MX2020011008A - Implantes que usan comunicación ultrasónica para modular la actividad del nervio esplénico. - Google Patents

Implantes que usan comunicación ultrasónica para modular la actividad del nervio esplénico.

Info

Publication number
MX2020011008A
MX2020011008A MX2020011008A MX2020011008A MX2020011008A MX 2020011008 A MX2020011008 A MX 2020011008A MX 2020011008 A MX2020011008 A MX 2020011008A MX 2020011008 A MX2020011008 A MX 2020011008A MX 2020011008 A MX2020011008 A MX 2020011008A
Authority
MX
Mexico
Prior art keywords
splenic nerve
modulating
nerve activity
monitoring
implants
Prior art date
Application number
MX2020011008A
Other languages
English (en)
Inventor
Jose M Carmena
Michel M Maharbiz
Ryan Neely
Joshua Kay
Original Assignee
Iota Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iota Biosciences Inc filed Critical Iota Biosciences Inc
Publication of MX2020011008A publication Critical patent/MX2020011008A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/416—Evaluating particular organs or parts of the immune or lymphatic systems the spleen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6877—Nerve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6879—Means for maintaining contact with the body
    • A61B5/6884—Clamps or clips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36121—Production of neurotransmitters; Modulation of genes expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36178—Burst or pulse train parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A61N1/37223—Circuits for electromagnetic coupling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/378—Electrical supply
    • A61N1/3787—Electrical supply from an external energy source
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
    • H02J50/15—Circuit arrangements or systems for wireless supply or distribution of electric power using ultrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0556—Cuff electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/37518—Anchoring of the implants, e.g. fixation
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J2310/00—The network for supplying or distributing electric power characterised by its spatial reach or by the load
    • H02J2310/10—The network having a local or delimited stationary reach
    • H02J2310/20—The network being internal to a load
    • H02J2310/23—The load being a medical device, a medical implant, or a life supporting device

Abstract

Se describen en la presente métodos para monitorear o modular un sistema inmune en un sujeto; tratar, reducir o monitorear inflamación; monitorear presión sanguínea; tratar hipertensión; o administrar o ajustar una terapia para inflamación o hipertensión en un paciente al estimular eléctricamente el nervio esplénico o detectar actividad del nervio esplénico usando un dispositivo médico implantado; también se describen en la presente dispositivos médicos implantables para realizar tales métodos; el dispositivo médico implantado incluye un transductor ultrasónico configurado para recibir ondas ultrasónicas y convertir la energía de las ondas ultrasónicas en una energía eléctrica que alimenta el dispositivo, dos o más electrodos en comunicación eléctrica con el transductor ultrasónico que están configurados para estimular eléctricamente un nervio esplénico o detectar una actividad del nervio esplénico, y opcionalmente un miembro de unión del nervio esplénico.
MX2020011008A 2018-04-19 2019-04-19 Implantes que usan comunicación ultrasónica para modular la actividad del nervio esplénico. MX2020011008A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862660109P 2018-04-19 2018-04-19
PCT/US2019/028381 WO2019204769A1 (en) 2018-04-19 2019-04-19 Implants using ultrasonic communication for modulating splenic nerve activity

Publications (1)

Publication Number Publication Date
MX2020011008A true MX2020011008A (es) 2021-01-20

Family

ID=68237292

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020011008A MX2020011008A (es) 2018-04-19 2019-04-19 Implantes que usan comunicación ultrasónica para modular la actividad del nervio esplénico.

Country Status (11)

Country Link
US (2) US11890474B2 (es)
EP (1) EP3781255A4 (es)
JP (1) JP2021522032A (es)
KR (1) KR20210016346A (es)
CN (1) CN112351812A (es)
AU (1) AU2019255373A1 (es)
BR (1) BR112020021286A2 (es)
CA (1) CA3097139A1 (es)
IL (1) IL278031A (es)
MX (1) MX2020011008A (es)
WO (1) WO2019204769A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109982629B (zh) 2016-07-07 2023-07-14 加州大学评议会 使用超声波刺激组织的植入物
JP2021522033A (ja) 2018-04-19 2021-08-30 イオタ バイオサイエンシズ， インコーポレイテッドＩｏｔａ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 神経感知及び刺激のために超音波通信を用いる埋め込み
US20220347470A1 (en) * 2018-12-20 2022-11-03 Galvani Bioelectronics Limited Neurostimulation device for blocking blood flow between electrodes
CN113226455A (zh) * 2019-01-04 2021-08-06 艾奧塔生物科技公司 用于操作可植入设备的基于超声的协议
JP2023528596A (ja) * 2020-06-04 2023-07-05 イオタ バイオサイエンシズ， インコーポレイテッド 内蔵神経刺激による癌の治療のための装置及び方法
EP4208251A1 (en) * 2020-09-01 2023-07-12 Aarhus Universitet Implantable micro device with high data rate back scattering
CN116943030A (zh) * 2023-07-31 2023-10-27 清华大学 基于超声波信号的装置及植入式医疗设备

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5095905A (en) 1990-06-07 1992-03-17 Medtronic, Inc. Implantable neural electrode
US6402689B1 (en) 1998-09-30 2002-06-11 Sicel Technologies, Inc. Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors
US6170488B1 (en) 1999-03-24 2001-01-09 The B. F. Goodrich Company Acoustic-based remotely interrogated diagnostic implant device and system
US6200265B1 (en) 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
US6885888B2 (en) 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US7283874B2 (en) 2000-10-16 2007-10-16 Remon Medical Technologies Ltd. Acoustically powered implantable stimulating device
US7024248B2 (en) 2000-10-16 2006-04-04 Remon Medical Technologies Ltd Systems and methods for communicating with implantable devices
US7203548B2 (en) 2002-06-20 2007-04-10 Advanced Bionics Corporation Cavernous nerve stimulation via unidirectional propagation of action potentials
WO2004016315A1 (en) 2002-08-19 2004-02-26 Arizona Board Regents Neurostimulator
EP1608432B1 (en) 2003-04-02 2013-09-11 Neurostream Technologies General Partnership Implantable nerve signal sensing and stimulation device for treating foot drop and other neurological disorders
US7418292B2 (en) 2003-10-01 2008-08-26 Medtronic, Inc. Device and method for attenuating an immune response
US20050075702A1 (en) * 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for inhibiting release of pro-inflammatory mediator
US7783353B2 (en) 2003-12-24 2010-08-24 Cardiac Pacemakers, Inc. Automatic neural stimulation modulation based on activity and circadian rhythm
US7794499B2 (en) 2004-06-08 2010-09-14 Theken Disc, L.L.C. Prosthetic intervertebral spinal disc with integral microprocessor
US8332047B2 (en) 2004-11-18 2012-12-11 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
JP5111116B2 (ja) * 2004-12-21 2012-12-26 イービーアール システムズ， インコーポレイテッド ペーシングおよび不整脈処置のためのリード線のない心臓システム
CN102793972A (zh) 2004-12-27 2012-11-28 范因斯坦医学研究院 通过电刺激迷走神经治疗炎症性疾病
US7584004B2 (en) 2005-06-13 2009-09-01 Cardiac Pacemakers, Inc. Vascularly stabilized peripheral nerve cuff assembly
EP1946794A1 (en) 2005-07-20 2008-07-23 Cyberonics, Inc. Vagus nerve stimulation by electrical signals for controlling cerebellar tremor
US20070027486A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Medical devices for enhancing intrinsic neural activity
US7616990B2 (en) 2005-10-24 2009-11-10 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US10441780B2 (en) 2005-11-10 2019-10-15 Electrocore, Inc. Systems and methods for vagal nerve stimulation
WO2007090159A1 (en) 2006-01-31 2007-08-09 Medtronic, Inc. Implantable sensor
US8078283B2 (en) 2006-06-20 2011-12-13 Ebr Systems, Inc. Systems and methods for implantable leadless bone stimulation
US7899542B2 (en) 2006-06-20 2011-03-01 Ebr Systems, Inc. Systems and methods for implantable leadless spine stimulation
US7894907B2 (en) 2006-06-20 2011-02-22 Ebr Systems, Inc. Systems and methods for implantable leadless nerve stimulation
US7757565B2 (en) 2006-08-24 2010-07-20 Board Of Trustees Operating Michigan State University Self-powered sensor
US9186511B2 (en) 2006-10-13 2015-11-17 Cyberonics, Inc. Obstructive sleep apnea treatment devices, systems and methods
JP2010528814A (ja) 2007-06-14 2010-08-26 カーディアック ペースメイカーズ， インコーポレイテッド 多素子音響再充電システム
US20090018403A1 (en) 2007-07-12 2009-01-15 Sicel Technologies, Inc. Trackable implantable sensor devices, systems, and related methods of operation
CA2697822A1 (en) 2007-10-09 2009-04-16 Imthera Medical, Inc. Apparatus, system, and method for selective stimulation
DE102007053362B4 (de) 2007-11-06 2014-06-05 Universität Rostock Magnetisch gelagertes künstliches Gelenk
JP5189654B2 (ja) 2007-12-12 2013-04-24 カーディアック ペースメイカーズ， インコーポレイテッド 肺動脈から神経刺激を伝達する刺激システム
WO2009100531A1 (en) 2008-02-15 2009-08-20 Angeltear Solutions Inc. Adjustable tissue or nerve cuff and method of use
EP2265171B1 (en) 2008-03-12 2016-03-09 The Trustees of the University of Pennsylvania Flexible and scalable sensor arrays for recording and modulating physiologic activity
US9211409B2 (en) 2008-03-31 2015-12-15 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of T-cell activity
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
US20090275997A1 (en) 2008-05-01 2009-11-05 Michael Allen Faltys Vagus nerve stimulation electrodes and methods of use
US8126566B2 (en) 2008-08-14 2012-02-28 Cardiac Pacemakers, Inc. Performance assessment and adaptation of an acoustic communication link
WO2010059617A2 (en) 2008-11-18 2010-05-27 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
US8515520B2 (en) 2008-12-08 2013-08-20 Medtronic Xomed, Inc. Nerve electrode
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US8996116B2 (en) 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
CN102573986B (zh) 2009-06-09 2016-01-20 赛博恩特医疗器械公司 用于无导线刺激器的具有袋部的神经封套
US8224449B2 (en) 2009-06-29 2012-07-17 Boston Scientific Neuromodulation Corporation Microstimulator with flap electrodes
WO2011028763A2 (en) 2009-09-01 2011-03-10 Setpoint Medical Corporation Prescription pad for treatment of inflammatory disorders
WO2014169145A1 (en) 2013-04-10 2014-10-16 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
WO2011079309A2 (en) 2009-12-23 2011-06-30 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US8478428B2 (en) 2010-04-23 2013-07-02 Cyberonics, Inc. Helical electrode for nerve stimulation
US10022566B2 (en) 2010-08-31 2018-07-17 Arizona Board Of Regents On Behalf Of Arizona State University Apparatus, systems, and methods for current monitoring in ultrasound powered neurostimulation
US9095284B2 (en) 2010-10-28 2015-08-04 Medtronic, Inc. Distance measurement using implantable acoustic transducers
EP2651431B1 (en) 2010-12-17 2018-03-07 Neural Diabetes LLC System and apparatus for control of pancreatic beta cell function to improve glucose homeostatis and insulin production
US8781582B2 (en) * 2011-01-19 2014-07-15 Medtronic, Inc. Vagal stimulation
EP3821941A1 (en) 2011-01-28 2021-05-19 Stimwave Technologies Incorporated Neural stimulator system
US8849412B2 (en) 2011-01-28 2014-09-30 Micron Devices Llc Microwave field stimulator
US9399134B2 (en) * 2011-03-10 2016-07-26 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US9220897B2 (en) 2011-04-04 2015-12-29 Micron Devices Llc Implantable lead
JP6671843B2 (ja) 2011-04-04 2020-03-25 マイクロン デヴァイシーズ リミテッド ライアビリティ カンパニー 移植式導線
EP2707094B1 (en) 2011-05-09 2016-02-03 Setpoint Medical Corporation Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
JP2014524279A (ja) 2011-07-29 2014-09-22 スティムウェイブ テクノロジーズ インコーポレイテッド 神経刺激器のための電力又は極性選択の遠隔制御
JP5849158B2 (ja) 2011-08-23 2016-01-27 カーディアック ペースメイカーズ， インコーポレイテッド 迷走神経の捕捉を検出するシステムおよび方法
US8934992B2 (en) 2011-09-01 2015-01-13 Inspire Medical Systems, Inc. Nerve cuff
US8787526B2 (en) 2011-09-08 2014-07-22 Elwha Llc Systems, devices, and methods including implants for managing cumulative X-ray radiation dosage including X-ray radiation direction determination devices
US9242103B2 (en) 2011-09-15 2016-01-26 Micron Devices Llc Relay module for implant
AU2012358143B2 (en) * 2011-12-23 2015-06-11 Boston Scientific Scimed, Inc. Expandable balloon or an electrode pad with a heat sensing device
WO2013134479A1 (en) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg Sarl Neuromodulation and associated systems and methods for the management of pain
AU2013230906A1 (en) 2012-03-08 2014-09-18 Medtronic Af Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the treatment of sexual dysfunction
US10252085B2 (en) 2012-05-22 2019-04-09 Arizona Board Of Regents On Behalf Of Arizona State University Apparatus, system and method for neurostimulation by high frequency ultrasound
WO2014153228A1 (en) 2013-03-14 2014-09-25 Perryman Laura Tyler Miniature implantable device and methods
WO2014153218A1 (en) 2013-03-14 2014-09-25 Tyler Perryman Laura Devices and methods for treating craniofacial pain
US10245436B2 (en) 2012-07-17 2019-04-02 Stimwave Technologies Incorporated Miniature implantable device and methods
US9623253B2 (en) 2012-07-17 2017-04-18 Micron Devices, LLC Devices and methods for treating urological disorders
WO2014153223A1 (en) 2013-03-14 2014-09-25 Perryman Laura Tyler Treating inflammation, chronic pain and other disorders with neuromodulation
WO2014153219A1 (en) 2013-03-14 2014-09-25 Perryman Laura Tyler Devices and methods for treating urological disorders
US9717921B2 (en) 2012-07-17 2017-08-01 Micron Devices, LLC Treating inflammation, chronic pain and other disorders with neuromodulation
US10463858B2 (en) 2012-07-17 2019-11-05 Stimwave Technologies Incorporated Devices and methods for treating craniofacial pain
US9623238B2 (en) * 2012-08-23 2017-04-18 Endostim, Inc. Device and implantation system for electrical stimulation of biological systems
WO2014055393A1 (en) 2012-10-02 2014-04-10 Cardiac Pacemakers, Inc. Pinch to open cuff electrode
EP2928557B1 (en) 2012-12-05 2023-08-09 Curonix LLC Devices for connecting implantable devices to wireless energy
US20160007893A1 (en) 2013-02-06 2016-01-14 Loxbridge Research Llp Systems and methods for early disease detection and real-time disease monitoring
WO2014134075A1 (en) 2013-02-26 2014-09-04 The Regents Of The University Of California Electrical charge balancing method for functional stimulation using precision pulse width compensation
US8874233B2 (en) 2013-03-05 2014-10-28 The Charles Stark Draper Laboratory, Inc. Distributed neuro-modulation system with auxiliary stimulation-recording control units
US9323397B2 (en) 2013-03-11 2016-04-26 The Regents Of The University Of California In-air ultrasonic rangefinding and angle estimation
US8805537B1 (en) 2013-03-13 2014-08-12 Medtronic, Inc. Hybrid packing for implantable device
US10014570B2 (en) 2013-05-13 2018-07-03 The Board Of Trustees Of The Leland Stanford Junior University Single transducer for data and power in wirelessly powered devices
US9544068B2 (en) 2013-05-13 2017-01-10 The Board Of Trustees Of The Leland Stanford Junior University Hybrid communication system for implantable devices and ultra-low power sensors
EP2999395A1 (en) * 2013-05-20 2016-03-30 Cardiac Pacemakers, Inc. Methods and apparatus for detecting heart failure
CN104623808B (zh) 2013-11-14 2019-02-01 先健科技(深圳)有限公司 脑深部刺激系统
WO2015127476A1 (en) 2014-02-24 2015-08-27 Setpoint Medial Corporation Vagus nerve stimulation screening test
WO2015139053A1 (en) 2014-03-14 2015-09-17 Accelemed, Llc Method and apparatus for versatile minimally invasive neuromodulators
US10335596B2 (en) 2014-03-14 2019-07-02 Nalu Medical, Inc. Method and apparatus for neuromodulation treatments of pain and other conditions
WO2015142842A2 (en) 2014-03-17 2015-09-24 Towe Bruce C Methods and systems for measuring tissue impedance and monitoring pvd treatment using neuro-implants with improved ultrasound powering
US20170197082A1 (en) 2014-07-09 2017-07-13 Dexing Pang Device, system and method for nerve stimulation
EP3180072B1 (en) 2014-08-15 2018-11-28 Axonics Modulation Technologies Inc. Electromyographic lead positioning and stimulation titration in a nerve stimulation system for treatment of overactive bladder
EP3180069B1 (en) 2014-08-17 2020-05-13 Nine Continents Medical, Inc. Miniature implatable neurostimulator system for sciatic nerves and their branches
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
US20190030374A1 (en) 2014-12-19 2019-01-31 Universite Pierre Et Marie Curie (Paris 6) Implantable ultrasound generating treating device for brain treatment, apparatus comprising such device and method implementing such device
IL243231B (en) 2014-12-22 2019-05-30 Newpace Ltd System and method for wireless recharging of a flexible subcutaneously implanted medical device
AU2016205047B2 (en) 2015-01-09 2020-07-02 Axonics Modulation Technologies, Inc. Patient remote and associated methods of use with a nerve stimulation system
US11115475B2 (en) 2015-01-26 2021-09-07 Northeastern University Software-defined implantable ultrasonic device for use in the internet of medical things
US20160235329A1 (en) 2015-02-13 2016-08-18 The Charles Stark Draper Laboratory, Inc. Nerve bundle cuff including electrodes and transducers
CA2977244C (en) 2015-02-20 2023-08-01 The Feinstein Institute For Medical Research Bioelectronic pharmaceuticals
WO2016134199A1 (en) 2015-02-20 2016-08-25 The Feinstein Institute For Medical Research Nerve stimulation for treatment of diseases and disorders
US10974041B2 (en) 2015-04-24 2021-04-13 Galvani Bioelectronics Limited Neuromodulation device
WO2016183353A1 (en) 2015-05-12 2016-11-17 Setpoint Medical Corporation External programmer
US20170100605A1 (en) 2015-05-15 2017-04-13 Ohio State Innovation Foundation Systems and methods of improving an immune disorder
US20170100589A1 (en) 2015-05-15 2017-04-13 Ohio State Innovation Foundation Systems and methods of improving infections by neuromodulation of immune function
EP3294376A1 (en) 2015-05-15 2018-03-21 The Ohio State Innovation Foundation Methods for improving a patient's immune response by delivering a therapy signal to the patient's sympathetic nervous system
US20170100588A1 (en) 2015-05-15 2017-04-13 Ohio State Innovation Foundation Systems and methods of improving cancer symptoms by neuromodulation of immune function
US10201706B2 (en) 2015-05-15 2019-02-12 Ohio State Innovation Foundation Systems and methods of improving an inflammatory disorder
US20170100604A1 (en) 2015-05-15 2017-04-13 Ohio State Innovation Foundation Systems and methods of improving metabolic syndrome
WO2016183689A1 (en) 2015-05-21 2016-11-24 The Governing Council Of The University Of Toronto Systems and methods for treatment of urinary dysfunction
US20160361535A1 (en) 2015-06-11 2016-12-15 Micron Devices Llc Embedded fixation devices or leads
US20170007853A1 (en) * 2015-07-10 2017-01-12 Medtronic, Inc. Physiological monitoring for ultrasound therapy
US20180161002A1 (en) 2015-07-10 2018-06-14 Medtronic, Inc. Ultrasound delivery for diagnosis and/or therapy
JP6740531B2 (ja) * 2015-10-14 2020-08-19 国立大学法人 熊本大学 炎症及び過剰免疫を抑制する装置、並びに炎症及び過剰免疫を抑制するための方法
JP6940494B2 (ja) 2015-10-21 2021-09-29 ニュースペラ メディカル インク 刺激治療のための装置、システム、および方法
US10177606B2 (en) 2015-10-21 2019-01-08 The Board Of Trustees Of The Leland Stanford Junior University Dynamic reconfiguration for maximizing the overall link efficiency of energy receivers in a reliable implantable system
EP4252833A3 (en) 2015-11-17 2023-11-15 Inspire Medical Systems, Inc. Microstimulation sleep disordered breathing (sdb) therapy device
WO2017127758A1 (en) 2016-01-20 2017-07-27 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
WO2017143185A1 (en) 2016-02-17 2017-08-24 Verily Life Sciences Llc Wireless implant systems for sensing and stimulating nerves
WO2017143191A1 (en) 2016-02-17 2017-08-24 Verily Life Sciences Llc Nerve stimulation systems and methods using an external wireless power source
US9802055B2 (en) 2016-04-04 2017-10-31 Medtronic, Inc. Ultrasound powered pulse delivery device
US10252066B2 (en) 2016-05-05 2019-04-09 Piezo Energy Technologies Llc Miniaturized wireless ultrasound energy transfer system for powering a bio-implantable medical device
AU2017290353B2 (en) 2016-06-29 2023-05-18 Tulavi Therapeutics, Inc. Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system
CN109982629B (zh) 2016-07-07 2023-07-14 加州大学评议会 使用超声波刺激组织的植入物
CN109688902A (zh) 2016-07-18 2019-04-26 诺威适骨科专科公司 通信装置和方法
US9955882B2 (en) 2016-08-31 2018-05-01 Medtronic Xomed, Inc. System to monitor neural integrity
US20200054228A1 (en) 2016-10-31 2020-02-20 General Electric Company Techniques for neuromodulation
EP3538209A1 (en) * 2016-11-08 2019-09-18 Galvani Bioelectronics Limited Treatment of inflammatory disorders
US20190275330A1 (en) 2016-11-14 2019-09-12 Galvani Bioelectronics Limited Modular Neuromodulation Systems, Methods of Manufacture, and Methods of Treating Rheumatoid Arthritis
EP3548140B1 (en) 2016-12-02 2022-04-20 Boston Scientific Neuromodulation Corporation Systems for selecting stimulation parameters for electrical stimulation devices
US20180154142A1 (en) * 2016-12-05 2018-06-07 Old Dominion University Research Foundation Methods and devices for treatment of tumors with nano-pulse stimulation
WO2018118857A1 (en) 2016-12-19 2018-06-28 Ohio State Innovation Foundation Systems and methods of improving an immune disorder
WO2018118861A1 (en) 2016-12-19 2018-06-28 Ohio State Innovation Foundation Systems and methods of improving cancer symptoms by neuromodulation of immune function
WO2018118860A1 (en) 2016-12-19 2018-06-28 Ohio State Innovation Foundation Systems and methods of improving an inflammatory disorder
JP7050795B2 (ja) 2017-01-30 2022-04-08 ニュースペラ メディカル インク ミッドフィールド送信機および受信機システム
WO2019075203A1 (en) 2017-10-11 2019-04-18 The Board Of Trustees Of The Leland Stanford Junior University RF-ULTRASONIC RELAY FOR EFFICIENT POWER AND DATA TRANSFER IN INTERFACES
JP2021507759A (ja) 2017-12-20 2021-02-25 ガルバニ バイオエレクトロニクス リミテッド 炎症に関連する疾患の治療
CN111787975A (zh) * 2017-12-20 2020-10-16 加尔瓦尼生物电子有限公司 供应脾脏的神经的刺激
JP2021522033A (ja) 2018-04-19 2021-08-30 イオタ バイオサイエンシズ， インコーポレイテッドＩｏｔａ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 神経感知及び刺激のために超音波通信を用いる埋め込み
IL311077A (en) 2018-08-29 2024-04-01 Iota Biosciences Inc Implantable closed-loop neuromodulation device, systems and methods for use
AU2019394943A1 (en) 2018-12-06 2021-06-03 Iota Biosciences, Inc. Device networks for modulating neural activity
CA3124117A1 (en) 2019-01-04 2020-07-09 Michel M. Maharbiz Power controls for an implantable device powered using ultrasonic waves
CN113226455A (zh) 2019-01-04 2021-08-06 艾奧塔生物科技公司 用于操作可植入设备的基于超声的协议
EP3986535A1 (en) 2019-06-19 2022-04-27 Galvani Bioelectronics Limited System and method for monitoring response to neuromodulation
US20220409887A1 (en) 2019-06-19 2022-12-29 Galvani Bioelectronics Limited Stimulation of a Nerve Supplying the Spleen
JP2022552012A (ja) 2019-10-17 2022-12-14 イオタ バイオサイエンシズ， インコーポレイテッド ヘリカル神経カフおよび関連するインプランタブルデバイス
BR112022007324A2 (pt) 2019-10-17 2022-07-05 Iota Biosciences Inc Dispositivos ou métodos para modular atividade de sistema imunológico em um paciente com câncer ou tratar câncer
CN114945335A (zh) 2019-11-27 2022-08-26 加尔瓦尼生物电子有限公司 用于神经接口的腹腔镜递送和部署的系统和方法
US20230009490A1 (en) 2019-11-27 2023-01-12 Galvani Bioelectronics Limited Neural interface system
CN115279452A (zh) 2019-11-27 2022-11-01 加尔瓦尼生物电子有限公司 用于神经调制的电极装置和相关方法
EP4106863A4 (en) 2020-02-19 2024-02-21 Chan Zuckerberg Biohub Inc ANCHORING LOSS IN MILLIMETER SCALE ULTRASONIC WIRELESS IMPLANTABLE DEVICES
US20230095948A1 (en) 2020-02-19 2023-03-30 The Regents Of The University Of California A deep tissue ultrasonic implantable luminescence oxygen sensor
JP2023528596A (ja) 2020-06-04 2023-07-05 イオタ バイオサイエンシズ， インコーポレイテッド 内蔵神経刺激による癌の治療のための装置及び方法
US20230301514A1 (en) 2020-08-11 2023-09-28 Iota Biosciences, Inc. Ultrasonic implant and system for measurement of intraocular pressure
KR20230056703A (ko) 2020-08-24 2023-04-27 아이오타 바이오사이언시즈 인코퍼레이티드 초음파를 사용하여 전력을 공급받는 이식형 장치의 추적
WO2023183891A2 (en) 2022-03-23 2023-09-28 Iota Biosciences, Inc. Frequency modulated communication

Also Published As

Publication number Publication date
US20240017071A1 (en) 2024-01-18
US11890474B2 (en) 2024-02-06
JP2021522032A (ja) 2021-08-30
BR112020021286A2 (pt) 2021-01-26
CN112351812A (zh) 2021-02-09
EP3781255A1 (en) 2021-02-24
WO2019204769A1 (en) 2019-10-24
AU2019255373A1 (en) 2020-11-26
EP3781255A4 (en) 2021-12-01
CA3097139A1 (en) 2019-10-24
IL278031A (en) 2020-11-30
KR20210016346A (ko) 2021-02-15
US20190321640A1 (en) 2019-10-24

Similar Documents

Publication Publication Date Title
MX2020011008A (es) Implantes que usan comunicación ultrasónica para modular la actividad del nervio esplénico.
MX2020011010A (es) Implantes utilizando comunicación ultrasónica para detección y estimulación neuronales.
WO2014168957A3 (en) Noninvasive or percutaneous nerve stimulation
CO2019005709A2 (es) Un dispositivo de tens para el monitoreo de actividades, análisis de marcha y evaluación del equilibrio
EP4293828A3 (en) Apparatus for peripheral or spinal stimulation
EP3824945A3 (en) Electrical stimulation system
US20120259390A1 (en) Wearable Photvoltaic Ultra-Low frequency Acupoint Stimulator
US20170007823A1 (en) Electrical treatment of alzheimer's disease
WO2009023543A3 (en) Systems and methods of neuromodulation stimulation for the restoration of sexual function
WO2005051480A3 (en) Electrical stimulation system, lead, and method providing reduced neuroplasticity effects
MX2022004584A (es) Dispositivos y métodos para modular la actividad del sistema inmunitario en un paciente con cáncer y tratamiento del cáncer.
JP2014528265A5 (es)
WO2012024286A3 (en) Implantable medical device for urgency therapy through electrical nerve stimulation and c-afferent nerve desensitization
NZ711655A (en) Implantable electroacupuncture device employing a high impedance coin-cell battery as a primary power source
ATE439891T1 (de) Leitung zur stimulierung der barorezeptoren in der pulmonalarterie
WO2014200739A3 (en) Delivery system with pacing element
AU2014211625B2 (en) Device and method for electrical stimulation of neural or muscular tissue
PL421532A1 (pl) System do leczenia nowotworów wewnątrzczaszkowych z wykorzystaniem implantu, generującego ciągłe, zmienne pole elektryczne oraz ultradźwięki, zasilanego metodą przezskórnego transferu energii
EP3679979B1 (en) A device for neuromodulation treatment
EP4299107A3 (en) Systems for delivering therapy using an auricular stimulation device
WO2013042068A3 (en) Medical implant with current leakage circuitry
WO2017205047A3 (en) Systems and methods for increasing a delay in the gastric emptying time for a patient using a transcutaneous electro-dermal patch
MX2021002416A (es) Dispositivo de neuromodulacion de bucle cerrado implantable, sistemas, y metodos de uso.
WO2016049047A3 (en) Systems and methods for providing therapy using electrical stimulation to disrupt neuronal activity
WO2021035222A3 (en) Apparatus for systemic human enhancement from administration of frequency therapy including enhanced stem cell and genetic therapy