MX2019015155A - Modelo de raton para valorar toxicidades asociadas con inmunoterapias. - Google Patents

Modelo de raton para valorar toxicidades asociadas con inmunoterapias.

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Publication number
MX2019015155A
MX2019015155A MX2019015155A MX2019015155A MX2019015155A MX 2019015155 A MX2019015155 A MX 2019015155A MX 2019015155 A MX2019015155 A MX 2019015155A MX 2019015155 A MX2019015155 A MX 2019015155A MX 2019015155 A MX2019015155 A MX 2019015155A
Authority
MX
Mexico
Prior art keywords
mouse model
assessing
immunotherapy
immunotherapies
cell therapy
Prior art date
Application number
MX2019015155A
Other languages
English (en)
Inventor
Yue Jiang
Hyam I Levitsky
Ruth Amanda Salmon
Ronald James Hause Jr
Eric Martin Chadwick
Rafael Angel Ponce
Nels Eric Olson
Original Assignee
Juno Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2019015155A publication Critical patent/MX2019015155A/es

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
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    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
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    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K2239/47—Brain; Nervous system
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2750/14011—Parvoviridae
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Abstract

En la presente se proporciona un modelo, en particular un modelo de ratón, para valorar o evaluar toxicidad a una inmunoterapia, por ejemplo, una terapia celular terapéutica, tal como una terapia celular que contiene células modificadas, tal como células T, que expresan un receptor recombinante, por ejemplo un receptor de antígeno quimérico (CAR). También se proporciona un método para generar el modelo de ratón. También en la presente se proporcionan métodos de uso de los modelos de ratón en toxicidades, tal como para evaluar inmunoterapias modificadas o alternativas, y/o para evaluar agentes de prueba, incluyendo agentes a valorar como potenciales intervenciones para reducir, prevenir o mejorar la toxicidad a inmunoterapia en sujetos humanos y/o para uso en combinación con una inmunoterapia, por ejemplo, terapia de células T-CAR.
MX2019015155A 2017-06-29 2018-06-29 Modelo de raton para valorar toxicidades asociadas con inmunoterapias. MX2019015155A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762527030P 2017-06-29 2017-06-29
US201762563635P 2017-09-26 2017-09-26
US201762584731P 2017-11-10 2017-11-10
PCT/US2018/040497 WO2019006427A1 (en) 2017-06-29 2018-06-29 WALL MODEL FOR ASSESSING TOXICITIES ASSOCIATED WITH IMMUNOTHERAPIES

Publications (1)

Publication Number Publication Date
MX2019015155A true MX2019015155A (es) 2020-08-03

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MX2019015155A MX2019015155A (es) 2017-06-29 2018-06-29 Modelo de raton para valorar toxicidades asociadas con inmunoterapias.

Country Status (8)

Country Link
US (1) US20220225597A1 (es)
EP (1) EP3644721A1 (es)
JP (1) JP2020526194A (es)
CN (1) CN111050545A (es)
AU (1) AU2018291032A1 (es)
CA (1) CA3067602A1 (es)
MX (1) MX2019015155A (es)
WO (1) WO2019006427A1 (es)

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WO2021028469A1 (en) * 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
CN110692599A (zh) * 2019-11-21 2020-01-17 复旦大学附属中山医院 一种胸腹主动脉瘤小鼠模型的制备方法
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CN113215253B (zh) * 2020-06-05 2022-10-25 冠科生物技术(苏州)有限公司 用于评估鼠类肿瘤模型中的免疫反应的方法和组合物
RU2759487C1 (ru) * 2021-04-22 2021-11-15 федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии» Министерства здравоохранения Российской Федерации Способ усиления роста меланомы В16/F10 по сравнению с ростом меланомы В16/F10 при самостоятельной перевивке и замедления роста LLC (карциномы Льюиса) по сравнению с ростом LLC при самостоятельной перевивке при первично-множественных злокачественных опухолях на фоне первичного иммунодефицита
US20240033269A1 (en) * 2022-07-28 2024-02-01 Px Ing, Llc Pparaxanthine-based compositions for inhibiting inflammation, improving joint health, and enhancing immune function
WO2024065083A1 (zh) * 2022-09-26 2024-04-04 成都优洛生物科技有限公司 一种非鼠类哺乳动物IL-1α抗体的体内药效检测方法
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