018-10-17 | Ge Healthcare Bio Sciences Ab | Method for optimization of a bioprocessing system |
EP3640946A1 (en) * | 2018-10-15 | 2020-04-22 | Sartorius Stedim Data Analytics AB | Multivariate approach for biological cell selection |
EP3699697A1 (en) * | 2019-02-25 | 2020-08-26 | Bayer Aktiengesellschaft | Automated simultaneous process control |
WO2020188335A1 (en) * | 2019-03-15 | 2020-09-24 | 3M Innovative Properties Company | Manufacturing a biologic pharmaceutical using causal models |
WO2021021256A1 (en) * | 2019-07-29 | 2021-02-04 | LI, Guiyang | Online measurement of titer in antibody production |
AU2020352519A1 (en) * | 2019-09-23 | 2022-05-19 | Genzyme Corporation | Product quality attribute measurement |
CN112629659A (en) * | 2019-10-08 | 2021-04-09 | 中强光电股份有限公司 | Automated model training apparatus and automated model training method for training pipelines for different spectrometers |
CN112633307A (en) * | 2019-10-08 | 2021-04-09 | 中强光电股份有限公司 | Automatic model training device and automatic model training method for spectrometer |
BR112022007525A2 (en) * | 2019-10-22 | 2022-07-12 | Genzyme Corp | ONLINE PRODUCT MONITORING IN CONTINUOUS INTEGRATED BIOMANUFACTURING |
JP7388206B2 (en) * | 2020-01-22 | 2023-11-29 | 株式会社島津製作所 | Liquid chromatography and analytical methods |
US20230071627A1 (en) * | 2020-02-03 | 2023-03-09 | Amgen Inc. | Multivariate Bracketing Approach for Sterile Filter Validation |
CN110923366A (en) * | 2020-02-11 | 2020-03-27 | 上海复宏汉霖生物技术股份有限公司 | Method for on-line monitoring yield and quality of target protein |
WO2021171310A1 (en) * | 2020-02-24 | 2021-09-02 | Indian Institute Of Technology Delhi | A system for real-time monitoring of protein and excipients |
JP7452186B2 (en) * | 2020-03-30 | 2024-03-19 | 東ソー株式会社 | How to estimate the operating status of a chromatograph |
CN112151128A (en) * | 2020-10-16 | 2020-12-29 | 腾讯科技(深圳)有限公司 | Method, device and equipment for determining interaction information and storage medium |
CN112632854B (en) * | 2020-12-17 | 2022-04-12 | 衡阳师范学院 | Fault prediction method and system of TSK fuzzy model based on humanoid learning ability |
EP4317170A1 (en) * | 2021-03-30 | 2024-02-07 | FUJIFILM Corporation | Method for estimating purified state |
WO2022251194A1 (en) * | 2021-05-25 | 2022-12-01 | Boehringer Ingelheim International Gmbh | Titer method using uv measurement for continuous biological production |
WO2023090015A1 (en) * | 2021-11-22 | 2023-05-25 | 富士フイルム株式会社 | Information processing device, method for operating information processing device, operation program for information processing device, method for generating calibrated state prediction model, and calibrated state prediction model |
EP4286842A1 (en) * | 2022-05-31 | 2023-12-06 | Sartorius Stedim Data Analytics AB | Computer-implemented method, computer program product, control device and system for controlling a chromatography system |
WO2024006121A1 (en) * | 2022-06-30 | 2024-01-04 | Wyatt Technology, Llc | Controlling the purification of a macromolecule solution via real-time multi-angle light scattering |
CN114839343B (en) * | 2022-07-04 | 2022-09-27 | 成都博瑞科传科技有限公司 | Portable water quality monitoring and inspecting instrument device and using method |
CN115074409B (en) * | 2022-08-18 | 2022-12-06 | 意润健康产业(广州)有限公司 | Micromolecule active peptide separation and purification system based on organic animal and plant raw materials |
WO2024070543A1 (en) * | 2022-09-27 | 2024-04-04 | 富士フイルム株式会社 | Information processing device, operation method of information processing device, operation program of information processing device, and state prediction model |
CN115307949B (en) * | 2022-10-11 | 2023-01-24 | 巨野锦晨精细化工有限公司 | Monitoring and processing system for key parameters of chemical equipment |
JP7320894B1 (en) | 2023-02-09 | 2023-08-04 | 日本分光株式会社 | Spectrum analysis method, analysis device and analysis program |
CN117092304B (en) * | 2023-08-25 | 2024-02-06 | 南通森萱药业有限公司 | Full-flow monitoring analysis management system for pharmaceutical intermediate production process |
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2017
- 2017-04-04 AU AU2017248025A patent/AU2017248025B2/en active Active
- 2017-04-04 CN CN201780034771.4A patent/CN109313419B/en active Active
- 2017-04-04 SG SG10202009671UA patent/SG10202009671UA/en unknown
- 2017-04-04 WO PCT/EP2017/057986 patent/WO2017174580A1/en active Application Filing
- 2017-04-04 SG SG11201808401QA patent/SG11201808401QA/en unknown
- 2017-04-04 KR KR1020187032040A patent/KR102344339B1/en active IP Right Grant
- 2017-04-04 US US16/091,095 patent/US20210149361A1/en not_active Abandoned
- 2017-04-04 EP EP17714807.9A patent/EP3440518A1/en active Pending
- 2017-04-04 JP JP2019502156A patent/JP6953508B2/en active Active
- 2017-04-04 CA CA3019979A patent/CA3019979A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2019522802A (en) | 2019-08-15 |
WO2017174580A1 (en) | 2017-10-12 |
CN109313419A (en) | 2019-02-05 |
EP3440518A1 (en) | 2019-02-13 |
KR20180134942A (en) | 2018-12-19 |
SG10202009671UA (en) | 2020-11-27 |
KR102344339B1 (en) | 2021-12-28 |
CN109313419B (en) | 2022-07-15 |
US20210149361A1 (en) | 2021-05-20 |
AU2017248025A1 (en) | 2018-10-25 |
CA3019979A1 (en) | 2017-10-12 |
JP6953508B2 (en) | 2021-10-27 |
AU2017248025B2 (en) | 2022-03-03 |
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