MX2021009357A - Dianas de genes de combinacion para mejorar la inmunoterapia. - Google Patents

Dianas de genes de combinacion para mejorar la inmunoterapia.

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Publication number
MX2021009357A
MX2021009357A MX2021009357A MX2021009357A MX2021009357A MX 2021009357 A MX2021009357 A MX 2021009357A MX 2021009357 A MX2021009357 A MX 2021009357A MX 2021009357 A MX2021009357 A MX 2021009357A MX 2021009357 A MX2021009357 A MX 2021009357A
Authority
MX
Mexico
Prior art keywords
effector cells
immune effector
modified
reduce
gene targets
Prior art date
Application number
MX2021009357A
Other languages
English (en)
Spanish (es)
Inventor
Michael Schlabach
Micah Benson
Gregory Kryukov
Anne Louise Cadzow
Le Mercier Isabelle Fleur
Frank Stegmeier
Original Assignee
Ksq Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ksq Therapeutics Inc filed Critical Ksq Therapeutics Inc
Publication of MX2021009357A publication Critical patent/MX2021009357A/es

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    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31Chimeric antigen receptors [CAR]
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    • A61K40/32T-cell receptors [TCR]
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    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/27Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
    • A61K2239/29Multispecific CARs
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    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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MX2021009357A 2019-02-04 2020-02-04 Dianas de genes de combinacion para mejorar la inmunoterapia. MX2021009357A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962800999P 2019-02-04 2019-02-04
US201962818677P 2019-03-14 2019-03-14
PCT/US2020/016623 WO2020163365A2 (en) 2019-02-04 2020-02-04 Combination gene targets for improved immunotherapy

Publications (1)

Publication Number Publication Date
MX2021009357A true MX2021009357A (es) 2021-11-17

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MX2021009357A MX2021009357A (es) 2019-02-04 2020-02-04 Dianas de genes de combinacion para mejorar la inmunoterapia.

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US (1) US20200347386A1 (enExample)
EP (1) EP3920942A4 (enExample)
JP (2) JP2022519595A (enExample)
KR (1) KR20210138587A (enExample)
CN (1) CN113396216A (enExample)
AU (1) AU2020217715A1 (enExample)
BR (1) BR112021015170A2 (enExample)
CA (1) CA3128823A1 (enExample)
IL (1) IL285307A (enExample)
MX (1) MX2021009357A (enExample)
SG (1) SG11202108452WA (enExample)
WO (1) WO2020163365A2 (enExample)

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JP2025501358A (ja) * 2022-01-05 2025-01-17 蘇州系統医学研究所 T細胞受容体、その製造方法、及び使用
US20250127895A1 (en) * 2022-01-29 2025-04-24 Suzhou Grit Biotechnology Co., Ltd. Modified tumor infiltrating lymphocyte and use thereof
WO2024186656A1 (en) 2023-03-03 2024-09-12 Arsenal Biosciences, Inc. Systems targeting psma and ca9
AU2024276994A1 (en) 2023-05-24 2025-10-23 Kumquat Biosciences Inc. Heterocyclic compounds and uses thereof
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