MX2021005471A - Particulas inmunomodificadoras para el tratamiento de la inflamacion. - Google Patents

Particulas inmunomodificadoras para el tratamiento de la inflamacion.

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Publication number
MX2021005471A
MX2021005471A MX2021005471A MX2021005471A MX2021005471A MX 2021005471 A MX2021005471 A MX 2021005471A MX 2021005471 A MX2021005471 A MX 2021005471A MX 2021005471 A MX2021005471 A MX 2021005471A MX 2021005471 A MX2021005471 A MX 2021005471A
Authority
MX
Mexico
Prior art keywords
inflammation
immune
treatment
modifying particles
negatively charged
Prior art date
Application number
MX2021005471A
Other languages
English (en)
Inventor
Daniel Getts
Nicholas King
Original Assignee
Cour Pharmaceuticals Dev Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cour Pharmaceuticals Dev Company filed Critical Cour Pharmaceuticals Dev Company
Publication of MX2021005471A publication Critical patent/MX2021005471A/es

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Abstract

La presente invención implica la administración de partículas cargadas negativamente, tales como partículas de poliestireno, PLGA, o de diamante, a los sujetos para atenuar las respuestas inmunes inflamatorias. Adicionalmente, la presente invención describe métodos para tratar enfermedades inflamatorias mediante la administración de estas partículas cargadas negativamente.
MX2021005471A 2013-03-13 2015-09-02 Particulas inmunomodificadoras para el tratamiento de la inflamacion. MX2021005471A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361779182P 2013-03-13 2013-03-13
US201361844961P 2013-07-11 2013-07-11
US201361865392P 2013-08-13 2013-08-13
US201361887212P 2013-10-04 2013-10-04

Publications (1)

Publication Number Publication Date
MX2021005471A true MX2021005471A (es) 2021-06-18

Family

ID=51625647

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015011434A MX2015011434A (es) 2013-03-13 2014-03-13 Partículas inmunomodificadoras para el tratamiento de la inflamación.
MX2021005471A MX2021005471A (es) 2013-03-13 2015-09-02 Particulas inmunomodificadoras para el tratamiento de la inflamacion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015011434A MX2015011434A (es) 2013-03-13 2014-03-13 Partículas inmunomodificadoras para el tratamiento de la inflamación.

Country Status (13)

Country Link
US (6) US9913883B2 (es)
EP (2) EP2968160A4 (es)
JP (4) JP6725413B2 (es)
KR (3) KR20230025948A (es)
CN (3) CN105263476A (es)
AU (4) AU2014243758B2 (es)
BR (1) BR112015022597A2 (es)
CA (1) CA2903718A1 (es)
HK (1) HK1220368A1 (es)
IL (4) IL292823B2 (es)
MX (2) MX2015011434A (es)
RU (1) RU2015142245A (es)
WO (1) WO2014160465A2 (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101908445B1 (ko) 2010-11-12 2018-10-17 코어 파마슈티칼스 디벨롭먼트 컴퍼니 인크. 변형된 면역-조절 입자
SG11201405848UA (en) * 2012-03-23 2014-10-30 Univ Queensland Immunomodulatory agent and uses therefor
EP2841098A4 (en) 2012-04-23 2016-03-02 Allertein Therapeutics Llc NANOPARTICLES FOR THE TREATMENT OF ALLERGIES
RU2669346C2 (ru) 2012-06-21 2018-10-10 Норсвестерн Юниверсити Частицы, конъюгированные с пептидами
EP2908848B1 (en) * 2012-10-22 2018-04-25 University of Virginia Patent Foundation d/b/a University of Virginia Licensing & Ventures Group Compositions and methods for regulating arterial tone
EP2928500B1 (en) 2012-12-04 2019-03-06 Phosphorex Inc. Microparticles and nanoparticles having negative surface charges
IL292823B2 (en) * 2013-03-13 2023-11-01 Cour Pharmaceuticals Dev Company Secondary vaccine particles for the treatment of inflammation
MX2015013894A (es) 2013-04-03 2015-12-11 Allertein Therapeutics Llc Composiciones de nanoparticulas novedosas.
DK3033102T4 (da) * 2013-08-13 2024-02-26 Univ Northwestern Peptidkonjugerede partikler
US10137181B2 (en) * 2014-04-01 2018-11-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Isolated donor MHC-derived peptide and uses thereof
CA2957737A1 (en) 2014-09-07 2016-03-10 Selecta Biosciences, Inc. Methods and compositions for attenuating gene expression modulating anti-viral transfer vector immune responses
EP3247384B1 (en) 2015-01-14 2023-10-04 The Regents of the University of Colorado, a body corporate In vitro method of diagnosis of type 1 diabetes with insulin mimotopes
US20180296491A1 (en) * 2015-04-27 2018-10-18 University Of Rochester Nanoparticle therapeutics for treating skin inflammatory disorders
CA2985637A1 (en) 2015-05-12 2016-11-17 The General Hospital Corporation Autoantigens for diagnosis of rheumatoid arthritis
WO2017075053A1 (en) * 2015-10-26 2017-05-04 Cour Pharmaceuticals Development Company Inc. Immune-modifying particles for the treatment of malaria
GB201520568D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd Peptides
GB201520603D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520550D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
EP3402520A4 (en) * 2016-01-14 2019-01-02 BPS Bioscience, Inc. Anti-pd-1 antibodies and uses thereof
WO2017143346A1 (en) 2016-02-18 2017-08-24 Cour Pharmaceuticals Development Company, Inc. Process for the preparation of tolerizing immune-modulating particles
EP3436085A4 (en) * 2016-03-29 2020-07-29 Oneighty°C Technologies Corporation METHOD FOR QUICK DETERMINING EFFECTIVE STERILIZATION, DEIMMUNIZATION AND / OR DISINFECTION
US10908159B2 (en) 2016-06-07 2021-02-02 The General Hospital Corporation Identification of a T cell epitope of Prevotella copri that induces T cell responses in patients with Rheumatoid arthritis
WO2018017668A1 (en) * 2016-07-19 2018-01-25 Nano Mpi Holdings, Inc. Compositions and therapies using nanodiamonds suspended in a carrier
GB201700095D0 (en) * 2017-01-04 2017-02-22 Apitope Int Nv Composition
WO2019074343A1 (ko) * 2017-10-13 2019-04-18 주식회사 나이벡 고효율 줄기세포 선별을 위한 grp78 유래 펩타이드
US11919937B2 (en) 2018-01-09 2024-03-05 Board Of Regents, The University Of Texas System T cell receptors for immunotherapy
BR112020016221A2 (pt) * 2018-02-08 2020-12-15 Cour Pharmaceuticals Development Company, Inc. Tratamento da doença celíaca com partículas tolerogênicas
US11052060B2 (en) 2018-02-12 2021-07-06 The Regents Of The University Of Colorado, A Body Corporate Compounds and methods for treating autoimmunity
US11013707B2 (en) 2018-03-23 2021-05-25 The Regents Of The University Of Colorado, A Body Corporate Administration of oral methyldopa
WO2019217780A1 (en) 2018-05-11 2019-11-14 Phosphorex, Inc. Microparticles and nanoparticles having negative surface charges
BR102018010523A2 (pt) * 2018-05-23 2020-04-28 Univ Estadual Campinas Unicamp peptídeo, composição farmacêutica compreendendo o mesmo e uso
CN112823001A (zh) * 2018-07-31 2021-05-18 onCOUR制药股份有限公司 用于治疗癌症的免疫修饰粒子
GB201913408D0 (en) * 2019-09-17 2019-10-30 King S College London Proinsulin peptides for type 1 diabetes
CN112578125B (zh) * 2019-09-27 2022-10-25 成都中医药大学 检测粪钙卫蛋白含量的试剂在制备卵巢病变筛查试剂盒中的用途
US20220395563A1 (en) * 2019-11-11 2022-12-15 The Regents Of The University Of California Polymeric nanoparticles that target liver sinusoidal endothelial cells to induce antigen-specific immune tolerance
CN115348967A (zh) * 2019-12-03 2022-11-15 洪明奇 寡胜肽，其检测套组，其医药组合物与医药组合物的用途
JP7406983B2 (ja) * 2019-12-26 2023-12-28 住友化学株式会社 組成物および表示装置
IL297766A (en) * 2020-04-30 2022-12-01 Oncour Pharma Inc Negatively charged particles for the treatment of cytokine storm syndrome (css) and acute respiratory distress syndrome (ards)
US20230190676A1 (en) * 2020-07-09 2023-06-22 Musc Foundation For Research Development Methods of protecting cells from insults
JP7047949B1 (ja) 2021-02-18 2022-04-05 三菱電機株式会社 エレベータ制御装置及びビルシステム
KR102619897B1 (ko) * 2021-02-25 2024-01-04 주식회사 차메디텍 신규의 펩타이드 및 이를 포함하는 피부장벽 강화 또는 피부가려움증 억제를 위한 화장료 조성물
GB202103164D0 (en) * 2021-03-08 2021-04-21 Adiga Life Sciences Inc Therapy
WO2023056372A1 (en) * 2021-09-29 2023-04-06 Oncour Pharma, Inc. Negatively charged particles for the treatment of inflammation-related burn injuries
EP4219698A1 (en) * 2022-01-26 2023-08-02 Universität Ulm Peptide and use thereof in the prevention of therapy-related leukemia
WO2023173054A1 (en) * 2022-03-10 2023-09-14 The Trustees Of Dartmouth College Methods and materials for inhibiting/preventing the trafficking of monocytes to the central nervous system
CN115227819B (zh) * 2022-07-20 2023-08-29 徐州医科大学附属医院 一种介导光动力抑制皮肤光老化的自产氧纳米粒及其制备方法和应用

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9306042A (pt) 1992-02-28 1997-11-18 Autoimmune Inc Método para tratar uma doença auto-immune em um mamifero e formas de dosagens farmacêuticas oral e inalável
FR2695563B1 (fr) 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
US6004763A (en) 1992-09-11 1999-12-21 Institut Pasteur Antigen-carrying microparticles and their use in the induction of humoral or cellular responses
JPH06157592A (ja) 1992-11-24 1994-06-03 Hitachi Chem Co Ltd ペプチドもしくはその誘導体、それらとタンパク質との結合体、及びこれらを免疫源とする抗エンドセリン−１抗体の製造方法
WO1996035418A1 (en) 1995-05-08 1996-11-14 Texas Biotechnology Corporation Method for inhibiting the binding of selectins to sialyl-lewises
US5804201A (en) 1996-03-11 1998-09-08 The Rockefeller University Immunomodulatory peptides of vespid antigen 5
AU5307899A (en) 1999-08-18 2001-03-13 Catholic Educational Foundation Immunological tolerance-induction agent
US7582311B1 (en) 1999-10-15 2009-09-01 Genentech, Inc. Injection vehicle for polymer-based formulations
WO2001094944A2 (en) * 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
US7332168B2 (en) 2000-08-22 2008-02-19 Micromet Ag Composition for the elimination of autoreactive B-cells
US20060024270A1 (en) * 2000-08-23 2006-02-02 The New York Hospital Medical Center Of Queens Compositions and methods for preventing or treating encephalitis with interferon
EP2295533A3 (en) 2000-11-06 2011-07-13 Life Technologies Corporation Dry powder cells and cell culture reagents and methods of production thereof
US20030036639A1 (en) 2001-01-03 2003-02-20 Emery Daryll A. Immunizing compositions and methods of use
EP1458361A4 (en) 2001-11-20 2007-04-25 Advanced Inhalation Res Inc COMPOSITIONS FOR DISTRIBUTING PRODUCTS WITH LASTING EFFECT
PT1487485E (pt) 2002-03-19 2011-03-11 Powderject Res Ltd Adjuvantes de imidazoquinolina para vacinas de adn
AU2003243191B2 (en) 2002-05-02 2007-09-20 President And Fellows Of Harvard College Formulations limiting spread of pulmonary infections
JP5068931B2 (ja) 2002-07-12 2012-11-07 ザ ジョンズ ホプキンス ユニバーシティー 独自のクローン形質のリンパ球受容体に結合する試薬および方法
US7465463B2 (en) * 2002-09-04 2008-12-16 Polyheal, Ltd. Compositions comprising microspheres with anti-inflammatory properties for healing of ocular tissues
US20060189554A1 (en) 2002-09-24 2006-08-24 Russell Mumper Nanoparticle-Based vaccine delivery system containing adjuvant
US20050002999A1 (en) 2003-06-04 2005-01-06 Rahul Mehta Long-circulating liposomal compositions
US20060051407A1 (en) * 2003-06-27 2006-03-09 Yoram Richter Method of treating ischemia-reperfusion injury
WO2005015160A2 (en) 2003-08-07 2005-02-17 The Children's Hospital Of Philadelphia Functionalized polymeric colloids
WO2005020933A2 (en) 2003-09-02 2005-03-10 University Of South Florida Nanoparticles for drug-delivery
US20070275007A1 (en) 2003-11-05 2007-11-29 The Government Of The United States Of America, Represented By The Secretary Of Health And Human S Carbohydrate Antigen-Nanoparticle Conjugates and Uses Thereof as Antimetastatic Agents in Treating Cancer
JP2008512350A (ja) 2004-07-01 2008-04-24 イェール ユニバーシティ 標的化され、そして高密度で薬物が負荷されるポリマー性物質
WO2006082204A1 (en) 2005-02-02 2006-08-10 Novo Nordisk A/S Insulin derivatives
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
NZ563580A (en) 2005-06-07 2010-09-30 Esbatech An Alcon Biomedical R Stable and soluble antibodies inhibiting TNFaplha
CA2611985C (en) 2005-06-17 2016-08-16 The University Of North Carolina At Chapel Hill Nanoparticle fabrication methods, systems, and materials
WO2007003327A1 (en) 2005-07-01 2007-01-11 Roche Diagnostics Gmbh Carboxylated latex particles
WO2007008755A2 (en) * 2005-07-08 2007-01-18 The Board Of Regents, The University Of Texas System Surface functionalization of polymeric materials
GB0514262D0 (en) 2005-07-12 2005-08-17 Renovo Ltd Promotion of epithelial regeneration
US20070041934A1 (en) 2005-08-12 2007-02-22 Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
US20100028450A1 (en) 2006-01-25 2010-02-04 The Board Of Trustees Of The University Of Illinoi S Tolerogenic biodegradable artificial antigen presenting system
EP1991259B1 (en) 2006-02-15 2012-10-10 Ramot at Tel-Aviv University Ltd. Viral display vehicles for treating multiple sclerosis
WO2008011559A2 (en) 2006-07-20 2008-01-24 University Of Rochester Synthetic lung surfactant and use thereof
JP2009544750A (ja) 2006-07-28 2009-12-17 ザ ユニヴァーシティ コート オブ ザ ユニヴァーシティ オブ エディンバラ 治療
WO2008033924A2 (en) * 2006-09-12 2008-03-20 Board Of Regents Of The University Of Nebraska Methods and compositions for targeted delivery of therapeutic agents
TWI394564B (zh) 2006-09-21 2013-05-01 Alcon Res Ltd 自行保存型水性藥學組成物
JP2010505883A (ja) 2006-10-12 2010-02-25 ザ ユニバーシティー オブ クイーンズランド 免疫応答を調節するための組成物および方法
US20090214474A1 (en) 2006-11-01 2009-08-27 Barbara Brooke Jennings Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
RU2481125C2 (ru) 2006-12-18 2013-05-10 Колороббия Италия С.П.А. Магнитные наночастицы для применения при гипертермии, их приготовление и применение в магнитных системах для фармакологического использования
EP2842570B1 (en) 2007-03-07 2020-05-06 UTI Limited Partnership Compositions and methods for the prevention and treatment of autoimmune conditions
US20080311140A1 (en) 2007-05-29 2008-12-18 Baylor College Of Medicine Antigen specific immunosuppression by dendritic cell therapy
US8865216B2 (en) 2007-08-03 2014-10-21 National Institutes Of Health (Nih) Surface-modified nanoparticles for intracellular delivery of therapeutic agents and composition for making same
JP2011500569A (ja) 2007-10-12 2011-01-06 マサチューセッツ インスティテュート オブ テクノロジー ワクチンナノテクノロジー
EP2211841A4 (en) 2007-10-15 2013-03-13 Cooperative Res Ct For Asthma PROPHYLAXIS METHOD AND AGENTS FOR USE IN THIS METHOD
WO2009052561A1 (en) 2007-10-22 2009-04-30 The Walter And Eliza Hall Institute Of Medical Research Compositions and methods for manipulating an immune response
GB0721081D0 (en) 2007-10-26 2007-12-05 Metcalfe Susan M Immuno-modulatory composition
EP2057998A1 (en) 2007-10-31 2009-05-13 Universitätsklinikum Hamburg-Eppendorf Use of modified cells for the treatment of multiple sclerosis
US20090123509A1 (en) 2007-11-08 2009-05-14 Cory Berkland Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds
WO2009131712A2 (en) 2008-04-25 2009-10-29 Duke University Medical Center Regulatory b cells and their uses
EP2123261A1 (en) 2008-05-20 2009-11-25 Stallergenes S.A. Mucoadhesive particulate formulation for inducing antigen-specific immune tolerance
US20110206773A1 (en) * 2008-05-20 2011-08-25 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
US8323696B2 (en) 2008-08-29 2012-12-04 Ecole Polytechnique Federale De Lausanne Nanoparticles for immunotherapy
MX2011003569A (es) 2008-10-02 2011-06-09 Univ Pittsburgh Administracion de un polimero adsorbente para el tratamiento de inflamacion sistemica.
DK2977053T3 (en) 2008-11-30 2017-10-09 Immusant Inc COMPOSITIONS AND PROCEDURES FOR TREATMENT OF CELLIA
EP2376115A4 (en) 2008-12-11 2013-07-03 Univ Alberta METHODS AND SYSTEMS FOR INDUCING IMMUNOLOGICAL TOLERANCE TO NON-NONE ANTIGENS
AU2010206854A1 (en) * 2009-01-20 2011-08-04 Myelin Repair Foundation, Inc. Compositions and methods for induction of antigen-specific tolerance
WO2010120385A1 (en) 2009-04-18 2010-10-21 Massachusetts Institute Of Technology pH SENSITIVE BIODEGRADABLE POLYMERIC PARTICLES FOR DRUG DELIVERY
EP2255831A1 (en) 2009-05-25 2010-12-01 Institut Pasteur Liposome based diepitope constructs
US20110020388A1 (en) 2009-05-27 2011-01-27 Selecta Biosciences, Inc. Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents
WO2011031441A1 (en) 2009-08-28 2011-03-17 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Therapy with a chimeric molecule and a pro-apoptotic agent
US20110135744A1 (en) 2009-12-03 2011-06-09 The Regents Of The University Of California Nanoparticle Based Therapy for Dispersing Mucin
WO2011103588A1 (en) 2010-02-22 2011-08-25 Liquidia Technologies, Inc. Polysaccharide particle vaccines
US8207290B2 (en) 2010-03-26 2012-06-26 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
WO2011133617A1 (en) 2010-04-23 2011-10-27 The Board Of Trustees Of The University Of Illinois Nano-hybrid delivery system for sequential utilization of passive and active targeting
EP2575869B1 (en) 2010-06-04 2017-07-26 Flow Pharma Inc. Peptide particle formulation
EP2576645B1 (en) 2010-06-04 2015-03-18 Tongji University Copolymer of pyrene and pyrrole and method of producing the copolymer
EP2588123A2 (en) 2010-06-30 2013-05-08 Compugen Ltd. C1orf32 for the treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders
CN102714648B (zh) 2010-07-09 2015-07-15 联发科技（新加坡）私人有限公司 无线局域网设备及其传送、接收方法
WO2012018380A2 (en) 2010-07-31 2012-02-09 The Scripps Research Institute Compositions and methods for inducing immune tolerance
EP2600878A4 (en) 2010-08-04 2014-06-11 Univ Duke REGULATORY B-CELLS AND ITS USES
KR101908445B1 (ko) 2010-11-12 2018-10-17 코어 파마슈티칼스 디벨롭먼트 컴퍼니 인크. 변형된 면역-조절 입자
EP2643396B1 (en) 2010-11-24 2019-03-13 Nanyang Technological University Method for coating particles with calcium phosphate and particles, microparticles and nanoparticles formed thereof
US10064406B2 (en) 2011-01-06 2018-09-04 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products
CN105853393A (zh) 2011-01-24 2016-08-17 耶路撒冷希伯来大学伊森姆研究发展有限公司 用于药物的经皮递送和全身性递送的纳米粒子
EA027410B1 (ru) 2011-04-29 2017-07-31 Селекта Байосайенсиз, Инк. Наноносители, вызывающие иммунную толерантность, для снижения ответной реакции цитотоксических t-лимфоцитов
WO2013019658A2 (en) 2011-07-29 2013-02-07 Selecta Biosciences, Inc. Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents
WO2013032829A1 (en) * 2011-08-26 2013-03-07 Arrowhead Research Corporation Poly(vinyl ester) polymers for in vivo nucleic acid delivery
WO2013036296A1 (en) 2011-09-06 2013-03-14 Selecta Biosciences, Inc. Compositions and methods for producing antigen-specific induced tolerogenic dendritic cells with synthetic nanocarriers
EP2811980A4 (en) 2012-01-31 2015-12-23 Cerulean Pharma Inc POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS AND METHODS OF USE THEREOF
RU2669346C2 (ru) 2012-06-21 2018-10-10 Норсвестерн Юниверсити Частицы, конъюгированные с пептидами
EP2928500B1 (en) * 2012-12-04 2019-03-06 Phosphorex Inc. Microparticles and nanoparticles having negative surface charges
IL292823B2 (en) 2013-03-13 2023-11-01 Cour Pharmaceuticals Dev Company Secondary vaccine particles for the treatment of inflammation
DK3033102T4 (da) 2013-08-13 2024-02-26 Univ Northwestern Peptidkonjugerede partikler

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