MX2020009942A - Compuestos y usos de los mismos. - Google Patents
Compuestos y usos de los mismos.Info
- Publication number
- MX2020009942A MX2020009942A MX2020009942A MX2020009942A MX2020009942A MX 2020009942 A MX2020009942 A MX 2020009942A MX 2020009942 A MX2020009942 A MX 2020009942A MX 2020009942 A MX2020009942 A MX 2020009942A MX 2020009942 A MX2020009942 A MX 2020009942A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- neurological disorders
- alone
- treating
- treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
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- C07D237/14—Oxygen atoms
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- C07D237/20—Nitrogen atoms
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract
La presente invención comprende compuestos útiles en el tratamiento de trastornos neurológicos. Los compuestos de la invención, de manera individual o junto con otros agentes farmacéuticamente activos, pueden utilizarse para el tratamiento o la prevención de trastornos neurológicos.
Applications Claiming Priority (2)
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US201862647308P | 2018-03-23 | 2018-03-23 | |
PCT/US2019/023737 WO2019183587A1 (en) | 2018-03-23 | 2019-03-22 | Compounds and uses thereof |
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MX2020009942A true MX2020009942A (es) | 2021-01-08 |
Family
ID=67986384
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MX2020009942A MX2020009942A (es) | 2018-03-23 | 2019-03-22 | Compuestos y usos de los mismos. |
MX2024000349A MX2024000349A (es) | 2018-03-23 | 2020-09-23 | Compuestos y usos de los mismos. |
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MX2024000349A MX2024000349A (es) | 2018-03-23 | 2020-09-23 | Compuestos y usos de los mismos. |
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US (1) | US20220298168A1 (es) |
EP (1) | EP3768269A4 (es) |
JP (2) | JP7517992B2 (es) |
KR (1) | KR20210005593A (es) |
CN (3) | CN118084801A (es) |
AU (1) | AU2019238326A1 (es) |
BR (1) | BR112020019191A2 (es) |
CA (1) | CA3094527A1 (es) |
EA (1) | EA202092225A1 (es) |
IL (1) | IL277502A (es) |
MA (1) | MA52092A (es) |
MX (2) | MX2020009942A (es) |
SG (1) | SG11202009280RA (es) |
WO (1) | WO2019183587A1 (es) |
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JP2019533022A (ja) | 2016-10-24 | 2019-11-14 | ユマニティ セラピューティクス,インコーポレーテッド | 化合物及びその使用 |
US11873298B2 (en) | 2017-10-24 | 2024-01-16 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
EP3914593A4 (en) * | 2019-01-24 | 2022-11-02 | Yumanity Therapeutics, Inc. | COMPOUNDS AND THEIR USES |
WO2020198026A1 (en) * | 2019-03-22 | 2020-10-01 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
WO2022266236A1 (en) | 2021-06-18 | 2022-12-22 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
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KR20020064147A (ko) * | 1999-07-01 | 2002-08-07 | 아지노모토 가부시키가이샤 | 헤테로사이클릭 화합물 및 이의 의약 용도 |
US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
WO2004110418A2 (en) * | 2003-06-10 | 2004-12-23 | Kalypsys, Inc. | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
MXPA06001480A (es) * | 2003-08-06 | 2006-05-15 | Pfizer Prod Inc | Compuestos de oxazol para el tratamiento de trastornos neurodegenerativos. |
KR20060088537A (ko) * | 2003-09-06 | 2006-08-04 | 버텍스 파마슈티칼스 인코포레이티드 | Atp-결합 카세트 수송체의 조절자 |
WO2006022442A1 (ja) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
MX2007015216A (es) | 2005-06-03 | 2008-02-22 | Xenon Pharmaceuticals Inc | Derivados de aminotiazol y sus usos como agentes terapeuticos. |
US20090325956A1 (en) * | 2006-10-13 | 2009-12-31 | Takahiko Taniguchi | Aromatic amine derivative and use thereof |
KR101450356B1 (ko) | 2006-11-24 | 2014-10-15 | 에이씨 이뮨 에스.에이. | 알츠하이머와 같은 아밀로이드 또는 아밀로이드-유사 단백질과 관련된 질환의 치료를 위한 n-(메틸)-1h-피라졸-3-아민, n-(메틸)-피리딘-2-아민 및 n-(메틸)-티아졸-2-아민 유도체 |
WO2008123469A1 (ja) | 2007-03-30 | 2008-10-16 | Japan Tobacco Inc. | 6員環アミド化合物およびその用途 |
GB0721419D0 (en) * | 2007-10-31 | 2007-12-12 | Smithkline Beecham Corp | Compounds |
ES2647531T3 (es) * | 2008-02-28 | 2017-12-22 | Vertex Pharmaceuticals Incorporated | Derivados de heteroarilo como moduladores de CFTR |
EP2271621B1 (en) | 2008-03-31 | 2013-11-20 | Vertex Pharmaceuticals Incorporated | Pyridyl derivatives as cftr modulators |
GB0810913D0 (en) * | 2008-06-13 | 2008-07-23 | Smithkline Beecham Corp | Comppounds |
WO2011039358A1 (en) * | 2009-10-01 | 2011-04-07 | Novartis Ag | Pyrazole derivatives which modulate stearoyl-coa desaturase |
EP2651930B1 (en) * | 2010-12-16 | 2015-10-28 | Boehringer Ingelheim International GmbH | Biarylamide inhibitors of leukotriene production |
US20120316182A1 (en) * | 2011-06-10 | 2012-12-13 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
WO2014065860A1 (en) * | 2012-10-24 | 2014-05-01 | The General Hospital Corporation | Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions |
TWI594975B (zh) * | 2013-04-24 | 2017-08-11 | 第一三共股份有限公司 | 二羧酸化合物 |
WO2015054658A1 (en) * | 2013-10-11 | 2015-04-16 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
US20160223559A1 (en) * | 2015-02-02 | 2016-08-04 | The Regents Of The University Of California | Tetrazine-containing compounds and synthetic methods thereof |
CN108473447A (zh) * | 2015-11-30 | 2018-08-31 | 勃艮第大学 | 制备官能化的1,2,4,5-四嗪化合物的方法 |
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2019
- 2019-03-22 SG SG11202009280RA patent/SG11202009280RA/en unknown
- 2019-03-22 CN CN202410214688.7A patent/CN118084801A/zh active Pending
- 2019-03-22 EA EA202092225A patent/EA202092225A1/ru unknown
- 2019-03-22 KR KR1020207030056A patent/KR20210005593A/ko not_active Application Discontinuation
- 2019-03-22 EP EP19771620.2A patent/EP3768269A4/en active Pending
- 2019-03-22 CN CN202410169808.6A patent/CN118084800A/zh active Pending
- 2019-03-22 AU AU2019238326A patent/AU2019238326A1/en active Pending
- 2019-03-22 CN CN201980034106.4A patent/CN112312913B/zh active Active
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- 2019-03-22 BR BR112020019191-4A patent/BR112020019191A2/pt unknown
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2020
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- 2020-09-23 MX MX2024000349A patent/MX2024000349A/es unknown
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2023
- 2023-12-15 JP JP2023211982A patent/JP2024037913A/ja active Pending
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MA52092A (fr) | 2021-01-27 |
US20220298168A1 (en) | 2022-09-22 |
MX2024000349A (es) | 2024-01-26 |
JP2024037913A (ja) | 2024-03-19 |
IL277502A (en) | 2020-11-30 |
AU2019238326A1 (en) | 2020-10-15 |
CA3094527A1 (en) | 2019-09-26 |
CN118084801A (zh) | 2024-05-28 |
CN118084800A (zh) | 2024-05-28 |
CN112312913A (zh) | 2021-02-02 |
EA202092225A1 (ru) | 2021-02-09 |
SG11202009280RA (en) | 2020-10-29 |
CN112312913B (zh) | 2024-03-08 |
EP3768269A1 (en) | 2021-01-27 |
JP2021519263A (ja) | 2021-08-10 |
WO2019183587A1 (en) | 2019-09-26 |
EP3768269A4 (en) | 2022-03-23 |
JP7517992B2 (ja) | 2024-07-17 |
KR20210005593A (ko) | 2021-01-14 |
BR112020019191A2 (pt) | 2021-01-05 |
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