MX2020005437A - Preparacion en polvo para administracion nasal. - Google Patents
Preparacion en polvo para administracion nasal.Info
- Publication number
- MX2020005437A MX2020005437A MX2020005437A MX2020005437A MX2020005437A MX 2020005437 A MX2020005437 A MX 2020005437A MX 2020005437 A MX2020005437 A MX 2020005437A MX 2020005437 A MX2020005437 A MX 2020005437A MX 2020005437 A MX2020005437 A MX 2020005437A
- Authority
- MX
- Mexico
- Prior art keywords
- nasal administration
- powder preparation
- steroid hormone
- water
- particulate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se prepara una preparación en polvo para administración nasal que contiene un particulado de hormonas esteroides que tiene un tamaño de partícula promedio de 50 a 300 µm como un ingrediente activo. La preparación en polvo para administración nasal puede contener además un polímero hidrosoluble (particularmente, polisacáridos hidrosolubles, tales como una celulosa que tiene un grupo hidroxialquilo). El particulado de hormonas esteroides puede ser testosterona y/o un derivado del mismo. El polímero hidrosoluble puede estar en forma particulada. La proporción del polímero hidrosoluble puede ser de aproximadamente 1 a 50 partes en peso con respecto a 1 parte en peso de las partículas de hormonas esteroides. La preparación en polvo para administración nasal puede ser una preparación en polvo para administración nasal que puede controlar una Cmáx de hormonas esteroides en no más de 15 ng/mL. Se proporciona una preparación en polvo para administración nasal que puede controlar una concentración plasmática de hormonas esteroides tal como testosterona en un intervalo específico durante un largo período de tiempo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017227133 | 2017-11-27 | ||
PCT/JP2018/043233 WO2019103108A1 (ja) | 2017-11-27 | 2018-11-22 | 粉末経鼻投与製剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020005437A true MX2020005437A (es) | 2020-08-27 |
Family
ID=66631034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020005437A MX2020005437A (es) | 2017-11-27 | 2018-11-22 | Preparacion en polvo para administracion nasal. |
Country Status (10)
Country | Link |
---|---|
US (2) | US11234928B2 (es) |
EP (1) | EP3718550A4 (es) |
JP (2) | JP7321096B2 (es) |
KR (1) | KR20200092985A (es) |
CN (1) | CN111386119A (es) |
AU (1) | AU2018371435B2 (es) |
CA (1) | CA3083757A1 (es) |
MX (1) | MX2020005437A (es) |
TW (1) | TWI797202B (es) |
WO (1) | WO2019103108A1 (es) |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0187433B1 (en) * | 1983-08-01 | 1990-12-27 | Teijin Limited | Powdery pharmaceutical composition suitable for application to mucosa of oral or nasal cavity |
JPS60224616A (ja) * | 1984-04-24 | 1985-11-09 | Teijin Ltd | 経鼻投与用組成物 |
JPS6242888A (ja) | 1985-08-21 | 1987-02-24 | カシオ計算機株式会社 | 太陽電池を備えたicカ−ド |
ATE247456T1 (de) * | 1996-02-27 | 2003-09-15 | Teijin Ltd | Puderförmige zusammensetzung zur nasalen anwendung |
JP3197221B2 (ja) | 1996-02-27 | 2001-08-13 | 帝人株式会社 | 吸収性が改善された粉末状経鼻投与組成物 |
JP3197222B2 (ja) | 1996-02-28 | 2001-08-13 | 帝人株式会社 | 粉末状経鼻投与組成物 |
JP3197223B2 (ja) * | 1996-02-28 | 2001-08-13 | 帝人株式会社 | 即効性と持続性を兼ね備えた粉末状経鼻投与用組成物 |
JP3386349B2 (ja) | 1997-10-30 | 2003-03-17 | 帝人株式会社 | 水性懸濁医薬品組成物 |
JP4266399B2 (ja) * | 1997-12-04 | 2009-05-20 | 帝人株式会社 | 粉末状吸入用医薬品組成物 |
PT1025859E (pt) | 1998-08-26 | 2006-10-31 | Teijin Ltd | Formulacoes em po para administracao por via nasal |
JP2001002589A (ja) * | 1999-06-18 | 2001-01-09 | Teijin Ltd | 穏やかな薬物血中濃度の上昇を可能とする経鼻投与用組成物 |
JP2002128704A (ja) * | 2000-10-18 | 2002-05-09 | Dotto:Kk | 経鼻投与用組成物 |
WO2004043434A1 (en) * | 2002-11-14 | 2004-05-27 | Shear/Kershman Laboratories, Inc. | Oral testosterone delivery system with improved sustained release |
ATE319426T1 (de) | 2003-11-11 | 2006-03-15 | Mattern Udo | Nasenformulierung mit kontrollierter freisetzung von sexualhormonen |
JP2007001926A (ja) * | 2005-06-24 | 2007-01-11 | Ltt Bio-Pharma Co Ltd | 吸入・噴霧用ステロイド製剤 |
WO2007070851A2 (en) * | 2005-12-15 | 2007-06-21 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration |
SG10201401712QA (en) | 2009-04-24 | 2014-08-28 | Iceutica Pty Ltd | Method for the production of commercial nanoparticle and microparticle powders |
EP2429495A4 (en) | 2009-05-15 | 2014-01-22 | Shin Nippon Biomedical Lab Ltd | INTRANASAL PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PHARMACOKINETICS |
AU2012223245A1 (en) | 2011-03-03 | 2013-09-19 | Allergan, Inc. | Non-aqueous silicone-based ophthalmic formulations |
KR20210135003A (ko) * | 2011-05-15 | 2021-11-11 | 에이세러스 바이오파마 인크. | 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도 |
WO2014144366A1 (en) * | 2013-03-15 | 2014-09-18 | Monosol Rx, Llc. | Steroid hormone delivery systems and methods of preparing the same |
-
2018
- 2018-11-22 KR KR1020207017197A patent/KR20200092985A/ko not_active Application Discontinuation
- 2018-11-22 EP EP18882058.3A patent/EP3718550A4/en active Pending
- 2018-11-22 JP JP2019555371A patent/JP7321096B2/ja active Active
- 2018-11-22 MX MX2020005437A patent/MX2020005437A/es unknown
- 2018-11-22 CA CA3083757A patent/CA3083757A1/en active Pending
- 2018-11-22 CN CN201880076209.2A patent/CN111386119A/zh active Pending
- 2018-11-22 US US16/760,075 patent/US11234928B2/en active Active
- 2018-11-22 WO PCT/JP2018/043233 patent/WO2019103108A1/ja active Application Filing
- 2018-11-22 AU AU2018371435A patent/AU2018371435B2/en active Active
- 2018-11-27 TW TW107142253A patent/TWI797202B/zh active
-
2021
- 2021-12-20 US US17/556,354 patent/US11752102B2/en active Active
-
2023
- 2023-02-03 JP JP2023015215A patent/JP7470221B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
AU2018371435A2 (en) | 2020-07-16 |
JP2023041903A (ja) | 2023-03-24 |
CA3083757A1 (en) | 2019-05-31 |
TWI797202B (zh) | 2023-04-01 |
JP7470221B2 (ja) | 2024-04-17 |
AU2018371435A1 (en) | 2020-07-09 |
JPWO2019103108A1 (ja) | 2020-11-19 |
US11752102B2 (en) | 2023-09-12 |
EP3718550A1 (en) | 2020-10-07 |
EP3718550A4 (en) | 2021-08-25 |
CN111386119A (zh) | 2020-07-07 |
WO2019103108A1 (ja) | 2019-05-31 |
US20200360274A1 (en) | 2020-11-19 |
KR20200092985A (ko) | 2020-08-04 |
US20220125716A1 (en) | 2022-04-28 |
US11234928B2 (en) | 2022-02-01 |
AU2018371435B2 (en) | 2023-12-14 |
JP7321096B2 (ja) | 2023-08-04 |
TW201924660A (zh) | 2019-07-01 |
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