MX2020011122A - Bacteriofago indicador para seleccionar y monitorear la eficacia de agentes terapeuticos y metodos de uso del mismo. - Google Patents

Bacteriofago indicador para seleccionar y monitorear la eficacia de agentes terapeuticos y metodos de uso del mismo.

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Publication number
MX2020011122A
MX2020011122A MX2020011122A MX2020011122A MX2020011122A MX 2020011122 A MX2020011122 A MX 2020011122A MX 2020011122 A MX2020011122 A MX 2020011122A MX 2020011122 A MX2020011122 A MX 2020011122A MX 2020011122 A MX2020011122 A MX 2020011122A
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MX
Mexico
Prior art keywords
methods
selecting
monitoring
therapeutics
efficacy
Prior art date
Application number
MX2020011122A
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English (en)
Inventor
Dwight Lyman Anderson
Jose S Gil
Stephen Erickson
Minh Mindy Bao Nguyen
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Laboratory Corp America Holdings
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Publication date
Application filed by Laboratory Corp America Holdings filed Critical Laboratory Corp America Holdings
Publication of MX2020011122A publication Critical patent/MX2020011122A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/14—Streptococcus; Staphylococcus
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10131—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10141—Use of virus, viral particle or viral elements as a vector
    • C12N2795/10143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10151—Methods of production or purification of viral material
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/202—Pseudochromosomes, minichrosomosomes of bacteriophage origin
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

En la presente son divulgados métodos y sistemas para la detección de microorganismos en una muestra y la utilización de tales métodos para seleccionar y monitorear terapias. La especificidad del bacteriófago indiciador, como el bacteriófago específico para Staphylococcus, permite la detección de un microorganismo específico, tal como Staphylococcus y la señal indicadora puede amplificarse para optimizar la sensibilidad del ensayo.
MX2020011122A 2018-04-24 2019-04-24 Bacteriofago indicador para seleccionar y monitorear la eficacia de agentes terapeuticos y metodos de uso del mismo. MX2020011122A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862661739P 2018-04-24 2018-04-24
PCT/US2019/028967 WO2019209982A1 (en) 2018-04-24 2019-04-24 Indicator bacteriophage for selecting and monitoring for efficacy of therapeutics and methods for using same

Publications (1)

Publication Number Publication Date
MX2020011122A true MX2020011122A (es) 2020-11-11

Family

ID=67002338

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020011122A MX2020011122A (es) 2018-04-24 2019-04-24 Bacteriofago indicador para seleccionar y monitorear la eficacia de agentes terapeuticos y metodos de uso del mismo.

Country Status (9)

Country Link
US (1) US20210079443A1 (es)
EP (1) EP3784786A1 (es)
JP (2) JP2021521824A (es)
CN (1) CN112313337A (es)
AU (1) AU2019261608A1 (es)
BR (1) BR112020020622A2 (es)
CA (1) CA3096281A1 (es)
MX (1) MX2020011122A (es)
WO (1) WO2019209982A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023523627A (ja) * 2020-04-30 2023-06-06 ラボラトリー コーポレイション オブ アメリカ ホールディングス メチシリン耐性黄色ブドウ球菌を検出するための組成物、方法およびシステム
EP4165412A1 (en) * 2020-06-15 2023-04-19 Laboratory Corporation of America Holdings Methods for the diagnosis and treatment of biofilm-related infections
US20220214343A1 (en) * 2020-11-25 2022-07-07 Laboratory Corporation Of America Holdings Methods and Systems for the Detection of Microorganisms Using Infectious Agents
US20240151719A1 (en) * 2021-03-08 2024-05-09 Cobio Diagnostics Inc. Method and kit for identifying antimicrobial agents and effective concentrations thereof
WO2022232651A1 (en) * 2021-04-30 2022-11-03 Laboratory Corporation Of America Holdings Compositions and methods for multiplex detection of microorganisms using peptide-tagged recombinant infectious agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008030988A2 (en) 2006-09-06 2008-03-13 The Regents Of The University Of California Selectively targeted antimicrobial peptides and the use thereof
CN101680041A (zh) * 2007-04-18 2010-03-24 康奈尔大学 微生物检测方法和仪器
US8619257B2 (en) * 2007-12-13 2013-12-31 Kimberley-Clark Worldwide, Inc. Recombinant bacteriophage for detection of nosocomial infection
US7745194B2 (en) * 2008-09-16 2010-06-29 Intralytix, Inc. Staphylococcus aureus: bacteriophage and uses thereof
AU2010203698B2 (en) 2009-01-06 2016-07-21 C3 Jian, Inc. Targeted antimicrobial moieties
WO2014160418A2 (en) * 2013-03-13 2014-10-02 GeneWeave Biosciences, Inc. Non-replicative transduction particles and transduction particle-based reporter systems
CA2915820A1 (en) * 2013-06-19 2014-12-24 Michael Sandor Koeris Phage-based bacterial detection assay
CN115960844A (zh) * 2016-01-18 2023-04-14 美国控股实验室公司 使用感染原快速检测微生物的方法和系统

Also Published As

Publication number Publication date
CA3096281A1 (en) 2019-10-31
CN112313337A (zh) 2021-02-02
WO2019209982A1 (en) 2019-10-31
BR112020020622A2 (pt) 2021-01-12
AU2019261608A1 (en) 2020-10-15
JP2021521824A (ja) 2021-08-30
US20210079443A1 (en) 2021-03-18
JP2023166568A (ja) 2023-11-21
EP3784786A1 (en) 2021-03-03

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