BR112021023617A2 - Métodos para a produção de bacteriófagos mutantes para a detecção de listeria - Google Patents

Métodos para a produção de bacteriófagos mutantes para a detecção de listeria

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Publication number
BR112021023617A2
BR112021023617A2 BR112021023617A BR112021023617A BR112021023617A2 BR 112021023617 A2 BR112021023617 A2 BR 112021023617A2 BR 112021023617 A BR112021023617 A BR 112021023617A BR 112021023617 A BR112021023617 A BR 112021023617A BR 112021023617 A2 BR112021023617 A2 BR 112021023617A2
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Brazil
Prior art keywords
listeria
methods
detection
bacteriophages
bacteriophage
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Application number
BR112021023617A
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English (en)
Inventor
Lyman Anderson Dwight
S Gil Jose
Mindy Bao Nguyen Minh
Stephen Erickson
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Laboratory Corp America Holdings
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Publication date
Application filed by Laboratory Corp America Holdings filed Critical Laboratory Corp America Holdings
Publication of BR112021023617A2 publication Critical patent/BR112021023617A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00041—Use of virus, viral particle or viral elements as a vector
    • C12N2795/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10041—Use of virus, viral particle or viral elements as a vector
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10141—Use of virus, viral particle or viral elements as a vector
    • C12N2795/10143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10211—Podoviridae
    • C12N2795/10221—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10211—Podoviridae
    • C12N2795/10241—Use of virus, viral particle or viral elements as a vector
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10211—Podoviridae
    • C12N2795/10251—Methods of production or purification of viral material
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    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria

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Abstract

métodos para a produção de bacteriófagos mutantes para a detecção de listeria. são aqui divulgados métodos para a produção de bacteriófagos mutantes com intervalo de hospedeiro alterada. adicionalmente, são aqui divulgados métodos e sistemas para a detecção rápida de microrganismos tal como listeria spp. em uma amostra. um bacteriófago geneticamente modificado é também divulgado, o qual compreende um gene indicador na região tardia do gene. a especificidade do bacteriófago, tal como bacteriófago específico para listeria, permite a detecção de um microrganismo específico, tal como listeria spp. e um sinal indicador pode ser amplificado para otimizar a sensibilidade do ensaio.
BR112021023617A 2019-06-21 2020-06-18 Métodos para a produção de bacteriófagos mutantes para a detecção de listeria BR112021023617A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962864894P 2019-06-21 2019-06-21
PCT/US2020/038501 WO2020257502A1 (en) 2019-06-21 2020-06-18 Methods for producing mutant bacteriophages for the detection of listeria

Publications (1)

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BR112021023617A2 true BR112021023617A2 (pt) 2022-01-04

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BR112021023617A BR112021023617A2 (pt) 2019-06-21 2020-06-18 Métodos para a produção de bacteriófagos mutantes para a detecção de listeria

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US (1) US11674124B2 (pt)
EP (1) EP3987015A1 (pt)
JP (1) JP2022536960A (pt)
CN (1) CN114375330A (pt)
AU (1) AU2020298241A1 (pt)
BR (1) BR112021023617A2 (pt)
CA (1) CA3140294A1 (pt)
MX (1) MX2021015900A (pt)
WO (1) WO2020257502A1 (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4288527A1 (en) 2021-02-04 2023-12-13 Laboratory Corporation of America Holdings Methods and systems for the rapid detection of listeria using infectious agents
WO2024030896A2 (en) * 2022-08-01 2024-02-08 The University Of Chicago Bacteriophage compositions and methods for treatment of bacterial infections

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CA3140294A1 (en) 2020-12-24
MX2021015900A (es) 2022-02-03
CN114375330A (zh) 2022-04-19
US20200399614A1 (en) 2020-12-24
EP3987015A1 (en) 2022-04-27
JP2022536960A (ja) 2022-08-22
US11674124B2 (en) 2023-06-13
WO2020257502A1 (en) 2020-12-24
AU2020298241A1 (en) 2021-12-23

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