MX2020006174A - Tratamientos de combinación que comprenden la administración de 1h-pirazol[4,3-b]piridinas. - Google Patents

Tratamientos de combinación que comprenden la administración de 1h-pirazol[4,3-b]piridinas.

Info

Publication number
MX2020006174A
MX2020006174A MX2020006174A MX2020006174A MX2020006174A MX 2020006174 A MX2020006174 A MX 2020006174A MX 2020006174 A MX2020006174 A MX 2020006174A MX 2020006174 A MX2020006174 A MX 2020006174A MX 2020006174 A MX2020006174 A MX 2020006174A
Authority
MX
Mexico
Prior art keywords
pyrazolo
pyridines
administration
combination treatments
compound
Prior art date
Application number
MX2020006174A
Other languages
English (en)
Inventor
Jan Kehler
Karsten Juhl
Morten Langgård
Lars Kyhn Rasmussen
Mikkel Jessing
Paulo Jorge Vieira Vital
Mauro Marigo
Carl Martin Sebastian Clementson
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MX2020006174A publication Critical patent/MX2020006174A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona 1H-pirazol[4,3-b]piridin-7-amina s de fórmula (I) como inhibidores de PDE1 junto con un segundo compuesto, siendo dicho compuesto útil en el tratamiento de un trastorno psiquiátrico y su uso combinado como un medicamento, en particular para el tratamiento de trastornos psiquiátricos y/o cognitivos.
MX2020006174A 2017-12-14 2018-12-12 Tratamientos de combinación que comprenden la administración de 1h-pirazol[4,3-b]piridinas. MX2020006174A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201700708 2017-12-14
PCT/EP2018/084432 WO2019115566A1 (en) 2017-12-14 2018-12-12 Combination treatments comprising administration of 1h-pyrazolo[4,3-b]pyridines

Publications (1)

Publication Number Publication Date
MX2020006174A true MX2020006174A (es) 2022-09-27

Family

ID=64959282

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006174A MX2020006174A (es) 2017-12-14 2018-12-12 Tratamientos de combinación que comprenden la administración de 1h-pirazol[4,3-b]piridinas.

Country Status (26)

Country Link
US (1) US11634416B2 (es)
EP (1) EP3723807B1 (es)
JP (1) JP7261801B2 (es)
KR (1) KR20200099154A (es)
CN (1) CN111465410B (es)
AR (1) AR113931A1 (es)
AU (1) AU2018385453B2 (es)
BR (1) BR112019016815A2 (es)
CA (1) CA3085201A1 (es)
CL (1) CL2020001548A1 (es)
CO (1) CO2020007129A2 (es)
CY (1) CY1124751T1 (es)
ES (1) ES2899868T3 (es)
HR (1) HRP20211784T1 (es)
HU (1) HUE057202T2 (es)
IL (1) IL275290B2 (es)
LT (1) LT3723807T (es)
MX (1) MX2020006174A (es)
PL (1) PL3723807T3 (es)
PT (1) PT3723807T (es)
RS (1) RS62551B1 (es)
RU (1) RU2020118913A (es)
SG (1) SG11202005361RA (es)
SI (1) SI3723807T1 (es)
WO (1) WO2019115566A1 (es)
ZA (1) ZA202003514B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
HUE057202T2 (hu) 2017-12-14 2022-04-28 H Lundbeck As Kombinációs kezelések 1H-pirazolo[4,3-b]piridinek alkalmazásával
CN111511742B (zh) 2017-12-20 2023-10-27 H.隆德贝克有限公司 作为PDE1抑制剂的吡唑并[4,3-b]吡啶和咪唑并[1,5-a]嘧啶

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Also Published As

Publication number Publication date
SG11202005361RA (en) 2020-07-29
ZA202003514B (en) 2022-12-21
BR112019016815A2 (pt) 2020-04-07
JP2021506775A (ja) 2021-02-22
SI3723807T1 (sl) 2022-01-31
US11634416B2 (en) 2023-04-25
ES2899868T3 (es) 2022-03-15
HUE057202T2 (hu) 2022-04-28
EP3723807B1 (en) 2021-10-20
US20200385381A1 (en) 2020-12-10
JP7261801B2 (ja) 2023-04-20
AU2018385453A1 (en) 2020-07-02
PT3723807T (pt) 2021-11-26
CN111465410B (zh) 2022-10-25
AR113931A1 (es) 2020-07-01
IL275290B2 (en) 2023-06-01
CA3085201A1 (en) 2019-06-20
CY1124751T1 (el) 2022-07-22
IL275290A (en) 2020-07-30
EP3723807A1 (en) 2020-10-21
RU2020118913A (ru) 2022-01-14
LT3723807T (lt) 2021-12-10
CN111465410A (zh) 2020-07-28
KR20200099154A (ko) 2020-08-21
CL2020001548A1 (es) 2020-09-25
PL3723807T3 (pl) 2022-01-24
WO2019115566A1 (en) 2019-06-20
AU2018385453B2 (en) 2024-02-08
RS62551B1 (sr) 2021-12-31
CO2020007129A2 (es) 2020-06-19
HRP20211784T1 (hr) 2022-02-18

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