SG11202108452WA - Combination gene targets for improved immunotherapy - Google Patents

Combination gene targets for improved immunotherapy

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Publication number
SG11202108452WA
SG11202108452WA SG11202108452WA SG11202108452WA SG11202108452WA SG 11202108452W A SG11202108452W A SG 11202108452WA SG 11202108452W A SG11202108452W A SG 11202108452WA SG 11202108452W A SG11202108452W A SG 11202108452WA SG 11202108452W A SG11202108452W A SG 11202108452WA
Authority
SG
Singapore
Prior art keywords
gene targets
combination gene
improved immunotherapy
immunotherapy
improved
Prior art date
Application number
SG11202108452WA
Other languages
English (en)
Inventor
Micah Benson
Michael Schlabach
Gregory Kryukov
Anne Louise Cadzow
Le Mercier Isabelle Fleur
Frank Stegmeier
Original Assignee
Ksq Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ksq Therapeutics Inc filed Critical Ksq Therapeutics Inc
Publication of SG11202108452WA publication Critical patent/SG11202108452WA/en

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    • C12N5/06Animal cells or tissues; Human cells or tissues
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    • C12N5/0636T lymphocytes
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31Chimeric antigen receptors [CAR]
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    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32T-cell receptors [TCR]
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    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
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    • A61K40/4202Receptors, cell surface antigens or cell surface determinants
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    • A61K40/4273Glycoprotein 100 [Gp100]
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    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/27Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
    • A61K2239/29Multispecific CARs
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    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • AHUMAN NECESSITIES
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    • C12N2740/15011Lentivirus, not HIV, e.g. FIV, SIV
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SG11202108452WA 2019-02-04 2020-02-04 Combination gene targets for improved immunotherapy SG11202108452WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962800999P 2019-02-04 2019-02-04
US201962818677P 2019-03-14 2019-03-14
PCT/US2020/016623 WO2020163365A2 (en) 2019-02-04 2020-02-04 Combination gene targets for improved immunotherapy

Publications (1)

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SG11202108452WA true SG11202108452WA (en) 2021-09-29

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SG11202108452WA SG11202108452WA (en) 2019-02-04 2020-02-04 Combination gene targets for improved immunotherapy

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US (1) US20200347386A1 (enExample)
EP (1) EP3920942A4 (enExample)
JP (2) JP2022519595A (enExample)
KR (1) KR20210138587A (enExample)
CN (1) CN113396216A (enExample)
AU (1) AU2020217715A1 (enExample)
BR (1) BR112021015170A2 (enExample)
CA (1) CA3128823A1 (enExample)
IL (1) IL285307A (enExample)
MX (1) MX2021009357A (enExample)
SG (1) SG11202108452WA (enExample)
WO (1) WO2020163365A2 (enExample)

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EP4305153A1 (en) * 2021-03-09 2024-01-17 CRISPR Therapeutics AG Genetically engineered t cells with ptpn2 knockout have improved functionality and anti-tumor activity
WO2023015213A1 (en) * 2021-08-03 2023-02-09 Spotlight Therapeutics Ptpn2 specific guide rnas and uses thereof
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US20250352647A1 (en) * 2021-11-10 2025-11-20 Tsinghua University Method for enhancing durability of immune cell
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JP2025501358A (ja) * 2022-01-05 2025-01-17 蘇州系統医学研究所 T細胞受容体、その製造方法、及び使用
US20250127895A1 (en) * 2022-01-29 2025-04-24 Suzhou Grit Biotechnology Co., Ltd. Modified tumor infiltrating lymphocyte and use thereof
WO2024186656A1 (en) 2023-03-03 2024-09-12 Arsenal Biosciences, Inc. Systems targeting psma and ca9
AU2024276994A1 (en) 2023-05-24 2025-10-23 Kumquat Biosciences Inc. Heterocyclic compounds and uses thereof
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