MX2021004277A - Composiciones y metodos para expresar el factor ix. - Google Patents

Composiciones y metodos para expresar el factor ix.

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Publication number
MX2021004277A
MX2021004277A MX2021004277A MX2021004277A MX2021004277A MX 2021004277 A MX2021004277 A MX 2021004277A MX 2021004277 A MX2021004277 A MX 2021004277A MX 2021004277 A MX2021004277 A MX 2021004277A MX 2021004277 A MX2021004277 A MX 2021004277A
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MX
Mexico
Prior art keywords
compositions
methods
expressing factor
factor
expressing
Prior art date
Application number
MX2021004277A
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English (en)
Inventor
Christos Kyratsous
Kehdih Lai
Jonathan Douglas Finn
Hon-Ren Huang
Rachel Sattler
Moitri Roy
Cheng Wang
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Intellia Therapeutics Inc
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Publication date
Application filed by Intellia Therapeutics Inc filed Critical Intellia Therapeutics Inc
Publication of MX2021004277A publication Critical patent/MX2021004277A/es

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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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Abstract

Se proporcionan composiciones y métodos para expresar el Factor IX en una célula hospedadora o una población de células hospedadoras. También se proporcionan células hospedadoras modificadas genéticamente para expresar el Factor IX.
MX2021004277A 2018-10-18 2019-10-18 Composiciones y metodos para expresar el factor ix. MX2021004277A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862747509P 2018-10-18 2018-10-18
US201962829009P 2019-04-03 2019-04-03
US201962829621P 2019-04-04 2019-04-04
US201962840352P 2019-04-29 2019-04-29
PCT/US2019/057090 WO2020082046A2 (en) 2018-10-18 2019-10-18 Compositions and methods for expressing factor ix

Publications (1)

Publication Number Publication Date
MX2021004277A true MX2021004277A (es) 2021-09-08

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MX2021004277A MX2021004277A (es) 2018-10-18 2019-10-18 Composiciones y metodos para expresar el factor ix.

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US (1) US20200289628A1 (es)
EP (1) EP3867380A2 (es)
JP (1) JP2022512731A (es)
KR (1) KR20210102881A (es)
CN (1) CN113260701A (es)
AU (1) AU2019360270A1 (es)
BR (1) BR112021007301A2 (es)
CA (1) CA3116331A1 (es)
CO (1) CO2021006365A2 (es)
IL (1) IL282238A (es)
MX (1) MX2021004277A (es)
PH (1) PH12021550846A1 (es)
SG (1) SG11202103734PA (es)
TW (1) TW202027799A (es)
WO (1) WO2020082046A2 (es)

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