MX2020011528A - Inhibidores heterociclicos sustituidos de ptpn11. - Google Patents
Inhibidores heterociclicos sustituidos de ptpn11.Info
- Publication number
- MX2020011528A MX2020011528A MX2020011528A MX2020011528A MX2020011528A MX 2020011528 A MX2020011528 A MX 2020011528A MX 2020011528 A MX2020011528 A MX 2020011528A MX 2020011528 A MX2020011528 A MX 2020011528A MX 2020011528 A MX2020011528 A MX 2020011528A
- Authority
- MX
- Mexico
- Prior art keywords
- ptpn11
- substituted heterocyclic
- heterocyclic inhibitors
- inhibitors
- compounds
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- DDZGQYREBDXECY-UHFFFAOYSA-N 1h-pyrazolo[3,4-b]pyrazine Chemical class C1=CN=C2C=NNC2=N1 DDZGQYREBDXECY-UHFFFAOYSA-N 0.000 abstract 1
- 101001087416 Homo sapiens Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100028516 Receptor-type tyrosine-protein phosphatase U Human genes 0.000 abstract 1
- 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862665818P | 2018-05-02 | 2018-05-02 | |
| US201862773915P | 2018-11-30 | 2018-11-30 | |
| PCT/US2019/030277 WO2019213318A1 (en) | 2018-05-02 | 2019-05-01 | Substituted heterocyclic inhibitors of ptpn11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020011528A true MX2020011528A (es) | 2021-02-09 |
Family
ID=68386765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020011528A MX2020011528A (es) | 2018-05-02 | 2019-05-01 | Inhibidores heterociclicos sustituidos de ptpn11. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10954243B2 (https=) |
| EP (1) | EP3787627A4 (https=) |
| JP (1) | JP7297871B2 (https=) |
| KR (1) | KR102611661B1 (https=) |
| CN (1) | CN112351780B (https=) |
| AU (1) | AU2019263294B2 (https=) |
| BR (1) | BR112020022224A2 (https=) |
| CA (1) | CA3099151A1 (https=) |
| IL (1) | IL278297B2 (https=) |
| MX (1) | MX2020011528A (https=) |
| NZ (1) | NZ770260A (https=) |
| SG (1) | SG11202010822SA (https=) |
| WO (1) | WO2019213318A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12458640B2 (en) | 2019-08-20 | 2025-11-04 | Otsuka Pharmaceutical Co., Ltd. | Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors |
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| WO2019183364A1 (en) * | 2018-03-21 | 2019-09-26 | Relay Therapeutics, Inc. | Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof |
| SG11202009245TA (en) | 2018-03-21 | 2020-10-29 | Relay Therapeutics Inc | Shp2 phosphatase inhibitors and methods of use thereof |
| SG11202009793TA (en) | 2018-04-10 | 2020-10-29 | Revolution Medicines Inc | Shp2 inhibitor compositions, methods for treating cancer and methods for identifying a subject with shp2 mutations |
| KR102611661B1 (ko) | 2018-05-02 | 2023-12-08 | 나비레 파르마, 인코퍼레이티드 | Ptpn11의 치환된 헤테로사이클릭 억제제 |
| CN115721648A (zh) | 2018-05-09 | 2023-03-03 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| US20210230300A1 (en) | 2018-06-04 | 2021-07-29 | Bayer Aktiengesellschaft | Inhibitors of shp2 |
| JP7174143B2 (ja) | 2018-07-24 | 2022-11-17 | 大鵬薬品工業株式会社 | Ｓｈｐ２活性を阻害するヘテロ二環性化合物 |
| LT3833670T (lt) | 2018-08-10 | 2024-06-25 | Navire Pharma, Inc. | 6-(4-amino-3-metil-2-oksa-8-azaspiro[4.5]dekan-8-il)-3-(2,3-dichlorfenil)-2-metilpirimidin-4(3h)-ono dariniai ir susiję junginiai kaip ptpn11 (shp2) inhibitoriai, skirti vėžiui gydyti |
| TWI825144B (zh) | 2018-08-10 | 2023-12-11 | 美商思達利醫藥公司 | 第二型轉麩醯胺酸酶(tg2)抑制劑 |
| AR117200A1 (es) | 2018-11-30 | 2021-07-21 | Syngenta Participations Ag | Derivados de tiazol microbiocidas |
| PY1999867A (es) | 2018-11-30 | 2020-10-19 | Syngenta Crop Protection Ag | Derivados de tiazol microbiocidas |
| US12037354B2 (en) | 2018-11-30 | 2024-07-16 | Vectivbio Comet Ag | Cyclic pantetheine derivatives and uses thereof |
| AR117206A1 (es) | 2018-11-30 | 2021-07-21 | Glaxosmithkline Ip Dev Ltd | Derivados de octahidropirrolo[2,1-b][1,3]tiazepin-7-carboxamido útiles en la terapia para el vih y para el tratamiento del cáncer |
| TW202039496A (zh) | 2018-11-30 | 2020-11-01 | 美商默沙東藥廠 | 做為腺苷受體拮抗劑之9-經取代胺基三唑喹唑啉衍生物、醫藥組合物及其用途 |
-
2019
- 2019-05-01 KR KR1020207034430A patent/KR102611661B1/ko active Active
- 2019-05-01 US US16/401,047 patent/US10954243B2/en active Active
- 2019-05-01 NZ NZ770260A patent/NZ770260A/en unknown
- 2019-05-01 WO PCT/US2019/030277 patent/WO2019213318A1/en not_active Ceased
- 2019-05-01 IL IL278297A patent/IL278297B2/en unknown
- 2019-05-01 MX MX2020011528A patent/MX2020011528A/es unknown
- 2019-05-01 SG SG11202010822SA patent/SG11202010822SA/en unknown
- 2019-05-01 JP JP2021510272A patent/JP7297871B2/ja active Active
- 2019-05-01 EP EP19796849.8A patent/EP3787627A4/en active Pending
- 2019-05-01 CN CN201980029408.2A patent/CN112351780B/zh active Active
- 2019-05-01 AU AU2019263294A patent/AU2019263294B2/en active Active
- 2019-05-01 BR BR112020022224-0A patent/BR112020022224A2/pt not_active Application Discontinuation
- 2019-05-01 CA CA3099151A patent/CA3099151A1/en active Pending
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2021
- 2021-02-03 US US17/166,737 patent/US11932643B2/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12458640B2 (en) | 2019-08-20 | 2025-11-04 | Otsuka Pharmaceutical Co., Ltd. | Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors |
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| US10954243B2 (en) | 2021-03-23 |
| IL278297B2 (en) | 2023-12-01 |
| EP3787627A1 (en) | 2021-03-10 |
| BR112020022224A2 (pt) | 2021-06-08 |
| IL278297B1 (en) | 2023-08-01 |
| AU2019263294B2 (en) | 2024-03-21 |
| KR20210003901A (ko) | 2021-01-12 |
| NZ770260A (en) | 2024-12-20 |
| JP7297871B2 (ja) | 2023-06-26 |
| CN112351780A (zh) | 2021-02-09 |
| IL278297A (https=) | 2020-12-31 |
| KR102611661B1 (ko) | 2023-12-08 |
| JP2021523221A (ja) | 2021-09-02 |
| CA3099151A1 (en) | 2019-11-07 |
| AU2019263294A1 (en) | 2020-12-17 |
| EP3787627A4 (en) | 2021-12-01 |
| SG11202010822SA (en) | 2020-11-27 |
| CN112351780B (zh) | 2023-12-01 |
| WO2019213318A1 (en) | 2019-11-07 |
| US20190389867A1 (en) | 2019-12-26 |
| US11932643B2 (en) | 2024-03-19 |
| US20210317122A1 (en) | 2021-10-14 |
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