MX2020006586A - Metodos para potenciar la eliminacion de impurezas durante una cromatografia con proteina a. - Google Patents
Metodos para potenciar la eliminacion de impurezas durante una cromatografia con proteina a.Info
- Publication number
- MX2020006586A MX2020006586A MX2020006586A MX2020006586A MX2020006586A MX 2020006586 A MX2020006586 A MX 2020006586A MX 2020006586 A MX2020006586 A MX 2020006586A MX 2020006586 A MX2020006586 A MX 2020006586A MX 2020006586 A MX2020006586 A MX 2020006586A
- Authority
- MX
- Mexico
- Prior art keywords
- chromatography
- methods
- during protein
- impurities during
- enhanced removal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
En la presente se proporcionan métodos relacionados con la purificación de un polipéptido que comprende una región Fc (por ejemplo, un anticuerpo) a través de una cromatografía con proteína A; métodos relacionados con el uso de una disolución de lavado que comprende una sal benzoato y/o alcohol bencílico durante una cromatografía con proteína A; y métodos para ajustar una cosecha usando benzoato de sodio antes de una cromatografía con proteína A.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762609214P | 2017-12-21 | 2017-12-21 | |
| US201862694387P | 2018-07-05 | 2018-07-05 | |
| PCT/US2018/066890 WO2019126554A1 (en) | 2017-12-21 | 2018-12-20 | Methods for enhanced removal of impurities during protein a chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020006586A true MX2020006586A (es) | 2020-10-08 |
Family
ID=65241305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020006586A MX2020006586A (es) | 2017-12-21 | 2018-12-20 | Metodos para potenciar la eliminacion de impurezas durante una cromatografia con proteina a. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11236126B2 (es) |
| EP (2) | EP3728288B1 (es) |
| JP (2) | JP2021506925A (es) |
| KR (1) | KR20200103740A (es) |
| CN (2) | CN118496346A (es) |
| AU (1) | AU2018392697A1 (es) |
| BR (1) | BR112020012165A2 (es) |
| CA (1) | CA3086186A1 (es) |
| CY (1) | CY1125448T1 (es) |
| DK (1) | DK3728288T3 (es) |
| ES (1) | ES2907744T3 (es) |
| HU (1) | HUE057850T2 (es) |
| IL (2) | IL311002A (es) |
| MX (1) | MX2020006586A (es) |
| SG (1) | SG11202005809TA (es) |
| TW (2) | TW202400623A (es) |
| WO (1) | WO2019126554A1 (es) |
| ZA (1) | ZA202003440B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220314142A1 (en) * | 2019-07-01 | 2022-10-06 | Pfizer Inc. | Improvements to wash solutions for protein a chromatography in an antibody purification process |
| CN112827217A (zh) * | 2020-12-29 | 2021-05-25 | 苏州良辰生物医药科技有限公司 | 一种层析柱清洗液及其应用 |
| WO2024017826A2 (en) * | 2022-07-19 | 2024-01-25 | Glaxosmithkline Intellectual Property Development Limited | Methods for purifying recombinant polypeptides |
| CN115894604B (zh) * | 2022-12-16 | 2024-01-23 | 康日百奥生物科技(苏州)有限公司 | 重组蛋白澄清纯化方法 |
| EP4438614A1 (en) * | 2023-03-31 | 2024-10-02 | Sanofi | Methods for purifying heteromultimeric antibodies |
| CN116474744A (zh) * | 2023-05-19 | 2023-07-25 | 荆楚理工学院 | 一种多孔吸附剂及其制备方法及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4871667A (en) * | 1984-11-26 | 1989-10-03 | Agency Of Industrial Science & Technology | Process for preparing muconic acid |
| US5750402A (en) * | 1995-06-02 | 1998-05-12 | Plant Cell Technology, Inc. | Compositions and methods to prevent microbial contamination of plant tissue culture media |
| NZ562949A (en) * | 2005-04-11 | 2009-05-31 | Medarex Inc | Protein purification using HCIC and ion exchange chromatography |
| JP2006343214A (ja) * | 2005-06-09 | 2006-12-21 | Matsushita Electric Ind Co Ltd | 免疫反応測定方法及びそれに用いる免疫反応測定用試薬 |
| CA2636109A1 (en) * | 2006-01-06 | 2007-07-19 | Amgen Inc. | Methods and systems for isolating target molecules from complex solutions by column-chromatography using eluants containing organic solvents |
| MX2011004200A (es) * | 2008-10-20 | 2011-05-24 | Abbott Lab | Aislamento y purificacion de anticuerpos usando la cromatografia de afinidad de proteina a. |
| NZ597809A (en) * | 2009-08-06 | 2014-05-30 | Genentech Inc | Method to improve virus removal in protein purification |
| SG10201408384PA (en) * | 2009-12-18 | 2015-01-29 | Novartis Ag | Wash solution and method for affinity chromatography |
| US20120264920A1 (en) * | 2010-10-11 | 2012-10-18 | Abbott Laboratories | Processes for purification of proteins |
| MX339533B (es) * | 2011-05-27 | 2016-05-30 | Abbvie Biotechnology Ltd | Composiciones y metodos de daclizumab (dac) del proceso de alto rendimiento (hyp). |
| EP3041857B1 (en) * | 2013-09-04 | 2019-05-08 | EMD Millipore Corporation | Protein a chromatography |
| US20170066839A1 (en) * | 2015-09-08 | 2017-03-09 | Merck Patent Gmbh | Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies |
-
2018
- 2018-12-20 DK DK18842505.2T patent/DK3728288T3/da active
- 2018-12-20 SG SG11202005809TA patent/SG11202005809TA/en unknown
- 2018-12-20 CA CA3086186A patent/CA3086186A1/en active Pending
- 2018-12-20 HU HUE18842505A patent/HUE057850T2/hu unknown
- 2018-12-20 ES ES18842505T patent/ES2907744T3/es active Active
- 2018-12-20 BR BR112020012165-7A patent/BR112020012165A2/pt unknown
- 2018-12-20 CN CN202410679387.1A patent/CN118496346A/zh active Pending
- 2018-12-20 WO PCT/US2018/066890 patent/WO2019126554A1/en unknown
- 2018-12-20 AU AU2018392697A patent/AU2018392697A1/en active Pending
- 2018-12-20 EP EP18842505.2A patent/EP3728288B1/en active Active
- 2018-12-20 IL IL311002A patent/IL311002A/en unknown
- 2018-12-20 IL IL275418A patent/IL275418B2/en unknown
- 2018-12-20 MX MX2020006586A patent/MX2020006586A/es unknown
- 2018-12-20 EP EP21217361.1A patent/EP4050016A1/en active Pending
- 2018-12-20 CN CN201880089518.3A patent/CN111712510B/zh active Active
- 2018-12-20 KR KR1020207020808A patent/KR20200103740A/ko active IP Right Grant
- 2018-12-20 JP JP2020534539A patent/JP2021506925A/ja active Pending
- 2018-12-20 US US16/228,291 patent/US11236126B2/en active Active
- 2018-12-21 TW TW112133254A patent/TW202400623A/zh unknown
- 2018-12-21 TW TW107146337A patent/TWI815838B/zh active
-
2020
- 2020-06-09 ZA ZA2020/03440A patent/ZA202003440B/en unknown
-
2021
- 2021-12-17 US US17/554,758 patent/US20220242902A1/en active Pending
-
2022
- 2022-03-29 CY CY20221100241T patent/CY1125448T1/el unknown
-
2023
- 2023-08-04 JP JP2023127480A patent/JP2023145727A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2020123917A3 (es) | 2022-01-26 |
| IL275418B2 (en) | 2024-07-01 |
| US11236126B2 (en) | 2022-02-01 |
| US20190233468A1 (en) | 2019-08-01 |
| CN111712510B (zh) | 2024-06-14 |
| IL275418A (en) | 2020-08-31 |
| HUE057850T2 (hu) | 2022-06-28 |
| JP2023145727A (ja) | 2023-10-11 |
| CY1125448T1 (el) | 2024-02-16 |
| IL311002A (en) | 2024-04-01 |
| JP2021506925A (ja) | 2021-02-22 |
| KR20200103740A (ko) | 2020-09-02 |
| CA3086186A1 (en) | 2019-06-27 |
| IL275418B1 (en) | 2024-03-01 |
| TW201936629A (zh) | 2019-09-16 |
| ES2907744T3 (es) | 2022-04-26 |
| ZA202003440B (en) | 2021-10-27 |
| SG11202005809TA (en) | 2020-07-29 |
| DK3728288T3 (da) | 2022-03-28 |
| TWI815838B (zh) | 2023-09-21 |
| US20220242902A1 (en) | 2022-08-04 |
| CN118496346A (zh) | 2024-08-16 |
| BR112020012165A2 (pt) | 2020-11-24 |
| EP3728288B1 (en) | 2022-01-19 |
| EP3728288A1 (en) | 2020-10-28 |
| RU2020123917A (ru) | 2022-01-26 |
| EP4050016A1 (en) | 2022-08-31 |
| TW202400623A (zh) | 2024-01-01 |
| AU2018392697A1 (en) | 2020-08-06 |
| CN111712510A (zh) | 2020-09-25 |
| WO2019126554A1 (en) | 2019-06-27 |
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